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Items: 1 to 50 of 1031

1.

Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients.

Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M.

Haematologica. 2020 Apr;105(4):1166-1167. doi: 10.3324/haematol.2019.245720. No abstract available.

2.

Frequent FOXA1-Activating Mutations in Extramammary Paget's Disease.

Takeichi T, Okuno Y, Matsumoto T, Tsunoda N, Suzuki K, Tanahashi K, Kono M, Kikumori T, Muro Y, Akiyama M.

Cancers (Basel). 2020 Mar 29;12(4). pii: E820. doi: 10.3390/cancers12040820.

3.

Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat.

Kitadokoro K, Tanaka M, Hikima T, Okuno Y, Yamamoto M, Kamitani S.

Sci Rep. 2020 Mar 25;10(1):5469. doi: 10.1038/s41598-020-62427-8.

4.

Metagenomic analysis of bacterial species in tongue microbiome of current and never smokers.

Sato N, Kakuta M, Hasegawa T, Yamaguchi R, Uchino E, Kobayashi W, Sawada K, Tamura Y, Tokuda I, Murashita K, Nakaji S, Imoto S, Yanagita M, Okuno Y.

NPJ Biofilms Microbiomes. 2020 Mar 13;6(1):11. doi: 10.1038/s41522-020-0121-6.

5.

System-Based Differential Gene Network Analysis for Characterizing a Sample-Specific Subnetwork.

Tanaka Y, Tamada Y, Ikeguchi M, Yamashita F, Okuno Y.

Biomolecules. 2020 Feb 14;10(2). pii: E306. doi: 10.3390/biom10020306.

6.

Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.

Takeda K, Kawamoto Y, Nagasaki Y, Okuno Y, Goto Y, Iida M, Yajima I, Ohgami N, Kato M.

Am J Cancer Res. 2020 Jan 1;10(1):336-349. eCollection 2020.

7.

Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method.

Ono F, Chiba S, Isaka Y, Matsumoto S, Ma B, Katayama R, Araki M, Okuno Y.

Sci Rep. 2020 Feb 7;10(1):2161. doi: 10.1038/s41598-020-58877-9.

8.

[Renal Cancer Tissue after Nivolumab/Ipilimumab Combination Therapy for Metastatic Renal Cell Carcinoma].

Okuno Y, Tanaka R, Mikami K, Takeuchi T.

Hinyokika Kiyo. 2020 Jan;66(1):13-17. doi: 10.14989/ActaUrolJap_66_1_13. Japanese.

PMID:
32028750
9.

H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant.

Maeda S, Ohka F, Okuno Y, Aoki K, Motomura K, Takeuchi K, Kusakari H, Yanagisawa N, Sato S, Yamaguchi J, Tanahashi K, Hirano M, Kato A, Shimizu H, Kitano Y, Yamazaki S, Yamashita S, Takeshima H, Shinjo K, Kondo Y, Wakabayashi T, Natsume A.

Acta Neuropathol Commun. 2020 Feb 5;8(1):8. doi: 10.1186/s40478-020-0882-4.

10.

A Novel Surface Modification and Immobilization Method of Anti-CD25 Antibody on Nonwoven Fabric Filter Removing Regulatory T Cells Selectively.

Okuno Y, Yamazaki Y, Fukutomi H, Kuno S, Yasutake M, Sugiura M, Kim CJ, Kimura S, Uji H.

ACS Omega. 2019 Dec 30;5(1):772-780. doi: 10.1021/acsomega.9b03494. eCollection 2020 Jan 14.

11.

Prediction of blood pressure variability using deep neural networks.

Koshimizu H, Kojima R, Kario K, Okuno Y.

Int J Med Inform. 2020 Apr;136:104067. doi: 10.1016/j.ijmedinf.2019.104067. Epub 2020 Jan 8.

12.

Correction to: Field Assessment of Critical Stroke by Emergency Services for Acute Delivery to a Comprehensive Stroke Center: FACE2AD.

Okuno Y, Yamagami H, Kataoka H, Tahara Y, Tonomura S, Tokunaga H, Imahori T, Matsui D, Kobayashi M, Imamura H, Sakai N, Takahashi JC, Toyoda K, Nagatsuka K, Ihara M.

Transl Stroke Res. 2020 Jan 8. doi: 10.1007/s12975-019-00776-x. [Epub ahead of print]

PMID:
31916182
13.

Deep phenotyping of ichthyosis follicularis with atrichia and photophobia syndrome associated with MBTPS2 mutations.

Murase C, Takeichi T, Okuno Y, Ikumi K, Morita A, Akiyama M.

J Dermatol. 2020 Mar;47(3):e87-e88. doi: 10.1111/1346-8138.15210. Epub 2020 Jan 6. No abstract available.

PMID:
31907960
14.

Stabilization Mechanism for a Nonfibrillar Amyloid β Oligomer Based on Formation of a Hydrophobic Core Determined by Dissipative Particle Dynamics.

Kawai R, Chiba S, Okuwaki K, Kanada R, Doi H, Ono M, Mochizuki Y, Okuno Y.

ACS Chem Neurosci. 2020 Feb 5;11(3):385-394. doi: 10.1021/acschemneuro.9b00602. Epub 2020 Jan 15.

PMID:
31899612
15.

Novel compound heterozygous MCOLN1 mutations identified in a Japanese girl with severe developmental delay and thin corpus callosum.

Yamaguchi N, Ban K, Suzuki A, Nakamura Y, Kato K, Muramatsu H, Okuno Y, Hattori A, Kaname T, Takahashi Y, Saitoh S.

Brain Dev. 2020 Mar;42(3):298-301. doi: 10.1016/j.braindev.2019.12.003. Epub 2019 Dec 31.

PMID:
31899079
16.

Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy.

Hatae R, Chamoto K, Kim YH, Sonomura K, Taneishi K, Kawaguchi S, Yoshida H, Ozasa H, Sakamori Y, Akrami M, Fagarasan S, Masuda I, Okuno Y, Matsuda F, Hirai T, Honjo T.

JCI Insight. 2020 Jan 30;5(2). pii: 133501. doi: 10.1172/jci.insight.133501.

17.

Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genes.

Murata T, Okuno Y, Sato Y, Watanabe T, Kimura H.

Rev Med Virol. 2020 Mar;30(2):e2095. doi: 10.1002/rmv.2095. Epub 2019 Dec 17. Review.

PMID:
31845495
18.

MGeND: an integrated database for Japanese clinical and genomic information.

Kamada M, Nakatsui M, Kojima R, Nohara S, Uchino E, Tanishima S, Sugiyama M, Kosaki K, Tokunaga K, Mizokami M, Okuno Y.

Hum Genome Var. 2019 Dec 6;6:53. doi: 10.1038/s41439-019-0084-4. eCollection 2019.

19.

Novel biallelic FA2H mutations in a Japanese boy with fatty acid hydroxylase-associated neurodegeneration.

Kawaguchi M, Sassa T, Kidokoro H, Nakata T, Kato K, Muramatsu H, Okuno Y, Yamamoto H, Kaname T, Kihara A, Natsume J.

Brain Dev. 2020 Feb;42(2):217-221. doi: 10.1016/j.braindev.2019.11.006. Epub 2019 Dec 16.

PMID:
31837835
20.

Reduced stratum corneum acylceramides in autosomal recessive congenital ichthyosis with a NIPAL4 mutation.

Murase Y, Takeichi T, Kawamoto A, Tanahashi K, Okuno Y, Takama H, Shimizu E, Ishikawa J, Ogi T, Akiyama M.

J Dermatol Sci. 2020 Jan;97(1):50-56. doi: 10.1016/j.jdermsci.2019.12.001. Epub 2019 Dec 4.

PMID:
31836270
21.

Field Assessment of Critical Stroke by Emergency Services for Acute Delivery to a Comprehensive Stroke Center: FACE2AD.

Okuno Y, Yamagami H, Kataoka H, Tahara Y, Tonomura S, Tokunaga H, Imahori T, Matsui D, Kobayashi M, Imamura H, Sakai N, Takahashi JC, Toyoda K, Nagatsuka K, Ihara M.

Transl Stroke Res. 2019 Dec 12. doi: 10.1007/s12975-019-00751-6. [Epub ahead of print] Erratum in: Transl Stroke Res. 2020 Jan 8;:.

PMID:
31833034
22.

Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients.

Watanabe H, Yoneda S, Motoyama Y, Mukai K, Okuno Y, Kozawa J, Nishizawa H, Maeda N, Otsuki M, Matsuoka TA, Morii E, Iwahashi H, Shimomura I.

Intern Med. 2020 Mar 15;59(6):799-803. doi: 10.2169/internalmedicine.3009-19. Epub 2019 Nov 29.

23.

Prediction and Interpretable Visualization of Retrosynthetic Reactions Using Graph Convolutional Networks.

Ishida S, Terayama K, Kojima R, Takasu K, Okuno Y.

J Chem Inf Model. 2019 Dec 23;59(12):5026-5033. doi: 10.1021/acs.jcim.9b00538. Epub 2019 Dec 9.

PMID:
31769668
24.

Anti-Influenza Virus Activity of Adlay Tea Components.

Nagai E, Iwai M, Koketsu R, Okuno Y, Suzuki Y, Morimoto R, Sumitani H, Ohshima A, Enomoto T, Isegawa Y.

Plant Foods Hum Nutr. 2019 Dec;74(4):538-543. doi: 10.1007/s11130-019-00773-3.

PMID:
31728799
25.

Calculation of absolute binding free energies between the hERG channel and structurally diverse drugs.

Negami T, Araki M, Okuno Y, Terada T.

Sci Rep. 2019 Nov 12;9(1):16586. doi: 10.1038/s41598-019-53120-6.

26.

[Spontaneous remission of acquired factor XIII inhibitor concurrent to development of IgA-λ type multiple myeloma].

Ueno S, Nozaki J, Kusano S, Kawano Y, Kikukawa Y, Okuno Y, Hata H, Matsuoka M, Uchiba M.

Rinsho Ketsueki. 2019;60(10):1443-1448. doi: 10.11406/rinketsu.60.1443. Japanese.

PMID:
31695005
27.

Insulin secretion and sensitivity before and after surgical treatment for aldosterone-producing adenoma.

Komada H, Hirota Y, So A, Nakamura T, Okuno Y, Fukuoka H, Iguchi G, Takahashi Y, Sakaguchi K, Ogawa W.

Diabetes Metab. 2019 Oct 31. pii: S1262-3636(19)30158-2. doi: 10.1016/j.diabet.2019.10.002. [Epub ahead of print]

PMID:
31676325
28.

Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies.

Kita Y, Hamada A, Saito R, Teramoto Y, Tanaka R, Takano K, Nakayama K, Murakami K, Matsumoto K, Akamatsu S, Yamasaki T, Inoue T, Tabata Y, Okuno Y, Ogawa O, Kobayashi T.

Br J Cancer. 2019 Dec;121(12):1027-1038. doi: 10.1038/s41416-019-0609-0. Epub 2019 Nov 1.

PMID:
31673101
29.

SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.

Takeichi T, Hirabayashi T, Miyasaka Y, Kawamoto A, Okuno Y, Taguchi S, Tanahashi K, Murase C, Takama H, Tanaka K, Boeglin WE, Calcutt MW, Watanabe D, Kono M, Muro Y, Ishikawa J, Ohno T, Brash AR, Akiyama M.

J Clin Invest. 2020 Feb 3;130(2):890-903. doi: 10.1172/JCI130675.

30.

Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.

Shiba N, Yoshida K, Hara Y, Yamato G, Shiraishi Y, Matsuo H, Okuno Y, Chiba K, Tanaka H, Kaburagi T, Takeuchi M, Ohki K, Sanada M, Okubo J, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y.

Blood Adv. 2019 Oct 22;3(20):3157-3169. doi: 10.1182/bloodadvances.2019000404.

31.

A novel CUL4B splice site variant in a young male exhibiting less pronounced features.

Nakamura Y, Okuno Y, Muramatsu H, Kawai T, Satou K, Ieda D, Hori I, Ohashi K, Negishi Y, Hattori A, Takahashi Y, Kojima S, Saitoh S.

Hum Genome Var. 2019 Sep 4;6:43. doi: 10.1038/s41439-019-0074-6. eCollection 2019.

32.

An in silico Approach for Integrating Phenotypic and Target-based Approaches in Drug Discovery.

Iwata H, Kojima R, Okuno Y.

Mol Inform. 2020 Jan;39(1-2):e1900096. doi: 10.1002/minf.201900096. Epub 2019 Oct 22.

33.

A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India.

Donovan FX, Solanki A, Mori M, Chavan N, George M, C SK, Okuno Y, Muramastsu H, Yoshida K, Shimamoto A, Takaori-Kondo A, Yabe H, Ogawa S, Kojima S, Yabe M, Ramanagoudr-Bhojappa R, Smogorzewska A, Mohan S, Rajendran A, Auerbach AD, Takata M, Chandrasekharappa SC, Vundinti BR.

Hum Mutat. 2020 Jan;41(1):122-128. doi: 10.1002/humu.23914. Epub 2019 Sep 26.

PMID:
31513304
34.

Metagenomic analysis using next-generation sequencing of pathogens in bronchoalveolar lavage fluid from pediatric patients with respiratory failure.

Takeuchi S, Kawada JI, Horiba K, Okuno Y, Okumura T, Suzuki T, Torii Y, Kawabe S, Wada S, Ikeyama T, Ito Y.

Sci Rep. 2019 Sep 9;9(1):12909. doi: 10.1038/s41598-019-49372-x.

35.

[A Case of Unclassified Sex Cord-Stromal Tumor Containing hCG-Positive Cells].

Toriyama F, Okuno Y, Mikami K, Uekusa T, Takeuchi T.

Hinyokika Kiyo. 2019 Aug;65(8):347-350. doi: 10.14989/ActaUrolJap_65_8_347. Japanese.

PMID:
31501405
36.

Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma.

Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A.

Molecules. 2019 Aug 22;24(17). pii: E3046. doi: 10.3390/molecules24173046.

37.

Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas.

Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y.

Cancer Res. 2019 Oct 1;79(19):4814-4827. doi: 10.1158/0008-5472.CAN-19-1272. Epub 2019 Aug 20.

PMID:
31431463
38.

Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma.

Noyori O, Komohara Y, Nasser H, Hiyoshi M, Ma C, Pan C, Carreras J, Nakamura N, Sato A, Ando K, Okuno Y, Nosaka K, Matsuoka M, Suzu S.

Clin Transl Immunology. 2019 Aug 13;8(8):e1074. doi: 10.1002/cti2.1074. eCollection 2019.

39.

Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice.

Fukuchi M, Okuno Y, Nakayama H, Nakano A, Mori H, Mitazaki S, Nakano Y, Toume K, Jo M, Takasaki I, Watanabe K, Shibahara N, Komatsu K, Tabuchi A, Tsuda M.

Sci Rep. 2019 Aug 14;9(1):11833. doi: 10.1038/s41598-019-48361-4.

40.

Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.

Kedar PS, Harigae H, Ito E, Muramatsu H, Kojima S, Okuno Y, Fujiwara T, Dongerdiye R, Warang PP, Madkaikar MR.

Int J Hematol. 2019 Nov;110(5):618-626. doi: 10.1007/s12185-019-02716-9. Epub 2019 Aug 10.

PMID:
31401766
41.

Bioactivation mechanisms of N-hydroxyaristolactams: Nitroreduction metabolites of aristolochic acids.

Okuno Y, Bonala R, Attaluri S, Johnson F, Grollman AP, Sidorenko VS, Oda Y.

Environ Mol Mutagen. 2019 Dec;60(9):792-806. doi: 10.1002/em.22321. Epub 2019 Aug 16.

42.

Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.

Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y.

Cancer Sci. 2019 Oct;110(10):3275-3287. doi: 10.1111/cas.14154. Epub 2019 Aug 14.

43.

Force-field parametrization based on radial and energy distribution functions.

Chiba S, Okuno Y, Honma T, Ikeguchi M.

J Comput Chem. 2019 Nov 5;40(29):2577-2585. doi: 10.1002/jcc.26035. Epub 2019 Jul 25.

44.

Clinical potential of dual-energy cardiac CT in cardiac amyloidosis.

Oda S, Nakaura T, Utsunomiya D, Hirakawa K, Takashio S, Izumiya Y, Tsujita K, Kawano Y, Okuno Y, Hata H, Matsuoka M, Yamashita T, Ueda M, Ando Y, Yamashita Y.

Amyloid. 2019;26(sup1):91-92. doi: 10.1080/13506129.2019.1582021. No abstract available.

PMID:
31343298
45.

Corrigendum to "Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis." [Int. J. Cardiol., 274 (2019) 290-295].

Hayano S, Okuno Y, Tsutsumi M, Inagaki H, Fukasawa Y, Kurahashi H, Kojima S, Takahashi Y, Kato T.

Int J Cardiol. 2019 Oct 1;292:283. doi: 10.1016/j.ijcard.2019.06.020. Epub 2019 Jun 27. No abstract available.

PMID:
31256992
46.

DOCK8 mutation diagnosed using whole-exome sequencing of the dried blood spot-derived DNA: a case report of an Iraqi girl diagnosed in Japan.

Al-Kzayer LFY, Al-Aradi HMH, Shigemura T, Sano K, Tanaka M, Hamada M, Ali KH, Aldaghir OM, Nakazawa Y, Okuno Y.

BMC Med Genet. 2019 Jun 26;20(1):114. doi: 10.1186/s12881-019-0837-4.

47.

Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia.

Shigemura T, Matsuda K, Kurata T, Sakashita K, Okuno Y, Muramatsu H, Yue F, Ebihara Y, Tsuji K, Sasaki K, Nakahata T, Nakazawa Y, Koike K.

Br J Haematol. 2019 Oct;187(2):163-173. doi: 10.1111/bjh.16060. Epub 2019 Jun 20.

PMID:
31222725
48.

Alteration in ventricular pressure stimulates cardiac repair and remodeling.

Unno K, Oikonomopoulos A, Fujikawa Y, Okuno Y, Narita S, Kato T, Hayashida R, Kondo K, Shibata R, Murohara T, Yang Y, Dangwal S, Sereti KI, Yiling Q, Johnson K, Jha A, Sosnovik DE, Fann Y, Liao R.

J Mol Cell Cardiol. 2019 Aug;133:174-187. doi: 10.1016/j.yjmcc.2019.06.006. Epub 2019 Jun 17.

PMID:
31220468
49.

The rapid improvement in visual field defect observed with weekly perimetry during intensity-modulated radiotherapy for optic nerve sheath meningioma.

Inoue T, Mimura O, Ikenaga K, Okuno Y, Nishiguchi I.

Int Cancer Conf J. 2019 Apr 6;8(3):136-140. doi: 10.1007/s13691-019-00371-9. eCollection 2019 Jul.

50.

Targetable driver mutations in multicentric reticulohistiocytosis.

Murakami N, Sakai T, Arai E, Muramatsu H, Ichikawa D, Asai S, Shimoyama Y, Ishiguro N, Takahashi Y, Okuno Y, Nishida Y.

Haematologica. 2020 Jan 31;105(2):e61-e64. doi: 10.3324/haematol.2019.218735. Print 2020. No abstract available.

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