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Items: 1 to 50 of 86

1.

Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.

Sorensen AB, Tuneew I, Svensson LA, Persson E, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS.

J Biol Chem. 2020 Jan 10;295(2):517-528. doi: 10.1074/jbc.RA119.009183. Epub 2019 Dec 4.

PMID:
31801825
2.

Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.

Sorensen AB, Madsen JJ, Frimurer TM, Overgaard MT, Gandhi PS, Persson E, Olsen OH.

Biophys J. 2019 May 21;116(10):1823-1835. doi: 10.1016/j.bpj.2019.03.024. Epub 2019 Apr 2.

PMID:
31003762
3.

Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: comment.

Madsen JJ, Persson E, Olsen OH.

J Thromb Haemost. 2018 Jul;16(7):1450-1454. doi: 10.1111/jth.14142. Epub 2018 Jun 6. No abstract available.

PMID:
29733494
4.

Engineering of a membrane-triggered activity switch in coagulation factor VIIa.

Nielsen AL, Sorensen AB, Holmberg HL, Gandhi PS, Karlsson J, Buchardt J, Lamberth K, Kjelgaard-Hansen M, Ley CD, Sørensen BB, Ruf W, Olsen OH, Østergaard H.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12454-12459. doi: 10.1073/pnas.1618713114. Epub 2017 Nov 6.

5.

Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.

Kristensen LH, Olsen OH, Blouse GE, Brandstetter H.

Biochem J. 2016 Aug 1;473(15):2395-411. doi: 10.1042/BCJ20160336. Epub 2016 May 19.

PMID:
27208168
6.

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.

Sorensen AB, Madsen JJ, Svensson LA, Pedersen AA, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS.

J Biol Chem. 2016 Feb 26;291(9):4671-83. doi: 10.1074/jbc.M115.698613. Epub 2015 Dec 22.

7.

Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail.

Madsen JJ, Ohkubo YZ, Peters GH, Faber JH, Tajkhorshid E, Olsen OH.

Biochemistry. 2015 Oct 6;54(39):6123-31. doi: 10.1021/acs.biochem.5b00417. Epub 2015 Sep 30.

8.

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.

van den Biggelaar M, Madsen JJ, Faber JH, Zuurveld MG, van der Zwaan C, Olsen OH, Stennicke HR, Mertens K, Meijer AB.

J Biol Chem. 2015 Jul 3;290(27):16463-76. doi: 10.1074/jbc.M115.650911. Epub 2015 Apr 21.

9.

Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.

Lund J, Troeberg L, Kjeldal H, Olsen OH, Nagase H, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT.

J Biol Chem. 2015 Mar 6;290(10):6620-9. doi: 10.1074/jbc.M114.601724. Epub 2015 Jan 6.

10.

Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes.

Madsen JJ, Persson E, Olsen OH.

J Thromb Haemost. 2015 Feb;13(2):262-7. doi: 10.1111/jth.12791. Epub 2014 Dec 12.

11.
12.

The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor.

Persson E, Madsen JJ, Olsen OH.

Protein Sci. 2014 Dec;23(12):1717-27. doi: 10.1002/pro.2553. Epub 2014 Oct 14.

13.

ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity.

Lund J, Olsen OH, Sørensen ES, Stennicke HR, Petersen HH, Overgaard MT.

J Biol Chem. 2013 Jul 19;288(29):21367-75. doi: 10.1074/jbc.M113.474536. Epub 2013 Jun 10.

14.

Evaluation of the metal binding sites in a recombinant coagulation factor VIII identifies two sites with unique metal binding properties.

Svensson LA, Thim L, Olsen OH, Nicolaisen EM.

Biol Chem. 2013 Jun;394(6):761-5. doi: 10.1515/hsz-2012-0298.

PMID:
23435097
15.

Vatreptacog alfa from conception to clinical proof of concept.

Persson E, Olsen OH, Bjørn SE, Ezban M.

Semin Thromb Hemost. 2012 Apr;38(3):274-81. doi: 10.1055/s-0032-1302442. Epub 2012 Feb 18. Review.

PMID:
22510860
16.

Tissue factor and factor VIIa cross-species compatibility.

Knudsen T, Olsen OH, Petersen LC.

Front Biosci (Landmark Ed). 2011 Jun 1;16:3196-215. Review.

PMID:
21622229
17.

Allosteric activation of coagulation factor VIIa.

Persson E, Olsen OH.

Front Biosci (Landmark Ed). 2011 Jun 1;16:3156-63. Review.

PMID:
21622226
18.

Characterization of canine coagulation factor VII and its complex formation with tissue factor: canine-human cross-species compatibility.

Knudsen T, Kristensen AT, Sørensen BB, Olsen OH, Stennicke HR, Petersen LC.

J Thromb Haemost. 2010 Aug;8(8):1763-72. doi: 10.1111/j.1538-7836.2010.03931.x. Epub 2010 May 27.

19.

Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.

Larsen KS, Ostergaard H, Olsen OH, Bjelke JR, Ruf W, Petersen LC.

J Biol Chem. 2010 Jun 25;285(26):19959-66. doi: 10.1074/jbc.M110.101030. Epub 2010 Apr 13.

20.

Current status on tissue factor activation of factor VIIa.

Persson E, Olsen OH.

Thromb Res. 2010 Apr;125 Suppl 1:S11-2. doi: 10.1016/j.thromres.2010.01.023. Epub 2010 Feb 13. Review.

PMID:
20153879
21.

Coagulation factor XIII variants with altered thrombin activation rates.

Andersen MD, Kjalke M, Bang S, Lautrup-Larsen I, Becker P, Andersen AS, Olsen OH, Stennicke HR.

Biol Chem. 2009 Dec;390(12):1279-83. doi: 10.1515/BC.2009.142.

PMID:
19804366
22.

Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa.

Persson E, Olsen OH.

FEBS J. 2009 Jun;276(11):3099-109. doi: 10.1111/j.1742-4658.2009.07028.x. Epub 2009 Apr 23.

23.

Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity.

Bjelke JR, Olsen OH, Fodje M, Svensson LA, Bang S, Bolt G, Kragelund BB, Persson E.

J Biol Chem. 2008 Sep 19;283(38):25863-70. doi: 10.1074/jbc.M800841200. Epub 2008 Jul 17.

24.

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.

Rand KD, Andersen MD, Olsen OH, Jørgensen TJ, Ostergaard H, Jensen ON, Stennicke HR, Persson E.

J Biol Chem. 2008 May 9;283(19):13378-87. doi: 10.1074/jbc.M709716200. Epub 2008 Mar 14.

25.

Cofactor-induced and mutational activity enhancement of coagulation factor VIIa.

Olsen OH, Persson E.

Cell Mol Life Sci. 2008 Mar;65(6):953-63. Review.

PMID:
18066494
26.

Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa.

Larsen KS, Østergaard H, Bjelke JR, Olsen OH, Rasmussen HB, Christensen L, Kragelund BB, Stennicke HR.

Biochem J. 2007 Aug 1;405(3):429-38.

27.
28.

A loop of coagulation factor VIIa influencing macromolecular substrate specificity.

Bjelke JR, Persson E, Rasmussen HB, Kragelund BB, Olsen OH.

FEBS Lett. 2007 Jan 9;581(1):71-6. Epub 2006 Dec 11.

29.

Computational study of coagulation factor VIIa's affinity for phospholipid membranes.

Taboureau O, Olsen OH.

Eur Biophys J. 2007 Feb;36(2):133-44. Epub 2006 Nov 28.

PMID:
17131117
30.

Design of novispirin antimicrobial peptides by quantitative structure-activity relationship.

Taboureau O, Olsen OH, Nielsen JD, Raventos D, Mygind PH, Kristensen HH.

Chem Biol Drug Des. 2006 Jul;68(1):48-57.

PMID:
16923026
31.

Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange.

Rand KD, Jørgensen TJ, Olsen OH, Persson E, Jensen ON, Stennicke HR, Andersen MD.

J Biol Chem. 2006 Aug 11;281(32):23018-24. Epub 2006 May 10.

32.
33.

Aquatic leech infestation: a rare cause of severe anaemia in an adolescent Tanzanian girl.

Krüger C, Malleyeck I, Olsen OH.

Eur J Pediatr. 2004 Jun;163(6):297-9.

PMID:
15346909
34.

Residue 259 in protein-tyrosine phosphatase PTP1B and PTPalpha determines the flexibility of glutamine 262.

Peters GH, Iversen LF, Andersen HS, Møller NP, Olsen OH.

Biochemistry. 2004 Jul 6;43(26):8418-28.

PMID:
15222753
35.

Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta.

Lund IK, Andersen HS, Iversen LF, Olsen OH, Møller KB, Pedersen AK, Ge Y, Holsworth DD, Newman MJ, Axe FU, Møller NP.

J Biol Chem. 2004 Jun 4;279(23):24226-35. Epub 2004 Mar 15.

36.
38.

Inequities among the very poor: effect of young age on care-seeking.

Krüger C, Olsen OH.

Lancet. 2003 May 17;361(9370):1744-5. No abstract available.

PMID:
12767764
39.

Ligand-induced conformational changes: improved predictions of ligand binding conformations and affinities.

Frimurer TM, Peters GH, Iversen LF, Andersen HS, Møller NP, Olsen OH.

Biophys J. 2003 Apr;84(4):2273-81.

40.

Causes and characteristics of maternal deaths in rural northern Tanzania.

Olsen BE, Hinderaker SG, Bergsjø P, Lie RT, Olsen OH, Gasheka P, Kvåle G.

Acta Obstet Gynecol Scand. 2002 Dec;81(12):1101-9.

PMID:
12519105
41.
42.

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

Andersen HS, Olsen OH, Iversen LF, Sørensen AL, Mortensen SB, Christensen MS, Branner S, Hansen TK, Lau JF, Jeppesen L, Moran EJ, Su J, Bakir F, Judge L, Shahbaz M, Collins T, Vo T, Newman MJ, Ripka WC, Møller NP.

J Med Chem. 2002 Sep 26;45(20):4443-59.

PMID:
12238924
43.

Low HIV-seroprevalence in pregnant women in a rural area in Tanzania.

Hinderaker SG, Krüger C, Olsen BE, Naman N, Bergsjø P, Olsen OH.

Acta Obstet Gynecol Scand. 2001 Dec;80(12):1152-3. No abstract available.

PMID:
11846719
44.

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.

Iversen LF, Andersen HS, Møller KB, Olsen OH, Peters GH, Branner S, Mortensen SB, Hansen TK, Lau J, Ge Y, Holsworth DD, Newman MJ, Hundahl Møller NP.

Biochemistry. 2001 Dec 11;40(49):14812-20.

PMID:
11732900
45.

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

Persson E, Kjalke M, Olsen OH.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13583-8. Epub 2001 Nov 6.

46.

Structural and evolutionary relationships among protein tyrosine phosphatase domains.

Andersen JN, Mortensen OH, Peters GH, Drake PG, Iversen LF, Olsen OH, Jansen PG, Andersen HS, Tonks NK, Møller NP.

Mol Cell Biol. 2001 Nov;21(21):7117-36. Review. No abstract available.

47.

A model of a segmental oscillator in the leech heartbeat neuronal network.

Hill AA, Lu J, Masino MA, Olsen OH, Calabrese RL.

J Comput Neurosci. 2001 May-Jun;10(3):281-302.

PMID:
11443286
48.

[Malaria epidemics in Tanzania].

Olsen OH.

Tidsskr Nor Laegeforen. 2001 Apr 20;121(10):1289. Norwegian. No abstract available.

49.

Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.

Persson E, Bak H, Olsen OH.

J Biol Chem. 2001 Aug 3;276(31):29195-9. Epub 2001 Jun 1.

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