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Items: 1 to 50 of 178

1.

Bis(monoacylglycero)phosphate regulates oxysterol binding protein-related protein 11 dependent sterol trafficking.

Arnal-Levron M, Chen Y, Greimel P, Calevro F, Gaget K, Riols F, Batut A, Bertrand-Michel J, Hullin-Matsuda F, Olkkonen VM, Delton I, Luquain-Costaz C.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep;1864(9):1247-1257. doi: 10.1016/j.bbalip.2019.05.011. Epub 2019 May 25.

PMID:
31136841
2.

Metabolomic Signature of Angiopoietin-Like Protein 3 Deficiency in Fasting and Postprandial State.

Tikkanen E, Minicocci I, Hällfors J, Di Costanzo A, D'Erasmo L, Poggiogalle E, Donini LM, Würtz P, Jauhiainen M, Olkkonen VM, Arca M.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):665-674. doi: 10.1161/ATVBAHA.118.312021.

PMID:
30816800
3.

ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.

Zhong W, Xu M, Li C, Zhu B, Cao X, Li D, Chen H, Hu C, Li R, Luo C, Pan G, Zhang W, Lai C, Wang T, Du X, Chen H, Xu G, Olkkonen VM, Lei P, Xu J, Yan D.

Cell Rep. 2019 Feb 19;26(8):2166-2177.e9. doi: 10.1016/j.celrep.2019.01.082.

4.

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2.

Pekkinen M, Terhal PA, Botto LD, Henning P, Mäkitie RE, Roschger P, Jain A, Kol M, Kjellberg MA, Paschalis EP, van Gassen K, Murray M, Bayrak-Toydemir P, Magnusson MK, Jans J, Kausar M, Carey JC, Somerharju P, Lerner UH, Olkkonen VM, Klaushofer K, Holthuis JC, Mäkitie O.

JCI Insight. 2019 Apr 4;4(7). pii: 126180. doi: 10.1172/jci.insight.126180. eCollection 2019 Apr 4.

5.

OSBP-related protein 2 (ORP2): Unraveling its functions in cellular lipid/carbohydrate metabolism, signaling and F-actin regulation.

Olkkonen VM, Koponen A, Arora A.

J Steroid Biochem Mol Biol. 2019 Feb 2. pii: S0960-0760(18)30769-6. doi: 10.1016/j.jsbmb.2019.01.016. [Epub ahead of print] Review.

PMID:
30716465
6.

Molecular determinants of ER-Golgi contacts identified through a new FRET-FLIM system.

Venditti R, Rega LR, Masone MC, Santoro M, Polishchuk E, Sarnataro D, Paladino S, D'Auria S, Varriale A, Olkkonen VM, Di Tullio G, Polishchuk R, De Matteis MA.

J Cell Biol. 2019 Mar 4;218(3):1055-1065. doi: 10.1083/jcb.201812020. Epub 2019 Jan 18.

PMID:
30659100
7.

The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1.

Venditti R, Masone MC, Rega LR, Di Tullio G, Santoro M, Polishchuk E, Serrano IC, Olkkonen VM, Harada A, Medina DL, La Montagna R, De Matteis MA.

J Cell Biol. 2019 Mar 4;218(3):783-797. doi: 10.1083/jcb.201812021. Epub 2019 Jan 18.

PMID:
30659099
8.

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol.

Koponen A, Arora A, Takahashi K, Kentala H, Kivelä AM, Jääskeläinen E, Peränen J, Somerharju P, Ikonen E, Viitala T, Olkkonen VM.

Biochimie. 2019 Mar;158:90-101. doi: 10.1016/j.biochi.2018.12.013. Epub 2018 Dec 24.

PMID:
30590084
9.

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.

Ruuth M, Soronen J, Kaiharju E, Merikanto K, Perttilä J, Metso J, Lee-Rueckert M, Taskinen MR, Kovanen PT, Öörni K, Olkkonen VM, Jauhiainen MS, Laurila PP.

Lipids Health Dis. 2018 Dec 13;17(1):285. doi: 10.1186/s12944-018-0930-2.

10.

miR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes.

Ahonen MA, Haridas PAN, Mysore R, Wabitsch M, Fischer-Posovszky P, Olkkonen VM.

Mol Cell Endocrinol. 2019 Jan 5;479:110-116. doi: 10.1016/j.mce.2018.09.007. Epub 2018 Sep 24.

PMID:
30261211
11.

OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells.

Pan G, Cao X, Liu B, Li C, Li D, Zheng J, Lai C, Olkkonen VM, Zhong W, Yan D.

J Biol Chem. 2018 Nov 9;293(45):17430-17441. doi: 10.1074/jbc.RA118.005437. Epub 2018 Sep 20.

PMID:
30237164
12.

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism.

Kentala H, Koponen A, Vihinen H, Pirhonen J, Liebisch G, Pataj Z, Kivelä A, Li S, Karhinen L, Jääskeläinen E, Andrews R, Meriläinen L, Matysik S, Ikonen E, Zhou Y, Jokitalo E, Olkkonen VM.

Cell Mol Life Sci. 2018 Nov;75(21):4041-4057. doi: 10.1007/s00018-018-2850-8. Epub 2018 Jun 12.

PMID:
29947926
13.

Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments.

Pulli I, Lassila T, Pan G, Yan D, Olkkonen VM, Törnquist K.

Cell Calcium. 2018 Jun;72:62-69. doi: 10.1016/j.ceca.2018.03.001. Epub 2018 Mar 13.

PMID:
29748134
14.

New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk?

Olkkonen VM, Sinisalo J, Jauhiainen M.

Atherosclerosis. 2018 May;272:27-32. doi: 10.1016/j.atherosclerosis.2018.03.019. Epub 2018 Mar 8. Review.

PMID:
29544086
15.

Analysis of ORP2-knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation.

Kentala H, Koponen A, Kivelä AM, Andrews R, Li C, Zhou Y, Olkkonen VM.

FASEB J. 2018 Mar;32(3):1281-1295. doi: 10.1096/fj.201700604R. Epub 2018 Jan 3.

PMID:
29092904
16.

MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes.

Mysore R, Ortega FJ, Latorre J, Ahonen M, Savolainen-Peltonen H, Fischer-Posovszky P, Wabitsch M, Olkkonen VM, Fernández-Real JM, Haridas PAN.

J Clin Endocrinol Metab. 2017 Nov 1;102(11):4001-4012. doi: 10.1210/jc.2017-00453.

PMID:
28938482
17.

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition.

Mysore R, Liebisch G, Zhou Y, Olkkonen VM, Nidhina Haridas PA.

Chem Phys Lipids. 2017 Oct;207(Pt B):246-252. doi: 10.1016/j.chemphyslip.2017.05.002. Epub 2017 May 18.

PMID:
28528274
18.

Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells.

Ruhanen H, Nidhina Haridas PA, Eskelinen EL, Eriksson O, Olkkonen VM, Käkelä R.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jul;1862(7):676-685. doi: 10.1016/j.bbalip.2017.04.004. Epub 2017 Apr 18.

PMID:
28434889
19.

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD.

Luukkonen PK, Zhou Y, Nidhina Haridas PA, Dwivedi OP, Hyötyläinen T, Ali A, Juuti A, Leivonen M, Tukiainen T, Ahonen L, Scott E, Palmer JM, Arola J, Orho-Melander M, Vikman P, Anstee QM, Olkkonen VM, Orešič M, Groop L, Yki-Järvinen H.

J Hepatol. 2017 Jul;67(1):128-136. doi: 10.1016/j.jhep.2017.02.014. Epub 2017 Feb 22.

PMID:
28235613
20.

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

Albulescu L, Bigay J, Biswas B, Weber-Boyvat M, Dorobantu CM, Delang L, van der Schaar HM, Jung YS, Neyts J, Olkkonen VM, van Kuppeveld FJM, Strating JRPM.

Antiviral Res. 2017 Apr;140:37-44. doi: 10.1016/j.antiviral.2017.01.008. Epub 2017 Jan 11.

21.

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A.

Kara B, Köroğlu Ç, Peltonen K, Steinberg RC, Maraş Genç H, Hölttä-Vuori M, Güven A, Kanerva K, Kotil T, Solakoğlu S, Zhou Y, Olkkonen VM, Ikonen E, Laiho M, Tolun A.

Eur J Hum Genet. 2017 Feb;25(3):315-323. doi: 10.1038/ejhg.2016.183. Epub 2017 Jan 4.

22.

Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans.

Lallukka S, Luukkonen PK, Zhou Y, Isokuortti E, Leivonen M, Juuti A, Hakkarainen A, Orho-Melander M, Lundbom N, Olkkonen VM, Lassila R, Yki-Järvinen H.

Thromb Haemost. 2017 Jan 26;117(2):286-294. doi: 10.1160/TH16-09-0716. Epub 2016 Dec 8.

PMID:
27929200
23.

ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis.

Zhong W, Pan G, Wang L, Li S, Ou J, Xu M, Li J, Zhu B, Cao X, Ma H, Li C, Xu J, Olkkonen VM, Staels B, Yan D.

Circ Res. 2016 Dec 9;119(12):1296-1312. Epub 2016 Oct 11.

PMID:
27729467
24.

ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.

Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, Zhu B, Hoffmann PR, Ji G, Lei P, Li G, Li J, Li J, Olkkonen VM, Yan D.

Nat Commun. 2016 Sep 1;7:12702. doi: 10.1038/ncomms12702.

25.

Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes.

Huttala O, Mysore R, Sarkanen JR, Heinonen T, Olkkonen VM, Ylikomi T.

Cell Tissue Res. 2016 Oct;366(1):63-74. doi: 10.1007/s00441-016-2409-7. Epub 2016 Apr 29.

PMID:
27130571
26.

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.

Motazacker MM, Pirhonen J, van Capelleveen JC, Weber-Boyvat M, Kuivenhoven JA, Shah S, Hovingh GK, Metso J, Li S, Ikonen E, Jauhiainen M, Dallinga-Thie GM, Olkkonen VM.

Atherosclerosis. 2016 Jun;249:140-7. doi: 10.1016/j.atherosclerosis.2016.04.005. Epub 2016 Apr 11.

PMID:
27105157
27.

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.

Aho V, Ollila HM, Kronholm E, Bondia-Pons I, Soininen P, Kangas AJ, Hilvo M, Seppälä I, Kettunen J, Oikonen M, Raitoharju E, Hyötyläinen T, Kähönen M, Viikari JS, Härmä M, Sallinen M, Olkkonen VM, Alenius H, Jauhiainen M, Paunio T, Lehtimäki T, Salomaa V, Orešič M, Raitakari OT, Ala-Korpela M, Porkka-Heiskanen T.

Sci Rep. 2016 Apr 22;6:24828. doi: 10.1038/srep24828.

28.

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

PMID:
26819196
29.

OSBP-Related Protein Family: Mediators of Lipid Transport and Signaling at Membrane Contact Sites.

Kentala H, Weber-Boyvat M, Olkkonen VM.

Int Rev Cell Mol Biol. 2016;321:299-340. doi: 10.1016/bs.ircmb.2015.09.006. Epub 2015 Nov 18. Review.

PMID:
26811291
30.

MicroRNA-192* impairs adipocyte triglyceride storage.

Mysore R, Zhou Y, Sädevirta S, Savolainen-Peltonen H, Nidhina Haridas PA, Soronen J, Leivonen M, Sarin AP, Fischer-Posovszky P, Wabitsch M, Yki-Järvinen H, Olkkonen VM.

Biochim Biophys Acta. 2016 Apr;1861(4):342-51. doi: 10.1016/j.bbalip.2015.12.019. Epub 2015 Dec 30.

PMID:
26747651
31.

Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease.

Soronen J, Yki-Järvinen H, Zhou Y, Sädevirta S, Sarin AP, Leivonen M, Sevastianova K, Perttilä J, Laurila PP, Sigruener A, Schmitz G, Olkkonen VM.

Physiol Rep. 2016 Jan;4(1). pii: e12661. doi: 10.14814/phy2.12661.

32.

Plant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects.

Olkkonen VM, Gylling H, Ikonen E.

J Steroid Biochem Mol Biol. 2017 May;169:4-9. doi: 10.1016/j.jsbmb.2015.12.026. Epub 2015 Dec 28. Review.

PMID:
26733205
33.

OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites.

Olkkonen VM.

Lipid Insights. 2015 Nov 12;8(Suppl 1):1-9. doi: 10.4137/LPI.S31726. eCollection 2015. Review.

34.

The Sec1/Munc18 Protein Groove Plays a Conserved Role in Interaction with Sec9p/SNAP-25.

Weber-Boyvat M, Chernov KG, Aro N, Wohlfahrt G, Olkkonen VM, Jäntti J.

Traffic. 2016 Feb;17(2):131-53. doi: 10.1111/tra.12349. Epub 2015 Dec 21.

35.

[Plant sterols, cholesterol precursors and oxysterols: small amounts, big effects].

Olkkonen VM, Gylling H, Ikonen E.

Duodecim. 2015;131(3):235-41. Review. Finnish.

PMID:
26245073
36.

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.

Nidhina Haridas PA, Soronen J, Sädevirta S, Mysore R, Quagliarini F, Pasternack A, Metso J, Perttilä J, Leivonen M, Smas CM, Fischer-Posovszky P, Wabitsch M, Ehnholm C, Ritvos O, Jauhiainen M, Olkkonen VM, Yki-Järvinen H.

J Clin Endocrinol Metab. 2015 Oct;100(10):E1299-307. doi: 10.1210/jc.2015-1254. Epub 2015 Jul 23.

PMID:
26204133
37.

Bimolecular fluorescence complementation (BiFC) technique in yeast Saccharomyces cerevisiae and mammalian cells.

Weber-Boyvat M, Li S, Skarp KP, Olkkonen VM, Yan D, Jäntti J.

Methods Mol Biol. 2015;1270:277-88. doi: 10.1007/978-1-4939-2309-0_20.

PMID:
25702124
38.

Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure.

Kentala H, Pfisterer SG, Olkkonen VM, Weber-Boyvat M.

Steroids. 2015 Jul;99(Pt B):248-58. doi: 10.1016/j.steroids.2015.01.027. Epub 2015 Feb 11.

PMID:
25681634
39.

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ.

Cell Rep. 2015 Feb 3;10(4):600-15. doi: 10.1016/j.celrep.2014.12.054. Epub 2015 Jan 29.

40.

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.

Weber-Boyvat M, Kentala H, Lilja J, Vihervaara T, Hanninen R, Zhou Y, Peränen J, Nyman TA, Ivaska J, Olkkonen VM.

Exp Cell Res. 2015 Feb 15;331(2):278-91. doi: 10.1016/j.yexcr.2014.10.019. Epub 2014 Oct 29.

PMID:
25447204
41.

Ligand-dependent localization and function of ORP-VAP complexes at membrane contact sites.

Weber-Boyvat M, Kentala H, Peränen J, Olkkonen VM.

Cell Mol Life Sci. 2015 May;72(10):1967-87. doi: 10.1007/s00018-014-1786-x. Epub 2014 Nov 25.

PMID:
25420878
42.

Extendable blocking probe in reverse transcription for analysis of RNA variants with superior selectivity.

Ho TH, Dang KX, Lintula S, Hotakainen K, Feng L, Olkkonen VM, Verschuren EW, Tenkanen T, Haglund C, Kolho KL, Stenman UH, Stenman J.

Nucleic Acids Res. 2015 Jan;43(1):e4. doi: 10.1093/nar/gku1048. Epub 2014 Nov 5.

43.

Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice.

van Kampen E, Beaslas O, Hildebrand RB, Lammers B, Van Berkel TJ, Olkkonen VM, Van Eck M.

PLoS One. 2014 Oct 27;9(10):e109024. doi: 10.1371/journal.pone.0109024. eCollection 2014.

44.

Impact of non-alcoholic fatty liver disease on liver volume in humans.

Bian H, Hakkarainen A, Zhou Y, Lundbom N, Olkkonen VM, Yki-Järvinen H.

Hepatol Res. 2015 Jan;45(2):210-9. doi: 10.1111/hepr.12338. Epub 2014 Jul 18.

PMID:
24698021
45.

PNPLA3 mediates hepatocyte triacylglycerol remodeling.

Ruhanen H, Perttilä J, Hölttä-Vuori M, Zhou Y, Yki-Järvinen H, Ikonen E, Käkelä R, Olkkonen VM.

J Lipid Res. 2014 Apr;55(4):739-46. doi: 10.1194/jlr.M046607. Epub 2014 Feb 7.

46.

OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.

Zhong W, Zhou Y, Li J, Mysore R, Luo W, Li S, Chang MS, Olkkonen VM, Yan D.

Exp Cell Res. 2014 Apr 1;322(2):227-35. doi: 10.1016/j.yexcr.2014.01.002. Epub 2014 Jan 11.

PMID:
24424245
47.

Cholesterol precursors: more than mere markers of biosynthesis.

Brown AJ, Ikonen E, Olkkonen VM.

Curr Opin Lipidol. 2014 Apr;25(2):133-9. doi: 10.1097/MOL.0000000000000038. Review.

PMID:
24378747
48.

A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human.

Zhou Y, Wohlfahrt G, Paavola J, Olkkonen VM.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):675-80. doi: 10.1016/j.bbrc.2013.12.002. Epub 2013 Dec 8.

PMID:
24326072
49.

OSBP-related proteins: liganding by glycerophospholipids opens new insight into their function.

Olkkonen VM.

Molecules. 2013 Nov 5;18(11):13666-79. doi: 10.3390/molecules181113666. Review.

50.

Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.

Hyysalo J, Gopalacharyulu P, Bian H, Hyötyläinen T, Leivonen M, Jaser N, Juuti A, Honka MJ, Nuutila P, Olkkonen VM, Oresic M, Yki-Järvinen H.

Diabetes. 2014 Jan;63(1):312-22. doi: 10.2337/db13-0774. Epub 2013 Sep 5.

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