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Items: 1 to 50 of 506

1.

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance.

Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM.

Diabetes. 2019 Jul;68(7):1415-1426. doi: 10.2337/db18-1307. Epub 2019 Apr 22.

PMID:
31010956
2.

Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction.

Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG.

J Endocr Soc. 2018 Dec 24;3(2):427-445. doi: 10.1210/js.2018-00318. eCollection 2019 Feb 1.

3.

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity.

Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W.

Cell Metab. 2019 Feb 5;29(2):457-474.e5. doi: 10.1016/j.cmet.2018.12.003. Epub 2018 Dec 27.

PMID:
30595478
4.

CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice.

Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS.

Mol Metab. 2019 Feb;20:89-101. doi: 10.1016/j.molmet.2018.11.011. Epub 2018 Dec 2.

5.

N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.

Hoveyda HR, Fraser GL, Zoute L, Dutheuil G, Schils D, Brantis C, Lapin A, Parcq J, Guitard S, Lenoir F, Bousmaqui ME, Rorive S, Hospied S, Blanc S, Bernard J, Ooms F, McNelis JC, Olefsky JM.

Bioorg Med Chem. 2018 Oct 1;26(18):5169-5180. doi: 10.1016/j.bmc.2018.09.015. Epub 2018 Sep 18.

PMID:
30253886
6.

Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer.

Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Olefsky JM, Cohen P, Aronson WJ.

J Natl Cancer Inst. 2019 Jan 1;111(1):52-59. doi: 10.1093/jnci/djy125.

PMID:
30202902
7.

RalA controls glucose homeostasis by regulating glucose uptake in brown fat.

Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7819-7824. doi: 10.1073/pnas.1801050115. Epub 2018 Jun 18.

8.

Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function.

Riopel M, Seo JB, Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung SR, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh DS, Larson CJ, Olefsky JM, Lee YS.

J Clin Invest. 2018 Apr 2;128(4):1458-1470. doi: 10.1172/JCI94330. Epub 2018 Mar 5.

9.

An Integrated View of Immunometabolism.

Lee YS, Wollam J, Olefsky JM.

Cell. 2018 Jan 11;172(1-2):22-40. doi: 10.1016/j.cell.2017.12.025. Review.

10.

Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity.

Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM.

Cell. 2017 Oct 5;171(2):372-384.e12. doi: 10.1016/j.cell.2017.08.035. Epub 2017 Sep 21.

11.

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.

Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM.

J Clin Invest. 2017 Mar 1;127(3):1019-1030. doi: 10.1172/JCI90350. Epub 2017 Feb 13.

12.

Inflammatory mechanisms linking obesity and metabolic disease.

Saltiel AR, Olefsky JM.

J Clin Invest. 2017 Jan 3;127(1):1-4. doi: 10.1172/JCI92035. Epub 2017 Jan 3. Review.

13.

Obese Neuronal PPARγ Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility.

Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ.

Endocrinology. 2017 Jan 1;158(1):121-133. doi: 10.1210/en.2016-1818.

14.

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.

Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM.

Cell. 2016 Nov 3;167(4):973-984.e12. doi: 10.1016/j.cell.2016.10.025.

15.

G protein-coupled receptors as targets for anti-diabetic therapeutics.

Oh DY, Olefsky JM.

Nat Rev Drug Discov. 2016 Mar;15(3):161-72. doi: 10.1038/nrd.2015.4. Epub 2016 Jan 29. Review.

PMID:
26822831
16.

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K.

Cell Rep. 2016 Jan 12;14(2):255-68. doi: 10.1016/j.celrep.2015.12.028. Epub 2015 Dec 31.

17.

Regulation of metabolism by the innate immune system.

Lackey DE, Olefsky JM.

Nat Rev Endocrinol. 2016 Jan;12(1):15-28. doi: 10.1038/nrendo.2015.189. Epub 2015 Nov 10. Review.

PMID:
26553134
18.

Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet.

Kesby JP, Kim JJ, Scadeng M, Woods G, Kado DM, Olefsky JM, Jeste DV, Achim CL, Semenova S.

PLoS One. 2015 Oct 8;10(10):e0140034. doi: 10.1371/journal.pone.0140034. eCollection 2015.

19.

GPR43 Potentiates β-Cell Function in Obesity.

McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM.

Diabetes. 2015 Sep;64(9):3203-17. doi: 10.2337/db14-1938. Epub 2015 May 28.

20.

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.

Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM.

Mol Metab. 2015 Mar 5;4(5):378-91. doi: 10.1016/j.molmet.2015.02.007. eCollection 2015 May.

21.

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability.

Johnson AM, Costanzo A, Gareau MG, Armando AM, Quehenberger O, Jameson JM, Olefsky JM.

PLoS One. 2015 Apr 2;10(4):e0122195. doi: 10.1371/journal.pone.0122195. eCollection 2015.

22.

Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM.

Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14304. Epub 2015 Mar 4. No abstract available.

PMID:
25739500
23.

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes.

Li P, Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM.

Nat Med. 2015 Mar;21(3):239-247. doi: 10.1038/nm.3800. Epub 2015 Feb 23.

24.

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM.

Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5.

25.

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice.

Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY.

Diabetes. 2015 Apr;64(4):1120-30. doi: 10.2337/db14-1238. Epub 2014 Oct 14.

26.

Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer.

Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG.

Oncogene. 2015 Jul;34(27):3504-13. doi: 10.1038/onc.2014.283. Epub 2014 Sep 15.

27.

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM.

Nature. 2014 Sep 18;513(7518):436-9. doi: 10.1038/nature13540. Epub 2014 Jul 16. Erratum in: Nature. 2015 Apr 16;520(7547):388.

28.

Macrophages, immunity, and metabolic disease.

McNelis JC, Olefsky JM.

Immunity. 2014 Jul 17;41(1):36-48. doi: 10.1016/j.immuni.2014.05.010. Review.

29.

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.

Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky JM.

Nat Med. 2014 Aug;20(8):942-7. doi: 10.1038/nm.3614. Epub 2014 Jul 6.

30.

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.

Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E.

J Clin Invest. 2014 Aug;124(8):3566-78. doi: 10.1172/JCI74068. Epub 2014 Jul 1.

31.

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity.

Lee YS, Kim JW, Osborne O, Oh DY, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS, Olefsky JM.

Cell. 2014 Jun 5;157(6):1339-52. doi: 10.1016/j.cell.2014.05.012.

32.

C/EBPα regulates macrophage activation and systemic metabolism.

Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J.

Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1144-54. doi: 10.1152/ajpendo.00002.2014. Epub 2014 Apr 1.

33.

NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids.

Li P, Spann NJ, Kaikkonen MU, Lu M, Oh DY, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM.

Cell. 2013 Sep 26;155(1):200-214. doi: 10.1016/j.cell.2013.08.054.

34.

Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans.

Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, Blüher M, Olefsky JM, Sams A, Klip A.

Obesity (Silver Spring). 2014 Mar;22(3):747-57. doi: 10.1002/oby.20615. Epub 2013 Oct 16.

35.

Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice.

Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS.

Mol Cell Proteomics. 2013 Dec;12(12):3744-58. doi: 10.1074/mcp.M113.027441. Epub 2013 Sep 12.

36.

Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.

Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky JM, Webster NJ.

Endocrinology. 2013 Jun;154(6):2188-99. doi: 10.1210/en.2012-2218. Epub 2013 Mar 22.

37.

Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.

Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky JM.

J Biol Chem. 2013 Apr 12;288(15):10722-35. doi: 10.1074/jbc.M112.443606. Epub 2013 Mar 1.

38.

The origins and drivers of insulin resistance.

Johnson AM, Olefsky JM.

Cell. 2013 Feb 14;152(4):673-84. doi: 10.1016/j.cell.2013.01.041.

39.

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.

Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR.

Nat Med. 2013 Mar;19(3):313-21. doi: 10.1038/nm.3082. Epub 2013 Feb 10.

40.

The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design.

Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD.

Cancer Causes Control. 2013 Apr;24(4):695-704. doi: 10.1007/s10552-013-0150-z. Epub 2013 Feb 3.

41.

Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats.

Jiao J, Bae EJ, Bandyopadhyay G, Oliver J, Marathe C, Chen M, Hsu JY, Chen Y, Tian H, Olefsky JM, Saberi M.

Diabetes. 2013 Apr;62(4):1074-83. doi: 10.2337/db12-0681. Epub 2012 Dec 17.

42.

Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients.

Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky JM, Sears DD, Kaplan LM, Kemp DM.

Diabetes. 2013 Mar;62(3):855-63. doi: 10.2337/db12-0399. Epub 2012 Dec 6.

43.

Fetuin-A: the missing link in lipid-induced inflammation.

Heinrichsdorff J, Olefsky JM.

Nat Med. 2012 Aug;18(8):1182-3. doi: 10.1038/nm.2869. No abstract available.

PMID:
22869185
44.

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.

Talukdar S, Oh DY, Bandyopadhyay G, Li D, Xu J, McNelis J, Lu M, Li P, Yan Q, Zhu Y, Ofrecio J, Lin M, Brenner MB, Olefsky JM.

Nat Med. 2012 Sep;18(9):1407-12.

45.

GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity.

Xu J, Morinaga H, Oh D, Li P, Chen A, Talukdar S, Mamane Y, Mancini JA, Nawrocki AR, Lazarowski E, Olefsky JM, Kim JJ.

J Immunol. 2012 Aug 15;189(4):1992-9. doi: 10.4049/jimmunol.1103207. Epub 2012 Jul 9. Erratum in: J Immunol. 2013 Feb 1;190(3):1380. Mamane, Yaël [added]; Mancini, Joseph A [added]; Nawrocki, Andrea R [added].

46.

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.

Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM.

J Clin Invest. 2012 Jul;122(7):2444-53. doi: 10.1172/JCI61953. Epub 2012 Jun 1.

47.

Inflammation and lipid signaling in the etiology of insulin resistance.

Glass CK, Olefsky JM.

Cell Metab. 2012 May 2;15(5):635-45. doi: 10.1016/j.cmet.2012.04.001. Review.

48.

Omega 3 fatty acids and GPR120.

Oh DY, Olefsky JM.

Cell Metab. 2012 May 2;15(5):564-5. doi: 10.1016/j.cmet.2012.04.009. Review.

49.

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.

Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, Whyte J, He M, Juguilon H, Yin YQ, Phillips CT, Yu RT, Olefsky JM, Henry RR, Downes M, Evans RM.

Nature. 2012 May 17;485(7398):391-4. doi: 10.1038/nature10998.

50.

Putting the brakes on FOXO1 in fat.

Kim JJ, Fan W, Olefsky JM.

EMBO J. 2012 May 16;31(10):2240-1. doi: 10.1038/emboj.2012.116. Epub 2012 Apr 17. No abstract available.

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