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Items: 18

1.

Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole.

Simonsen U, Winther AK, Oliván-Viguera A, Comerma-Steffensen S, Köhler R, Bek T.

Int J Mol Sci. 2019 Apr 25;20(8). pii: E2032. doi: 10.3390/ijms20082032.

2.

KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility.

Valero MS, Ramón-Gimenez M, Lozano-Gerona J, Delgado-Wicke P, Calmarza P, Oliván-Viguera A, López V, Garcia-Otín ÁL, Valero S, Pueyo E, Hamilton KL, Miura H, Köhler R.

Int J Mol Sci. 2019 Mar 8;20(5). pii: E1193. doi: 10.3390/ijms20051193.

3.

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes.

Olivan-Viguera A, Garcia-Otin AL, Lozano-Gerona J, Abarca-Lachen E, Garcia-Malinis AJ, Hamilton KL, Gilaberte Y, Pueyo E, Köhler R.

PLoS One. 2018 Jan 2;13(1):e0190307. doi: 10.1371/journal.pone.0190307. eCollection 2018.

4.

Inhibition of Intermediate-Conductance Calcium-Activated K Channel (KCa3.1) and Fibroblast Mitogenesis by α-Linolenic Acid and Alterations of Channel Expression in the Lysosomal Storage Disorders, Fabry Disease, and Niemann Pick C.

Oliván-Viguera A, Lozano-Gerona J, López de Frutos L, Cebolla JJ, Irún P, Abarca-Lachen E, García-Malinis AJ, García-Otín ÁL, Gilaberte Y, Giraldo P, Köhler R.

Front Physiol. 2017 Jan 31;8:39. doi: 10.3389/fphys.2017.00039. eCollection 2017.

5.

Nuclear localization of the CK2α-subunit correlates with poor prognosis in clear cell renal cell carcinoma.

Rabjerg M, Guerra B, Oliván-Viguera A, Mikkelsen ML, Köhler R, Issinger OG, Marcussen N.

Oncotarget. 2017 Jan 3;8(1):1613-1627. doi: 10.18632/oncotarget.13693.

6.

Emerging roles of calcium-activated K channels and TRPV4 channels in lung oedema and pulmonary circulatory collapse.

Simonsen U, Wandall-Frostholm C, Oliván-Viguera A, Köhler R.

Acta Physiol (Oxf). 2017 Jan;219(1):176-187. doi: 10.1111/apha.12768. Epub 2016 Sep 16. Review.

PMID:
27497091
7.

Endothelial Small- and Intermediate-Conductance K Channels and Endothelium-Dependent Hyperpolarization as Drug Targets in Cardiovascular Disease.

Köhler R, Oliván-Viguera A, Wulff H.

Adv Pharmacol. 2016;77:65-104. doi: 10.1016/bs.apha.2016.04.002. Epub 2016 May 4. Review.

PMID:
27451095
8.

Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed.

Oliván-Viguera A, Valero MS, Pinilla E, Amor S, García-Villalón ÁL, Coleman N, Laría C, Calvín-Tienza V, García-Otín ÁL, Fernández-Fernández JM, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Badorrey R, Simonsen U, Rivera L, Wulff H, Köhler R.

Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. doi: 10.1111/bcpt.12560. Epub 2016 Feb 29.

9.

Rock Tea extract (Jasonia glutinosa) relaxes rat aortic smooth muscle by inhibition of L-type Ca(2+) channels.

Valero MS, Oliván-Viguera A, Garrido I, Langa E, Berzosa C, López V, Gómez-Rincón C, Murillo MD, Köhler R.

J Physiol Biochem. 2015 Dec;71(4):785-93.

PMID:
26464340
10.

Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation.

Wandall-Frostholm C, Dalsgaard T, Bajoriūnas V, Oliván-Viguera A, Sadda V, Beck L, Mogensen S, Stankevicius E, Simonsen U, Köhler R.

Br J Pharmacol. 2015 Sep;172(18):4493-4505. doi: 10.1111/bph.13234. Epub 2015 Jul 24.

11.

High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival.

Rabjerg M, Oliván-Viguera A, Hansen LK, Jensen L, Sevelsted-Møller L, Walter S, Jensen BL, Marcussen N, Köhler R.

PLoS One. 2015 Apr 7;10(4):e0122992. doi: 10.1371/journal.pone.0122992. eCollection 2015.

12.

Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.

Fernández-Mariño AI, Cidad P, Zafra D, Nocito L, Domínguez J, Oliván-Viguera A, Köhler R, López-López JR, Pérez-García MT, Valverde MÁ, Guinovart JJ, Fernández-Fernández JM.

PLoS One. 2015 Feb 6;10(2):e0118148. doi: 10.1371/journal.pone.0118148. eCollection 2015.

13.

A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.

Oliván-Viguera A, Valero MS, Coleman N, Brown BM, Laría C, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Wulff H, Badorrey R, Köhler R.

Mol Pharmacol. 2015 Feb;87(2):338-48. doi: 10.1124/mol.114.095745. Epub 2014 Dec 2.

14.

Modulation of K(Ca)3.1 channels by eicosanoids, omega-3 fatty acids, and molecular determinants.

Kacik M, Oliván-Viguera A, Köhler R.

PLoS One. 2014 Nov 5;9(11):e112081. doi: 10.1371/journal.pone.0112081. eCollection 2014.

15.

New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.

Coleman N, Brown BM, Oliván-Viguera A, Singh V, Olmstead MM, Valero MS, Köhler R, Wulff H.

Mol Pharmacol. 2014 Sep;86(3):342-57. doi: 10.1124/mol.114.093286. Epub 2014 Jun 23.

16.

Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension.

Nielsen G, Wandall-Frostholm C, Sadda V, Oliván-Viguera A, Lloyd EE, Bryan RM Jr, Simonsen U, Köhler R.

Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):250-8. doi: 10.1111/bcpt.12092. Epub 2013 Jun 27.

17.

Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3.

Oliván-Viguera A, Valero MS, Murillo MD, Wulff H, García-Otín AL, Arbonés-Mainar JM, Köhler R.

PLoS One. 2013;8(3):e58614. doi: 10.1371/journal.pone.0058614. Epub 2013 Mar 14.

18.

Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels.

Lambertsen KL, Gramsbergen JB, Sivasaravanaparan M, Ditzel N, Sevelsted-Møller LM, Oliván-Viguera A, Rabjerg M, Wulff H, Köhler R.

PLoS One. 2012;7(10):e47744. doi: 10.1371/journal.pone.0047744. Epub 2012 Oct 15.

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