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Items: 39


Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion.

Freeman AJ, Vervoort SJ, Ramsbottom KM, Kelly MJ, Michie J, Pijpers L, Johnstone RW, Kearney CJ, Oliaro J.

Cell Rep. 2019 Sep 10;28(11):2784-2794.e5. doi: 10.1016/j.celrep.2019.08.017.


Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery.

Wilson AS, Law HD, Knobbe-Thomsen CB, Kearney CJ, Oliaro J, Binsfeld C, Burgio G, Starrs L, Brenner D, Randall KL, Brüstle A.

Eur J Immunol. 2019 May;49(5):770-781. doi: 10.1002/eji.201847960. Epub 2019 Feb 20.


A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy.

Lelliott EJ, Cullinane C, Martin CA, Walker R, Ramsbottom KM, Souza-Fonseca-Guimaraes F, Abuhammad S, Michie J, Kirby L, Young RJ, Slater A, Lau P, Meeth K, Oliaro J, Haynes N, McArthur GA, Sheppard KE.

Sci Rep. 2019 Feb 4;9(1):1225. doi: 10.1038/s41598-018-37883-y.


Antagonism of IAPs Enhances CAR T-cell Efficacy.

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J.

Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16.


Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.


DOCK8 Drives Src-Dependent NK Cell Effector Function.

Kearney CJ, Vervoort SJ, Ramsbottom KM, Freeman AJ, Michie J, Peake J, Casanova JL, Picard C, Tangye SG, Ma CS, Johnstone RW, Randall KL, Oliaro J.

J Immunol. 2017 Aug 9. pii: ji1700751. doi: 10.4049/jimmunol.1700751. [Epub ahead of print]


PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF.

Kearney CJ, Lalaoui N, Freeman AJ, Ramsbottom KM, Silke J, Oliaro J.

Cell Death Differ. 2017 Oct;24(10):1705-1716. doi: 10.1038/cdd.2017.94. Epub 2017 Jun 30.


DOCK8 regulates signal transduction events to control immunity.

Kearney CJ, Randall KL, Oliaro J.

Cell Mol Immunol. 2017 May;14(5):406-411. doi: 10.1038/cmi.2017.9. Epub 2017 Apr 3. Review.


Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing.

Kearney CJ, Ramsbottom KM, Voskoboinik I, Darcy PK, Oliaro J.

Oncoimmunology. 2016 Jun 27;5(8):e1196308. doi: 10.1080/2162402X.2016.1196308. eCollection 2016 Aug.


The Role of the immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor immunity.

Kearney CJ, Brennan AJ, Darcy PK, Oliaro J.

Crit Rev Immunol. 2015;35(4):325-47. Review.


Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

Ramsbottom KM, Sacirbegovic F, Hawkins ED, Kallies A, Belz GT, Van Ham V, Haynes NM, Durrant MJ, Humbert PO, Russell SM, Oliaro J.

Immunol Cell Biol. 2016 Mar;94(3):306-11. doi: 10.1038/icb.2015.82. Epub 2015 Sep 22.


Asymmetric cell division during T cell development controls downstream fate.

Pham K, Shimoni R, Charnley M, Ludford-Menting MJ, Hawkins ED, Ramsbottom K, Oliaro J, Izon D, Ting SB, Reynolds J, Lythe G, Molina-Paris C, Melichar H, Robey E, Humbert PO, Gu M, Russell SM.

J Cell Biol. 2015 Sep 14;210(6):933-50. doi: 10.1083/jcb.201502053.


Scribble acts as an oncogene in Eμ-myc-driven lymphoma.

Hawkins ED, Oliaro J, Ramsbottom KM, Newbold A, Humbert PO, Johnstone RW, Russell SM.

Oncogene. 2016 Mar 3;35(9):1193-7. doi: 10.1038/onc.2015.167. Epub 2015 May 18.


A method for detecting intracellular perforin in mouse lymphocytes.

Brennan AJ, House IG, Oliaro J, Ramsbottom KM, Hagn M, Yagita H, Trapani JA, Voskoboinik I.

J Immunol. 2014 Dec 1;193(11):5744-50. doi: 10.4049/jimmunol.1402207. Epub 2014 Oct 27.


Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

Hawkins ED, Oliaro J, Ramsbottom KM, Ting SB, Sacirbegovic F, Harvey M, Kinwell T, Ghysdael J, Johnstone RW, Humbert PO, Russell SM.

PLoS One. 2014 Jan 27;9(1):e87376. doi: 10.1371/journal.pone.0087376. eCollection 2014.


Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity.

Ramsbottom KM, Hawkins ED, Shimoni R, McGrath M, Chan CJ, Russell SM, Smyth MJ, Oliaro J.

J Immunol. 2014 Jan 15;192(2):553-7. doi: 10.4049/jimmunol.1302197. Epub 2013 Dec 13.


Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO, Russell SM.

Nat Commun. 2013;4:1801. doi: 10.1038/ncomms2796.


Interplay of polarity proteins and GTPases in T-lymphocyte function.

Fung I, Russell SM, Oliaro J.

Clin Dev Immunol. 2012;2012:417485. doi: 10.1155/2012/417485. Epub 2012 Feb 22. Review.


DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.

Randall KL, Chan SS, Ma CS, Fung I, Mei Y, Yabas M, Tan A, Arkwright PD, Al Suwairi W, Lugo Reyes SO, Yamazaki-Nakashimada MA, Garcia-Cruz Mde L, Smart JM, Picard C, Okada S, Jouanguy E, Casanova JL, Lambe T, Cornall RJ, Russell S, Oliaro J, Tangye SG, Bertram EM, Goodnow CC.

J Exp Med. 2011 Oct 24;208(11):2305-20. doi: 10.1084/jem.20110345. Epub 2011 Oct 17.


Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.

Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL.

Immunity. 2011 Apr 22;34(4):492-504. doi: 10.1016/j.immuni.2011.03.017. Epub 2011 Apr 14.


The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts.

Ludford-Menting MJ, Crimeen-Irwin B, Oliaro J, Pasam A, Williamson D, Pedersen N, Guillaumot P, Christansen D, Manie S, Gaus K, Russell SM.

J Lipids. 2011;2011:521863. doi: 10.1155/2011/521863. Epub 2011 Jan 20.


Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues.

Melichar HJ, Li O, Herzmark P, Padmanabhan RK, Oliaro J, Ludford-Menting MJ, Bousso P, Russell SM, Roysam B, Robey EA.

Immunol Cell Biol. 2011 May;89(4):549-57. doi: 10.1038/icb.2010.122. Epub 2010 Oct 19.


CD46 signaling in T cells: linking pathogens with polarity.

Hawkins ED, Oliaro J.

FEBS Lett. 2010 Dec 15;584(24):4838-44. doi: 10.1016/j.febslet.2010.09.003. Epub 2010 Sep 7. Review.


Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.

Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM.

J Immunol. 2010 Jul 1;185(1):367-75. doi: 10.4049/jimmunol.0903627. Epub 2010 Jun 7.


A method for prolonged imaging of motile lymphocytes.

Day D, Pham K, Ludford-Menting MJ, Oliaro J, Izon D, Russell SM, Gu M.

Immunol Cell Biol. 2009 Feb;87(2):154-8. doi: 10.1038/icb.2008.79. Epub 2008 Nov 4.


Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

Sedelies KA, Ciccone A, Clarke CJ, Oliaro J, Sutton VR, Scott FL, Silke J, Susanto O, Green DR, Johnstone RW, Bird PI, Trapani JA, Waterhouse NJ.

Cell Death Differ. 2008 Apr;15(4):708-17. doi: 10.1038/sj.cdd.4402300. Epub 2008 Jan 18.


Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL.

Science. 2007 Mar 23;315(5819):1687-91. Epub 2007 Mar 1.


Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation.

Oliaro J, Pasam A, Waterhouse NJ, Browne KA, Ludford-Menting MJ, Trapani JA, Russell SM.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18685-90. Epub 2006 Nov 20.


A 'polarized' look at alpha-tubulin cleavage by granzyme B.

Waterhouse NJ, Oliaro J, Pinkoski MJ.

Cell Death Differ. 2006 Nov;13(11):1839-41. Epub 2006 Aug 18. No abstract available.


A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.

Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, Ellis S, Smyth MJ, Kershaw MH, Darcy PK, Humbert PO, Russell SM.

Immunity. 2005 Jun;22(6):737-48.


Vgamma9Vdelta2 T cells use a combination of mechanisms to limit the spread of the pathogenic bacteria Brucella.

Oliaro J, Dudal S, Liautard J, Andrault JB, Liautard JP, Lafont V.

J Leukoc Biol. 2005 May;77(5):652-60. Epub 2005 Jan 24.


A central role for Bid in granzyme B-induced apoptosis.

Waterhouse NJ, Sedelies KA, Browne KA, Wowk ME, Newbold A, Sutton VR, Clarke CJ, Oliaro J, Lindemann RK, Bird PI, Johnstone RW, Trapani JA.

J Biol Chem. 2005 Feb 11;280(6):4476-82. Epub 2004 Dec 1.


Impairment of intramacrophagic Brucella suis multiplication by human natural killer cells through a contact-dependent mechanism.

Dornand J, Lafont V, Oliaro J, Terraza A, Castaneda-Roldan E, Liautard JP.

Infect Immun. 2004 Apr;72(4):2303-11.


The innate immune response against Brucella in humans.

Dornand J, Gross A, Lafont V, Liautard J, Oliaro J, Liautard JP.

Vet Microbiol. 2002 Dec 20;90(1-4):383-94. Review.


Identification of an immunogenic 18-kDa protein of Helicobacter pylori by alkaline phosphatase gene fusions.

Oliaro J, Johnson RD, Chen W, Chadwick VS, Murray A.

J Med Microbiol. 2000 Jul;49(7):643-50.


Immune response to an 18-kilodalton outer membrane antigen identifies lipoprotein 20 as a Helicobacter pylori vaccine candidate.

Keenan J, Oliaro J, Domigan N, Potter H, Aitken G, Allardyce R, Roake J.

Infect Immun. 2000 Jun;68(6):3337-43.


Bacteria from humidifiers?

Oliaro JJ.

Respir Care. 1977 Sep;22(9):912. No abstract available.


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