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Items: 1 to 50 of 975

1.

Structural modification of indomethacin toward selective inhibition of COX-2 with a significant increase in van der Waals contributions.

Ikeda A, Funakoshi E, Araki M, Ma B, Karuo Y, Tarui A, Sato K, Okuno Y, Kawai K, Omote M.

Bioorg Med Chem. 2019 Mar 14. pii: S0968-0896(19)30095-1. doi: 10.1016/j.bmc.2019.03.021. [Epub ahead of print]

PMID:
30898436
2.

KLF1 Mutation E325K Induces Cell-cycle Arrest in Erythroid Cells Differentiated from Congenital Dyserythropoietic Anemia (CDA) Patient-specific Induced Pluripotent Stem Cells.

Kohara H, Utsugisawa T, Sakamoto C, Hirose L, Ogawa Y, Ogura H, Sugawara A, Aoki T, Iwasaki T, Asai T, Doisaki S, Okuno Y, Muramatsu H, Abe T, Kurita R, Miyamoto S, Sakuma T, Shiba M, Yamamoto T, Ohga S, Yoshida K, Ogawa S, Ito E, Kojima S, Kanno H, Tani K.

Exp Hematol. 2019 Mar 12. pii: S0301-472X(19)30128-6. doi: 10.1016/j.exphem.2019.03.001. [Epub ahead of print]

PMID:
30876823
3.

Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma.

Ranjit M, Hirano M, Aoki K, Okuno Y, Ohka F, Yamamichi A, Kato A, Maeda S, Motomura K, Matsuo K, Enomoto A, Ino Y, Todo T, Takahashi M, Wakabayashi T, Kato T, Natsume A.

Cell Rep. 2019 Feb 26;26(9):2274-2281.e5. doi: 10.1016/j.celrep.2019.01.109.

4.

Dynamic Docking of a Medium-Sized Molecule to Its Receptor by Multicanonical MD Simulations.

Bekker GJ, Araki M, Oshima K, Okuno Y, Kamiya N.

J Phys Chem B. 2019 Mar 21;123(11):2479-2490. doi: 10.1021/acs.jpcb.8b12419. Epub 2019 Mar 12.

PMID:
30808168
5.

Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients.

Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M.

Haematologica. 2019 Feb 21. pii: haematol.2018.207241. doi: 10.3324/haematol.2018.207241. [Epub ahead of print]

6.

A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots.

Al-Kzayer LFY, Yassin AK, Salih KH, Shigemura T, Sano K, Al-Simaani RBY, Tanaka M, Nakazawa Y, Okuno Y.

Front Immunol. 2019 Jan 25;10:58. doi: 10.3389/fimmu.2019.00058. eCollection 2019.

7.

Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.

Mizumoto A, Ohashi S, Kamada M, Saito T, Nakai Y, Baba K, Hirohashi K, Mitani Y, Kikuchi O, Matsubara J, Yamada A, Takahashi T, Lee H, Okuno Y, Kanai M, Muto M.

J Gastroenterol. 2019 Feb 8. doi: 10.1007/s00535-019-01549-x. [Epub ahead of print]

PMID:
30737573
8.

Suppression of IgE-Independent Degranulation of Murine Connective Tissue-Type Mast Cells by Dexamethasone.

Yamada K, Sato H, Sakamaki K, Kamada M, Okuno Y, Fukuishi N, Furuta K, Tanaka S.

Cells. 2019 Feb 1;8(2). pii: E112. doi: 10.3390/cells8020112.

9.

Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

Nat Microbiol. 2019 Mar;4(3):544. doi: 10.1038/s41564-019-0387-8.

PMID:
30705423
10.

Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

Nat Microbiol. 2019 Mar;4(3):404-413. doi: 10.1038/s41564-018-0334-0. Epub 2019 Jan 21. Erratum in: Nat Microbiol. 2019 Jan 30;:.

PMID:
30664667
11.

Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.

Okada K, Araki M, Sakashita T, Ma B, Kanada R, Yanagitani N, Horiike A, Koike S, Oh-Hara T, Watanabe K, Tamai K, Maemondo M, Nishio M, Ishikawa T, Okuno Y, Fujita N, Katayama R.

EBioMedicine. 2019 Jan 17. pii: S2352-3964(19)30024-6. doi: 10.1016/j.ebiom.2019.01.019. [Epub ahead of print]

12.

Sleep Shortage Is Associated With Postherpetic Neuralgia Development Through Hyperesthesia and Acute Pain Intensity: A Community-Based Prospective Cohort Study.

Yamada K, Kubota Y, Shimizu Y, Cui R, Mori Y, Okuno Y, Asada H, Yamanishi K, Iso H; SHEZ Study Group.

Pain Pract. 2019 Jan 19. doi: 10.1111/papr.12766. [Epub ahead of print]

PMID:
30659740
13.

Therapy-related acute myeloid leukemia after chemotherapy in extensive disease-small cell lung cancer.

Ueda N, Fujita K, Okuno Y, Nakatani K, Mio T.

Clin Case Rep. 2018 Nov 19;7(1):100-103. doi: 10.1002/ccr3.1931. eCollection 2019 Jan.

14.

Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome.

Hayashi R, Okuno Y, Mukai K, Kitamura T, Hayakawa T, Onodera T, Murata M, Fukuhara A, Imamura R, Miyagawa Y, Nonomura N, Otsuki M, Shimomura I.

Endocrinology. 2019 Mar 1;160(3):504-521. doi: 10.1210/en.2018-01029.

PMID:
30649271
15.

Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.

Komohara Y, Noyori O, Saito Y, Takeya H, Baghdadi M, Kitagawa F, Hama N, Ishikawa K, Okuno Y, Nosaka K, Seino KI, Matsuoka M, Suzu S.

J Clin Exp Hematop. 2018;58(4):152-160. doi: 10.3960/jslrt.18034.

16.

Improving the Accuracy of Protein-Ligand Binding Mode Prediction Using a Molecular Dynamics-Based Pocket Generation Approach.

Araki M, Iwata H, Ma B, Fujita A, Terayama K, Sagae Y, Ono F, Tsuda K, Kamiya N, Okuno Y.

J Comput Chem. 2018 Dec 15;39(32):2679-2689. doi: 10.1002/jcc.25715.

PMID:
30515903
17.

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells.

Ichikawa T, Okuno Y, Sato Y, Goshima F, Yoshiyama H, Kanda T, Kimura H, Murata T.

mSphere. 2018 Nov 28;3(6). pii: e00478-18. doi: 10.1128/mSphere.00478-18.

18.

Effect of Transcatheter Arterial Microembolization on Phantom Limb Pain Persisting for 17 Years.

Shibuya M, Yamamoto M, Okuno Y.

Cardiovasc Intervent Radiol. 2019 Mar;42(3):471-474. doi: 10.1007/s00270-018-2109-7. Epub 2018 Nov 13.

PMID:
30426150
19.

MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells.

Endo S, Nishimura N, Kawano Y, Ueno N, Ueno S, Tatetsu H, Komohara Y, Takeya M, Hata H, Mitsuya H, Masao M, Okuno Y.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):246-252. doi: 10.1016/j.bbrc.2018.11.016. Epub 2018 Nov 10.

PMID:
30420285
20.

A simple quantitative chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance using the modified James-Bull method.

Hamaguchi N, Okuno Y, Oe Y, Ohta T.

Chirality. 2019 Jan;31(1):34-40. doi: 10.1002/chir.23028. Epub 2018 Nov 5.

PMID:
30395695
21.

Dopamine and Serotonin Receptors Cooperatively Modulate Pacemaker Activity of Intestinal Cells of Cajal.

Liu HN, Hirata H, Okuno Y, Okabe M, Furukawa K.

Chin J Physiol. 2018 Oct 31;61(5):302-312. doi: 10.4077/CJP.2018.BAH607.

PMID:
30384551
22.

Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.

Yabe M, Koike T, Ohtsubo K, Imai E, Morimoto T, Takakura H, Koh K, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Mori M, Hira A, Takata M, Yabe H.

Ann Hematol. 2019 Feb;98(2):271-280. doi: 10.1007/s00277-018-3517-0. Epub 2018 Oct 27.

PMID:
30368588
23.

Base-to-apex gradient pattern of cardiac impairment identified on myocardial T1 mapping in cardiac amyloidosis.

Oda S, Kawano Y, Okuno Y, Utsunomiya D, Nakaura T, Tsujita K, Yamashita Y.

Radiol Case Rep. 2018 Oct 18;14(1):72-74. doi: 10.1016/j.radcr.2018.09.025. eCollection 2019 Jan.

24.

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.

Noda Y, Kuzuya A, Tanigawa K, Araki M, Kawai R, Ma B, Sasakura Y, Maesako M, Tashiro Y, Miyamoto M, Uemura K, Okuno Y, Kinoshita A.

Mol Brain. 2018 Oct 24;11(1):61. doi: 10.1186/s13041-018-0401-8.

25.

Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency.

Takeichi T, Okuno Y, Kawamoto A, Inoue T, Nagamoto E, Murase C, Shimizu E, Tanaka K, Kageshita Y, Fukushima S, Kono M, Ishikawa J, Ihn H, Takahashi Y, Akiyama M.

J Lipid Res. 2018 Dec;59(12):2413-2420. doi: 10.1194/jlr.P087536. Epub 2018 Oct 22.

PMID:
30348640
26.

Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 1.

Hoshino A, Yang X, Tanita K, Yoshida K, Ono T, Nishida N, Okuno Y, Kanzaki T, Goi K, Fujino H, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Morio T, Kanegane H.

J Allergy Clin Immunol. 2019 Jan;143(1):421-424.e11. doi: 10.1016/j.jaci.2018.07.044. Epub 2018 Oct 17. No abstract available.

PMID:
30342818
27.

Gain-of-function IKBKB mutation causes human combined immune deficiency.

Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G, Morio T, Vinuesa CG, Kanegane H, Cook MC.

J Exp Med. 2018 Nov 5;215(11):2715-2724. doi: 10.1084/jem.20180639. Epub 2018 Oct 18.

PMID:
30337470
28.

A Platform for Comprehensive Genomic Profiling in Human Cancers and Pharmacogenomics Therapy Selection.

Kou T, Kanai M, Kamada M, Nakatsui M, Matsumoto S, Okuno Y, Muto M.

Methods Mol Biol. 2018;1825:413-424. doi: 10.1007/978-1-4939-8639-2_14.

PMID:
30334215
29.

Prediction of prostate cancer by deep learning with multilayer artificial neural network.

Takeuchi T, Hattori-Kato M, Okuno Y, Iwai S, Mikami K.

Can Urol Assoc J. 2018 Oct 15. doi: 10.5489/cuaj.5526. [Epub ahead of print]

PMID:
30332595
30.

Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity

Hayakawa T, Minemura T, Onodera T, Shin J, Okuno Y, Fukuhara A, Otsuki M, Shimomura I.

J Endocrinol. 2018 Oct 1;239(1):63–71. doi: 10.1530/JOE-18-0026.

PMID:
30307154
31.

Convulsive seizure and pulmonary edema during hyperbaric oxygen therapy:A case report.

Cho K, Minami T, Okuno Y, Kakuda Y, Tsutsumi T, Kogame T, Ohtsuru S, Sato N, Koike K.

J Med Invest. 2018;65(3.4):286-288. doi: 10.2152/jmi.65.286.

32.

Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis.

Hayano S, Okuno Y, Tsutsumi M, Inagaki H, Fukasawa Y, Kurahashi H, Kojima S, Takahashi Y, Kato T.

Int J Cardiol. 2019 Jan 1;274:290-295. doi: 10.1016/j.ijcard.2018.09.032. Epub 2018 Sep 13.

PMID:
30228022
33.

Biotransformation of (+)-Carvone and (-)-Carvone by the Common Cutworm Spodoptera litura Larvae.

Marumoto S, Okuno Y, Hagiwara Y, Miyazawa M.

J Oleo Sci. 2018 Oct 11;67(10):1253-1257. doi: 10.5650/jos.ess18105. Epub 2018 Sep 13.

34.

Impaired glucagon secretion in patients with fulminant type 1 diabetes mellitus.

Komada H, Hirota Y, Sakaguchi K, Okuno Y, Ogawa W, Seino S.

Endocrine. 2019 Mar;63(3):476-479. doi: 10.1007/s12020-018-1750-x. Epub 2018 Sep 10.

PMID:
30203124
35.

De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.

Toki T, Yoshida K, Wang R, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa S, Ito E.

Am J Hum Genet. 2018 Sep 6;103(3):440-447. doi: 10.1016/j.ajhg.2018.07.020. Epub 2018 Aug 23.

36.

Reliable patient-reported outcome measure and survivorship of UKA for primary spontaneous osteonecrosis.

Kaneko T, Kono N, Sunakawa T, Okuno Y, Ikegami H, Musha Y.

Eur J Orthop Surg Traumatol. 2019 Jan;29(1):119-124. doi: 10.1007/s00590-018-2296-6. Epub 2018 Aug 23.

PMID:
30141028
37.

Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR.

Hamada M, Nishio N, Okuno Y, Suzuki S, Kawashima N, Muramatsu H, Tsubota S, Wilson MH, Morita D, Kataoka S, Ichikawa D, Murakami N, Taniguchi R, Suzuki K, Kojima D, Sekiya Y, Nishikawa E, Narita A, Hama A, Kojima S, Nakazawa Y, Takahashi Y.

EBioMedicine. 2018 Aug;34:18-26. doi: 10.1016/j.ebiom.2018.07.008. Epub 2018 Aug 3.

38.

Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume).

Kono R, Nakamura M, Nomura S, Kitano N, Kagiya T, Okuno Y, Inada KI, Tokuda A, Utsunomiya H, Ueno M.

Sci Rep. 2018 Aug 3;8(1):11638. doi: 10.1038/s41598-018-30086-5.

39.

Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity.

Hayakawa T, Minemura T, Onodera T, Shin J, Okuno Y, Fukuhara A, Otsuki M, Shimomura I.

J Endocrinol. 2018 Jul 26. pii: JOE-18-0026. doi: 10.1530/JOE-18-0026. [Epub ahead of print]

PMID:
30049823
40.

Cytokine production in whole-blood cultures following immunization with an influenza vaccine.

Nakayama T, Kumagai T, Kashiwagi Y, Yoshii H, Honjo K, Kubota-Koketsu R, Okuno Y, Suga S.

Hum Vaccin Immunother. 2018 Jul 23:1-9. doi: 10.1080/21645515.2018.1498435. [Epub ahead of print]

PMID:
30036123
41.

Identification of potential pathogenic viruses in patients with acute myocarditis using next-generation sequencing.

Takeuchi S, Kawada JI, Okuno Y, Horiba K, Suzuki T, Torii Y, Yasuda K, Numaguchi A, Kato T, Takahashi Y, Ito Y.

J Med Virol. 2018 Dec;90(12):1814-1821. doi: 10.1002/jmv.25263. Epub 2018 Aug 13.

PMID:
30011073
42.

Kinetic Trapping of Folded Proteins Relative to Aggregates under Physiologically Relevant Conditions.

Varela AE, Lang JF, Wu Y, Dalphin MD, Stangl AJ, Okuno Y, Cavagnero S.

J Phys Chem B. 2018 Aug 9;122(31):7682-7698. doi: 10.1021/acs.jpcb.8b05360. Epub 2018 Jul 26.

PMID:
30001623
43.

Probing the nanoscale light emission properties of a CVD-grown MoS2 monolayer by tip-enhanced photoluminescence.

Okuno Y, Lancry O, Tempez A, Cairone C, Bosi M, Fabbri F, Chaigneau M.

Nanoscale. 2018 Aug 7;10(29):14055-14059. doi: 10.1039/c8nr02421a. Epub 2018 Jul 12.

PMID:
29999092
44.

Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia.

Hamada M, Doisaki S, Okuno Y, Muramatsu H, Hama A, Kawashima N, Narita A, Nishio N, Yoshida K, Kanno H, Manabe A, Taga T, Takahashi Y, Miyano S, Ogawa S, Kojima S.

Int J Hematol. 2018 Sep;108(3):306-311. doi: 10.1007/s12185-018-2482-7. Epub 2018 Jun 23.

PMID:
29936674
45.

A patient with a GNAO1 mutation with decreased spontaneous movements, hypotonia, and dystonic features.

Okumura A, Maruyama K, Shibata M, Kurahashi H, Ishii A, Numoto S, Hirose S, Kawai T, Iso M, Kataoka S, Okuno Y, Muramatsu H, Kojima S.

Brain Dev. 2018 Nov;40(10):926-930. doi: 10.1016/j.braindev.2018.06.005. Epub 2018 Jun 21.

PMID:
29935962
46.

Metabolomic and microarray analyses of adipose tissue of dapagliflozin-treated mice, and effects of 3-hydroxybutyrate on induction of adiponectin in adipocytes.

Nishitani S, Fukuhara A, Shin J, Okuno Y, Otsuki M, Shimomura I.

Sci Rep. 2018 Jun 11;8(1):8805. doi: 10.1038/s41598-018-27181-y.

47.

Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.

Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S.

J Invest Dermatol. 2018 Dec;138(12):2550-2557. doi: 10.1016/j.jid.2018.05.015. Epub 2018 May 31.

PMID:
29859927
48.

Three Types of Broadly Reacting Antibodies against Influenza B Viruses Induced by Vaccination with Seasonal Influenza Viruses.

Hirano D, Ohshima N, Kubota-Koketsu R, Yamasaki A, Kurosawa G, Okuno Y, Yoshida S, Kurosawa Y.

J Immunol Res. 2018 May 8;2018:7251793. doi: 10.1155/2018/7251793. eCollection 2018.

49.

Sterol profiles are valuable biomarkers for phenotype expression of Conradi-Hünermann-Happle syndrome with EBP mutations.

Takeichi T, Honda A, Okuno Y, Kojima D, Kono M, Nakamura Y, Tohyama M, Tanaka T, Aoyama Y, Akiyama M.

Br J Dermatol. 2018 Nov;179(5):1186-1188. doi: 10.1111/bjd.16823. Epub 2018 Aug 6. No abstract available.

PMID:
29851033
50.

Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer.

Kondo T, Kanai M, Kou T, Sakuma T, Mochizuki H, Kamada M, Nakatsui M, Uza N, Kodama Y, Masui T, Takaori K, Matsumoto S, Miyake H, Okuno Y, Muto M.

Oncotarget. 2018 Apr 13;9(28):19817-19825. doi: 10.18632/oncotarget.24865. eCollection 2018 Apr 13.

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