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Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.

Stewart M, Lau P, Banks G, Bains RS, Castroflorio E, Oliver PL, Dixon CL, Kruer MC, Kullmann DM, Acevedo-Arozena A, Wells SE, Corrochano S, Nolan PM.

Dis Model Mech. 2019 Feb 22;12(2). pii: dmm036806. doi: 10.1242/dmm.036806.


Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.

Svistunova DM, Simon JN, Rembeza E, Crabtree M, Yue WW, Oliver PL, Finelli MJ.

Free Radic Biol Med. 2019 Jan;130:151-162. doi: 10.1016/j.freeradbiomed.2018.10.447. Epub 2018 Oct 31.


The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons.

Finelli MJ, Aprile D, Castroflorio E, Jeans A, Moschetta M, Chessum L, Degiacomi MT, Grasegger J, Lupien-Meilleur A, Bassett A, Rossignol E, Campeau PM, Bowl MR, Benfenati F, Fassio A, Oliver PL.

Hum Mol Genet. 2019 Feb 15;28(4):584-597. doi: 10.1093/hmg/ddy370.


Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.

Gordon D, Dafinca R, Scaber J, Alegre-Abarrategui J, Farrimond L, Scott C, Biggs D, Kent L, Oliver PL, Davies B, Ansorge O, Wade-Martins R, Talbot K.

Neurobiol Dis. 2019 Jan;121:148-162. doi: 10.1016/j.nbd.2018.09.024. Epub 2018 Oct 2.


Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.

Ang G, McKillop LE, Purple R, Blanco-Duque C, Peirson SN, Foster RG, Harrison PJ, Sprengel R, Davies KE, Oliver PL, Bannerman DM, Vyazovskiy VV.

Transl Psychiatry. 2018 Aug 14;8(1):154. doi: 10.1038/s41398-018-0199-2.


Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.

Finelli MJ, Paramo T, Pires E, Ryan BJ, Wade-Martins R, Biggin PC, McCullagh J, Oliver PL.

Mol Neurobiol. 2019 Mar;56(3):1558-1577. doi: 10.1007/s12035-018-1174-x. Epub 2018 Jun 15.


Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice.

Merkulova M, Păunescu TG, Nair AV, Wang CY, Capen DE, Oliver PL, Breton S, Brown D.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F173-F185. doi: 10.1152/ajprenal.00407.2017. Epub 2018 Jan 31.


TLDc proteins: new players in the oxidative stress response and neurological disease.

Finelli MJ, Oliver PL.

Mamm Genome. 2017 Oct;28(9-10):395-406. doi: 10.1007/s00335-017-9706-7. Epub 2017 Jul 13. Review.


Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau-/- mice.

Vargas-Caballero M, Denk F, Wobst HJ, Arch E, Pegasiou CM, Oliver PL, Shipton OA, Paulsen O, Wade-Martins R.

Front Neurosci. 2017 Apr 24;11:201. doi: 10.3389/fnins.2017.00201. eCollection 2017.


Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy.

Wobst HJ, Denk F, Oliver PL, Livieratos A, Taylor TN, Knudsen MH, Bengoa-Vergniory N, Bannerman D, Wade-Martins R.

Sci Rep. 2017 Feb 24;7:43198. doi: 10.1038/srep43198.


Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.

Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J; FReJA, Oliver PL, Gomez-Nicola D, Isaacs AM.

Hum Mol Genet. 2017 Mar 1;26(5):873-887. doi: 10.1093/hmg/ddx003.


Stereotypic wheel running decreases cortical activity in mice.

Fisher SP, Cui N, McKillop LE, Gemignani J, Bannerman DM, Oliver PL, Peirson SN, Vyazovskiy VV.

Nat Commun. 2016 Oct 17;7:13138. doi: 10.1038/ncomms13138.


TBC1D24 genotype-phenotype correlation: Epilepsies and other neurologic features.

Balestrini S, Milh M, Castiglioni C, Lüthy K, Finelli MJ, Verstreken P, Cardon A, Stražišar BG, Holder JL Jr, Lesca G, Mancardi MM, Poulat AL, Repetto GM, Banka S, Bilo L, Birkeland LE, Bosch F, Brockmann K, Cross JH, Doummar D, Félix TM, Giuliano F, Hori M, Hüning I, Kayserili H, Kini U, Lees MM, Meenakshi G, Mewasingh L, Pagnamenta AT, Peluso S, Mey A, Rice GM, Rosenfeld JA, Taylor JC, Troester MM, Stanley CM, Ville D, Walkiewicz M, Falace A, Fassio A, Lemke JR, Biskup S, Tardif J, Ajeawung NF, Tolun A, Corbett M, Gecz J, Afawi Z, Howell KB, Oliver KL, Berkovic SF, Scheffer IE, de Falco FA, Oliver PL, Striano P, Zara F, Campeau PM, Sisodiya SM.

Neurology. 2016 Jul 5;87(1):77-85. doi: 10.1212/WNL.0000000000002807. Epub 2016 Jun 8.


Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H.

Cell Metab. 2016 May 10;23(5):821-36. doi: 10.1016/j.cmet.2016.04.003. Epub 2016 Apr 28.


The antioxidant protein Oxr1 influences aspects of mitochondrial morphology.

Wu Y, Davies KE, Oliver PL.

Free Radic Biol Med. 2016 Jun;95:255-67. doi: 10.1016/j.freeradbiomed.2016.03.029. Epub 2016 Mar 29.


The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.

Finelli MJ, Sanchez-Pulido L, Liu KX, Davies KE, Oliver PL.

J Biol Chem. 2016 Feb 5;291(6):2751-63. doi: 10.1074/jbc.M115.685222. Epub 2015 Dec 14.


Temporal transcriptomics suggest that twin-peaking genes reset the clock.

Pembroke WG, Babbs A, Davies KE, Ponting CP, Oliver PL.

Elife. 2015 Nov 2;4. pii: e10518. doi: 10.7554/eLife.10518.


Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease.

Richardson K, Livieratos A, Dumbill R, Hughes S, Ang G, Smith DA, Morris L, Brown LA, Peirson SN, Platt FM, Davies KE, Oliver PL.

Behav Brain Res. 2016 Jan 15;297:213-23. doi: 10.1016/j.bbr.2015.10.021. Epub 2015 Oct 20.


The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Parsons MJ, Brancaccio M, Sethi S, Maywood ES, Satija R, Edwards JK, Jagannath A, Couch Y, Finelli MJ, Smyllie NJ, Esapa C, Butler R, Barnard AR, Chesham JE, Saito S, Joynson G, Wells S, Foster RG, Oliver PL, Simon MM, Mallon AM, Hastings MH, Nolan PM.

Cell. 2015 Jul 30;162(3):607-21. doi: 10.1016/j.cell.2015.06.060.


The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.

Dulneva A, Lee S, Oliver PL, Di Gleria K, Kessler BM, Davies KE, Becker EB.

Hum Mol Genet. 2015 Jul 15;24(14):4114-25. doi: 10.1093/hmg/ddv150. Epub 2015 Apr 23.


Long-term history and immediate preceding state affect EEG slow wave characteristics at NREM sleep onset in C57BL/6 mice.

Cui N, Mckillop LE, Fisher SP, Oliver PL, Vyazovskiy VV.

Arch Ital Biol. 2014 Jun-Sep;152(2-3):156-68. doi: 10.12871/0002982920142310.


Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.

Finelli MJ, Liu KX, Wu Y, Oliver PL, Davies KE.

Hum Mol Genet. 2015 Jun 15;24(12):3529-44. doi: 10.1093/hmg/ddv104. Epub 2015 Mar 19.


Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.

Liu KX, Edwards B, Lee S, Finelli MJ, Davies B, Davies KE, Oliver PL.

Brain. 2015 May;138(Pt 5):1167-81. doi: 10.1093/brain/awv039. Epub 2015 Mar 9.


Corrigendum: Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.

Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, Marinello M, Alves S, Steinkraus BR, Cooper S, Nesterova T, Brockdorff N, Fulga TA, Brice A, Sittler A, Oliver PL, Wood MJ, Ponting CP, Marques AC.

Nat Struct Mol Biol. 2015 Mar;22(3):272. doi: 10.1038/nsmb0315-272b. No abstract available.


Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7.

Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, Marinello M, Alves S, Steinkraus B, Cooper S, Nesterova T, Brockdorff N, Fulga T, Brice A, Sittler A, Oliver PL, Wood MJ, Ponting CP, Marques AC.

Nat Struct Mol Biol. 2014 Nov;21(11):955-961. doi: 10.1038/nsmb.2902. Epub 2014 Oct 12. Erratum in: Nat Struct Mol Biol. 2015 Mar;22(3):272.


Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype.

Oliver PL, Chodroff RA, Gosal A, Edwards B, Cheung AF, Gomez-Rodriguez J, Elliot G, Garrett LJ, Lickiss T, Szele F, Green ED, Molnár Z, Ponting CP.

Cereb Cortex. 2015 Oct;25(10):3572-85. doi: 10.1093/cercor/bhu196. Epub 2014 Sep 10.


Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.

Moore JM, Oliver PL, Finelli MJ, Lee S, Lickiss T, Molnár Z, Davies KE.

PLoS One. 2014 Aug 27;9(8):e105933. doi: 10.1371/journal.pone.0105933. eCollection 2014.


A novel mouse model of a patient mucolipidosis II mutation recapitulates disease pathology.

Paton L, Bitoun E, Kenyon J, Priestman DA, Oliver PL, Edwards B, Platt FM, Davies KE.

J Biol Chem. 2014 Sep 26;289(39):26709-21. doi: 10.1074/jbc.M114.586156. Epub 2014 Aug 8.


The long non-coding RNA Paupar regulates the expression of both local and distal genes.

Vance KW, Sansom SN, Lee S, Chalei V, Kong L, Cooper SE, Oliver PL, Ponting CP.

EMBO J. 2014 Feb 18;33(4):296-311. doi: 10.1002/embj.201386225. Epub 2014 Feb 1.


Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.

Taylor TN, Potgieter D, Anwar S, Senior SL, Janezic S, Threlfell S, Ryan B, Parkkinen L, Deltheil T, Cioroch M, Livieratos A, Oliver PL, Jennings KA, Davies KE, Ansorge O, Bannerman DM, Cragg SJ, Wade-Martins R.

Neurobiol Dis. 2014 Feb;62:193-207. doi: 10.1016/j.nbd.2013.10.005. Epub 2013 Oct 10.


Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.

Sleigh JN, Barreiro-Iglesias A, Oliver PL, Biba A, Becker T, Davies KE, Becker CG, Talbot K.

Hum Mol Genet. 2014 Feb 15;23(4):855-69. doi: 10.1093/hmg/ddt477. Epub 2013 Sep 25.


Brain, know thy transcriptome, know thyself.

Ponting CP, Oliver PL.

Neuron. 2012 Aug 23;75(4):543-5. doi: 10.1016/j.neuron.2012.08.005.


New insights into behaviour using mouse ENU mutagenesis.

Oliver PL, Davies KE.

Hum Mol Genet. 2012 Oct 15;21(R1):R72-81. Epub 2012 Aug 13. Review.


Evaluating the links between schizophrenia and sleep and circadian rhythm disruption.

Pritchett D, Wulff K, Oliver PL, Bannerman DM, Davies KE, Harrison PJ, Peirson SN, Foster RG.

J Neural Transm (Vienna). 2012 Oct;119(10):1061-75. Epub 2012 May 10. Review.


Disrupted circadian rhythms in a mouse model of schizophrenia.

Oliver PL, Sobczyk MV, Maywood ES, Edwards B, Lee S, Livieratos A, Oster H, Butler R, Godinho SI, Wulff K, Peirson SN, Fisher SP, Chesham JE, Smith JW, Hastings MH, Davies KE, Foster RG.

Curr Biol. 2012 Feb 21;22(4):314-9. doi: 10.1016/j.cub.2011.12.051. Epub 2012 Jan 19.


Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.

Oliver PL, Finelli MJ, Edwards B, Bitoun E, Butts DL, Becker EB, Cheeseman MT, Davies B, Davies KE.

PLoS Genet. 2011 Oct;7(10):e1002338. doi: 10.1371/journal.pgen.1002338. Epub 2011 Oct 20.


HspB8 mutation causing hereditary distal motor neuropathy impairs lysosomal delivery of autophagosomes.

Kwok AS, Phadwal K, Turner BJ, Oliver PL, Raw A, Simon AK, Talbot K, Agashe VR.

J Neurochem. 2011 Dec;119(6):1155-61. doi: 10.1111/j.1471-4159.2011.07521.x. Epub 2011 Nov 3.


Mouse genomic variation and its effect on phenotypes and gene regulation.

Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, Janowitz D, Hernandez-Pliego P, Edwards A, Belgard TG, Oliver PL, McIntyre RE, Bhomra A, Nicod J, Gan X, Yuan W, van der Weyden L, Steward CA, Bala S, Stalker J, Mott R, Durbin R, Jackson IJ, Czechanski A, Guerra-Assunção JA, Donahue LR, Reinholdt LG, Payseur BA, Ponting CP, Birney E, Flint J, Adams DJ.

Nature. 2011 Sep 14;477(7364):289-94. doi: 10.1038/nature10413.


Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse.

Edwards A, Treiber CD, Breuss M, Pidsley R, Huang GJ, Cleak J, Oliver PL, Flint J, Keays DA.

Neuroscience. 2011 Nov 10;195:191-200. doi: 10.1016/j.neuroscience.2011.08.035. Epub 2011 Aug 22.


A transcriptomic atlas of mouse neocortical layers.

Belgard TG, Marques AC, Oliver PL, Abaan HO, Sirey TM, Hoerder-Suabedissen A, García-Moreno F, Molnár Z, Margulies EH, Ponting CP.

Neuron. 2011 Aug 25;71(4):605-16. doi: 10.1016/j.neuron.2011.06.039.


Challenges of analysing gene-environment interactions in mouse models of schizophrenia.

Oliver PL.

ScientificWorldJournal. 2011 Jul 7;11:1411-20. doi: 10.1100/tsw.2011.128. Review.


Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.

Vernes SC, Oliver PL, Spiteri E, Lockstone HE, Puliyadi R, Taylor JM, Ho J, Mombereau C, Brewer A, Lowy E, Nicod J, Groszer M, Baban D, Sahgal N, Cazier JB, Ragoussis J, Davies KE, Geschwind DH, Fisher SE.

PLoS Genet. 2011 Jul;7(7):e1002145. doi: 10.1371/journal.pgen.1002145. Epub 2011 Jul 7.


Genomic and Post-Genomic Tools for Studying Synapse Biology.

Kittler JT, Oliver PL.

In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 15.


Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes.

Chodroff RA, Goodstadt L, Sirey TM, Oliver PL, Davies KE, Green ED, Molnár Z, Ponting CP.

Genome Biol. 2010;11(7):R72. doi: 10.1186/gb-2010-11-7-r72. Epub 2010 Jul 12.


Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons.

Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ, Kittler JT.

Mol Cell Neurosci. 2010 Aug;44(4):330-41. doi: 10.1016/j.mcn.2010.04.004. Epub 2010 Apr 22.


AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development.

Bitoun E, Finelli MJ, Oliver PL, Lee S, Davies KE.

J Neurosci. 2009 Dec 9;29(49):15366-74. doi: 10.1523/JNEUROSCI.5188-09.2009.


Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.

Oliver PL, Goodstadt L, Bayes JJ, Birtle Z, Roach KC, Phadnis N, Beatson SA, Lunter G, Malik HS, Ponting CP.

PLoS Genet. 2009 Dec;5(12):e1000753. doi: 10.1371/journal.pgen.1000753. Epub 2009 Dec 4.


Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice.

Deakin IH, Law AJ, Oliver PL, Schwab MH, Nave KA, Harrison PJ, Bannerman DM.

Neuroreport. 2009 Nov 25;20(17):1523-8. doi: 10.1097/WNR.0b013e328330f6e7.


Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss.

Mackenzie FE, Parker A, Parkinson NJ, Oliver PL, Brooker D, Underhill P, Lukashkina VA, Lukashkin AN, Holmes C, Brown SD.

Genes Brain Behav. 2009 Oct;8(7):699-713. doi: 10.1111/j.1601-183X.2009.00514.x. Epub 2009 Jun 22.


Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk.

Oliver PL, Davies KE.

Hum Mol Genet. 2009 Dec 1;18(23):4576-89. doi: 10.1093/hmg/ddp425. Epub 2009 Sep 3.

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