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Direct evidence using a controlled greenhouse study for threshold effects of soil organic matter on crop growth.

Oldfield EE, Wood SA, Bradford MA.

Ecol Appl. 2020 Jan 21. doi: 10.1002/eap.2073. [Epub ahead of print]


SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular Ca2+ homeostasis, collapsing the mitochondrial electrochemical potential (ΔΨm) and affecting acidocalcisomes.

Gil Z, Martinez-Sotillo N, Pinto-Martinez A, Mejias F, Martinez JC, Galindo I, Oldfield E, Benaim G.

Parasitol Res. 2020 Feb;119(2):649-657. doi: 10.1007/s00436-019-06560-y. Epub 2020 Jan 2.


Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells.

Han S, Li X, Xia Y, Yu Z, Cai N, Malwal SR, Han X, Oldfield E, Zhang Y.

J Med Chem. 2019 Dec 12;62(23):10867-10896. doi: 10.1021/acs.jmedchem.9b01405. Epub 2019 Dec 2.


Mycobacterium tuberculosis releases an antacid that remodels phagosomes.

Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB.

Nat Chem Biol. 2019 Sep;15(9):889-899. doi: 10.1038/s41589-019-0336-0. Epub 2019 Aug 19.


Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition.

Song J, Shang N, Baig N, Yao J, Shin C, Kim BK, Li Q, Malwal SR, Oldfield E, Feng X, Guo RT.

Biochem Biophys Res Commun. 2019 May 7;512(3):517-523. doi: 10.1016/j.bbrc.2019.03.070. Epub 2019 Mar 21.


A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation.

Yang Y, Li L, Yuan L, Zhou X, Duan J, Xiao H, Cai N, Han S, Ma X, Liu W, Chen CC, Wang L, Li X, Chen J, Kang N, Chen J, Shen Z, Malwal SR, Liu W, Shi Y, Oldfield E, Guo RT, Zhang Y.

Immunity. 2019 Apr 16;50(4):1043-1053.e5. doi: 10.1016/j.immuni.2019.02.016. Epub 2019 Mar 19.


Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism.

Zhang L, Ko TP, Malwal SR, Liu W, Zhou S, Yu X, Oldfield E, Guo RT, Chen CC.

Biochem Biophys Res Commun. 2019 Apr 16;511(4):800-805. doi: 10.1016/j.bbrc.2019.02.131. Epub 2019 Mar 2.


Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.

Malwal SR, Chen L, Hicks H, Qu F, Liu W, Shillo A, Law WX, Zhang J, Chandnani N, Han X, Zheng Y, Chen CC, Guo RT, AbdelKhalek A, Seleem MN, Oldfield E.

J Med Chem. 2019 Mar 14;62(5):2564-2581. doi: 10.1021/acs.jmedchem.8b01878. Epub 2019 Feb 21.


Cross-biome patterns in soil microbial respiration predictable from evolutionary theory on thermal adaptation.

Bradford MA, McCulley RL, Crowther TW, Oldfield EE, Wood SA, Fierer N.

Nat Ecol Evol. 2019 Jan 14;3(2):223-231. doi: 10.1038/s41559-018-0771-4.


Bowel preparation for colonoscopy: what is best and necessary for quality?

Parekh PJ, Oldfield EC 4th, Johnson DA.

Curr Opin Gastroenterol. 2019 Jan;35(1):51-57. doi: 10.1097/MOG.0000000000000494. Review.


Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes.

Malwal SR, Gao J, Hu X, Yang Y, Liu W, Huang JW, Ko TP, Li L, Chen CC, O'Dowd B, Khade RL, Zhang Y, Zhang Y, Oldfield E, Guo RT.

ACS Catal. 2018 May 4;8(5):4299-4312. doi: 10.1021/acscatal.8b00543. Epub 2018 Apr 6.


The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.

Xia Y, Xie Y, Yu Z, Xiao H, Jiang G, Zhou X, Yang Y, Li X, Zhao M, Li L, Zheng M, Han S, Zong Z, Meng X, Deng H, Ye H, Fa Y, Wu H, Oldfield E, Hu X, Liu W, Shi Y, Zhang Y.

Cell. 2018 Nov 1;175(4):1059-1073.e21. doi: 10.1016/j.cell.2018.08.070. Epub 2018 Sep 27.


Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors.

Kang L, Gao XH, Liu HR, Men X, Wu HN, Cui PW, Oldfield E, Yan JY.

Mol Divers. 2018 Nov;22(4):893-906. doi: 10.1007/s11030-018-9839-y. Epub 2018 Jun 22.


Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.

Malwal SR, O'Dowd B, Feng X, Turhanen P, Shin C, Yao J, Kim BK, Baig N, Zhou T, Bansal S, Khade RL, Zhang Y, Oldfield E.

J Am Chem Soc. 2018 Jun 20;140(24):7568-7578. doi: 10.1021/jacs.8b02363. Epub 2018 Jun 5.


Origin of Syrinx Fluid in Syringomyelia: A Physiological Study.

Heiss JD, Jarvis K, Smith RK, Eskioglu E, Gierthmuehlen M, Patronas NJ, Butman JA, Argersinger DP, Lonser RR, Oldfield EH.

Neurosurgery. 2019 Feb 1;84(2):457-468. doi: 10.1093/neuros/nyy072.


Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).

Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 Mar 25;148:195-209. doi: 10.1016/j.ejmech.2018.02.031. Epub 2018 Feb 12.


Central Nervous System Germinomas Express Programmed Death Ligand 1.

Wildeman ME, Shepard MJ, Oldfield EH, Lopes MBS.

J Neuropathol Exp Neurol. 2018 Apr 1;77(4):312-316. doi: 10.1093/jnen/nly008.


Variable response of CNS hemangioblastomas to Pazopanib in a single patient with von Hippel-Lindau disease: Case report.

Taylor DG, Ilyas A, Mehta GU, Chen CJ, Schiff D, Oldfield EH, Asthagiri AR.

J Clin Neurosci. 2018 Apr;50:154-156. doi: 10.1016/j.jocn.2018.01.040. Epub 2018 Feb 1.


Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design.

Venkatramani A, Gravina Ricci C, Oldfield E, McCammon JA.

Chem Biol Drug Des. 2018 Jun;91(6):1068-1077. doi: 10.1111/cbdd.13170. Epub 2018 Feb 4.


"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.

Gao J, Ko TP, Chen L, Malwal SR, Zhang J, Hu X, Qu F, Liu W, Huang JW, Cheng YS, Chen CC, Yang Y, Zhang Y, Oldfield E, Guo RT.

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):683-687. doi: 10.1002/anie.201710185. Epub 2017 Dec 21.


The Effects of Sleep on the Commensal Microbiota: Eyes Wide Open?

Parekh PJ, Oldfield EC 4th, Johnson DA.

J Clin Gastroenterol. 2018 Mar;52(3):204-209. doi: 10.1097/MCG.0000000000000965. Review.


Wake-up Call to Clinicians: The Impact of Sleep Dysfunction on Gastrointestinal Health and Disease.

Parekh PJ, Oldfield EC 4th, Johnson DA.

J Clin Gastroenterol. 2018 Mar;52(3):194-203. doi: 10.1097/MCG.0000000000000963. Review.


Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells.

Zhou X, Gu Y, Xiao H, Kang N, Xie Y, Zhang G, Shi Y, Hu X, Oldfield E, Zhang X, Zhang Y.

Front Immunol. 2017 Oct 24;8:1381. doi: 10.3389/fimmu.2017.01381. eCollection 2017.


Agenesis of Anterior Falx Cerebri in Patient with Planned Interhemispheric Approach to Third Ventricle Mass.

Finch NW, Ding D, Oldfield EH, Druzgal J.

World Neurosurg. 2018 Jan;109:162-164. doi: 10.1016/j.wneu.2017.09.166. Epub 2017 Oct 4.


Cushing's Disease: Lessons Learned From 1500 Cases.

Oldfield EH.

Neurosurgery. 2017 Sep 1;64(CN_suppl_1):27-36. doi: 10.1093/neuros/nyx378. No abstract available.


Pathogenesis of Chiari I - Pathophysiology of Syringomyelia: Implications for Therapy: A Summary of 3 Decades of Clinical Research.

Oldfield EH.

Neurosurgery. 2017 Sep 1;64(CN_suppl_1):66-77. doi: 10.1093/neuros/nyx377. No abstract available.


Functional Outcome After Resection of Von Hippel-Lindau Disease-Associated Cauda Equina Hemangioblastomas: An Observational Cohort Study.

Mehta GU, Montgomery BK, Maggio DM, Chittiboina P, Oldfield EH, Lonser RR.

Oper Neurosurg (Hagerstown). 2017 Aug 1;13(4):435-440. doi: 10.1093/ons/opx019.


Resection of pituitary macroadenomas via the pseudocapsule along the posterior tumor margin: a cohort study and technical note.

Taylor DG, Jane JA, Oldfield EH.

J Neurosurg. 2018 Feb;128(2):422-428. doi: 10.3171/2017.7.JNS171658. Epub 2017 Aug 18.


Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.

Rao G, Bansal S, Law WX, O'Dowd B, Dikanov SA, Oldfield E.

Biochemistry. 2017 Jul 25;56(29):3770-3779. doi: 10.1021/acs.biochem.7b00308. Epub 2017 Jul 12.


Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results.

Boulmier A, Feng X, Oms O, Mialane P, Rivière E, Shin CJ, Yao J, Kubo T, Furuta T, Oldfield E, Dolbecq A.

Inorg Chem. 2017 Jul 3;56(13):7558-7565. doi: 10.1021/acs.inorgchem.7b01114. Epub 2017 Jun 20.


Comparison of MRI techniques for detecting microadenomas in Cushing's disease.

Grober Y, Grober H, Wintermark M, Jane JA, Oldfield EH.

J Neurosurg. 2018 Apr;128(4):1051-1057. doi: 10.3171/2017.3.JNS163122. Epub 2017 Apr 28.


Head-to-Head Prenyl Synthases in Pathogenic Bacteria.

Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E.

Chembiochem. 2017 Jun 1;18(11):985-991. doi: 10.1002/cbic.201700099. Epub 2017 Apr 25.


Normalized Early Postoperative Cortisol and ACTH Values Predict Nonremission After Surgery for Cushing Disease.

Asuzu D, Chatain GP, Hayes C, Benzo S, McGlotten R, Keil M, Beri A, Sharma ST, Nieman L, Lodish M, Stratakis C, Lonser RR, Oldfield EH, Chittiboina P.

J Clin Endocrinol Metab. 2017 Jul 1;102(7):2179-2187. doi: 10.1210/jc.2016-3908.


Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.

O'Dowd B, Williams S, Wang H, No JH, Rao G, Wang W, McCammon JA, Cramer SP, Oldfield E.

Chembiochem. 2017 May 18;18(10):914-920. doi: 10.1002/cbic.201700052. Epub 2017 Apr 7.


Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.

Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper B, Zhang J, Mayhoub A, Oldfield E, Cushman M, Seleem MN.

J Med Chem. 2017 Mar 23;60(6):2425-2438. doi: 10.1021/acs.jmedchem.6b01780. Epub 2017 Mar 15.


The longest stalk: preserved pituitary function after regression of a giant prolactinoma.

Lundgren JA, Oldfield EH, Marshall JC.

Pituitary. 2017 Aug;20(4):485-487. doi: 10.1007/s11102-017-0796-8. No abstract available.


Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly.

Yu M, Bruns DE, Jane JA Jr, Nass RM, Oldfield EH, Vance ML, Thorner MO.

Clin Chem. 2017 Feb;63(2):486-494. doi: 10.1373/clinchem.2016.262592. Epub 2016 Dec 14.


Clinical Features, Management Considerations and Outcomes in Case Series of Patients with Parasellar Intracranial Aneurysms Undergoing Anterior Skull Base Surgery.

Raper DM, Ding D, Evans E, Starke RM, Crowley RW, Liu KC, Oldfield EH, Jane JA Jr.

World Neurosurg. 2017 Mar;99:424-432. doi: 10.1016/j.wneu.2016.11.150. Epub 2016 Dec 10.


Correlation between GH and IGF-1 during treatment for acromegaly.

Oldfield EH, Jane JA Jr, Thorner MO, Pledger CL, Sheehan JP, Vance ML.

J Neurosurg. 2017 Jun;126(6):1959-1966. doi: 10.3171/2016.8.JNS161123. Epub 2016 Nov 18.


Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase.

Wang Y, Desai J, Zhang Y, Malwal SR, Shin CJ, Feng X, Sun H, Liu G, Guo RT, Oldfield E.

ChemMedChem. 2016 Oct 19;11(20):2311-2319. doi: 10.1002/cmdc.201600342. Epub 2016 Aug 31.


Loss of Quiescence in von Hippel-Lindau Hemangioblastomas is Associated with Erythropoietin Signaling.

Feldman MJ, Sizdahkhani S, Edwards NA, Merrill MJ, Ray-Chaudhury A, Zhuang Z, Lonser RR, Oldfield EH, Chittiboina P.

Sci Rep. 2016 Oct 17;6:35486. doi: 10.1038/srep35486.


Two distinct populations of Chiari I malformation based on presence or absence of posterior fossa crowdedness on magnetic resonance imaging.

Taylor DG, Mastorakos P, Jane JA Jr, Oldfield EH.

J Neurosurg. 2017 Jun;126(6):1934-1940. doi: 10.3171/2016.6.JNS152998. Epub 2016 Sep 2.


Dexlansoprazole: delayed-release orally disintegrating tablets for the treatment of heartburn associated with non-erosive gastroesophageal reflux disease and the maintenance of erosive esophagitis.

Oldfield EC 4th, Parekh PJ, Johnson DA.

Expert Rev Gastroenterol Hepatol. 2016 Oct;10(10):1083-1089. doi: 10.1080/17474124.2016.1230496.


Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.

Desai J, Wang Y Dr, Wang K Dr, Malwal SR Dr, Oldfield E.

ChemMedChem. 2016 Oct 6;11(19):2205-2215. doi: 10.1002/cmdc.201600343. Epub 2016 Aug 30.


Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.

G Ricci C, Liu YL, Zhang Y, Wang Y, Zhu W, Oldfield E, McCammon JA.

Biochemistry. 2016 Sep 13;55(36):5180-90. doi: 10.1021/acs.biochem.6b00398. Epub 2016 Sep 1.


A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells.

Bai Y, Feng X, Xing H, Xu Y, Kim BK, Baig N, Zhou T, Gewirth AA, Lu Y, Oldfield E, Zimmerman SC.

J Am Chem Soc. 2016 Sep 7;138(35):11077-80. doi: 10.1021/jacs.6b04477. Epub 2016 Aug 26.


Surgical Management of Carney Complex-Associated Pituitary Pathology.

Lonser RR, Mehta GU, Kindzelski BA, Ray-Chaudhury A, Vortmeyer AO, Dickerman R, Oldfield EH.

Neurosurgery. 2017 May 1;80(5):780-786. doi: 10.1227/NEU.0000000000001384.


Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109.

García-García V, Oldfield E, Benaim G.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6386-9. doi: 10.1128/AAC.00945-16. Print 2016 Oct.


Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.

Desai J, Liu YL, Wei H, Liu W, Ko TP, Guo RT, Oldfield E.

ChemMedChem. 2016 Sep 6;11(17):1915-23. doi: 10.1002/cmdc.201600311. Epub 2016 Jul 26.


Structure and Function of Four Classes of the 4Fe-4S Protein, IspH.

Rao G, Oldfield E.

Biochemistry. 2016 Jul 26;55(29):4119-29. doi: 10.1021/acs.biochem.6b00474. Epub 2016 Jul 12.

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