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Items: 1 to 50 of 1008

1.

Anti-Influenza Virus Activity of Adlay Tea Components.

Nagai E, Iwai M, Koketsu R, Okuno Y, Suzuki Y, Morimoto R, Sumitani H, Ohshima A, Enomoto T, Isegawa Y.

Plant Foods Hum Nutr. 2019 Nov 15. doi: 10.1007/s11130-019-00773-3. [Epub ahead of print]

PMID:
31728799
2.

Calculation of absolute binding free energies between the hERG channel and structurally diverse drugs.

Negami T, Araki M, Okuno Y, Terada T.

Sci Rep. 2019 Nov 12;9(1):16586. doi: 10.1038/s41598-019-53120-6.

3.

[Spontaneous remission of acquired factor XIII inhibitor concurrent to development of IgA-λ type multiple myeloma].

Ueno S, Nozaki J, Kusano S, Kawano Y, Kikukawa Y, Okuno Y, Hata H, Matsuoka M, Uchiba M.

Rinsho Ketsueki. 2019;60(10):1443-1448. doi: 10.11406/rinketsu.60.1443. Japanese.

PMID:
31695005
4.

Insulin secretion and sensitivity before and after surgical treatment for aldosterone-producing adenoma.

Komada H, Hirota Y, So A, Nakamura T, Okuno Y, Fukuoka H, Iguchi G, Takahashi Y, Sakaguchi K, Ogawa W.

Diabetes Metab. 2019 Oct 31. pii: S1262-3636(19)30158-2. doi: 10.1016/j.diabet.2019.10.002. [Epub ahead of print]

PMID:
31676325
5.

Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies.

Kita Y, Hamada A, Saito R, Teramoto Y, Tanaka R, Takano K, Nakayama K, Murakami K, Matsumoto K, Akamatsu S, Yamasaki T, Inoue T, Tabata Y, Okuno Y, Ogawa O, Kobayashi T.

Br J Cancer. 2019 Nov 1. doi: 10.1038/s41416-019-0609-0. [Epub ahead of print]

PMID:
31673101
6.

SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.

Takeichi T, Hirabayashi T, Miyasaka Y, Kawamoto A, Okuno Y, Taguchi S, Tanahashi K, Murase C, Takama H, Tanaka K, Boeglin WE, Calcutt MW, Watanabe D, Kono M, Muro Y, Ishikawa J, Ohno T, Brash AR, Akiyama M.

J Clin Invest. 2019 Oct 31. pii: 130675. doi: 10.1172/JCI130675. [Epub ahead of print]

7.

Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia.

Shiba N, Yoshida K, Hara Y, Yamato G, Shiraishi Y, Matsuo H, Okuno Y, Chiba K, Tanaka H, Kaburagi T, Takeuchi M, Ohki K, Sanada M, Okubo J, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y.

Blood Adv. 2019 Oct 22;3(20):3157-3169. doi: 10.1182/bloodadvances.2019000404.

8.

A novel CUL4B splice site variant in a young male exhibiting less pronounced features.

Nakamura Y, Okuno Y, Muramatsu H, Kawai T, Satou K, Ieda D, Hori I, Ohashi K, Negishi Y, Hattori A, Takahashi Y, Kojima S, Saitoh S.

Hum Genome Var. 2019 Sep 4;6:43. doi: 10.1038/s41439-019-0074-6. eCollection 2019.

9.

An in Silico Approach for Integrating Phenotypic and Target-Based Approaches in Drug Discovery.

Iwata H, Kojima R, Okuno Y.

Mol Inform. 2019 Oct 22. doi: 10.1002/minf.201900096. [Epub ahead of print]

PMID:
31638744
10.

A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India.

Donovan FX, Solanki A, Mori M, Chavan N, George M, C SK, Okuno Y, Muramastsu H, Yoshida K, Shimamoto A, Takaori-Kondo A, Yabe H, Ogawa S, Kojima S, Yabe M, Ramanagoudr-Bhojappa R, Smogorzewska A, Mohan S, Rajendran A, Auerbach AD, Takata M, Chandrasekharappa SC, Vundinti BR.

Hum Mutat. 2019 Sep 12. doi: 10.1002/humu.23914. [Epub ahead of print]

PMID:
31513304
11.

Metagenomic analysis using next-generation sequencing of pathogens in bronchoalveolar lavage fluid from pediatric patients with respiratory failure.

Takeuchi S, Kawada JI, Horiba K, Okuno Y, Okumura T, Suzuki T, Torii Y, Kawabe S, Wada S, Ikeyama T, Ito Y.

Sci Rep. 2019 Sep 9;9(1):12909. doi: 10.1038/s41598-019-49372-x.

12.

[A Case of Unclassified Sex Cord-Stromal Tumor Containing hCG-Positive Cells].

Toriyama F, Okuno Y, Mikami K, Uekusa T, Takeuchi T.

Hinyokika Kiyo. 2019 Aug;65(8):347-350. doi: 10.14989/ActaUrolJap_65_8_347. Japanese.

PMID:
31501405
13.

Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma.

Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A.

Molecules. 2019 Aug 22;24(17). pii: E3046. doi: 10.3390/molecules24173046.

14.

Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas.

Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y.

Cancer Res. 2019 Oct 1;79(19):4814-4827. doi: 10.1158/0008-5472.CAN-19-1272. Epub 2019 Aug 20.

PMID:
31431463
15.

Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma.

Noyori O, Komohara Y, Nasser H, Hiyoshi M, Ma C, Pan C, Carreras J, Nakamura N, Sato A, Ando K, Okuno Y, Nosaka K, Matsuoka M, Suzu S.

Clin Transl Immunology. 2019 Aug 13;8(8):e1074. doi: 10.1002/cti2.1074. eCollection 2019.

16.

Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice.

Fukuchi M, Okuno Y, Nakayama H, Nakano A, Mori H, Mitazaki S, Nakano Y, Toume K, Jo M, Takasaki I, Watanabe K, Shibahara N, Komatsu K, Tabuchi A, Tsuda M.

Sci Rep. 2019 Aug 14;9(1):11833. doi: 10.1038/s41598-019-48361-4.

17.

Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.

Kedar PS, Harigae H, Ito E, Muramatsu H, Kojima S, Okuno Y, Fujiwara T, Dongerdiye R, Warang PP, Madkaikar MR.

Int J Hematol. 2019 Nov;110(5):618-626. doi: 10.1007/s12185-019-02716-9. Epub 2019 Aug 10.

PMID:
31401766
18.

Bioactivation mechanisms of N-hydroxyaristolactams: Nitroreduction metabolites of aristolochic acids.

Okuno Y, Bonala R, Attaluri S, Johnson F, Grollman AP, Sidorenko VS, Oda Y.

Environ Mol Mutagen. 2019 Dec;60(9):792-806. doi: 10.1002/em.22321. Epub 2019 Aug 16.

PMID:
31374128
19.

Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.

Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y.

Cancer Sci. 2019 Oct;110(10):3275-3287. doi: 10.1111/cas.14154. Epub 2019 Aug 14.

20.

Force-field parametrization based on radial and energy distribution functions.

Chiba S, Okuno Y, Honma T, Ikeguchi M.

J Comput Chem. 2019 Nov 5;40(29):2577-2585. doi: 10.1002/jcc.26035. Epub 2019 Jul 25.

21.

Clinical potential of dual-energy cardiac CT in cardiac amyloidosis.

Oda S, Nakaura T, Utsunomiya D, Hirakawa K, Takashio S, Izumiya Y, Tsujita K, Kawano Y, Okuno Y, Hata H, Matsuoka M, Yamashita T, Ueda M, Ando Y, Yamashita Y.

Amyloid. 2019;26(sup1):91-92. doi: 10.1080/13506129.2019.1582021. No abstract available.

PMID:
31343298
22.

Corrigendum to "Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis." [Int. J. Cardiol., 274 (2019) 290-295].

Hayano S, Okuno Y, Tsutsumi M, Inagaki H, Fukasawa Y, Kurahashi H, Kojima S, Takahashi Y, Kato T.

Int J Cardiol. 2019 Oct 1;292:283. doi: 10.1016/j.ijcard.2019.06.020. Epub 2019 Jun 27. No abstract available.

PMID:
31256992
23.

DOCK8 mutation diagnosed using whole-exome sequencing of the dried blood spot-derived DNA: a case report of an Iraqi girl diagnosed in Japan.

Al-Kzayer LFY, Al-Aradi HMH, Shigemura T, Sano K, Tanaka M, Hamada M, Ali KH, Aldaghir OM, Nakazawa Y, Okuno Y.

BMC Med Genet. 2019 Jun 26;20(1):114. doi: 10.1186/s12881-019-0837-4.

24.

Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia.

Shigemura T, Matsuda K, Kurata T, Sakashita K, Okuno Y, Muramatsu H, Yue F, Ebihara Y, Tsuji K, Sasaki K, Nakahata T, Nakazawa Y, Koike K.

Br J Haematol. 2019 Oct;187(2):163-173. doi: 10.1111/bjh.16060. Epub 2019 Jun 20.

PMID:
31222725
25.

Alteration in ventricular pressure stimulates cardiac repair and remodeling.

Unno K, Oikonomopoulos A, Fujikawa Y, Okuno Y, Narita S, Kato T, Hayashida R, Kondo K, Shibata R, Murohara T, Yang Y, Dangwal S, Sereti KI, Yiling Q, Johnson K, Jha A, Sosnovik DE, Fann Y, Liao R.

J Mol Cell Cardiol. 2019 Aug;133:174-187. doi: 10.1016/j.yjmcc.2019.06.006. Epub 2019 Jun 17.

PMID:
31220468
26.

The rapid improvement in visual field defect observed with weekly perimetry during intensity-modulated radiotherapy for optic nerve sheath meningioma.

Inoue T, Mimura O, Ikenaga K, Okuno Y, Nishiguchi I.

Int Cancer Conf J. 2019 Apr 6;8(3):136-140. doi: 10.1007/s13691-019-00371-9. eCollection 2019 Jul.

27.

Targetable driver mutations in multicentric reticulohistiocytosis.

Murakami N, Sakai T, Arai E, Muramatsu H, Ichikawa D, Asai S, Shimoyama Y, Ishiguro N, Takahashi Y, Okuno Y, Nishida Y.

Haematologica. 2019 Jun 6. pii: haematol.2019.218735. doi: 10.3324/haematol.2019.218735. [Epub ahead of print]

28.

Laser- and cryogenic probe-assisted NMR enables hypersensitive analysis of biomolecules at submicromolar concentration.

Okuno Y, Mecha MF, Yang H, Zhu L, Fry CG, Cavagnero S.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11602-11611. doi: 10.1073/pnas.1820573116. Epub 2019 May 29.

PMID:
31142651
29.

Polypharmacy in >75-year-Old Patients on Admission to Tokyo-Area Hospitals.

Momo K, Yasu T, Hayashi D, Saitoh M, Ito Y, Yashiro Y, Nagumo J, Seki R, Furuya J, Okuno Y, Horii T, Abe K, Shirota M.

Am J Ther. 2019 Nov/Dec;26(6):e736-e738. doi: 10.1097/MJT.0000000000000889. No abstract available.

PMID:
31135386
30.

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations.

Ikemura S, Yasuda H, Matsumoto S, Kamada M, Hamamoto J, Masuzawa K, Kobayashi K, Manabe T, Arai D, Nakachi I, Kawada I, Ishioka K, Nakamura M, Namkoong H, Naoki K, Ono F, Araki M, Kanada R, Ma B, Hayashi Y, Mimaki S, Yoh K, Kobayashi SS, Kohno T, Okuno Y, Goto K, Tsuchihara K, Soejima K.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10025-10030. doi: 10.1073/pnas.1819430116. Epub 2019 May 1.

31.

Elucidation of the pathogenic mechanism and potential treatment strategy for a female patient with spastic paraplegia derived from a single-nucleotide deletion in PLP1.

Yamamoto-Shimojima K, Imaizumi T, Aoki Y, Inoue K, Kaname T, Okuno Y, Muramatsu H, Kato K, Yamamoto T.

J Hum Genet. 2019 Jul;64(7):665-671. doi: 10.1038/s10038-019-0600-x. Epub 2019 Apr 19.

PMID:
31004103
32.

Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides.

Shiraishi A, Okuda T, Miyasaka N, Osugi T, Okuno Y, Inoue J, Satake H.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7847-7856. doi: 10.1073/pnas.1816640116. Epub 2019 Apr 1.

33.

Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation.

Korchi AM, Cengarle-Samak A, Okuno Y, Martel-Pelletier J, Pelletier JP, Boesen M, Doyon J, Bodson-Clermont P, Lussier B, Héon H, Sapoval M, Bureau NJ, Soulez G.

J Vasc Interv Radiol. 2019 Jul;30(7):1116-1127. doi: 10.1016/j.jvir.2018.09.031. Epub 2019 Mar 29.

PMID:
30935868
34.

Structural modification of indomethacin toward selective inhibition of COX-2 with a significant increase in van der Waals contributions.

Ikeda A, Funakoshi E, Araki M, Ma B, Karuo Y, Tarui A, Sato K, Okuno Y, Kawai K, Omote M.

Bioorg Med Chem. 2019 May 1;27(9):1789-1794. doi: 10.1016/j.bmc.2019.03.021. Epub 2019 Mar 14.

PMID:
30898436
35.

KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells.

Kohara H, Utsugisawa T, Sakamoto C, Hirose L, Ogawa Y, Ogura H, Sugawara A, Liao J, Aoki T, Iwasaki T, Asai T, Doisaki S, Okuno Y, Muramatsu H, Abe T, Kurita R, Miyamoto S, Sakuma T, Shiba M, Yamamoto T, Ohga S, Yoshida K, Ogawa S, Ito E, Kojima S, Kanno H, Tani K.

Exp Hematol. 2019 May;73:25-37.e8. doi: 10.1016/j.exphem.2019.03.001. Epub 2019 Mar 12.

PMID:
30876823
36.

Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma.

Ranjit M, Hirano M, Aoki K, Okuno Y, Ohka F, Yamamichi A, Kato A, Maeda S, Motomura K, Matsuo K, Enomoto A, Ino Y, Todo T, Takahashi M, Wakabayashi T, Kato T, Natsume A.

Cell Rep. 2019 Feb 26;26(9):2274-2281.e5. doi: 10.1016/j.celrep.2019.01.109.

37.

Dynamic Docking of a Medium-Sized Molecule to Its Receptor by Multicanonical MD Simulations.

Bekker GJ, Araki M, Oshima K, Okuno Y, Kamiya N.

J Phys Chem B. 2019 Mar 21;123(11):2479-2490. doi: 10.1021/acs.jpcb.8b12419. Epub 2019 Mar 12.

PMID:
30808168
38.

Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients.

Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M.

Haematologica. 2019 Oct;104(10):1962-1973. doi: 10.3324/haematol.2018.207241. Epub 2019 Feb 21.

39.

A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots.

Al-Kzayer LFY, Yassin AK, Salih KH, Shigemura T, Sano K, Al-Simaani RBY, Tanaka M, Nakazawa Y, Okuno Y.

Front Immunol. 2019 Jan 25;10:58. doi: 10.3389/fimmu.2019.00058. eCollection 2019.

40.

Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.

Mizumoto A, Ohashi S, Kamada M, Saito T, Nakai Y, Baba K, Hirohashi K, Mitani Y, Kikuchi O, Matsubara J, Yamada A, Takahashi T, Lee H, Okuno Y, Kanai M, Muto M.

J Gastroenterol. 2019 Aug;54(8):687-698. doi: 10.1007/s00535-019-01549-x. Epub 2019 Feb 8.

41.

Suppression of IgE-Independent Degranulation of Murine Connective Tissue-Type Mast Cells by Dexamethasone.

Yamada K, Sato H, Sakamaki K, Kamada M, Okuno Y, Fukuishi N, Furuta K, Tanaka S.

Cells. 2019 Feb 1;8(2). pii: E112. doi: 10.3390/cells8020112.

42.

Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

Nat Microbiol. 2019 Mar;4(3):544. doi: 10.1038/s41564-019-0387-8.

PMID:
30705423
43.

Defective Epstein-Barr virus in chronic active infection and haematological malignancy.

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

Nat Microbiol. 2019 Mar;4(3):404-413. doi: 10.1038/s41564-018-0334-0. Epub 2019 Jan 21. Erratum in: Nat Microbiol. 2019 Jan 30;:.

PMID:
30664667
44.

Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.

Okada K, Araki M, Sakashita T, Ma B, Kanada R, Yanagitani N, Horiike A, Koike S, Oh-Hara T, Watanabe K, Tamai K, Maemondo M, Nishio M, Ishikawa T, Okuno Y, Fujita N, Katayama R.

EBioMedicine. 2019 Mar;41:105-119. doi: 10.1016/j.ebiom.2019.01.019. Epub 2019 Jan 17.

45.

Sleep Shortage Is Associated With Postherpetic Neuralgia Development Through Hyperesthesia and Acute Pain Intensity: A Community-Based Prospective Cohort Study.

Yamada K, Kubota Y, Shimizu Y, Cui R, Mori Y, Okuno Y, Asada H, Yamanishi K, Iso H; SHEZ Study Group.

Pain Pract. 2019 Jun;19(5):476-483. doi: 10.1111/papr.12766. Epub 2019 Feb 28.

PMID:
30659740
46.

Therapy-related acute myeloid leukemia after chemotherapy in extensive disease-small cell lung cancer.

Ueda N, Fujita K, Okuno Y, Nakatani K, Mio T.

Clin Case Rep. 2018 Nov 19;7(1):100-103. doi: 10.1002/ccr3.1931. eCollection 2019 Jan.

47.

Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome.

Hayashi R, Okuno Y, Mukai K, Kitamura T, Hayakawa T, Onodera T, Murata M, Fukuhara A, Imamura R, Miyagawa Y, Nonomura N, Otsuki M, Shimomura I.

Endocrinology. 2019 Mar 1;160(3):504-521. doi: 10.1210/en.2018-01029.

PMID:
30649271
48.

Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.

Komohara Y, Noyori O, Saito Y, Takeya H, Baghdadi M, Kitagawa F, Hama N, Ishikawa K, Okuno Y, Nosaka K, Seino KI, Matsuoka M, Suzu S.

J Clin Exp Hematop. 2018;58(4):152-160. doi: 10.3960/jslrt.18034.

49.

Improving the Accuracy of Protein-Ligand Binding Mode Prediction Using a Molecular Dynamics-Based Pocket Generation Approach.

Araki M, Iwata H, Ma B, Fujita A, Terayama K, Sagae Y, Ono F, Tsuda K, Kamiya N, Okuno Y.

J Comput Chem. 2018 Dec 15;39(32):2679-2689. doi: 10.1002/jcc.25715.

PMID:
30515903
50.

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells.

Ichikawa T, Okuno Y, Sato Y, Goshima F, Yoshiyama H, Kanda T, Kimura H, Murata T.

mSphere. 2018 Nov 28;3(6). pii: e00478-18. doi: 10.1128/mSphere.00478-18.

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