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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment.

Salahuddin S, Thomson E, Méziane O, Farnos O, Pagliuzza A, Chomont N, Olivenstein R, Costiniuk C, Jenabian MA.

J Vis Exp. 2019 Jun 23;(148). doi: 10.3791/59427.


Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma.

Ichikawa T, Panariti A, Audusseau S, Mogas AK, Olivenstein R, Chakir J, Laviolette M, Allakhverdi Z, Al Heialy S, Martin JG, Hamid Q.

Respir Med. 2019 Apr;150:165-172. doi: 10.1016/j.rmed.2019.03.005. Epub 2019 Mar 20.


HIV persistence in mucosal CD4+ T cells within the lungs of adults receiving long-term suppressive antiretroviral therapy.

Costiniuk CT, Salahuddin S, Farnos O, Olivenstein R, Pagliuzza A, Orlova M, Schurr E, De Castro C, Bourbeau J, Routy JP, Ancuta P, Chomont N, Jenabian MA.

AIDS. 2018 Oct 23;32(16):2279-2289. doi: 10.1097/QAD.0000000000001962.


Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial.

Russell RJ, Chachi L, FitzGerald JM, Backer V, Olivenstein R, Titlestad IL, Ulrik CS, Harrison T, Singh D, Chaudhuri R, Leaker B, McGarvey L, Siddiqui S, Wang M, Braddock M, Nordenmark LH, Cohen D, Parikh H, Colice G, Brightling CE; MESOS study investigators.

Lancet Respir Med. 2018 Jul;6(7):499-510. doi: 10.1016/S2213-2600(18)30201-7. Epub 2018 May 21.


Interleukin-17A and vascular remodelling in severe asthma; lack of evidence for a direct role.

Panariti A, Baglole CJ, Sanchez V, Eidelman DH, Hussain S, Olivenstein R, Martin JG, Hamid Q.

Clin Exp Allergy. 2018 Apr;48(4):365-378. doi: 10.1111/cea.13093. Epub 2018 Feb 20.


Asthma biomarkers in the age of biologics.

Kim H, Ellis AK, Fischer D, Noseworthy M, Olivenstein R, Chapman KR, Lee J.

Allergy Asthma Clin Immunol. 2017 Nov 17;13:48. doi: 10.1186/s13223-017-0219-4. eCollection 2017. Review.


Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris suum-induced Allergic Asthma in Nonhuman Primates.

Camateros P, Kanagaratham C, Najdekr L, Holub D, Vrbkova J, Coté L, Fournier J, Gourdon J, Creery D, Olivenstein R, Kopriva F, Adam T, Friedecký D, Džubák P, Hajdúch M, Radzioch D.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):55-65. doi: 10.1165/rcmb.2017-0184OC.


It's better to be lucky … successful management of an acute endobronchial tumour embolism in the ICU: a case report and review of the literature.

Walsh CJ, Olivenstein R, Forget E, Gonzalez AV.

Respirol Case Rep. 2017 Mar 7;5(3):e00225. doi: 10.1002/rcr2.225. eCollection 2017 May.


Exacerbation risk in severe asthma is stratified by inflammatory phenotype using longitudinal measures of sputum eosinophils.

Walsh CJ, Zaihra T, Benedetti A, Fugère C, Olivenstein R, Lemière C, Hamid Q, Martin JG.

Clin Exp Allergy. 2016 Oct;46(10):1291-302. doi: 10.1111/cea.12762. Epub 2016 Jun 27.


Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters.

Zaihra T, Walsh CJ, Ahmed S, Fugère C, Hamid QA, Olivenstein R, Martin JG, Benedetti A.

BMC Pulm Med. 2016 May 10;16(1):74. doi: 10.1186/s12890-016-0232-2.


Disconnect between sputum neutrophils and other measures of airway inflammation in asthma.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM.

Eur Respir J. 2014 Feb;43(2):627-9. doi: 10.1183/09031936.00117013. Epub 2013 Oct 31. No abstract available.


Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.

Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Hales JB, McEvoy C, Slebos DJ, Holmes M, Phillips MJ, Erzurum SC, Hanania NA, Sumino K, Kraft M, Cox G, Sterman DH, Hogarth K, Kline JN, Mansur AH, Louie BE, Leeds WM, Barbers RG, Austin JH, Shargill NS, Quiring J, Armstrong B, Castro M; Asthma Intervention Research 2 Trial Study Group.

J Allergy Clin Immunol. 2013 Dec;132(6):1295-302. doi: 10.1016/j.jaci.2013.08.009. Epub 2013 Aug 30.


Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia.

Laviolette M, Gossage DL, Gauvreau G, Leigh R, Olivenstein R, Katial R, Busse WW, Wenzel S, Wu Y, Datta V, Kolbeck R, Molfino NA.

J Allergy Clin Immunol. 2013 Nov;132(5):1086-1096.e5. doi: 10.1016/j.jaci.2013.05.020. Epub 2013 Jul 16. Erratum in: J Allergy Clin Immunol. 2014 Apr;133(4):1232.


Genetic and histologic evidence for autophagy in asthma pathogenesis.

Poon AH, Chouiali F, Tse SM, Litonjua AA, Hussain SN, Baglole CJ, Eidelman DH, Olivenstein R, Martin JG, Weiss ST, Hamid Q, Laprise C.

J Allergy Clin Immunol. 2012 Feb;129(2):569-71. doi: 10.1016/j.jaci.2011.09.035. Epub 2011 Oct 29. No abstract available.


Effects of a short course of inhaled corticosteroids in noneosinophilic asthmatic subjects.

Lemière C, Tremblay C, FitzGerald M, Aaron SD, Leigh R, Boulet LP, Martin JG, Nair P, Olivenstein R, Chaboillez S.

Can Respir J. 2011 Sep-Oct;18(5):278-82.


Steroid-insensitive ERK1/2 activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle.

Robins S, Roussel L, Schachter A, Risse PA, Mogas AK, Olivenstein R, Martin JG, Hamid Q, Rousseau S.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):984-90. doi: 10.1165/rcmb.2010-0450OC. Epub 2011 Apr 14.


Asthma in the elderly … Their time is right now.

Olivenstein R, Hamid Q.

Clin Exp Allergy. 2011 Apr;41(4):457-8. doi: 10.1111/j.1365-2222.2011.03702.x. No abstract available.


Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial.

Thomson NC, Rubin AS, Niven RM, Corris PA, Siersted HC, Olivenstein R, Pavord ID, McCormack D, Laviolette M, Shargill NS, Cox G; AIR Trial Study Group.

BMC Pulm Med. 2011 Feb 11;11:8. doi: 10.1186/1471-2466-11-8.


Montelukast added to fluticasone propionate does not alter inflammation or outcomes.

Djukanović R, Wilson SJ, Moore WC, Koenig SM, Laviolette M, Bleecker ER, Davis WB, Doherty DE, Olivenstein R, Israel E, Kavuru MS, Kleerup E, Reilly DS, Yancey SW, Edwards LD, Stauffer JL, Dorinsky PM, Jarjour NN.

Respir Med. 2010 Oct;104(10):1425-35. doi: 10.1016/j.rmed.2010.04.004. Epub 2010 Aug 14.


Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma.

Hassan M, Jo T, Risse PA, Tolloczko B, Lemière C, Olivenstein R, Hamid Q, Martin JG.

J Allergy Clin Immunol. 2010 May;125(5):1037-1045.e3. doi: 10.1016/j.jaci.2010.02.031.


T Cells localize with proliferating smooth muscle alpha-actin+ cell compartments in asthma.

Ramos-Barbón D, Fraga-Iriso R, Brienza NS, Montero-Martínez C, Verea-Hernando H, Olivenstein R, Lemiere C, Ernst P, Hamid QA, Martin JG.

Am J Respir Crit Care Med. 2010 Aug 1;182(3):317-24. doi: 10.1164/rccm.200905-0745OC. Epub 2010 Apr 15.


Variability of sputum inflammatory cells in asthmatic patients receiving corticosteroid therapy: A prospective study using multiple samples.

Al-Samri MT, Benedetti A, Préfontaine D, Olivenstein R, Lemière C, Nair P, Martin JG, Hamid Q.

J Allergy Clin Immunol. 2010 May;125(5):1161-1163.e4. doi: 10.1016/j.jaci.2010.02.005. Epub 2010 Apr 14. No abstract available.


IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation.

Roussel L, Houle F, Chan C, Yao Y, Bérubé J, Olivenstein R, Martin JG, Huot J, Hamid Q, Ferri L, Rousseau S.

J Immunol. 2010 Apr 15;184(8):4531-7. doi: 10.4049/jimmunol.0903162. Epub 2010 Mar 12.


Psychologic distress and maladaptive coping styles in patients with severe vs moderate asthma.

Lavoie KL, Bouthillier D, Bacon SL, Lemière C, Martin J, Hamid Q, Ludwig M, Olivenstein R, Ernst P.

Chest. 2010 Jun;137(6):1324-31. doi: 10.1378/chest.09-1979. Epub 2010 Jan 22.


Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial.

Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G; AIR2 Trial Study Group.

Am J Respir Crit Care Med. 2010 Jan 15;181(2):116-24. doi: 10.1164/rccm.200903-0354OC. Epub 2009 Oct 8.


Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

Préfontaine D, Lajoie-Kadoch S, Foley S, Audusseau S, Olivenstein R, Halayko AJ, Lemière C, Martin JG, Hamid Q.

J Immunol. 2009 Oct 15;183(8):5094-103. doi: 10.4049/jimmunol.0802387.


Benefits of low-dose inhaled fluticasone on airway response and inflammation in mild asthma.

Boulet LP, Turcotte H, Prince P, Lemière C, Olivenstein R, Laprise C, Larivée P, Bégin P, Laviolette M.

Respir Med. 2009 Oct;103(10):1554-63. doi: 10.1016/j.rmed.2009.02.015. Epub 2009 Aug 18.


Prevalence of obstructive sleep apnea-hypopnea in severe versus moderate asthma.

Julien JY, Martin JG, Ernst P, Olivenstein R, Hamid Q, Lemière C, Pepe C, Naor N, Olha A, Kimoff RJ.

J Allergy Clin Immunol. 2009 Aug;124(2):371-6. doi: 10.1016/j.jaci.2009.05.016. Epub 2009 Jun 26.


Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction.

Kaminska M, Foley S, Maghni K, Storness-Bliss C, Coxson H, Ghezzo H, Lemière C, Olivenstein R, Ernst P, Hamid Q, Martin J.

J Allergy Clin Immunol. 2009 Jul;124(1):45-51.e1-4. doi: 10.1016/j.jaci.2009.03.049. Epub 2009 May 29.


T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma.

Al-Ramli W, Préfontaine D, Chouiali F, Martin JG, Olivenstein R, Lemière C, Hamid Q.

J Allergy Clin Immunol. 2009 May;123(5):1185-7. doi: 10.1016/j.jaci.2009.02.024. Epub 2009 Apr 10. No abstract available.


Safety, pharmacodynamics and pharmacokinetics of TPI 1020 in smokers with asthma.

Boulet LP, Lemière C, Gauvreau G, Olivenstein R, Lougheed D, Paradis B, O'Byrne P, Pageau R, Renzi PM.

Respir Med. 2009 Aug;103(8):1159-66. doi: 10.1016/j.rmed.2009.02.011. Epub 2009 Mar 16.


Quality of bronchial biopsies for morphology study and cell sampling: a comparison of asthmatic and healthy subjects.

Labonté I, Laviolette M, Olivenstein R, Chakir J, Boulet LP, Hamid Q.

Can Respir J. 2008 Nov-Dec;15(8):431-5.


Differences in airway cytokine profile in severe asthma compared to moderate asthma.

Shannon J, Ernst P, Yamauchi Y, Olivenstein R, Lemiere C, Foley S, Cicora L, Ludwig M, Hamid Q, Martin JG.

Chest. 2008 Feb;133(2):420-6. Epub 2007 Dec 10.


Structural changes and airway remodelling in occupational asthma at a mean interval of 14 years after cessation of exposure.

Sumi Y, Foley S, Daigle S, L'Archevêque J, Olivenstein R, Letuvé S, Malo JL, Hamid Q.

Clin Exp Allergy. 2007 Dec;37(12):1781-7. Epub 2007 Sep 27.


Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial.

Bourbeau J, Christodoulopoulos P, Maltais F, Yamauchi Y, Olivenstein R, Hamid Q.

Thorax. 2007 Nov;62(11):938-43. Epub 2007 Jun 8.


Asthma control during the year after bronchial thermoplasty.

Cox G, Thomson NC, Rubin AS, Niven RM, Corris PA, Siersted HC, Olivenstein R, Pavord ID, McCormack D, Chaudhuri R, Miller JD, Laviolette M; AIR Trial Study Group.

N Engl J Med. 2007 Mar 29;356(13):1327-37.


Increased expression of ADAM33 and ADAM8 with disease progression in asthma.

Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, Ernst P, Lemière C, Martin JG, Hamid Q.

J Allergy Clin Immunol. 2007 Apr;119(4):863-71. Epub 2007 Mar 6.


Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes.

Lemière C, Ernst P, Olivenstein R, Yamauchi Y, Govindaraju K, Ludwig MS, Martin JG, Hamid Q.

J Allergy Clin Immunol. 2006 Nov;118(5):1033-9. Epub 2006 Sep 25.


Differences in proteoglycan deposition in the airways of moderate and severe asthmatics.

Pini L, Hamid Q, Shannon J, Lemelin L, Olivenstein R, Ernst P, Lemière C, Martin JG, Ludwig MS.

Eur Respir J. 2007 Jan;29(1):71-7. Epub 2006 Oct 18.


Does dynamic hyperinflation impair submaximal exercise cardiac output in chronic obstructive pulmonary disease?

Baril J, de Souza M, Leroy D, Ofir D, Aguilaniu B, Glady C, Olivenstein R, Bourbeau J, Perrault H.

Clin Invest Med. 2006 Apr;29(2):104-9. No abstract available.


Effects of hydrofluoroalkane and dry powder-formulated corticosteroids on sputum inflammatory markers in asthmatic patients.

Hauber H, Taha R, Bergeron C, Migounov V, Hamid Q, Olivenstein R.

Can Respir J. 2006 Mar;13(2):73-8.


Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma.

Bergeron C, Fukakusa M, Olivenstein R, Lemiere C, Shannon J, Ernst P, Martin JG, Hamid Q.

J Allergy Clin Immunol. 2006 Mar;117(3):703-5. No abstract available.


Differences in airway remodeling between subjects with severe and moderate asthma.

Pepe C, Foley S, Shannon J, Lemiere C, Olivenstein R, Ernst P, Ludwig MS, Martin JG, Hamid Q.

J Allergy Clin Immunol. 2005 Sep;116(3):544-9.


Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness.

Boulet LP, Prince P, Turcotte H, Lemière C, Olivenstein R, Laprise C, Larivée P, Bégin P, Laviolette M.

Respir Med. 2006 Feb;100(2):292-9. Epub 2005 Jun 9.


Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis.

Hauber HP, Bergeron C, Tsicopoulos A, Wallaert B, Olivenstein R, Holroyd KJ, Levitt RC, Hamid Q.

Can Respir J. 2005 Apr;12(3):143-6.


Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis.

Hauber HP, Tulic MK, Tsicopoulos A, Wallaert B, Olivenstein R, Daigneault P, Hamid Q.

Can Respir J. 2005 Jan-Feb;12(1):13-8.


Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction.

Hauber HP, Tsicopoulos A, Wallaert B, Griffin S, McElvaney NG, Daigneault P, Mueller Z, Olivenstein R, Holroyd KJ, Levitt RC, Hamid Q.

Eur Respir J. 2004 Jun;23(6):846-50.


The expression of stem cell factor and c-kit receptor in human asthmatic airways.

Al-Muhsen SZ, Shablovsky G, Olivenstein R, Mazer B, Hamid Q.

Clin Exp Allergy. 2004 Jun;34(6):911-6.


Fractional analysis of Th2-type cytokines in sequential samples of induced sputum.

Taha R, Hamid Q, Olivenstein R.

Can Respir J. 2004 Mar;11(2):146-50.


5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin.

Muro S, Hamid Q, Olivenstein R, Taha R, Rokach J, Powell WS.

J Allergy Clin Immunol. 2003 Oct;112(4):768-74.


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