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Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production.

Wu UI, Olivier KN, Kuhns DB, Fink DL, Sampaio EP, Zelazny AM, Shallom SJ, Marciano BE, Lionakis MS, Holland SM.

Open Forum Infect Dis. 2019 Nov 28;6(12):ofz484. doi: 10.1093/ofid/ofz484. eCollection 2019 Dec.


Nontuberculous Mycobacteria in Cystic Fibrosis.

Richards CJ, Olivier KN.

Semin Respir Crit Care Med. 2019 Dec;40(6):737-750. doi: 10.1055/s-0039-1693706. Epub 2019 Oct 28.


Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.

Takeda AJ, Maher TJ, Zhang Y, Lanahan SM, Bucklin ML, Compton SR, Tyler PM, Comrie WA, Matsuda M, Olivier KN, Pittaluga S, McElwee JJ, Long Priel DA, Kuhns DB, Williams RL, Mustillo PJ, Wymann MP, Koneti Rao V, Lucas CL.

Nat Commun. 2019 Sep 25;10(1):4364. doi: 10.1038/s41467-019-12311-5.


Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance.

Ferré EMN, Break TJ, Burbelo PD, Allgäuer M, Kleiner DE, Jin D, Xu Z, Folio LR, Mollura DJ, Swamydas M, Gu W, Hunsberger S, Lee CR, Bondici A, Hoffman KW, Lim JK, Dobbs K, Niemela JE, Fleisher TA, Hsu AP, Snow LN, Darnell DN, Ojaimi S, Cooper MA, Bozzola M, Kleiner GI, Martinez JC, Deterding RR, Kuhns DB, Heller T, Winer KK, Rajan A, Holland SM, Notarangelo LD, Fennelly KP, Olivier KN, Lionakis MS.

Sci Transl Med. 2019 Jun 5;11(495). pii: eaav5597. doi: 10.1126/scitranslmed.aav5597.


Amikacin exposure and susceptibility of macrolide-resistant Mycobacterium abscessus.

Daniel-Wayman S, Shallom S, Azeem N, Olivier KN, Zelazny AM, Prevots DR.

ERJ Open Res. 2019 May 10;5(2). pii: 00154-2018. doi: 10.1183/23120541.00154-2018. eCollection 2019 Apr.


Rheumatoid arthritis-associated bronchiectasis - Authors' reply.

Flume PA, Chalmers JD, Olivier KN.

Lancet. 2019 May 18;393(10185):2036. doi: 10.1016/S0140-6736(19)30012-1. No abstract available.


Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis.

Liou TG, Adler FR, Argel N, Asfour F, Brown PS, Chatfield BA, Daines CL, Durham D, Francis JA, Glover B, Heynekamp T, Hoidal JR, Jensen JL, Keogh R, Kopecky CM, Lechtzin N, Li Y, Lysinger J, Molina O, Nakamura C, Packer KA, Poch KR, Quittner AL, Radford P, Redway AJ, Sagel SD, Sprandel S, Taylor-Cousar JL, Vroom JB, Yoshikawa R, Clancy JP, Elborn JS, Olivier KN, Cox DR.

BMC Med Res Methodol. 2019 Apr 26;19(1):88. doi: 10.1186/s12874-019-0705-0.


The Clinical Features of Bronchiectasis Associated with Alpha-1 Antitrypsin Deficiency, Common Variable Immunodeficiency and Primary Ciliary Dyskinesia--Results from the U.S. Bronchiectasis Research Registry.

Eden E, Choate R, Barker A, Addrizzo-Harris D, Aksamit TR, Daley CL, Daniels MLA, DiMango A, Fennelly K, Griffith DE, Johnson MM, Knowles MR, Metersky ML, Noone PG, O'Donnell AE, Olivier KN, Salathe MA, Schmid A, Thomashow B, Tino G, Turino GM, Winthrop KL.

Chronic Obstr Pulm Dis. 2019 Apr 9;6(2):145-153. doi: 10.15326/jcopdf.6.2.2018.0156. Epub 2019 Apr 9.


Relative risk of all-cause mortality in patients with nontuberculous mycobacterial lung disease in a US managed care population.

Marras TK, Vinnard C, Zhang Q, Hamilton K, Adjemian J, Eagle G, Zhang R, Chou E, Olivier KN.

Respir Med. 2018 Dec;145:80-88. doi: 10.1016/j.rmed.2018.10.022. Epub 2018 Oct 22.


Performance of RGM Medium for Isolation of Nontuberculous Mycobacteria from Respiratory Specimens from Non-Cystic Fibrosis Patients.

Rotcheewaphan S, Odusanya OE, Henderson CM, Stephenson D, Olivier KN, Perry JD, Zelazny AM.

J Clin Microbiol. 2019 Jan 30;57(2). pii: e01519-18. doi: 10.1128/JCM.01519-18. Print 2019 Feb.


Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.

Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, Olivier KN, Ordway DJ, Prevots DR, Sacchettini JC, Salfinger M, Sassetti CM, Sizemore CF, Winthrop KL, Zelazny AM.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):947-951. doi: 10.1164/rccm.201807-1273PP. No abstract available.


Hospital-based antibiotic use in patients with Mycobacterium avium complex.

Ricotta EE, Olivier KN, Lai YL, Prevots DR, Adjemian J.

ERJ Open Res. 2018 Nov 2;4(4). pii: 00109-2018. doi: 10.1183/23120541.00109-2018. eCollection 2018 Oct.


ALIS (Amikacin Liposome Inhalation Suspension): The Beginning of a Wonderland?

Daley CL, Olivier KN.

Am J Respir Crit Care Med. 2018 Oct 26. doi: 10.1164/rccm.201810-1901ED. [Epub ahead of print] No abstract available.


Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity.

Flume PA, Chalmers JD, Olivier KN.

Lancet. 2018 Sep 8;392(10150):880-890. doi: 10.1016/S0140-6736(18)31767-7. Review.


Sarcoidosis-associated Hospitalizations in the United States, 2002 to 2012.

Wills AB, Adjemian J, Fontana JR, Steiner CA, Daniel-Wayman S, Olivier KN, Prevots DR.

Ann Am Thorac Soc. 2018 Dec;15(12):1490-1493. doi: 10.1513/AnnalsATS.201806-401RL. No abstract available.


Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.

Shapiro AJ, Davis SD, Polineni D, Manion M, Rosenfeld M, Dell SD, Chilvers MA, Ferkol TW, Zariwala MA, Sagel SD, Josephson M, Morgan L, Yilmaz O, Olivier KN, Milla C, Pittman JE, Daniels MLA, Jones MH, Janahi IA, Ware SM, Daniel SJ, Cooper ML, Nogee LM, Anton B, Eastvold T, Ehrne L, Guadagno E, Knowles MR, Leigh MW, Lavergne V; American Thoracic Society Assembly on Pediatrics.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):e24-e39. doi: 10.1164/rccm.201805-0819ST.


Epidemiology of Pulmonary Nontuberculous Mycobacterial Sputum Positivity in Patients with Cystic Fibrosis in the United States, 2010-2014.

Adjemian J, Olivier KN, Prevots DR.

Ann Am Thorac Soc. 2018 Jul;15(7):817-826. doi: 10.1513/AnnalsATS.201709-727OC. Erratum in: Ann Am Thorac Soc. 2018 Sep;15(9):1114-1115.


Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement.

van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ Jr, Winthrop KL, Wagner D; for NTM-NET.

Eur Respir J. 2018 Mar 22;51(3). pii: 1800170. doi: 10.1183/13993003.00170-2018. Print 2018 Mar. No abstract available.


Renal Fanconi syndrome with meropenem/amoxicillin-clavulanate during treatment of extensively drug-resistant tuberculosis.

Abadie ME, Strich JR, Kim T, Xie YL, Fennelly KP, Olivier KN, Waldman M, Arora K, Holland SM, Chen RY.

Eur Respir J. 2017 Dec 28;50(6). pii: 1702023. doi: 10.1183/13993003.02023-2017. Print 2017 Dec. No abstract available.


Survival of pathogenic Mycobacterium abscessus subsp. massiliense in Acanthamoeba castellanii.

da Silva JL, Nguyen J, Fennelly KP, Zelazny AM, Olivier KN.

Res Microbiol. 2018 Jan;169(1):56-60. doi: 10.1016/j.resmic.2017.10.001. Epub 2017 Oct 19.


Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria.

Matsuyama M, Martins AJ, Shallom S, Kamenyeva O, Kashyap A, Sampaio EP, Kabat J, Olivier KN, Zelazny AM, Tsang JS, Holland SM.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):241-252. doi: 10.1165/rcmb.2017-0218OC.


Geographic Distribution of Nontuberculous Mycobacterial Species Identified among Clinical Isolates in the United States, 2009-2013.

Spaulding AB, Lai YL, Zelazny AM, Olivier KN, Kadri SS, Prevots DR, Adjemian J.

Ann Am Thorac Soc. 2017 Nov;14(11):1655-1661. doi: 10.1513/AnnalsATS.201611-860OC.


Whole-Exome Sequencing Identifies the 6q12-q16 Linkage Region and a Candidate Gene, TTK, for Pulmonary Nontuberculous Mycobacterial Disease.

Chen F, Szymanski EP, Olivier KN, Liu X, Tettelin H, Holland SM, Duggal P.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1599-1604. doi: 10.1164/rccm.201612-2479OC.


Frequency of untreated hypogammaglobulinemia in bronchiectasis.

Ruffner MA, Aksamit TR, Thomashow B, Choate R, DiMango A, Turino GM, O'Donnell AE, Johnson MM, Olivier KN, Fennelly K, Daley CL, Winthrop KL, Metersky ML, Salathe MA, Knowles MR, Daniels MLA, Noone PG, Tino G, Griffith DE, Sullivan KE.

Ann Allergy Asthma Immunol. 2017 Jul;119(1):83-85. doi: 10.1016/j.anai.2017.04.020. Epub 2017 May 20. No abstract available.


Pharmacotherapy for Non-Cystic Fibrosis Bronchiectasis: Results From an NTM Info & Research Patient Survey and the Bronchiectasis and NTM Research Registry.

Henkle E, Aksamit TR, Barker AF, Curtis JR, Daley CL, Anne Daniels ML, DiMango A, Eden E, Fennelly K, Griffith DE, Johnson M, Knowles MR, Leitman A, Leitman P, Malanga E, Metersky ML, Noone PG, O'Donnell AE, Olivier KN, Prieto D, Salathe M, Thomashow B, Tino G, Turino G, Wisclenny S, Winthrop KL.

Chest. 2017 Dec;152(6):1120-1127. doi: 10.1016/j.chest.2017.04.167. Epub 2017 May 5.


MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections.

McCormack RM, Szymanski EP, Hsu AP, Perez E, Olivier KN, Fisher E, Goodhew EB, Podack ER, Holland SM.

JCI Insight. 2017 Apr 20;2(8). pii: 89635. doi: 10.1172/jci.insight.89635. eCollection 2017 Apr 20.


Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring.

Liu C, Zhao Z, Fan J, Lyon CJ, Wu HJ, Nedelkov D, Zelazny AM, Olivier KN, Cazares LH, Holland SM, Graviss EA, Hu Y.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3969-3974. doi: 10.1073/pnas.1621360114. Epub 2017 Mar 27.


Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA.

Adjemian J, Frankland TB, Daida YG, Honda JR, Olivier KN, Zelazny A, Honda S, Prevots DR.

Emerg Infect Dis. 2017 Mar;23(3):439-447. doi: 10.3201/eid2303.161827.


Pneumocystis colonization in asthmatic patients not receiving oral corticosteroid therapy.

Davey EL, Colombo RE, Fiorentino C, Fahle G, Davey RT Jr, Olivier KN, Kovacs JA.

J Investig Med. 2017 Apr;65(4):800-802. doi: 10.1136/jim-2016-000381. Epub 2017 Feb 13.


Respiratory manifestations in 38 patients with Alström syndrome.

Boerwinkle C, Marshall JD, Bryant J, Gahl WA, Olivier KN, Gunay-Aygun M.

Pediatr Pulmonol. 2017 Apr;52(4):487-493. doi: 10.1002/ppul.23607. Epub 2016 Dec 28.


Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry.

Aksamit TR, O'Donnell AE, Barker A, Olivier KN, Winthrop KL, Daniels MLA, Johnson M, Eden E, Griffith D, Knowles M, Metersky M, Salathe M, Thomashow B, Tino G, Turino G, Carretta B, Daley CL; Bronchiectasis Research Registry Consortium.

Chest. 2017 May;151(5):982-992. doi: 10.1016/j.chest.2016.10.055. Epub 2016 Nov 23.


Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency.

Kuhns DB, Fink DL, Choi U, Sweeney C, Lau K, Priel DL, Riva D, Mendez L, Uzel G, Freeman AF, Olivier KN, Anderson VL, Currens R, Mackley V, Kang A, Al-Adeli M, Mace E, Orange JS, Kang E, Lockett SJ, Chen, Steinbach PJ, Hsu AP, Zarember KA, Malech HL, Gallin JI, Holland SM.

Blood. 2016 Oct 27;128(17):2135-2143. Epub 2016 Aug 24.


Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease.

Olivier KN, Griffith DE, Eagle G, McGinnis JP 2nd, Micioni L, Liu K, Daley CL, Winthrop KL, Ruoss S, Addrizzo-Harris DJ, Flume PA, Dorgan D, Salathe M, Brown-Elliott BA, Gupta R, Wallace RJ Jr.

Am J Respir Crit Care Med. 2017 Mar 15;195(6):814-823. doi: 10.1164/rccm.201604-0700OC.


Lady Windermere Dissected: More Form Than Fastidious.

Olivier KN.

Ann Am Thorac Soc. 2016 Oct;13(10):1674-1676. No abstract available.


Patient-Centered Research Priorities for Pulmonary Nontuberculous Mycobacteria (NTM) Infection. An NTM Research Consortium Workshop Report.

Henkle E, Aksamit T, Barker A, Daley CL, Griffith D, Leitman P, Leitman A, Malanga E, Marras TK, Olivier KN, Prevots DR, Prieto D, Quittner AL, Skach W, Walsh JW, Winthrop KL; NTMRC Patient Advisory Panel.

Ann Am Thorac Soc. 2016 Sep;13(9):S379-84. doi: 10.1513/AnnalsATS.201605-387WS.


Mediastinal and Disseminated Mycobacterium kansasii Disease in GATA2 Deficiency.

Lovell JP, Zerbe CS, Olivier KN, Claypool RJ, Frein C, Anderson VL, Freeman AF, Holland SM.

Ann Am Thorac Soc. 2016 Dec;13(12):2169-2173.


Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

Ferre EM, Rose SR, Rosenzweig SD, Burbelo PD, Romito KR, Niemela JE, Rosen LB, Break TJ, Gu W, Hunsberger S, Browne SK, Hsu AP, Rampertaap S, Swamydas M, Collar AL, Kong HH, Lee CR, Chascsa D, Simcox T, Pham A, Bondici A, Natarajan M, Monsale J, Kleiner DE, Quezado M, Alevizos I, Moutsopoulos NM, Yockey L, Frein C, Soldatos A, Calvo KR, Adjemian J, Similuk MN, Lang DM, Stone KD, Uzel G, Kopp JB, Bishop RJ, Holland SM, Olivier KN, Fleisher TA, Heller T, Winer KK, Lionakis MS.

JCI Insight. 2016 Aug 18;1(13). pii: e88782.


Hyper-IgE Syndromes and the Lung.

Freeman AF, Olivier KN.

Clin Chest Med. 2016 Sep;37(3):557-67. doi: 10.1016/j.ccm.2016.04.016. Epub 2016 Jun 10. Review.


Exercise-induced haemoptysis as a rare presentation of a rare lung disease.

Mihalek AD, Haney C, Merino M, Roy-Chowdhuri S, Moss J, Olivier KN.

Thorax. 2016 Sep;71(9):865-8. doi: 10.1136/thoraxjnl-2015-208020. Epub 2016 Jun 7.


Pulmonary Manifestations of the Autoimmune Lymphoproliferative Syndrome. A Retrospective Study of a Unique Patient Cohort.

Lau CY, Mihalek AD, Wang J, Dodd LE, Perkins K, Price S, Webster S, Pittaluga S, Folio LR, Rao VK, Olivier KN.

Ann Am Thorac Soc. 2016 Aug;13(8):1279-88. doi: 10.1513/AnnalsATS.201601-079OC.


Mortality among patients with pulmonary non-tuberculous mycobacteria disease.

Fleshner M, Olivier KN, Shaw PA, Adjemian J, Strollo S, Claypool RJ, Folio L, Zelazny A, Holland SM, Prevots DR.

Int J Tuberc Lung Dis. 2016 May;20(5):582-7. doi: 10.5588/ijtld.15.0807.


Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents.

Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer J, Hazucha MJ, Knowles MR.

Ann Am Thorac Soc. 2016 Aug;13(8):1305-13. doi: 10.1513/AnnalsATS.201511-748OC.


Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.

Song T, Lee M, Jeon HS, Park Y, Dodd LE, Dartois V, Follman D, Wang J, Cai Y, Goldfeder LC, Olivier KN, Xie Y, Via LE, Cho SN, Barry CE 3rd, Chen RY.

EBioMedicine. 2015 Oct 9;2(11):1627-33. doi: 10.1016/j.ebiom.2015.09.051. eCollection 2015 Nov.


Micro-CT scouting for transmission electron microscopy of human tissue specimens.

Morales AG, Stempinski ES, Xiao X, Patel A, Panna A, Olivier KN, McShane PJ, Robinson C, George AJ, Donahue DR, Chen P, Wen H.

J Microsc. 2016 Jul;263(1):113-7. doi: 10.1111/jmi.12385. Epub 2016 Feb 8.


A phase 1 randomized, double-blind, placebo-controlled, crossover trial of DAS181 (Fludase®) in adult subjects with well-controlled asthma.

Colombo RE, Fiorentino C, Dodd LE, Hunsberger S, Haney C, Barrett K, Nabha L, Davey RT Jr, Olivier KN.

BMC Infect Dis. 2016 Feb 1;16:54. doi: 10.1186/s12879-016-1358-9.


US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary.

Floto RA, Olivier KN, Saiman L, Daley CL, Herrmann JL, Nick JA, Noone PG, Bilton D, Corris P, Gibson RL, Hempstead SE, Koetz K, Sabadosa KA, Sermet-Gaudelus I, Smyth AR, van Ingen J, Wallace RJ, Winthrop KL, Marshall BC, Haworth CS.

Thorax. 2016 Jan;71(1):88-90. doi: 10.1136/thoraxjnl-2015-207983.


US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis.

Floto RA, Olivier KN, Saiman L, Daley CL, Herrmann JL, Nick JA, Noone PG, Bilton D, Corris P, Gibson RL, Hempstead SE, Koetz K, Sabadosa KA, Sermet-Gaudelus I, Smyth AR, van Ingen J, Wallace RJ, Winthrop KL, Marshall BC, Haworth CS; US Cystic Fibrosis Foundation and European Cystic Fibrosis Society.

Thorax. 2016 Jan;71 Suppl 1:i1-22. doi: 10.1136/thoraxjnl-2015-207360.


Reply: Cure Not Possible, by Definition.

Griffith DE, Adjemian J, Brown-Elliott BA, Prevots DR, Philley JV, Olivier KN, Wallace RJ Jr.

Am J Respir Crit Care Med. 2015 Nov 15;192(10):1256-7. doi: 10.1164/rccm.201508-1515LE. No abstract available.


Beyond Marfan: the clinical impact of bronchiectasis and non-tuberculous mycobacteria in connective tissue diseases.

Leung JM, Olivier KN, Prevots DR, McDonnell NB.

Int J Tuberc Lung Dis. 2015 Nov;19(11):1409. doi: 10.5588/ijtld.15.0597. No abstract available.


Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review.

Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD, Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MW; Genetic Disorders of Mucociliary Clearance Consortium.

Pediatr Pulmonol. 2016 Feb;51(2):115-32. doi: 10.1002/ppul.23304. Epub 2015 Sep 29. Review.

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