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Macrophage IFN-I signaling promotes autoreactive T cell infiltration into islets in type 1 diabetes model.

Marro BS, Legrain S, Ware BC, Oldstone MB.

JCI Insight. 2019 Jan 24;4(2). pii: 125067. doi: 10.1172/jci.insight.125067. [Epub ahead of print]


High Constitutive Interleukin 10 Level Interferes With the Immune Response to Varicella-Zoster Virus in Elderly Recipients of Live Attenuated Zoster Vaccine.

Gershon AA, Brooks D, Stevenson DD, Chin WK, Oldstone MBA, Gershon MD.

J Infect Dis. 2019 Apr 8;219(8):1338-1346. doi: 10.1093/infdis/jiy660.


Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition.

Gonzalez-Quintial R, Nguyen A, Kono DH, Oldstone MBA, Theofilopoulos AN, Baccala R.

PLoS One. 2018 Sep 10;13(9):e0203118. doi: 10.1371/journal.pone.0203118. eCollection 2018.


Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics.

Oldstone MBA, Ware BC, Horton LE, Welch MJ, Aiolfi R, Zarpellon A, Ruggeri ZM, Sullivan BM.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7814-E7823. doi: 10.1073/pnas.1804674115. Epub 2018 Jul 30.


Analysis of CD8+ T cell response during the 2013-2016 Ebola epidemic in West Africa.

Sakabe S, Sullivan BM, Hartnett JN, Robles-Sikisaka R, Gangavarapu K, Cubitt B, Ware BC, Kotliar D, Branco LM, Goba A, Momoh M, Sandi JD, Kanneh L, Grant DS, Garry RF, Andersen KG, de la Torre JC, Sabeti PC, Schieffelin JS, Oldstone MBA.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7578-E7586. doi: 10.1073/pnas.1806200115. Epub 2018 Jul 23.


Influenza NS1 directly modulates Hedgehog signaling during infection.

Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zúñiga EI, Krug RM, Oldstone MB, Bier E.

PLoS Pathog. 2017 Aug 24;13(8):e1006588. doi: 10.1371/journal.ppat.1006588. eCollection 2017 Aug.


Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling.

Marro BS, Ware BC, Zak J, de la Torre JC, Rosen H, Oldstone MB.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3708-3713. doi: 10.1073/pnas.1700878114. Epub 2017 Mar 21.


An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.

Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, French I, Mustapha I, Kanneh F, Foday M, McCarthy H, Kallon T, Kallon M, Naiebu J, Sellu J, Jalloh AA, Gbakie M, Kanneh L, Massaly JL, Kargbo D, Kargbo B, Vandi M, Gbetuwa M, Gevao SM, Sandi JD, Jalloh SC, Grant DS, Blyden SO, Crozier I, Schieffelin JS, McLellan SL, Jacob ST, Boisen ML, Hartnett JN, Cross RW, Branco LM, Andersen KG, Yozwiak NL, Gire SK, Tariyal R, Park DJ, Haislip AM, Bishop CM, Melnik LI, Gallaher WR, Wimley WC, He J, Shaffer JG, Sullivan BM, Grillo S, Oman S, Garry CE, Edwards DR, McCormick SJ, Elliott DH, Rouelle JA, Kannadka CB, Reyna AA, Bradley BT, Yu H, Yenni RE, Hastie KM, Geisbert JB, Kulakosky PC, Wilson RB, Oldstone MB, Pitts KR, Henderson LA, Robinson JE, Geisbert TW, Saphire EO, Happi CT, Asogun DA, Sabeti PC, Garry RF; Viral Hemorrhagic Fever Consortium.

J Infect Dis. 2016 Oct 15;214(suppl 3):S110-S121. Epub 2016 Jul 11.


Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV.

Hastie KM, Igonet S, Sullivan BM, Legrand P, Zandonatti MA, Robinson JE, Garry RF, Rey FA, Oldstone MB, Saphire EO.

Nat Struct Mol Biol. 2016 Jun;23(6):513-521. doi: 10.1038/nsmb.3210. Epub 2016 Apr 25.


The Anatomy of a Career in Science.

Oldstone MB.

DNA Cell Biol. 2016 Mar;35(3):109-17. doi: 10.1089/dna.2016.3232. Epub 2016 Feb 2. No abstract available.


Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes.

Ng CT, Mendoza JL, Garcia KC, Oldstone MB.

Cell. 2016 Jan 28;164(3):349-52. doi: 10.1016/j.cell.2015.12.027. Review.


S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.

Teijaro JR, Studer S, Leaf N, Kiosses WB, Nguyen N, Matsuki K, Negishi H, Taniguchi T, Oldstone MB, Rosen H.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1351-6. doi: 10.1073/pnas.1525356113. Epub 2016 Jan 19.


An Odyssey to Viral Pathogenesis.

Oldstone MB.

Annu Rev Pathol. 2016 May 23;11:1-19. doi: 10.1146/annurev-pathol-012615-044107. Epub 2015 Oct 22.


Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.

Siggs OM, Popkin DL, Krebs P, Li X, Tang M, Zhan X, Zeng M, Lin P, Xia Y, Oldstone MB, Cornall RJ, Beutler B.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5706-14. doi: 10.1073/pnas.1515619112. Epub 2015 Oct 5.


Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection.

Ng CT, Sullivan BM, Teijaro JR, Lee AM, Welch M, Rice S, Sheehan KC, Schreiber RD, Oldstone MB.

Cell Host Microbe. 2015 May 13;17(5):653-61. doi: 10.1016/j.chom.2015.04.005.


Early virus-host interactions dictate the course of a persistent infection.

Sullivan BM, Teijaro JR, de la Torre JC, Oldstone MB.

PLoS Pathog. 2015 Jan 8;11(1):e1004588. doi: 10.1371/journal.ppat.1004588. eCollection 2015 Jan.


IL-10: achieving balance during persistent viral infection.

Ng CT, Oldstone MB.

Curr Top Microbiol Immunol. 2014;380:129-44. doi: 10.1007/978-3-662-43492-5_6. Review.


Type I interferon is a therapeutic target for virus-induced lethal vascular damage.

Baccala R, Welch MJ, Gonzalez-Quintial R, Walsh KB, Teijaro JR, Nguyen A, Ng CT, Sullivan BM, Zarpellon A, Ruggeri ZM, de la Torre JC, Theofilopoulos AN, Oldstone MB.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30. doi: 10.1073/pnas.1408148111. Epub 2014 Jun 2.


Molecular mimicry: its evolution from concept to mechanism as a cause of autoimmune diseases.

Oldstone MB.

Monoclon Antib Immunodiagn Immunother. 2014 Jun;33(3):158-65. doi: 10.1089/mab.2013.0090. Epub 2014 Apr 2.


Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy.

Walsh KB, Teijaro JR, Brock LG, Fremgen DM, Collins PL, Rosen H, Oldstone MB.

J Virol. 2014 Jun;88(11):6281-93. doi: 10.1128/JVI.00464-14. Epub 2014 Mar 26.


Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy.

Teijaro JR, Walsh KB, Long JP, Tordoff KP, Stark GV, Eisfeld AJ, Kawaoka Y, Rosen H, Oldstone MB.

Virology. 2014 Mar;452-453:152-7. doi: 10.1016/j.virol.2014.01.003. Epub 2014 Jan 31.


Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.

Teijaro JR, Walsh KB, Rice S, Rosen H, Oldstone MB.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3799-804. doi: 10.1073/pnas.1400593111. Epub 2014 Feb 26.


In memoriam: Hilary Koprowski: a Renaissance scientist.

Oldstone MB.

Virology. 2013 Jul 20;442(1):1-2. No abstract available.


CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice.

Walsh KB, Sidney J, Welch M, Fremgen DM, Sette A, Oldstone MB.

J Virol. 2013 Sep;87(17):9949-52. doi: 10.1128/JVI.00339-13. Epub 2013 Jul 3.


MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation.

Kang SG, Liu WH, Lu P, Jin HY, Lim HW, Shepherd J, Fremgen D, Verdin E, Oldstone MB, Qi H, Teijaro JR, Xiao C.

Nat Immunol. 2013 Aug;14(8):849-57. doi: 10.1038/ni.2648. Epub 2013 Jun 30.


Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease.

Priola SA, Ward AE, McCall SA, Trifilo M, Choi YP, Solforosi L, Williamson RA, Cruite JT, Oldstone MB.

J Virol. 2013 Sep;87(17):9501-10. doi: 10.1128/JVI.00692-13. Epub 2013 Jun 19.


Networking at the level of host immunity: immune cell interactions during persistent viral infections.

Ng CT, Snell LM, Brooks DG, Oldstone MB.

Cell Host Microbe. 2013 Jun 12;13(6):652-64. doi: 10.1016/j.chom.2013.05.014. Review.


Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus.

Lee AM, Cruite J, Welch MJ, Sullivan B, Oldstone MB.

Virology. 2013 Aug 1;442(2):114-21. doi: 10.1016/j.virol.2013.04.010. Epub 2013 May 16.


Defining the conformational features of anchorless, poorly neuroinvasive prions.

Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB, Sigurdson CJ.

PLoS Pathog. 2013;9(4):e1003280. doi: 10.1371/journal.ppat.1003280. Epub 2013 Apr 18.


Persistent LCMV infection is controlled by blockade of type I interferon signaling.

Teijaro JR, Ng C, Lee AM, Sullivan BM, Sheehan KC, Welch M, Schreiber RD, de la Torre JC, Oldstone MB.

Science. 2013 Apr 12;340(6129):207-11. doi: 10.1126/science.1235214.


Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy.

Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD.

PLoS One. 2013;8(3):e58033. doi: 10.1371/journal.pone.0058033. Epub 2013 Mar 22.


Sphingosine-1-phosphate and its receptors: structure, signaling, and influence.

Rosen H, Stevens RC, Hanson M, Roberts E, Oldstone MB.

Annu Rev Biochem. 2013;82:637-62. doi: 10.1146/annurev-biochem-062411-130916. Epub 2013 Mar 18. Review.


Profile of Michael B. A. Oldstone. Interview by Nicholette Zeliadt.

Oldstone MB.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4155-7. doi: 10.1073/pnas.1302391110. Epub 2013 Mar 4. No abstract available.


Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza.

Oldstone MB.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4180-3. doi: 10.1073/pnas.1222025110. Epub 2013 Jan 22. Review.


Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?

Sullivan BM, Welch MJ, Lemke G, Oldstone MB.

J Virol. 2013 Apr;87(7):4071-4. doi: 10.1128/JVI.03268-12. Epub 2013 Jan 16.


The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomain.

Burri DJ, Pasquato A, da Palma JR, Igonet S, Oldstone MB, Kunz S.

Virology. 2013 Feb 5;436(1):127-33. doi: 10.1016/j.virol.2012.10.038. Epub 2012 Dec 4.


Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection.

Oldstone MB, Teijaro JR, Walsh KB, Rosen H.

Virology. 2013 Jan 5;435(1):92-101. doi: 10.1016/j.virol.2012.09.039. Review.


Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.

Oldstone MB, Edelmann KH, McGavern DB, Cruite JT, Welch MJ.

PLoS Pathog. 2012;8(11):e1003044. doi: 10.1371/journal.ppat.1003044. Epub 2012 Nov 29.


Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes.

Chabot S, Fakhfakh A, Béland K, Lamarre A, Oldstone MB, Alvarez F, Djilali-Saiah I.

J Autoimmun. 2013 May;42:19-28. doi: 10.1016/j.jaut.2012.10.002. Epub 2012 Nov 5.


Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection.

Blasius AL, Krebs P, Sullivan BM, Oldstone MB, Popkin DL.

PLoS Pathog. 2012 Sep;8(9):e1002915. doi: 10.1371/journal.ppat.1002915. Epub 2012 Sep 13.


Infected CD8α- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection.

Ng CT, Oldstone MB.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14116-21. doi: 10.1073/pnas.1211910109. Epub 2012 Aug 14.


Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease.

Siggs OM, Cruite JT, Du X, Rutschmann S, Masliah E, Beutler B, Oldstone MB.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13733-8. doi: 10.1073/pnas.1211499109. Epub 2012 Aug 6.


Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.

Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB.

Cell Host Microbe. 2012 Jun 14;11(6):643-53. doi: 10.1016/j.chom.2012.04.016.


CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.

Welch MJ, Teijaro JR, Lewicki HA, Colonna M, Oldstone MB.

Virology. 2012 Aug 1;429(2):163-70. doi: 10.1016/j.virol.2012.04.006. Epub 2012 May 12.


Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection.

Ng CT, Nayak BP, Schmedt C, Oldstone MB.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7823-8. doi: 10.1073/pnas.1205850109. Epub 2012 May 1.


The game's afoot: seeking viruses that cause chronic and degenerative neurologic and psychiatric disorder.

Oldstone MB.

Mol Psychiatry. 2012 May;17(5):472-3. doi: 10.1038/mp.2012.5. Epub 2012 Feb 7. No abstract available.


Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.

Hara Y, Kanagawa M, Kunz S, Yoshida-Moriguchi T, Satz JS, Kobayashi YM, Zhu Z, Burden SJ, Oldstone MB, Campbell KP.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17426-31. doi: 10.1073/pnas.1114836108. Epub 2011 Oct 10.


Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.

Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H.

Cell. 2011 Sep 16;146(6):980-91. doi: 10.1016/j.cell.2011.08.015.

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