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Characterization of the First Conotoxin from Conus ateralbus, a Vermivorous Cone Snail from the Cabo Verde Archipelago.

Neves JLB, Imperial JS, Morgenstern D, Ueberheide B, Gajewiak J, Antunes A, Robinson SD, Espino S, Watkins M, Vasconcelos V, Olivera BM.

Mar Drugs. 2019 Jul 24;17(8). pii: E432. doi: 10.3390/md17080432.


α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors.

van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM, McIntosh JM.

Neuropharmacology. 2019 Oct;157:107691. doi: 10.1016/j.neuropharm.2019.107691. Epub 2019 Jun 28.


The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework.

Nielsen LD, Foged MM, Albert A, Bertelsen AB, Søltoft CL, Robinson SD, Petersen SV, Purcell AW, Olivera BM, Norton RS, Vasskog T, Safavi-Hemami H, Teilum K, Ellgaard L.

J Biol Chem. 2019 May 31;294(22):8745-8759. doi: 10.1074/jbc.RA119.007491. Epub 2019 Apr 11.


trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel.

Memon T, Yarishkin O, Reilly CA, Križaj D, Olivera BM, Teichert RW.

Mol Pharmacol. 2019 Apr;95(4):433-441. doi: 10.1124/mol.118.114561. Epub 2019 Jan 24.


Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels.

Cordeiro S, Finol-Urdaneta RK, Köpfer D, Markushina A, Song J, French RJ, Kopec W, de Groot BL, Giacobassi MJ, Leavitt LS, Raghuraman S, Teichert RW, Olivera BM, Terlau H.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):1059-1064. doi: 10.1073/pnas.1813161116. Epub 2018 Dec 28.


Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins.

O'Brien H, Kanemura S, Okumura M, Baskin RP, Bandyopadhyay PK, Olivera BM, Ellgaard L, Inaba K, Safavi-Hemami H.

Int J Mol Sci. 2018 Oct 31;19(11). pii: E3418. doi: 10.3390/ijms19113418.


Conopeptides promote itch through human itch receptor hMgprX1.

Espino SS, Robinson SD, Safavi-Hemami H, Gajewiak J, Yang W, Olivera BM, Liu Q.

Toxicon. 2018 Nov;154:28-34. doi: 10.1016/j.toxicon.2018.09.002. Epub 2018 Sep 21.


Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways.

Safavi-Hemami H, Brogan SE, Olivera BM.

J Proteomics. 2019 Jan 6;190:12-20. doi: 10.1016/j.jprot.2018.05.009. Epub 2018 May 16.


Structure and Biological Activity of a Turripeptide from Unedogemmula bisaya Venom.

Omaga CA, Carpio LD, Imperial JS, Daly NL, Gajewiak J, Flores MS, Espino SS, Christensen S, Filchakova OM, López-Vera E, Raghuraman S, Olivera BM, Concepcion GP.

Biochemistry. 2017 Nov 14;56(45):6051-6060. doi: 10.1021/acs.biochem.7b00485. Epub 2017 Nov 1.


Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts.

Torres JP, Tianero MD, Robes JMD, Kwan JC, Biggs JS, Concepcion GP, Olivera BM, Haygood MG, Schmidt EW.

Appl Environ Microbiol. 2017 Nov 16;83(23). pii: e01418-17. doi: 10.1128/AEM.01418-17. Print 2017 Dec 1.


Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus.

Li Q, Barghi N, Lu A, Fedosov AE, Bandyopadhyay PK, Lluisma AO, Concepcion GP, Yandell M, Olivera BM, Safavi-Hemami H.

Genome Biol Evol. 2017 Sep 1;9(9):2211-2225. doi: 10.1093/gbe/evx157.


Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products.

Lin Z, Smith MD, Concepcion GP, Haygood MG, Olivera BM, Light A, Schmidt EW.

J Nat Prod. 2017 Aug 25;80(8):2360-2370. doi: 10.1021/acs.jnatprod.7b00317. Epub 2017 Jul 26.


Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.

Olivera BM, Raghuraman S, Schmidt EW, Safavi-Hemami H.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Sep;203(9):717-735. doi: 10.1007/s00359-017-1183-7. Epub 2017 May 27. Review.


The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.

Robinson SD, Li Q, Lu A, Bandyopadhyay PK, Yandell M, Olivera BM, Safavi-Hemami H.

Mar Drugs. 2017 May 20;15(5). pii: E145. doi: 10.3390/md15050145.


TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons.

Memon T, Chase K, Leavitt LS, Olivera BM, Teichert RW.

Neuroscience. 2017 Jun 14;353:76-86. doi: 10.1016/j.neuroscience.2017.04.001. Epub 2017 Apr 10.


Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.

Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh JM.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1825-E1832. doi: 10.1073/pnas.1621433114. Epub 2017 Feb 21.


Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue.

Drane SB, Robinson SD, MacRaild CA, Chhabra S, Chittoor B, Morales RA, Leung EW, Belgi A, Espino SS, Olivera BM, Robinson AJ, Chalmers DK, Norton RS.

Toxicon. 2017 Apr;129:113-122. doi: 10.1016/j.toxicon.2017.02.012. Epub 2017 Feb 17.


A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC.

Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12.


Venom Peptides From Cone Snails: Pharmacological Probes for Voltage-Gated Sodium Channels.

Green BR, Olivera BM.

Curr Top Membr. 2016;78:65-86. doi: 10.1016/bs.ctm.2016.07.001. Epub 2016 Jul 29. Review.


Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa.

Safavi-Hemami H, Lu A, Li Q, Fedosov AE, Biggs J, Showers Corneli P, Seger J, Yandell M, Olivera BM.

Mol Biol Evol. 2016 Nov;33(11):2924-2934. Epub 2016 Aug 14.


Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides.

Safavi-Hemami H, Li Q, Jackson RL, Song AS, Boomsma W, Bandyopadhyay PK, Gruber CW, Purcell AW, Yandell M, Olivera BM, Ellgaard L.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3227-32. doi: 10.1073/pnas.1525790113. Epub 2016 Mar 8.


Glycine-rich conotoxins from the Virgiconus clade.

Espino SS, Dilanyan T, Imperial JS, Aguilar MB, Teichert RW, Bandyopadhyay P, Olivera BM.

Toxicon. 2016 Apr;113:11-7. doi: 10.1016/j.toxicon.2016.02.001. Epub 2016 Feb 4.


Metabolic model for diversity-generating biosynthesis.

Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE, Schmidt EW.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1772-7. doi: 10.1073/pnas.1525438113. Epub 2016 Feb 1.


Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.

Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D, Norton RS.

J Biol Chem. 2016 Mar 25;291(13):7205-20. doi: 10.1074/jbc.M115.697672. Epub 2016 Jan 27.


Classifying neuronal subclasses of the cerebellum through constellation pharmacology.

Curtice KJ, Leavitt LS, Chase K, Raghuraman S, Horvath MP, Olivera BM, Teichert RW.

J Neurophysiol. 2016 Feb 1;115(2):1031-42. doi: 10.1152/jn.00894.2015. Epub 2015 Nov 18.


Characterization of the complete mitochondrial genome of Conus tribblei Walls, 1977.

Barghi N, Concepcion GP, Olivera BM, Lluisma AO.

Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Nov;27(6):4451-4452. Epub 2015 Oct 16.


Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome.

Barghi N, Concepcion GP, Olivera BM, Lluisma AO.

Mol Genet Genomics. 2016 Feb;291(1):411-22. doi: 10.1007/s00438-015-1119-2. Epub 2015 Sep 30.


Small Molecules in the Cone Snail Arsenal.

Neves JL, Lin Z, Imperial JS, Antunes A, Vasconcelos V, Olivera BM, Schmidt EW.

Org Lett. 2015 Oct 16;17(20):4933-5. doi: 10.1021/acs.orglett.5b02389. Epub 2015 Sep 30.


Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution.

Olivera BM, Seger J, Horvath MP, Fedosov AE.

Brain Behav Evol. 2015 Sep;86(1):58-74. doi: 10.1159/000438449. Epub 2015 Sep 24. Review.


One, four or 100 genera? A new classification of the cone snails.

Puillandre N, Duda TF, Meyer C, Olivera BM, Bouchet P.

J Molluscan Stud. 2015 Feb;81(1):1-23. Epub 2014 Sep 5.


αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors.

Christensen SB, Bandyopadhyay PK, Olivera BM, McIntosh JM.

Biochem Pharmacol. 2015 Aug 15;96(4):349-56. doi: 10.1016/j.bcp.2015.06.007. Epub 2015 Jun 11.


Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus Exogenomes.

Barghi N, Concepcion GP, Olivera BM, Lluisma AO.

Genome Biol Evol. 2015 Jun 4;7(6):1797-814. doi: 10.1093/gbe/evv109.


Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ.

Zhang MM, Gajewiak J, Azam L, Bulaj G, Olivera BM, Yoshikami D.

Biochemistry. 2015 Jun 30;54(25):3911-20. doi: 10.1021/acs.biochem.5b00390. Epub 2015 Jun 18.


Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus.

Aman JW, Imperial JS, Ueberheide B, Zhang MM, Aguilar M, Taylor D, Watkins M, Yoshikami D, Showers-Corneli P, Safavi-Hemami H, Biggs J, Teichert RW, Olivera BM.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5087-92. doi: 10.1073/pnas.1424435112. Epub 2015 Apr 6.


A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties.

Lee HK, Zhang L, Smith MD, Walewska A, Vellore NA, Baron R, McIntosh JM, White HS, Olivera BM, Bulaj G.

Front Pharmacol. 2015 Feb 10;6:11. doi: 10.3389/fphar.2015.00011. eCollection 2015.


Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.

Wilson MJ, Zhang MM, Gajewiak J, Azam L, Rivier JE, Olivera BM, Yoshikami D.

J Neurophysiol. 2015 Apr 1;113(7):2289-301. doi: 10.1152/jn.01004.2014. Epub 2015 Jan 28.


Specialized insulin is used for chemical warfare by fish-hunting cone snails.

Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8. doi: 10.1073/pnas.1423857112. Epub 2015 Jan 20.


Constellation pharmacology: a new paradigm for drug discovery.

Teichert RW, Schmidt EW, Olivera BM.

Annu Rev Pharmacol Toxicol. 2015;55:573-89. doi: 10.1146/annurev-pharmtox-010814-124551. Review.


Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom.

Robinson SD, Safavi-Hemami H, Raghuraman S, Imperial JS, Papenfuss AT, Teichert RW, Purcell AW, Olivera BM, Norton RS.

J Proteomics. 2015 Jan 30;114:38-47. doi: 10.1016/j.jprot.2014.11.003. Epub 2014 Nov 15.


Biodiversity of cone snails and other venomous marine gastropods: evolutionary success through neuropharmacology.

Olivera BM, Showers Corneli P, Watkins M, Fedosov A.

Annu Rev Anim Biosci. 2014 Feb;2:487-513. doi: 10.1146/annurev-animal-022513-114124. Epub 2013 Nov 14. Review.


High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platforms.

Barghi N, Concepcion GP, Olivera BM, Lluisma AO.

Mar Biotechnol (NY). 2015 Feb;17(1):81-98. doi: 10.1007/s10126-014-9595-7. Epub 2014 Aug 13.


From foe to friend: using animal toxins to investigate ion channel function.

Kalia J, Milescu M, Salvatierra J, Wagner J, Klint JK, King GF, Olivera BM, Bosmans F.

J Mol Biol. 2015 Jan 16;427(1):158-175. doi: 10.1016/j.jmb.2014.07.027. Epub 2014 Aug 1. Review.


A family of excitatory peptide toxins from venomous crassispirine snails: using Constellation Pharmacology to assess bioactivity.

Imperial JS, Cabang AB, Song J, Raghuraman S, Gajewiak J, Watkins M, Showers-Corneli P, Fedosov A, Concepcion GP, Terlau H, Teichert RW, Olivera BM.

Toxicon. 2014 Oct;89:45-54. doi: 10.1016/j.toxicon.2014.06.014. Epub 2014 Jul 2.


Molecular phylogeny and evolution of the cone snails (Gastropoda, Conoidea).

Puillandre N, Bouchet P, Duda TF Jr, Kauferstein S, Kohn AJ, Olivera BM, Watkins M, Meyer C.

Mol Phylogenet Evol. 2014 Sep;78:290-303. doi: 10.1016/j.ympev.2014.05.023. Epub 2014 May 28.


Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3.

Green BR, Zhang MM, Chhabra S, Robinson SD, Wilson MJ, Redding A, Olivera BM, Yoshikami D, Bulaj G, Norton RS.

FEBS J. 2014 Jul;281(13):2885-98. doi: 10.1111/febs.12835. Epub 2014 Jun 9.


Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis.

Lin Z, Zachariah MM, Marett L, Hughen RW, Teichert RW, Concepcion GP, Haygood MG, Olivera BM, Light AR, Schmidt EW.

J Nat Prod. 2014 May 23;77(5):1224-30. doi: 10.1021/np500155d. Epub 2014 May 1.


Animal toxins influence voltage-gated sodium channel function.

Gilchrist J, Olivera BM, Bosmans F.

Handb Exp Pharmacol. 2014;221:203-29. doi: 10.1007/978-3-642-41588-3_10. Review.


Defining modulatory inputs into CNS neuronal subclasses by functional pharmacological profiling.

Raghuraman S, Garcia AJ, Anderson TM, Twede VD, Curtice KJ, Chase K, Ramirez JM, Olivera BM, Teichert RW.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6449-54. doi: 10.1073/pnas.1404421111. Epub 2014 Apr 14.


From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes.

Platt RJ, Curtice KJ, Twede VD, Watkins M, Gruszczyński P, Bulaj G, Horvath MP, Olivera BM.

Toxicon. 2014 Apr;81:67-79. doi: 10.1016/j.toxicon.2014.01.016. Epub 2014 Feb 7.


A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.

Gajewiak J, Azam L, Imperial J, Walewska A, Green BR, Bandyopadhyay PK, Raghuraman S, Ueberheide B, Bern M, Zhou HM, Minassian NA, Hagan RH, Flinspach M, Liu Y, Bulaj G, Wickenden AD, Olivera BM, Yoshikami D, Zhang MM.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2758-63. doi: 10.1073/pnas.1324189111. Epub 2014 Feb 4.

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