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Items: 33

1.

Paradoxical Embolization via Large Pulmonary Arteriovenous Malformation.

Sternschein RM, Oldham WM.

Am J Respir Crit Care Med. 2019 Apr 19. doi: 10.1164/rccm.201806-1047IM. [Epub ahead of print] No abstract available.

PMID:
31002526
2.

Innate T cells in the intensive care unit.

Kim EY, Oldham WM.

Mol Immunol. 2019 Jan;105:213-223. doi: 10.1016/j.molimm.2018.09.026. Epub 2018 Dec 13. Review.

PMID:
30554082
3.

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.

Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C.

Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012. Epub 2018 Oct 4.

PMID:
30293773
4.

GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis.

Yang JS, Hsu JW, Park SY, Li J, Oldham WM, Beznoussenko GV, Mironov AA, Loscalzo J, Hsu VW.

Nature. 2018 Sep;561(7722):263-267. doi: 10.1038/s41586-018-0475-6. Epub 2018 Sep 12.

5.

[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM.

Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C.

Clin Cancer Res. 2018 Dec 1;24(23):5925-5938. doi: 10.1158/1078-0432.CCR-17-3693. Epub 2018 Jul 27.

PMID:
30054282
6.

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap7294. doi: 10.1126/scitranslmed.aap7294.

7.

MicroRNA Dysregulation in Pulmonary Arteries from Chronic Obstructive Pulmonary Disease. Relationships with Vascular Remodeling.

Musri MM, Coll-Bonfill N, Maron BA, Peinado VI, Wang RS, Altirriba J, Blanco I, Oldham WM, Tura-Ceide O, GarcĂ­a-Lucio J, de la Cruz-Thea B, Meister G, Loscalzo J, BarberĂ  JA.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):490-499. doi: 10.1165/rcmb.2017-0040OC.

PMID:
29757677
8.

Network Analysis to Risk Stratify Patients With Exercise Intolerance.

Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA.

Circ Res. 2018 Mar 16;122(6):864-876. doi: 10.1161/CIRCRESAHA.117.312482. Epub 2018 Feb 5.

9.

The Long Noncoding RNA LnRPT Puts the Brakes on Pulmonary Artery Smooth Muscle Cell Proliferation.

Oldham WM.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):138-139. doi: 10.1165/rcmb.2017-0342ED. No abstract available.

10.

Systems Biology Approaches to Redox Metabolism in Stress and Disease States.

Wang RS, Oldham WM, Maron BA, Loscalzo J.

Antioxid Redox Signal. 2018 Oct 1;29(10):953-972. doi: 10.1089/ars.2017.7256. Epub 2017 Dec 20.

PMID:
29121773
11.

Nicotine Adenine Dinucleotides: The Redox Currency of the Cell.

Fessel JP, Oldham WM.

Antioxid Redox Signal. 2018 Jan 20;28(3):165-166. doi: 10.1089/ars.2017.7439.

12.

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.

Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP.

Oncotarget. 2017 Aug 4;8(39):64714-64727. doi: 10.18632/oncotarget.19947. eCollection 2017 Sep 12.

13.

Pyridine Dinucleotides from Molecules to Man.

Fessel JP, Oldham WM.

Antioxid Redox Signal. 2018 Jan 20;28(3):180-212. doi: 10.1089/ars.2017.7120. Epub 2017 Jul 25. Review.

14.

Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry.

Oldham WM, Loscalzo J.

Bio Protoc. 2016 Aug 20;6(16). pii: e1908. doi: 10.21769/BioProtoc.1908.

15.

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP.

Cancer Res. 2017 Jun 15;77(12):3255-3267. doi: 10.1158/0008-5472.CAN-16-2458. Epub 2017 May 16.

16.

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.

Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J 3rd, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY.

J Clin Invest. 2016 Sep 1;126(9):3313-35. doi: 10.1172/JCI86387. Epub 2016 Aug 22.

17.

Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing.

Oldham WM, Lewis GD, Opotowsky AR, Waxman AB, Systrom DM.

Pulm Circ. 2016 Mar;6(1):55-62. doi: 10.1086/685054.

18.

Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice.

Berry NC, Manyoo A, Oldham WM, Stephens TE, Goldstein RH, Waxman AB, Tracy JA, Leary PJ, Leopold JA, Kinlay S, Opotowsky AR, Systrom DM, Maron BA.

Pulm Circ. 2015 Dec;5(4):610-8. doi: 10.1086/683815. Review.

19.

Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study.

Maron BA, Stephens TE, Farrell LA, Oldham WM, Loscalzo J, Leopold JA, Lewis GD.

J Heart Lung Transplant. 2016 Mar;35(3):342-351. doi: 10.1016/j.healun.2015.10.019. Epub 2015 Oct 19.

20.

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.

Oldham WM, Clish CB, Yang Y, Loscalzo J.

Cell Metab. 2015 Aug 4;22(2):291-303. doi: 10.1016/j.cmet.2015.06.021. Epub 2015 Jul 23.

21.

Network-based association of hypoxia-responsive genes with cardiovascular diseases.

Wang RS, Oldham WM, Loscalzo J.

New J Phys. 2014 Oct 24;16(10):105014.

22.

Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis.

Maron BA, Oldham WM, Chan SY, Vargas SO, Arons E, Zhang YY, Loscalzo J, Leopold JA.

Circulation. 2014 Jul 8;130(2):168-79. doi: 10.1161/CIRCULATIONAHA.113.007690. Epub 2014 Apr 28.

23.

A workshop on leadership for MD/PhD students.

Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS.

Med Educ Online. 2011;16. doi: 10.3402/meo.v16i0.7075. Epub 2011 Aug 10.

24.

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.

Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E.

Sci Signal. 2010 May 11;3(121):ra37. doi: 10.1126/scisignal.2000647.

25.

Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.

Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM.

Biochemistry. 2009 Mar 31;48(12):2630-42. doi: 10.1021/bi801853a. Erratum in: Biochemistry. 2010 Nov 23;49(46):10037.

26.

Heterotrimeric G protein activation by G-protein-coupled receptors.

Oldham WM, Hamm HE.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):60-71. Review.

PMID:
18043707
27.

How do receptors activate G proteins?

Oldham WM, Hamm HE.

Adv Protein Chem. 2007;74:67-93. Review.

PMID:
17854655
28.

Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.

Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7927-32. Epub 2007 Apr 26.

29.

Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway.

Van Eps N, Oldham WM, Hamm HE, Hubbell WL.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16194-9. Epub 2006 Oct 19.

30.

Structural basis of function in heterotrimeric G proteins.

Oldham WM, Hamm HE.

Q Rev Biophys. 2006 May;39(2):117-66. Epub 2006 Aug 21. Review.

PMID:
16923326
31.
32.

Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.

Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE.

Nat Struct Mol Biol. 2006 Sep;13(9):772-7. Epub 2006 Aug 6.

PMID:
16892066
33.

Direct modulation of phospholipase D activity by Gbetagamma.

Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA.

Mol Pharmacol. 2006 Jul;70(1):311-8. Epub 2006 Apr 25.

PMID:
16638972

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