Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 99

1.

Pharmacokinetic and pharmacodynamic considerations for NMDA-receptor antagonist ketamine in the treatment of chronic neuropathic pain: an update of the most recent literature.

Kamp J, Van Velzen M, Olofsen E, Boon M, Dahan A, Niesters M.

Expert Opin Drug Metab Toxicol. 2019 Nov 13:1-9. doi: 10.1080/17425255.2019.1689958. [Epub ahead of print]

PMID:
31693437
2.

Analgesic and Respiratory Depressant Effects of R-dihydroetorphine: A Pharmacokinetic-Pharmacodynamic Analysis in Healthy Male Volunteers.

Olofsen E, Boom M, Sarton E, van Velzen M, Baily P, Smith KJ, Oksche A, Dahan A, Niesters M.

Anesthesiology. 2019 Dec;131(6):1327-1339. doi: 10.1097/ALN.0000000000002991.

PMID:
31651529
3.

Does nociception monitor-guided anesthesia affect opioid consumption? A systematic review of randomized controlled trials.

Meijer FS, Niesters M, van Velzen M, Martini CH, Olofsen E, Edry R, Sessler DI, van Dorp ELA, Dahan A, Boon M.

J Clin Monit Comput. 2019 Jul 20. doi: 10.1007/s10877-019-00362-4. [Epub ahead of print] Review.

PMID:
31327102
4.

Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal.

Algera MH, Kamp J, van der Schrier R, van Velzen M, Niesters M, Aarts L, Dahan A, Olofsen E.

Br J Anaesth. 2019 Jun;122(6):e168-e179. doi: 10.1016/j.bja.2018.12.023. Epub 2019 Feb 1. Review.

PMID:
30915997
5.

Nociception-guided versus Standard Care during Remifentanil-Propofol Anesthesia: A Randomized Controlled Trial.

Meijer FS, Martini CH, Broens S, Boon M, Niesters M, Aarts L, Olofsen E, van Velzen M, Dahan A.

Anesthesiology. 2019 May;130(5):745-755. doi: 10.1097/ALN.0000000000002634.

PMID:
30829658
6.

Comparison of the TOF-Cuff® monitor with electromyography and acceleromyography during recovery from neuromuscular block.

Krijtenburg P, Honing G, Martini C, Olofsen E, van Elst HJ, Scheffer GJ, Dahan A, Keijzer C, Boon M.

Br J Anaesth. 2019 Feb;122(2):e22-e24. doi: 10.1016/j.bja.2018.11.011. Epub 2018 Dec 10. No abstract available.

PMID:
30686321
7.

Where's the Beef?: How Much Can We Skimp on Pharmacokinetic-Pharmacodynamic Data?

Henthorn TK, Olofsen E.

Anesthesiology. 2019 Feb;130(2):186-188. doi: 10.1097/ALN.0000000000002552. No abstract available.

PMID:
30589650
8.

An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia.

van de Donk T, Niesters M, Kowal MA, Olofsen E, Dahan A, van Velzen M.

Pain. 2019 Apr;160(4):860-869. doi: 10.1097/j.pain.0000000000001464.

9.

A Pragmatic Utility Function to Describe the Risk-Benefit Composite of Opioid and Nonopioid Analgesic Medication.

Olesen AE, Broens S, Olesen SS, Niesters M, van Velzen M, Drewes AM, Dahan A, Olofsen E.

J Pharmacol Exp Ther. 2019 Nov;371(2):416-421. doi: 10.1124/jpet.118.253716. Epub 2018 Nov 15.

PMID:
30442653
10.

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(-) Ketamine Concentrations.

Henthorn TK, Avram MJ, Dahan A, Gustafsson LL, Persson J, Krejcie TC, Olofsen E.

Anesthesiology. 2018 Aug;129(2):260-270. doi: 10.1097/ALN.0000000000002265.

PMID:
29771709
11.

Esketamine counters opioid-induced respiratory depression.

Jonkman K, van Rijnsoever E, Olofsen E, Aarts L, Sarton E, van Velzen M, Niesters M, Dahan A.

Br J Anaesth. 2018 May;120(5):1117-1127. doi: 10.1016/j.bja.2018.02.021. Epub 2018 Mar 26.

12.

Differential role of nitric oxide in the psychedelic symptoms induced by racemic ketamine and esketamine in human volunteers.

Jonkman K, van der Schrier R, van Velzen M, Aarts L, Olofsen E, Sarton E, Niesters M, Dahan A.

Br J Anaesth. 2018 May;120(5):1009-1018. doi: 10.1016/j.bja.2018.01.022. Epub 2018 Feb 27.

13.

Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression.

Roozekrans M, van der Schrier R, Aarts L, Sarton E, van Velzen M, Niesters M, Dahan A, Olofsen E.

Anesthesiology. 2018 May;128(5):932-942. doi: 10.1097/ALN.0000000000002138.

PMID:
29498950
14.

An experimental study comparing the respiratory effects of tapentadol and oxycodone in healthy volunteers.

van der Schrier R, Jonkman K, van Velzen M, Olofsen E, Drewes AM, Dahan A, Niesters M.

Br J Anaesth. 2017 Dec 1;119(6):1169-1177. doi: 10.1093/bja/aex295.

15.

Frequent respiratory events in postoperative patients aged 60 years and above.

Broens SJ, He X, Evley R, Olofsen E, Niesters M, Mahajan RP, Dahan A, van Velzen M.

Ther Clin Risk Manag. 2017 Aug 26;13:1091-1098. doi: 10.2147/TCRM.S135923. eCollection 2017.

16.

Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers.

Jonkman K, Duma A, Olofsen E, Henthorn T, van Velzen M, Mooren R, Siebers L, van den Beukel J, Aarts L, Niesters M, Dahan A.

Anesthesiology. 2017 Oct;127(4):675-683. doi: 10.1097/ALN.0000000000001798.

PMID:
28759464
17.

An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics.

Eleveld DJ, Proost JH, Vereecke H, Absalom AR, Olofsen E, Vuyk J, Struys MMRF.

Anesthesiology. 2017 Jun;126(6):1005-1018. doi: 10.1097/ALN.0000000000001634.

PMID:
28509794
18.

Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers.

Dahan A, Boom M, Sarton E, Hay J, Groeneveld GJ, Neukirchen M, Bothmer J, Aarts L, Olofsen E.

Anesthesiology. 2017 Apr;126(4):697-707. doi: 10.1097/ALN.0000000000001529.

PMID:
28291085
19.

Influence of Ethanol on Oxycodone-induced Respiratory Depression: A Dose-escalating Study in Young and Elderly Individuals.

van der Schrier R, Roozekrans M, Olofsen E, Aarts L, van Velzen M, de Jong M, Dahan A, Niesters M.

Anesthesiology. 2017 Mar;126(3):534-542. doi: 10.1097/ALN.0000000000001505.

PMID:
28170358
20.

Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers.

Roozekrans M, Olofsen E, van der Schrier R, Boom M, Mooren R, Dahan A.

Clin Pharmacol Ther. 2017 Jul;102(1):115-122. doi: 10.1002/cpt.601. Epub 2017 Mar 25.

PMID:
28001306
21.

Deep Neuromuscular Block Improves Surgical Conditions during Bariatric Surgery and Reduces Postoperative Pain: A Randomized Double Blind Controlled Trial.

Torensma B, Martini CH, Boon M, Olofsen E, In 't Veld B, Liem RS, Knook MT, Swank DJ, Dahan A.

PLoS One. 2016 Dec 9;11(12):e0167907. doi: 10.1371/journal.pone.0167907. eCollection 2016.

22.

High inspired oxygen concentration increases the speed of onset of remifentanil-induced respiratory depression.

Dahan A, Douma M, Olofsen E, Niesters M.

Br J Anaesth. 2016 Jun;116(6):879-80. doi: 10.1093/bja/aew130. No abstract available.

23.

Response: Limited sampling strategies for once daily tacrolimus exposure monitoring.

Moes DJ, Swen JJ, van der Bent SA, van der Straaten T, Inderson A, Olofsen E, Verspaget HW, Guchelaar HJ, den Hartigh J, van Hoek B.

Eur J Clin Pharmacol. 2016 Jun;72(6):775-6. doi: 10.1007/s00228-016-2036-y. Epub 2016 Mar 2. No abstract available.

PMID:
26931555
24.

Epidural Blockade Affects the Pharmacokinetics of Propofol in Surgical Patients.

Sitsen E, Olofsen E, Lesman A, Dahan A, Vuyk J.

Anesth Analg. 2016 May;122(5):1341-9. doi: 10.1213/ANE.0000000000001090.

PMID:
26649908
25.

Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients.

Moes DJ, van der Bent SA, Swen JJ, van der Straaten T, Inderson A, Olofsen E, Verspaget HW, Guchelaar HJ, den Hartigh J, van Hoek B.

Eur J Clin Pharmacol. 2016 Feb;72(2):163-74. doi: 10.1007/s00228-015-1963-3. Epub 2015 Oct 31.

26.

Stochastic Pharmacokinetic-Pharmacodynamic Analysis of the Effect of Transdermal Buprenorphine on Electroencephalogram and Analgesia.

Olesen AE, Olofsen E, Andresen T, Graversen C, Drewes AM, Dahan A.

Anesth Analg. 2015 Nov;121(5):1165-75. doi: 10.1213/ANE.0000000000000939.

PMID:
26372412
27.

Translation of random painful stimuli into numerical responses in fibromyalgia and perioperative patients.

Oudejans L, van Velzen M, Olofsen E, Beun R, Dahan A, Niesters M.

Pain. 2016 Jan;157(1):128-36. doi: 10.1097/j.pain.0000000000000338.

PMID:
26307857
28.

Effect of subanaesthetic ketamine on plasma and saliva cortisol secretion.

Khalili-Mahani N, Martini CH, Olofsen E, Dahan A, Niesters M.

Br J Anaesth. 2015 Jul;115(1):68-75. doi: 10.1093/bja/aev135. Epub 2015 May 16.

29.

Pharmacotherapy for pain: efficacy and safety issues examined by subgroup analyses.

Dahan A, Olofsen E, Niesters M.

Pain. 2015 Apr;156 Suppl 1:S119-26. doi: 10.1016/j.pain.0000000000000023. Review.

PMID:
25789429
30.

Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.

Roozekrans M, Olofsen E, van der Schrier R, van Gerven J, Peng S, McLeod J, Dahan A.

Clin Pharmacol Ther. 2015 Jun;97(6):641-9. doi: 10.1002/cpt.99. Epub 2015 May 2.

PMID:
25704491
31.

Big brain, small world?

Olofsen E, Dahan A.

Anesthesiology. 2015 Jan;122(1):8-11. doi: 10.1097/ALN.0000000000000517. No abstract available.

PMID:
25383570
32.

A randomized controlled trial and novel mathematical analysis of the analgesic effect of oxycodone versus paracetamol orodispersible tablets.

Martini CH, Proto P, Olofsen E, van Velzen M, Aarts L, Dahan A, Niesters M.

Eur J Pain. 2015 Mar;19(3):295-304. doi: 10.1002/ejp.546.

PMID:
24947675
33.

Improvements in the application and reporting of advanced Bland-Altman methods of comparison.

Olofsen E, Dahan A, Borsboom G, Drummond G.

J Clin Monit Comput. 2015 Feb;29(1):127-39. doi: 10.1007/s10877-014-9577-3. Epub 2014 May 8.

PMID:
24806333
34.

Fentanyl utility function: a risk-benefit composite of pain relief and breathing responses.

Boom M, Olofsen E, Neukirchen M, Fussen R, Hay J, Groeneveld GJ, Aarts L, Sarton E, Dahan A.

Anesthesiology. 2013 Sep;119(3):663-74. doi: 10.1097/ALN.0b013e31829ce4cb.

PMID:
23756452
35.

A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia.

Martini CH, Yassen A, Krebs-Brown A, Passier P, Stoker M, Olofsen E, Dahan A.

Eur J Pain. 2013 Nov;17(10):1491-501. doi: 10.1002/j.1532-2149.2013.00329.x. Epub 2013 May 6.

PMID:
23650124
36.

Using Akaike's information theoretic criterion in mixed-effects modeling of pharmacokinetic data: a simulation study.

Olofsen E, Dahan A.

Version 2. F1000Res. 2013 Mar 4 [revised 2014 Jan 1];2:71. doi: 10.12688/f1000research.2-71.v2. eCollection 2013.

37.

Validation of a novel respiratory rate monitor based on exhaled humidity.

Niesters M, Mahajan R, Olofsen E, Boom M, Garcia Del Valle S, Aarts L, Dahan A.

Br J Anaesth. 2012 Dec;109(6):981-9. doi: 10.1093/bja/aes275. Epub 2012 Aug 19.

38.

The absorption profile of pregabalin in chronic pancreatitis.

Olesen AE, Olofsen E, Olesen SS, Staahl C, Andresen T, Dahan A, Drewes AM.

Basic Clin Pharmacol Toxicol. 2012 Dec;111(6):385-90. doi: 10.1111/j.1742-7843.2012.00914.x. Epub 2012 Jul 11.

39.

Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers.

Olofsen E, Noppers I, Niesters M, Kharasch E, Aarts L, Sarton E, Dahan A.

Anesthesiology. 2012 Aug;117(2):353-64. doi: 10.1097/ALN.0b013e31825b6c91.

40.

The dose-dependent effect of S(+)-ketamine on cardiac output in healthy volunteers and complex regional pain syndrome type 1 chronic pain patients.

Olofsen E, Sigtermans M, Noppers I, Niesters M, Mooren R, Bauer M, Aarts L, Sarton E, Dahan A.

Anesth Analg. 2012 Sep;115(3):536-46. doi: 10.1213/ANE.0b013e31825496f6. Epub 2012 May 10.

PMID:
22575567
41.

Pharmacodynamic analysis of the analgesic effect of capsaicin 8% patch (Qutenza™) in diabetic neuropathic pain patients: detection of distinct response groups.

Martini C, Yassen A, Olofsen E, Passier P, Stoker M, Dahan A.

J Pain Res. 2012;5:51-9. doi: 10.2147/JPR.S30406. Epub 2012 Mar 15.

42.

Pharmacokinetic-pharmacodynamic modeling in acute and chronic pain: an overview of the recent literature.

Martini C, Olofsen E, Yassen A, Aarts L, Dahan A.

Expert Rev Clin Pharmacol. 2011 Nov;4(6):719-28. doi: 10.1586/ecp.11.59. Review.

PMID:
22111858
43.

Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.

Noppers I, Olofsen E, Niesters M, Aarts L, Mooren R, Dahan A, Kharasch E, Sarton E.

Anesthesiology. 2011 Jun;114(6):1435-45. doi: 10.1097/ALN.0b013e318218a881.

44.

Opioid chronopharmacology: influence of timing of infusion on fentanyl's analgesic efficacy in healthy human volunteers.

Boom M, Grefkens J, van Dorp E, Olofsen E, Lourenssen G, Aarts L, Dahan A, Sarton E.

J Pain Res. 2010 Sep 21;3:183-90. doi: 10.2147/JPR.S13616.

45.

Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain.

Dahan A, Olofsen E, Sigtermans M, Noppers I, Niesters M, Aarts L, Bauer M, Sarton E.

Eur J Pain. 2011 Mar;15(3):258-67. doi: 10.1016/j.ejpain.2010.06.016. Epub 2010 Jul 17.

PMID:
20638877
46.

Arterial and venous pharmacokinetics of morphine-6-glucuronide and impact of sample site on pharmacodynamic parameter estimates.

Olofsen E, Mooren R, van Dorp E, Aarts L, Smith T, den Hartigh J, Dahan A, Sarton E.

Anesth Analg. 2010 Sep;111(3):626-32. doi: 10.1213/ANE.0b013e3181e5e8af. Epub 2010 Jun 14.

PMID:
20547824
47.

Naloxone reversal of morphine- and morphine-6-glucuronide-induced respiratory depression in healthy volunteers: a mechanism-based pharmacokinetic-pharmacodynamic modeling study.

Olofsen E, van Dorp E, Teppema L, Aarts L, Smith TW, Dahan A, Sarton E.

Anesthesiology. 2010 Jun;112(6):1417-27. doi: 10.1097/ALN.0b013e3181d5e29d.

PMID:
20461002
48.

Modeling the non-steady state respiratory effects of remifentanil in awake and propofol-sedated healthy volunteers.

Olofsen E, Boom M, Nieuwenhuijs D, Sarton E, Teppema L, Aarts L, Dahan A.

Anesthesiology. 2010 Jun;112(6):1382-95. doi: 10.1097/ALN.0b013e3181d69087.

PMID:
20461001
49.

Propofol reduces the distribution and clearance of midazolam.

Lichtenbelt BJ, Olofsen E, Dahan A, van Kleef JW, Struys MM, Vuyk J.

Anesth Analg. 2010 Jun 1;110(6):1597-606. doi: 10.1213/ANE.0b013e3181da91bb. Epub 2010 Apr 30.

PMID:
20435936
50.

S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers.

Sigtermans M, Dahan A, Mooren R, Bauer M, Kest B, Sarton E, Olofsen E.

Anesthesiology. 2009 Oct;111(4):892-903. doi: 10.1097/ALN.0b013e3181b437b1.

PMID:
19741495

Supplemental Content

Loading ...
Support Center