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Items: 1 to 50 of 87

1.

Structural basis for chain release from the enacyloxin polyketide synthase.

Kosol S, Gallo A, Griffiths D, Valentic TR, Masschelein J, Jenner M, de Los Santos ELC, Manzi L, Sydor PK, Rea D, Zhou S, Fülöp V, Oldham NJ, Tsai SC, Challis GL, Lewandowski JR.

Nat Chem. 2019 Oct;11(10):913-923. doi: 10.1038/s41557-019-0335-5. Epub 2019 Sep 23.

PMID:
31548674
2.

PepFoot: A Software Package for Semiautomated Processing of Protein Footprinting Data.

Bellamy-Carter J, Oldham NJ.

J Proteome Res. 2019 Jul 5;18(7):2925-2930. doi: 10.1021/acs.jproteome.9b00238. Epub 2019 Jun 7.

PMID:
31132275
3.

Tyrosinase-Mediated Bioconjugation. A Versatile Approach to Chimeric Macromolecules.

Montanari E, Gennari A, Pelliccia M, Manzi L, Donno R, Oldham NJ, MacDonald A, Tirelli N.

Bioconjug Chem. 2018 Aug 15;29(8):2550-2560. doi: 10.1021/acs.bioconjchem.8b00227. Epub 2018 Jul 19.

PMID:
29975838
4.

Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases.

Jenner M, Kosol S, Griffiths D, Prasongpholchai P, Manzi L, Barrow AS, Moses JE, Oldham NJ, Lewandowski JR, Challis GL.

Nat Chem Biol. 2018 Mar;14(3):270-275. doi: 10.1038/nchembio.2549. Epub 2018 Jan 8.

5.

Carbene Footprinting Reveals Binding Interfaces of a Multimeric Membrane-Spanning Protein.

Manzi L, Barrow AS, Hopper JTS, Kaminska R, Kleanthous C, Robinson CV, Moses JE, Oldham NJ.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14873-14877. doi: 10.1002/anie.201708254. Epub 2017 Oct 20.

PMID:
28960650
6.

A front-face 'SNi synthase' engineered from a retaining 'double-SN2' hydrolase.

Iglesias-Fernández J, Hancock SM, Lee SS, Khan M, Kirkpatrick J, Oldham NJ, McAuley K, Fordham-Skelton A, Rovira C, Davis BG.

Nat Chem Biol. 2017 Aug;13(8):874-881. doi: 10.1038/nchembio.2394. Epub 2017 Jun 12.

PMID:
28604696
7.

Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions.

Manzi L, Barrow AS, Scott D, Layfield R, Wright TG, Moses JE, Oldham NJ.

Nat Commun. 2016 Nov 16;7:13288. doi: 10.1038/ncomms13288.

8.

Method for the Purification of Endogenous Unanchored Polyubiquitin Chains.

Scott D, Strachan J, Krishna VG, Shaw B, Tooth DJ, Searle MS, Oldham NJ, Layfield R.

Methods Mol Biol. 2016;1449:203-13. doi: 10.1007/978-1-4939-3756-1_11.

PMID:
27613037
9.

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.

Soukarieh F, Nowicki MW, Bastide A, Pöyry T, Jones C, Dudek K, Patwardhan G, Meullenet F, Oldham NJ, Walkinshaw MD, Willis AE, Fischer PM.

Eur J Med Chem. 2016 Nov 29;124:200-217. doi: 10.1016/j.ejmech.2016.08.047. Epub 2016 Aug 24.

10.

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.

Goode A, Butler K, Long J, Cavey J, Scott D, Shaw B, Sollenberger J, Gell C, Johansen T, Oldham NJ, Searle MS, Layfield R.

Autophagy. 2016 Jul 2;12(7):1094-104. doi: 10.1080/15548627.2016.1170257. Epub 2016 May 9.

11.

Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.

Scott D, Garner TP, Long J, Strachan J, Mistry SC, Bottrill AR, Tooth DJ, Searle MS, Oldham NJ, Layfield R.

Proteomics. 2016 Jul;16(14):1961-9. doi: 10.1002/pmic.201600067.

PMID:
27037516
12.

Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.

Jenner M, Afonso JP, Kohlhaas C, Karbaum P, Frank S, Piel J, Oldham NJ.

Chem Commun (Camb). 2016 Apr 18;52(30):5262-5. doi: 10.1039/c6cc01453d. Epub 2016 Mar 22.

PMID:
27003309
13.
14.

Relative binding affinities of integrin antagonists by equilibrium dialysis and liquid chromatography-mass spectrometry.

Tipping WJ, Tshuma N, Adams J, Haywood HT, Rowedder JE, Fray MJ, McInally T, Macdonald SJ, Oldham NJ.

ACS Med Chem Lett. 2014 Dec 22;6(2):221-4. doi: 10.1021/ml500395v. eCollection 2015 Feb 12.

15.

Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.

Scott D, Layfield R, Oldham NJ.

Proteomics. 2015 Aug;15(16):2835-41. doi: 10.1002/pmic.201400457. Epub 2015 Mar 9.

PMID:
25641936
16.

Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases.

Jenner M, Afonso JP, Bailey HR, Frank S, Kampa A, Piel J, Oldham NJ.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1817-21. doi: 10.1002/anie.201410219. Epub 2014 Dec 21.

PMID:
25529827
17.

Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes.

Scott D, Oldham NJ, Strachan J, Searle MS, Layfield R.

Proteomics. 2015 Mar;15(5-6):844-61. doi: 10.1002/pmic.201400341. Epub 2014 Dec 28. Review.

PMID:
25327553
18.

A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.

Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT.

Structure. 2014 Mar 4;22(3):444-51. doi: 10.1016/j.str.2013.12.016. Epub 2014 Feb 6.

19.

Defensive bacteriome symbiont with a drastically reduced genome.

Nakabachi A, Ueoka R, Oshima K, Teta R, Mangoni A, Gurgui M, Oldham NJ, van Echten-Deckert G, Okamura K, Yamamoto K, Inoue H, Ohkuma M, Hongoh Y, Miyagishima SY, Hattori M, Piel J, Fukatsu T.

Curr Biol. 2013 Aug 5;23(15):1478-84. doi: 10.1016/j.cub.2013.06.027. Epub 2013 Jul 11.

20.

Insights into the structure and assembly of the Bacillus subtilis clamp-loader complex and its interaction with the replicative helicase.

Afonso JP, Chintakayala K, Suwannachart C, Sedelnikova S, Giles K, Hoyes JB, Soultanas P, Rafferty JB, Oldham NJ.

Nucleic Acids Res. 2013 May;41(9):5115-26. doi: 10.1093/nar/gkt173. Epub 2013 Mar 21.

21.

Substrate specificity in ketosynthase domains from trans-AT polyketide synthases.

Jenner M, Frank S, Kampa A, Kohlhaas C, Pöplau P, Briggs GS, Piel J, Oldham NJ.

Angew Chem Int Ed Engl. 2013 Jan 21;52(4):1143-7. doi: 10.1002/anie.201207690. Epub 2012 Dec 4. No abstract available.

PMID:
23212972
22.

Cyclisation of Lys48-linked diubiquitin in vitro and in vivo.

Sokratous K, Strachan J, Roach LV, Layfield R, Oldham NJ.

FEBS Lett. 2012 Nov 30;586(23):4144-7. doi: 10.1016/j.febslet.2012.10.011. Epub 2012 Oct 17.

23.

Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides.

Freeman MF, Gurgui C, Helf MJ, Morinaka BI, Uria AR, Oldham NJ, Sahl HG, Matsunaga S, Piel J.

Science. 2012 Oct 19;338(6105):387-90. doi: 10.1126/science.1226121. Epub 2012 Sep 13.

24.

Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization.

Hopper JT, Rawlings A, Afonso JP, Channing D, Layfield R, Oldham NJ.

J Am Soc Mass Spectrom. 2012 Oct;23(10):1757-67. Epub 2012 Jul 14.

PMID:
22797884
25.

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry.

Sokratous K, Roach LV, Channing D, Strachan J, Long J, Searle MS, Layfield R, Oldham NJ.

J Am Chem Soc. 2012 Apr 11;134(14):6416-24. doi: 10.1021/ja300749d. Epub 2012 Mar 28.

PMID:
22428841
26.

Insights into the molecular composition of endogenous unanchored polyubiquitin chains.

Strachan J, Roach L, Sokratous K, Tooth D, Long J, Garner TP, Searle MS, Oldham NJ, Layfield R.

J Proteome Res. 2012 Mar 2;11(3):1969-80. doi: 10.1021/pr201167n. Epub 2012 Feb 14.

PMID:
22268864
27.

Charge state and adduct reduction in electrospray ionization-mass spectrometry using solvent vapor exposure.

Hopper JT, Sokratous K, Oldham NJ.

Anal Biochem. 2012 Feb 15;421(2):788-90. doi: 10.1016/j.ab.2011.10.034. Epub 2011 Oct 25.

28.

Alkali metal cation-induced destabilization of gas-phase protein-ligand complexes: consequences and prevention.

Hopper JT, Oldham NJ.

Anal Chem. 2011 Oct 1;83(19):7472-9. doi: 10.1021/ac201686f. Epub 2011 Sep 8.

PMID:
21863818
29.

Structural insights into dissimilatory sulfite reductases: structure of desulforubidin from desulfomicrobium norvegicum.

Oliveira TF, Franklin E, Afonso JP, Khan AR, Oldham NJ, Pereira IA, Archer M.

Front Microbiol. 2011 Apr 13;2:71. doi: 10.3389/fmicb.2011.00071. eCollection 2011.

30.

Detection of a protein conformational equilibrium by electrospray ionisation-ion mobility-mass spectrometry.

Jenner M, Ellis J, Huang WC, Lloyd Raven E, Roberts GC, Oldham NJ.

Angew Chem Int Ed Engl. 2011 Aug 29;50(36):8291-4. doi: 10.1002/anie.201101077. Epub 2011 Jun 17. No abstract available.

PMID:
21688358
31.

Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.

Dufour M, Yan C, Siegel D, Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Li Y, De Matteis CI, Ross D, Moody CJ.

Chembiochem. 2011 May 16;12(8):1203-8. doi: 10.1002/cbic.201100085. Epub 2011 Apr 19.

32.

A soluble RecN homologue provides means for biochemical and genetic analysis of DNA double-strand break repair in Escherichia coli.

Grove JI, Wood SR, Briggs GS, Oldham NJ, Lloyd RG.

DNA Repair (Amst). 2009 Dec 3;8(12):1434-43. doi: 10.1016/j.dnarep.2009.09.015. Epub 2009 Oct 20.

PMID:
19846353
33.

Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.

Garner TP, Williams HE, Gluszyk KI, Roe S, Oldham NJ, Stevens MF, Moses JE, Searle MS.

Org Biomol Chem. 2009 Oct 21;7(20):4194-200. doi: 10.1039/b910505k. Epub 2009 Aug 14.

PMID:
19795057
34.

Photoinduced, family-specific, site-selective cleavage of TIM-barrel proteins.

Floyd N, Oldham NJ, Eyles CJ, Taylor S, Filatov DA, Brouard M, Davis BG.

J Am Chem Soc. 2009 Sep 9;131(35):12518-9. doi: 10.1021/ja9026105.

PMID:
19722713
35.

Collision induced unfolding of protein ions in the gas phase studied by ion mobility-mass spectrometry: the effect of ligand binding on conformational stability.

Hopper JT, Oldham NJ.

J Am Soc Mass Spectrom. 2009 Oct;20(10):1851-8. doi: 10.1016/j.jasms.2009.06.010. Epub 2009 Jul 1.

36.

Site-selective chemical protein glycosylation protects from autolysis and proteolytic degradation.

Russell D, Oldham NJ, Davis BG.

Carbohydr Res. 2009 Aug 17;344(12):1508-14. doi: 10.1016/j.carres.2009.06.033. Epub 2009 Jun 26.

PMID:
19608158
37.

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.

Lienard BM, Conejo-García A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ.

Chem Commun (Camb). 2008 Dec 21;(47):6393-5. doi: 10.1039/b814440k. Epub 2008 Nov 5.

PMID:
19048166
38.

Chemical site-selective prenylation of proteins.

Gamblin DP, van Kasteren S, Bernardes GJ, Chalker JM, Oldham NJ, Fairbanks AJ, Davis BG.

Mol Biosyst. 2008 Jun;4(6):558-61. doi: 10.1039/b802199f. Epub 2008 May 2.

PMID:
18493653
39.

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.

Mecinović J, Chowdhury R, Liénard BM, Flashman E, Buck MR, Oldham NJ, Schofield CJ.

ChemMedChem. 2008 Apr;3(4):569-72. No abstract available.

PMID:
18058781
40.
41.

Bile acid interactions with rabbit ileal lipid binding protein and an engineered helixless variant reveal novel ligand binding properties of a versatile beta-clam shell protein scaffold.

Kouvatsos N, Thurston V, Ball K, Oldham NJ, Thomas NR, Searle MS.

J Mol Biol. 2007 Aug 31;371(5):1365-77. Epub 2007 Jun 16.

PMID:
17618650
42.

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ.

J Biol Chem. 2007 Aug 17;282(33):24027-38. Epub 2007 Jun 15.

43.

Expanding the diversity of chemical protein modification allows post-translational mimicry.

van Kasteren SI, Kramer HB, Jensen HH, Campbell SJ, Kirkpatrick J, Oldham NJ, Anthony DC, Davis BG.

Nature. 2007 Apr 26;446(7139):1105-9.

PMID:
17460675
44.

Combined mass spectrometry and dynamic chemistry approach to identify metalloenzyme inhibitors.

Liénard BM, Selevsek N, Oldham NJ, Schofield CJ.

ChemMedChem. 2007 Feb;2(2):175-9. No abstract available.

PMID:
17206734
45.

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.

Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ.

J Biol Chem. 2007 Feb 2;282(5):3293-301. Epub 2006 Nov 29.

46.

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. Epub 2006 Sep 26.

47.

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

McNeill LA, Flashman E, Buck MR, Hewitson KS, Clifton IJ, Jeschke G, Claridge TD, Ehrismann D, Oldham NJ, Schofield CJ.

Mol Biosyst. 2005 Oct;1(4):321-4. Epub 2005 Aug 22.

PMID:
16880998
48.

Studies on ternary metallo-β lactamase-inhibitor complexes using electrospray ionization mass spectrometry.

Selevsek N, Tholey A, Heinzle E, Liénard BMR, Oldham NJ, Schofield CJ, Heinz U, Adolph HW, Frère JM.

J Am Soc Mass Spectrom. 2006 Jul;17(7):1000-1004. doi: 10.1016/j.jasms.2006.03.010. Epub 2006 Jul 1.

PMID:
29500809
49.

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. Epub 2006 Jun 16.

50.

Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry.

Selevsek N, Tholey A, Heinzle E, Liénard BM, Oldham NJ, Schofield CJ, Heinz U, Adolph HW, Frère JM.

J Am Soc Mass Spectrom. 2006 Jul;17(7):1000-4. Epub 2006 May 19.

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