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Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury.

de Jong IEM, Matton APM, van Praagh JB, van Haaften WT, Wiersema-Buist J, van Wijk LA, Oosterhuis D, Iswandana R, Suriguga S, Overi D, Lisman T, Carpino G, Gouw ASH, Olinga P, Gaudio E, Porte RJ.

Hepatology. 2018 Dec 2. doi: 10.1002/hep.30365. [Epub ahead of print]


siRNA-mediated protein knockdown in precision-cut lung slices.

Ruigrok MJR, Xian JL, Frijlink HW, Melgert BN, Hinrichs WLJ, Olinga P.

Eur J Pharm Biopharm. 2018 Dec;133:339-348. doi: 10.1016/j.ejpb.2018.11.005. Epub 2018 Nov 7.


Regional Differences in Human Intestinal Drug Metabolism.

Iswandana R, Irianti MI, Oosterhuis D, Hofker HS, Merema MT, de Jager MH, Mutsaers HAM, Olinga P.

Drug Metab Dispos. 2018 Dec;46(12):1879-1885. doi: 10.1124/dmd.118.083428. Epub 2018 Oct 1.


In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β.

Luangmonkong T, Suriguga S, Adhyatmika A, Adlia A, Oosterhuis D, Suthisisang C, de Jong KP, Mutsaers HAM, Olinga P.

Toxicol Appl Pharmacol. 2018 Sep 15;355:127-137. doi: 10.1016/j.taap.2018.07.001. Epub 2018 Jul 3.


Targeting Oxidative Stress for the Treatment of Liver Fibrosis.

Luangmonkong T, Suriguga S, Mutsaers HAM, Groothuis GMM, Olinga P, Boersema M.

Rev Physiol Biochem Pharmacol. 2018;175:71-102. doi: 10.1007/112_2018_10.


Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis.

Stribos EGD, Seelen MA, van Goor H, Olinga P, Mutsaers HAM.

Front Physiol. 2017 Dec 12;8:1026. doi: 10.3389/fphys.2017.01026. eCollection 2017.


Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage.

van Praagh JB, de Goffau MC, Bakker IS, van Goor H, Harmsen HJM, Olinga P, Havenga K.

Ann Surg. 2018 Jan 9. doi: 10.1097/SLA.0000000000002651. [Epub ahead of print]


Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver.

van Dijk F, Teekamp N, Beljaars L, Post E, Zuidema J, Steendam R, Kim YO, Frijlink HW, Schuppan D, Poelstra K, Hinrichs WLJ, Olinga P.

J Control Release. 2018 Jan 10;269:258-265. doi: 10.1016/j.jconrel.2017.11.029. Epub 2017 Nov 21. No abstract available.


MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis.

Caviglia JM, Yan J, Jang MK, Gwak GY, Affo S, Yu L, Olinga P, Friedman RA, Chen X, Schwabe RF.

Hepatology. 2018 Jun;67(6):2414-2429. doi: 10.1002/hep.29627. Epub 2018 Jan 18.


Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney.

Teekamp N, Van Dijk F, Broesder A, Evers M, Zuidema J, Steendam R, Post E, Hillebrands JL, Frijlink HW, Poelstra K, Beljaars L, Olinga P, Hinrichs WLJ.

Int J Pharm. 2017 Dec 20;534(1-2):229-236. doi: 10.1016/j.ijpharm.2017.09.072. Epub 2017 Oct 14.


A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages.

Boorsma CE, van der Veen TA, Putri KSS, de Almeida A, Draijer C, Mauad T, Fejer G, Brandsma CA, van den Berge M, Bossé Y, Sin D, Hao K, Reithmeier A, Andersson G, Olinga P, Timens W, Casini A, Melgert BN.

Sci Rep. 2017 Oct 3;7(1):12570. doi: 10.1038/s41598-017-12623-w.


Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions.

Teekamp N, Tian Y, Visser JC, Olinga P, Frijlink HW, Woerdenbag HJ, Hinrichs WLJ.

Carbohydr Polym. 2017 Nov 15;176:374-380. doi: 10.1016/j.carbpol.2017.08.084. Epub 2017 Aug 24.


siRNA-Mediated RNA Interference in Precision-Cut Tissue Slices Prepared from Mouse Lung and Kidney.

Ruigrok MJR, Maggan N, Willaert D, Frijlink HW, Melgert BN, Olinga P, Hinrichs WLJ.

AAPS J. 2017 Nov;19(6):1855-1863. doi: 10.1208/s12248-017-0136-y. Epub 2017 Sep 11.


Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H.

Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z.


Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis.

Luangmonkong T, Suriguga S, Bigaeva E, Boersema M, Oosterhuis D, de Jong KP, Schuppan D, Mutsaers HAM, Olinga P.

Br J Pharmacol. 2017 Sep;174(18):3107-3117. doi: 10.1111/bph.13945. Epub 2017 Aug 11.


Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease.

van Haaften WT, Mortensen JH, Karsdal MA, Bay-Jensen AC, Dijkstra G, Olinga P.

Aliment Pharmacol Ther. 2017 Jul;46(1):26-39. doi: 10.1111/apt.14092. Epub 2017 May 8.


Non-invasive quantification of collagen turnover in renal transplant recipients.

Stribos EGD, Nielsen SH, Brix S, Karsdal MA, Seelen MA, van Goor H, Bakker SJL, Olinga P, Mutsaers HAM, Genovese F.

PLoS One. 2017 Apr 21;12(4):e0175898. doi: 10.1371/journal.pone.0175898. eCollection 2017.


Editorial: Organ Fibrosis: Triggers, Pathways, and Cellular Plasticity.

Mutsaers HA, Olinga P.

Front Med (Lausanne). 2016 Nov 15;3:55. eCollection 2016. No abstract available.


Renal fibrosis in precision-cut kidney slices.

Stribos EG, Hillebrands JL, Olinga P, Mutsaers HA.

Eur J Pharmacol. 2016 Nov 5;790:57-61. doi: 10.1016/j.ejphar.2016.06.057. Epub 2016 Jun 30. Review.


Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.

Vatakuti S, Olinga P, Pennings JLA, Groothuis GMM.

Arch Toxicol. 2017 Mar;91(3):1401-1412. doi: 10.1007/s00204-016-1778-8. Epub 2016 Jun 25.


Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis.

Westra IM, Mutsaers HA, Luangmonkong T, Hadi M, Oosterhuis D, de Jong KP, Groothuis GM, Olinga P.

Toxicol In Vitro. 2016 Sep;35:77-85. doi: 10.1016/j.tiv.2016.05.012. Epub 2016 May 26.


Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.

Vatakuti S, Pennings JL, Gore E, Olinga P, Groothuis GM.

Chem Res Toxicol. 2016 Mar 21;29(3):342-51. doi: 10.1021/acs.chemrestox.5b00491. Epub 2016 Mar 9.


Organ- and species-specific biological activity of rosmarinic acid.

Iswandana R, Pham BT, van Haaften WT, Luangmonkong T, Oosterhuis D, Mutsaers HA, Olinga P.

Toxicol In Vitro. 2016 Apr;32:261-8. doi: 10.1016/j.tiv.2016.01.009. Epub 2016 Jan 19.


Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis.

Stribos EGD, Luangmonkong T, Leliveld AM, de Jong IJ, van Son WJ, Hillebrands JL, Seelen MA, van Goor H, Olinga P, Mutsaers HAM.

Transl Res. 2016 Apr;170:8-16.e1. doi: 10.1016/j.trsl.2015.11.007. Epub 2015 Nov 25.


Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma.

van Dijk F, Olinga P, Poelstra K, Beljaars L.

Front Med (Lausanne). 2015 Oct 5;2:72. doi: 10.3389/fmed.2015.00072. eCollection 2015. Review.


Intestinal microbiota and anastomotic leakage of stapled colorectal anastomoses: a pilot study.

van Praagh JB, de Goffau MC, Bakker IS, Harmsen HJ, Olinga P, Havenga K.

Surg Endosc. 2016 Jun;30(6):2259-65. doi: 10.1007/s00464-015-4508-z. Epub 2015 Sep 18.


Chronic Kidney Disease and Fibrosis: The Role of Uremic Retention Solutes.

Mutsaers HA, Stribos EG, Glorieux G, Vanholder R, Olinga P.

Front Med (Lausanne). 2015 Aug 31;2:60. doi: 10.3389/fmed.2015.00060. eCollection 2015. Review.


The Authors Reply.

Mutsaers HA, Masereeuw R, Olinga P.

Kidney Int. 2015 Sep;88(3):637. doi: 10.1038/ki.2015.188. No abstract available.


Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to Differentiate Crohn's Disease from Ulcerative Colitis.

Mortensen JH, Godskesen LE, Jensen MD, Van Haaften WT, Klinge LG, Olinga P, Dijkstra G, Kjeldsen J, Karsdal MA, Bay-Jensen AC, Krag A.

J Crohns Colitis. 2015 Oct;9(10):863-72. doi: 10.1093/ecco-jcc/jjv123. Epub 2015 Jul 17.


Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo.

Poosti F, Pham BT, Oosterhuis D, Poelstra K, van Goor H, Olinga P, Hillebrands JL.

Dis Model Mech. 2015 Oct 1;8(10):1227-36. doi: 10.1242/dmm.020172. Epub 2015 Jun 25.


Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosis.

Pham BT, van Haaften WT, Oosterhuis D, Nieken J, de Graaf IA, Olinga P.

Physiol Rep. 2015 Apr;3(4). pii: e12323. doi: 10.14814/phy2.12323.


Acute toxicity of CCl4 but not of paracetamol induces a transcriptomic signature of fibrosis in precision-cut liver slices.

Vatakuti S, Schoonen WG, Elferink ML, Groothuis GM, Olinga P.

Toxicol In Vitro. 2015 Aug;29(5):1012-20. doi: 10.1016/j.tiv.2015.03.015. Epub 2015 Apr 6.


Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and proteins.

Teekamp N, Duque LF, Frijlink HW, Hinrichs WL, Olinga P.

Expert Opin Drug Deliv. 2015 Aug;12(8):1311-31. doi: 10.1517/17425247.2015.1003807. Epub 2015 Jan 19. Review.


Renal expression of Toll-like receptor 2 and 4: dynamics in human allograft injury and comparison to rodents.

Stribos EG, van Werkhoven MB, Poppelaars F, van Goor H, Olinga P, van Son WJ, Damman J, Seelen MA.

Mol Immunol. 2015 Mar;64(1):82-9. doi: 10.1016/j.molimm.2014.11.003. Epub 2014 Nov 29.


Altered tryptophan metabolism and CKD-associated fatigue.

Mutsaers HA, Masereeuw R, Olinga P.

Kidney Int. 2014 Nov;86(5):1061-2. doi: 10.1038/ki.2014.237. No abstract available.


The effect of antifibrotic drugs in rat precision-cut fibrotic liver slices.

Westra IM, Oosterhuis D, Groothuis GM, Olinga P.

PLoS One. 2014 Apr 22;9(4):e95462. doi: 10.1371/journal.pone.0095462. eCollection 2014.


Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.

Westra IM, Oosterhuis D, Groothuis GM, Olinga P.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):328-38. doi: 10.1016/j.taap.2013.11.017. Epub 2013 Dec 7.


Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.


Complement mediated renal inflammation induced by donor brain death: role of renal C5a-C5aR interaction.

van Werkhoven MB, Damman J, van Dijk MCRF, Daha MR, de Jong IJ, Leliveld A, Krikke C, Leuvenink HG, van Goor H, van Son WJ, Olinga P, Hillebrands JL, Seelen MAJ.

Am J Transplant. 2013 Apr;13(4):875-882. doi: 10.1111/ajt.12130. Epub 2013 Feb 7.


Precision-cut liver slices: a tool to model the liver ex vivo.

Olinga P, Schuppan D.

J Hepatol. 2013 Jun;58(6):1252-3. doi: 10.1016/j.jhep.2013.01.009. Epub 2013 Jan 18. No abstract available.


Evaluation of fibrosis in precision-cut tissue slices.

Westra IM, Pham BT, Groothuis GM, Olinga P.

Xenobiotica. 2013 Jan;43(1):98-112. doi: 10.3109/00498254.2012.723151. Epub 2012 Sep 25. Review.


Repair pathways evident in human liver organ slices.

Vickers AE, Fisher R, Olinga P, Dial S.

Toxicol In Vitro. 2011 Oct;25(7):1485-92. doi: 10.1016/j.tiv.2011.04.029. Epub 2011 May 7.


Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes.

Elferink MG, Olinga P, van Leeuwen EM, Bauerschmidt S, Polman J, Schoonen WG, Heisterkamp SH, Groothuis GM.

Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69. doi: 10.1016/j.taap.2011.03.010. Epub 2011 Mar 21.


Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.

de Graaf IA, Olinga P, de Jager MH, Merema MT, de Kanter R, van de Kerkhof EG, Groothuis GM.

Nat Protoc. 2010 Sep;5(9):1540-51. doi: 10.1038/nprot.2010.111. Epub 2010 Aug 19.


Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis.

Schaffert CS, Duryee MJ, Bennett RG, DeVeney AL, Tuma DJ, Olinga P, Easterling KC, Thiele GM, Klassen LW.

Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G661-8. doi: 10.1152/ajpgi.00287.2009. Epub 2010 Jul 1.


An in vitro method of alcoholic liver injury using precision-cut liver slices from rats.

Klassen LW, Thiele GM, Duryee MJ, Schaffert CS, DeVeney AL, Hunter CD, Olinga P, Tuma DJ.

Biochem Pharmacol. 2008 Aug 1;76(3):426-36. doi: 10.1016/j.bcp.2008.05.012. Epub 2008 May 21.


Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.

Elferink MG, Olinga P, Draaisma AL, Merema MT, Bauerschmidt S, Polman J, Schoonen WG, Groothuis GM.

Toxicol Appl Pharmacol. 2008 Jun 15;229(3):300-9. doi: 10.1016/j.taap.2008.01.037. Epub 2008 Feb 15.


Coordinated induction of drug transporters and phase I and II metabolism in human liver slices.

Olinga P, Elferink MG, Draaisma AL, Merema MT, Castell JV, Pérez G, Groothuis GM.

Eur J Pharm Sci. 2008 Apr 23;33(4-5):380-9. doi: 10.1016/j.ejps.2008.01.008. Epub 2008 Feb 2.


Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver.

van de Bovenkamp M, Groothuis GM, Meijer DK, Olinga P.

Toxicol In Vitro. 2008 Apr;22(3):771-8. doi: 10.1016/j.tiv.2007.11.019. Epub 2007 Dec 8.


Precision-cut tissue slices as a tool to predict metabolism of novel drugs.

Graaf IA, Groothuis GM, Olinga P.

Expert Opin Drug Metab Toxicol. 2007 Dec;3(6):879-98. Review.


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