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Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter.

Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi Y, Nagai H, Shimizu W, Saiki A, Ishikawa T, Elhanbly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg PA, Jung S, Matozaki T, Fukazawa Y, Ohnishi H.

Elife. 2019 Mar 26;8. pii: e42025. doi: 10.7554/eLife.42025.


Anti-human SIRPα antibody is a new tool for cancer immunotherapy.

Murata Y, Tanaka D, Hazama D, Yanagita T, Saito Y, Kotani T, Oldenborg PA, Matozaki T.

Cancer Sci. 2018 May;109(5):1300-1308. doi: 10.1111/cas.13548. Epub 2018 Apr 15.


Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells.

Meinderts SM, Oldenborg PA, Beuger BM, Klei TRL, Johansson J, Kuijpers TW, Matozaki T, Huisman EJ, de Haas M, van den Berg TK, van Bruggen R.

Blood Adv. 2017 May 26;1(14):875-886. doi: 10.1182/bloodadvances.2017004671. eCollection 2017 Jun 13.


Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes.

Qadri SM, Bissinger R, Solh Z, Oldenborg PA.

Blood Rev. 2017 Nov;31(6):349-361. doi: 10.1016/j.blre.2017.06.001. Epub 2017 Jun 17. Review.


Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.

Yanagita T, Murata Y, Tanaka D, Motegi SI, Arai E, Daniwijaya EW, Hazama D, Washio K, Saito Y, Kotani T, Ohnishi H, Oldenborg PA, Garcia NV, Miyasaka M, Ishikawa O, Kanai Y, Komori T, Matozaki T.

JCI Insight. 2017 Jan 12;2(1):e89140. doi: 10.1172/jci.insight.89140.


Lack of SIRPα phosphorylation and concomitantly reduced SHP-2-PI3K-Akt2 signaling decrease osteoblast differentiation.

Holm CK, Engman S, Sulniute R, Matozaki T, Oldenborg PA, Lundberg P.

Biochem Biophys Res Commun. 2016 Sep 9;478(1):268-273. doi: 10.1016/j.bbrc.2016.07.048. Epub 2016 Jul 12.


Red blood cells with elevated cytoplasmic Ca(2+) are primarily taken up by splenic marginal zone macrophages and CD207+ dendritic cells.

Larsson A, Hult A, Nilsson A, Olsson M, Oldenborg PA.

Transfusion. 2016 Jul;56(7):1834-44. doi: 10.1111/trf.13612. Epub 2016 Apr 19.


Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.

Kolan SS, Lejon K, Koskinen Holm C, Sulniute R, Lundberg P, Matozaki T, Oldenborg PA.

PLoS One. 2015 Jul 29;10(7):e0134113. doi: 10.1371/journal.pone.0134113. eCollection 2015.


Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells.

Kolan SS, Boman A, Matozaki T, Lejon K, Oldenborg PA.

Biochem Biophys Res Commun. 2015 May 8;460(3):645-50. doi: 10.1016/j.bbrc.2015.03.084. Epub 2015 Mar 25.


Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation.

Stenberg Å, Karlsson A, Feuk-Lagerstedt E, Christenson K, Bylund J, Oldenborg A, Vesterlund L, Matozaki T, Sehlin J, Oldenborg PA.

J Innate Immun. 2014;6(4):553-60. doi: 10.1159/000357820. Epub 2014 Feb 7.


Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells.

Edin S, Wikberg ML, Rutegård J, Oldenborg PA, Palmqvist R.

PLoS One. 2013 Sep 18;8(9):e74982. doi: 10.1371/journal.pone.0074982. eCollection 2013.


Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling.

Koskinen C, Persson E, Baldock P, Stenberg Å, Boström I, Matozaki T, Oldenborg PA, Lundberg P.

J Biol Chem. 2013 Oct 11;288(41):29333-44. doi: 10.1074/jbc.M113.494591. Epub 2013 Aug 29.


Macrophages: Good guys in colorectal cancer.

Edin S, Wikberg ML, Oldenborg PA, Palmqvist R.

Oncoimmunology. 2013 Feb 1;2(2):e23038.


CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease.

Oldenborg PA.

ISRN Hematol. 2013;2013:614619. doi: 10.1155/2013/614619. Epub 2013 Jan 21.


Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRPα) from the cell surface.

Stenberg A, Sehlin J, Oldenborg PA.

J Leukoc Biol. 2013 Mar;93(3):403-12. doi: 10.1189/jlb.1110637. Epub 2012 Dec 27.


The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer.

Edin S, Wikberg ML, Dahlin AM, Rutegård J, Öberg Å, Oldenborg PA, Palmqvist R.

PLoS One. 2012;7(10):e47045. doi: 10.1371/journal.pone.0047045. Epub 2012 Oct 15.


The absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons.

Marschinke F, Hashemian S, Matozaki T, Oldenborg PA, Strömberg I.

PLoS One. 2012;7(9):e45218. doi: 10.1371/journal.pone.0045218. Epub 2012 Sep 26.


Transfusion of cryopreserved human red blood cells into healthy humans is associated with rapid extravascular hemolysis without a proinflammatory cytokine response.

Hult A, Malm C, Oldenborg PA.

Transfusion. 2013 Jan;53(1):28-33. doi: 10.1111/j.1537-2995.2012.03710.x. Epub 2012 May 21.


Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain.

Maruyama T, Kusakari S, Sato-Hashimoto M, Hayashi Y, Kotani T, Murata Y, Okazawa H, Oldenborg PA, Kishi S, Matozaki T, Ohnishi H.

J Neurochem. 2012 Jun;121(6):891-902. doi: 10.1111/j.1471-4159.2012.07748.x. Epub 2012 Apr 24.


Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be regulated by glucocorticoids.

Nilsson A, Vesterlund L, Oldenborg PA.

Biochem Biophys Res Commun. 2012 Jan 27;417(4):1304-9. doi: 10.1016/j.bbrc.2011.12.137. Epub 2012 Jan 3.


CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a maintained capacity to induce oral tolerance.

Westlund J, Livingston M, Fahlén-Yrlid L, Oldenborg PA, Yrlid U.

Immunology. 2012 Mar;135(3):236-44. doi: 10.1111/j.1365-2567.2011.03536.x.


Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.

Sato-Hashimoto M, Saito Y, Ohnishi H, Iwamura H, Kanazawa Y, Kaneko T, Kusakari S, Kotani T, Mori M, Murata Y, Okazawa H, Ware CF, Oldenborg PA, Nojima Y, Matozaki T.

J Immunol. 2011 Jul 1;187(1):291-7. doi: 10.4049/jimmunol.1100528. Epub 2011 Jun 1.


Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes.

Gitik M, Liraz-Zaltsman S, Oldenborg PA, Reichert F, Rotshenker S.

J Neuroinflammation. 2011 Mar 15;8:24. doi: 10.1186/1742-2094-8-24.


Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion.

Henriksson ML, Edin S, Dahlin AM, Oldenborg PA, Öberg Å, Van Guelpen B, Rutegård J, Stenling R, Palmqvist R.

Am J Pathol. 2011 Mar;178(3):1387-94. doi: 10.1016/j.ajpath.2010.12.008.


Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test.

Ohnishi H, Murata T, Kusakari S, Hayashi Y, Takao K, Maruyama T, Ago Y, Koda K, Jin FJ, Okawa K, Oldenborg PA, Okazawa H, Murata Y, Furuya N, Matsuda T, Miyakawa T, Matozaki T.

J Neurosci. 2010 Aug 4;30(31):10472-83. doi: 10.1523/JNEUROSCI.0257-10.2010.


Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues.

Saito Y, Iwamura H, Kaneko T, Ohnishi H, Murata Y, Okazawa H, Kanazawa Y, Sato-Hashimoto M, Kobayashi H, Oldenborg PA, Naito M, Kaneko Y, Nojima Y, Matozaki T.

Blood. 2010 Nov 4;116(18):3517-25. doi: 10.1182/blood-2010-03-277244. Epub 2010 Aug 3.


CD47 is required for suppression of allograft rejection by donor-specific transfusion.

Wang H, Wu X, Wang Y, Oldenborg PA, Yang YG.

J Immunol. 2010 Apr 1;184(7):3401-7. doi: 10.4049/jimmunol.0901550. Epub 2010 Mar 5.


CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration.

Broom OJ, Zhang Y, Oldenborg PA, Massoumi R, Sjölander A.

PLoS One. 2009 Jul 28;4(7):e6371. doi: 10.1371/journal.pone.0006371.


CD47 promotes both phosphatidylserine-independent and phosphatidylserine-dependent phagocytosis of apoptotic murine thymocytes by non-activated macrophages.

Nilsson A, Oldenborg PA.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):58-63. doi: 10.1016/j.bbrc.2009.06.121. Epub 2009 Jun 25.


Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.

Motegi S, Okazawa H, Murata Y, Kanazawa Y, Saito Y, Kobayashi H, Ohnishi H, Oldenborg PA, Ishikawa O, Matozaki T.

Immunol Lett. 2008 Nov 16;121(1):52-60. doi: 10.1016/j.imlet.2008.08.005. Epub 2008 Sep 20.


CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages.

Olsson M, Oldenborg PA.

Blood. 2008 Nov 15;112(10):4259-67. doi: 10.1182/blood-2008-03-143008. Epub 2008 Sep 8.


Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells.

Wang H, Madariaga ML, Wang S, Van Rooijen N, Oldenborg PA, Yang YG.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13744-9. Epub 2007 Aug 15.


CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42.

Murata T, Ohnishi H, Okazawa H, Murata Y, Kusakari S, Hayashi Y, Miyashita M, Itoh H, Oldenborg PA, Furuya N, Matozaki T.

J Neurosci. 2006 Nov 29;26(48):12397-407.


Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction.

Lundberg P, Koskinen C, Baldock PA, Löthgren H, Stenberg A, Lerner UH, Oldenborg PA.

Biochem Biophys Res Commun. 2007 Jan 12;352(2):444-8. Epub 2006 Nov 20.


Dose-dependent inhibitory effect of CD47 in macrophage uptake of IgG-opsonized murine erythrocytes.

Olsson M, Nilsson A, Oldenborg PA.

Biochem Biophys Res Commun. 2007 Jan 5;352(1):193-7. Epub 2006 Nov 10.


Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.

Wang H, VerHalen J, Madariaga ML, Xiang S, Wang S, Lan P, Oldenborg PA, Sykes M, Yang YG.

Blood. 2007 Jan 15;109(2):836-42. Epub 2006 Sep 28.


Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration.

Hagnerud S, Manna PP, Cella M, Stenberg A, Frazier WA, Colonna M, Oldenborg PA.

J Immunol. 2006 May 15;176(10):5772-8.


Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1.

Ishikawa-Sekigami T, Kaneko Y, Saito Y, Murata Y, Okazawa H, Ohnishi H, Oldenborg PA, Nojima Y, Matozaki T.

Biochem Biophys Res Commun. 2006 May 19;343(4):1197-200. Epub 2006 Mar 24.


Target cell CD47 regulates macrophage activation and erythrophagocytosis.

Olsson M, Nilsson A, Oldenborg PA.

Transfus Clin Biol. 2006 Mar-Apr;13(1-2):39-43. Epub 2006 Mar 29.


Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte.

Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM.

Cell. 2005 Oct 21;123(2):321-34.


CD47 augments Fas/CD95-mediated apoptosis.

Manna PP, Dimitry J, Oldenborg PA, Frazier WA.

J Biol Chem. 2005 Aug 19;280(33):29637-44. Epub 2005 May 24.


Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system.

Okazawa H, Motegi S, Ohyama N, Ohnishi H, Tomizawa T, Kaneko Y, Oldenborg PA, Ishikawa O, Matozaki T.

J Immunol. 2005 Feb 15;174(4):2004-11.


Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia.

Olsson M, Bruhns P, Frazier WA, Ravetch JV, Oldenborg PA.

Blood. 2005 May 1;105(9):3577-82. Epub 2005 Jan 21.


Role of CD47 in erythroid cells and in autoimmunity.

Oldenborg PA.

Leuk Lymphoma. 2004 Jul;45(7):1319-27. Review.


Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex.

Bruce LJ, Ghosh S, King MJ, Layton DM, Mawby WJ, Stewart GW, Oldenborg PA, Delaunay J, Tanner MJ.

Blood. 2002 Sep 1;100(5):1878-85.


Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice.

Oldenborg PA, Gresham HD, Chen Y, Izui S, Lindberg FP.

Blood. 2002 May 15;99(10):3500-4.


Selective increase of autoimmune epitope expression on aged erythrocytes in mice: implications in anti-erythrocyte autoimmune responses.

Fossati-Jimack L, Azeredo da Silveira S, Moll T, Kina T, Kuypers FA, Oldenborg PA, Reininger L, Izui S.

J Autoimmun. 2002 Feb;18(1):17-25.


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