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Items: 1 to 50 of 960

1.

Improving the Accuracy of Protein-Ligand Binding Mode Prediction Using a Molecular Dynamics-Based Pocket Generation Approach.

Araki M, Iwata H, Ma B, Fujita A, Terayama K, Sagae Y, Ono F, Tsuda K, Kamiya N, Okuno Y.

J Comput Chem. 2018 Dec 15;39(32):2679-2689. doi: 10.1002/jcc.25715.

PMID:
30515903
2.

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells.

Ichikawa T, Okuno Y, Sato Y, Goshima F, Yoshiyama H, Kanda T, Kimura H, Murata T.

mSphere. 2018 Nov 28;3(6). pii: e00478-18. doi: 10.1128/mSphere.00478-18.

3.

Effect of Transcatheter Arterial Microembolization on Phantom Limb Pain Persisting for 17 Years.

Shibuya M, Yamamoto M, Okuno Y.

Cardiovasc Intervent Radiol. 2018 Nov 13. doi: 10.1007/s00270-018-2109-7. [Epub ahead of print]

PMID:
30426150
4.

MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells.

Endo S, Nishimura N, Kawano Y, Ueno N, Ueno S, Tatetsu H, Komohara Y, Takeya M, Hata H, Mitsuya H, Masao M, Okuno Y.

Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):246-252. doi: 10.1016/j.bbrc.2018.11.016. Epub 2018 Nov 10.

PMID:
30420285
5.

A simple quantitative chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance using the modified James-Bull method.

Hamaguchi N, Okuno Y, Oe Y, Ohta T.

Chirality. 2018 Nov 5. doi: 10.1002/chir.23028. [Epub ahead of print]

PMID:
30395695
6.

Dopamine and Serotonin Receptors Cooperatively Modulate Pacemaker Activity of Intestinal Cells of Cajal.

Liu HN, Hirata H, Okuno Y, Okabe M, Furukawa K.

Chin J Physiol. 2018 Oct 31. [Epub ahead of print]

PMID:
30384551
7.

Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.

Yabe M, Koike T, Ohtsubo K, Imai E, Morimoto T, Takakura H, Koh K, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Mori M, Hira A, Takata M, Yabe H.

Ann Hematol. 2018 Oct 27. doi: 10.1007/s00277-018-3517-0. [Epub ahead of print]

PMID:
30368588
8.

Base-to-apex gradient pattern of cardiac impairment identified on myocardial T1 mapping in cardiac amyloidosis.

Oda S, Kawano Y, Okuno Y, Utsunomiya D, Nakaura T, Tsujita K, Yamashita Y.

Radiol Case Rep. 2018 Oct 18;14(1):72-74. doi: 10.1016/j.radcr.2018.09.025. eCollection 2019 Jan.

9.

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease.

Noda Y, Kuzuya A, Tanigawa K, Araki M, Kawai R, Ma B, Sasakura Y, Maesako M, Tashiro Y, Miyamoto M, Uemura K, Okuno Y, Kinoshita A.

Mol Brain. 2018 Oct 24;11(1):61. doi: 10.1186/s13041-018-0401-8.

10.

Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency.

Takeichi T, Okuno Y, Kawamoto A, Inoue T, Nagamoto E, Murase C, Shimizu E, Tanaka K, Kageshita Y, Fukushima S, Kono M, Ishikawa J, Ihn H, Takahashi Y, Akiyama M.

J Lipid Res. 2018 Dec;59(12):2413-2420. doi: 10.1194/jlr.P087536. Epub 2018 Oct 22.

PMID:
30348640
11.

Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 1.

Hoshino A, Yang X, Tanita K, Yoshida K, Ono T, Nishida N, Okuno Y, Kanzaki T, Goi K, Fujino H, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Morio T, Kanegane H.

J Allergy Clin Immunol. 2018 Oct 11. pii: S0091-6749(18)31288-0. doi: 10.1016/j.jaci.2018.07.044. [Epub ahead of print] No abstract available.

PMID:
30342818
12.

Gain-of-function IKBKB mutation causes human combined immune deficiency.

Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G, Morio T, Vinuesa CG, Kanegane H, Cook MC.

J Exp Med. 2018 Nov 5;215(11):2715-2724. doi: 10.1084/jem.20180639. Epub 2018 Oct 18.

PMID:
30337470
13.

A Platform for Comprehensive Genomic Profiling in Human Cancers and Pharmacogenomics Therapy Selection.

Kou T, Kanai M, Kamada M, Nakatsui M, Matsumoto S, Okuno Y, Muto M.

Methods Mol Biol. 2018;1825:413-424. doi: 10.1007/978-1-4939-8639-2_14.

PMID:
30334215
14.

Prediction of prostate cancer by deep learning with multilayer artificial neural network.

Takeuchi T, Hattori-Kato M, Okuno Y, Iwai S, Mikami K.

Can Urol Assoc J. 2018 Oct 15. doi: 10.5489/cuaj.5526. [Epub ahead of print]

PMID:
30332595
15.

Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity

Hayakawa T, Minemura T, Onodera T, Shin J, Okuno Y, Fukuhara A, Otsuki M, Shimomura I.

J Endocrinol. 2018 Oct 1;239(1):63–71. doi: 10.1530/JOE-18-0026.

PMID:
30307154
16.

Convulsive seizure and pulmonary edema during hyperbaric oxygen therapy:A case report.

Cho K, Minami T, Okuno Y, Kakuda Y, Tsutsumi T, Kogame T, Ohtsuru S, Sato N, Koike K.

J Med Invest. 2018;65(3.4):286-288. doi: 10.2152/jmi.65.286.

17.

Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis.

Hayano S, Okuno Y, Tsutsumi M, Inagaki H, Fukasawa Y, Kurahashi H, Kojima S, Takahashi Y, Kato T.

Int J Cardiol. 2019 Jan 1;274:290-295. doi: 10.1016/j.ijcard.2018.09.032. Epub 2018 Sep 13.

PMID:
30228022
18.

Biotransformation of (+)-Carvone and (-)-Carvone by the Common Cutworm Spodoptera litura Larvae.

Marumoto S, Okuno Y, Hagiwara Y, Miyazawa M.

J Oleo Sci. 2018 Oct 11;67(10):1253-1257. doi: 10.5650/jos.ess18105. Epub 2018 Sep 13.

19.

Impaired glucagon secretion in patients with fulminant type 1 diabetes mellitus.

Komada H, Hirota Y, Sakaguchi K, Okuno Y, Ogawa W, Seino S.

Endocrine. 2018 Sep 10. doi: 10.1007/s12020-018-1750-x. [Epub ahead of print]

PMID:
30203124
20.

De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.

Toki T, Yoshida K, Wang R, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa S, Ito E.

Am J Hum Genet. 2018 Sep 6;103(3):440-447. doi: 10.1016/j.ajhg.2018.07.020. Epub 2018 Aug 23.

PMID:
30146126
21.

Reliable patient-reported outcome measure and survivorship of UKA for primary spontaneous osteonecrosis.

Kaneko T, Kono N, Sunakawa T, Okuno Y, Ikegami H, Musha Y.

Eur J Orthop Surg Traumatol. 2018 Aug 23. doi: 10.1007/s00590-018-2296-6. [Epub ahead of print]

PMID:
30141028
22.

Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR.

Hamada M, Nishio N, Okuno Y, Suzuki S, Kawashima N, Muramatsu H, Tsubota S, Wilson MH, Morita D, Kataoka S, Ichikawa D, Murakami N, Taniguchi R, Suzuki K, Kojima D, Sekiya Y, Nishikawa E, Narita A, Hama A, Kojima S, Nakazawa Y, Takahashi Y.

EBioMedicine. 2018 Aug;34:18-26. doi: 10.1016/j.ebiom.2018.07.008. Epub 2018 Aug 3.

23.

Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume).

Kono R, Nakamura M, Nomura S, Kitano N, Kagiya T, Okuno Y, Inada KI, Tokuda A, Utsunomiya H, Ueno M.

Sci Rep. 2018 Aug 3;8(1):11638. doi: 10.1038/s41598-018-30086-5.

24.

Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity.

Hayakawa T, Minemura T, Onodera T, Shin J, Okuno Y, Fukuhara A, Otsuki M, Shimomura I.

J Endocrinol. 2018 Jul 26. pii: JOE-18-0026. doi: 10.1530/JOE-18-0026. [Epub ahead of print]

PMID:
30049823
25.

Cytokine production in whole-blood cultures following immunization with an influenza vaccine.

Nakayama T, Kumagai T, Kashiwagi Y, Yoshii H, Honjo K, Kubota-Koketsu R, Okuno Y, Suga S.

Hum Vaccin Immunother. 2018 Jul 23:1-9. doi: 10.1080/21645515.2018.1498435. [Epub ahead of print]

PMID:
30036123
26.

Identification of potential pathogenic viruses in patients with acute myocarditis using next-generation sequencing.

Takeuchi S, Kawada JI, Okuno Y, Horiba K, Suzuki T, Torii Y, Yasuda K, Numaguchi A, Kato T, Takahashi Y, Ito Y.

J Med Virol. 2018 Dec;90(12):1814-1821. doi: 10.1002/jmv.25263. Epub 2018 Aug 13.

PMID:
30011073
27.

Kinetic Trapping of Folded Proteins Relative to Aggregates under Physiologically Relevant Conditions.

Varela AE, Lang JF, Wu Y, Dalphin MD, Stangl AJ, Okuno Y, Cavagnero S.

J Phys Chem B. 2018 Aug 9;122(31):7682-7698. doi: 10.1021/acs.jpcb.8b05360. Epub 2018 Jul 26.

PMID:
30001623
28.

Probing the nanoscale light emission properties of a CVD-grown MoS2 monolayer by tip-enhanced photoluminescence.

Okuno Y, Lancry O, Tempez A, Cairone C, Bosi M, Fabbri F, Chaigneau M.

Nanoscale. 2018 Aug 7;10(29):14055-14059. doi: 10.1039/c8nr02421a. Epub 2018 Jul 12.

PMID:
29999092
29.

Whole-exome analysis to detect congenital hemolytic anemia mimicking congenital dyserythropoietic anemia.

Hamada M, Doisaki S, Okuno Y, Muramatsu H, Hama A, Kawashima N, Narita A, Nishio N, Yoshida K, Kanno H, Manabe A, Taga T, Takahashi Y, Miyano S, Ogawa S, Kojima S.

Int J Hematol. 2018 Jun 23. doi: 10.1007/s12185-018-2482-7. [Epub ahead of print]

PMID:
29936674
30.

A patient with a GNAO1 mutation with decreased spontaneous movements, hypotonia, and dystonic features.

Okumura A, Maruyama K, Shibata M, Kurahashi H, Ishii A, Numoto S, Hirose S, Kawai T, Iso M, Kataoka S, Okuno Y, Muramatsu H, Kojima S.

Brain Dev. 2018 Nov;40(10):926-930. doi: 10.1016/j.braindev.2018.06.005. Epub 2018 Jun 21.

PMID:
29935962
31.

Metabolomic and microarray analyses of adipose tissue of dapagliflozin-treated mice, and effects of 3-hydroxybutyrate on induction of adiponectin in adipocytes.

Nishitani S, Fukuhara A, Shin J, Okuno Y, Otsuki M, Shimomura I.

Sci Rep. 2018 Jun 11;8(1):8805. doi: 10.1038/s41598-018-27181-y.

32.

Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.

Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S.

J Invest Dermatol. 2018 Dec;138(12):2550-2557. doi: 10.1016/j.jid.2018.05.015. Epub 2018 May 31.

PMID:
29859927
33.

Three Types of Broadly Reacting Antibodies against Influenza B Viruses Induced by Vaccination with Seasonal Influenza Viruses.

Hirano D, Ohshima N, Kubota-Koketsu R, Yamasaki A, Kurosawa G, Okuno Y, Yoshida S, Kurosawa Y.

J Immunol Res. 2018 May 8;2018:7251793. doi: 10.1155/2018/7251793. eCollection 2018.

34.

Sterol profiles are valuable biomarkers for phenotype expression of Conradi-Hünermann-Happle syndrome with EBP mutations.

Takeichi T, Honda A, Okuno Y, Kojima D, Kono M, Nakamura Y, Tohyama M, Tanaka T, Aoyama Y, Akiyama M.

Br J Dermatol. 2018 Nov;179(5):1186-1188. doi: 10.1111/bjd.16823. Epub 2018 Aug 6. No abstract available.

PMID:
29851033
35.

Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer.

Kondo T, Kanai M, Kou T, Sakuma T, Mochizuki H, Kamada M, Nakatsui M, Uza N, Kodama Y, Masui T, Takaori K, Matsumoto S, Miyake H, Okuno Y, Muto M.

Oncotarget. 2018 Apr 13;9(28):19817-19825. doi: 10.18632/oncotarget.24865. eCollection 2018 Apr 13.

36.

Early intervention using high-precision radiotherapy preserved visual function for five consecutive patients with optic nerve sheath meningioma.

Inoue T, Mimura O, Masai N, Ohashi A, Ikenaga K, Okuno Y, Nishiguchi I, Oh R.

Int J Clin Oncol. 2018 Oct;23(5):826-834. doi: 10.1007/s10147-018-1284-5. Epub 2018 Apr 30.

37.

Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells.

Morita D, Nishio N, Saito S, Tanaka M, Kawashima N, Okuno Y, Suzuki S, Matsuda K, Maeda Y, Wilson MH, Dotti G, Rooney CM, Takahashi Y, Nakazawa Y.

Mol Ther Methods Clin Dev. 2017 Dec 22;8:131-140. doi: 10.1016/j.omtm.2017.12.003. eCollection 2018 Mar 16.

38.

Dysregulation of Epstein-Barr Virus Infection in Hypomorphic ZAP70 Mutation.

Hoshino A, Takashima T, Yoshida K, Morimoto A, Kawahara Y, Yeh TW, Okano T, Yamashita M, Mitsuiki N, Imai K, Sakatani T, Nakazawa A, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Morio T, Kanegane H.

J Infect Dis. 2018 Jul 24;218(5):825-834. doi: 10.1093/infdis/jiy231.

PMID:
29684201
39.

[Artificial Intelligence in Drug Discovery].

Fujiwara T, Kamada M, Okuno Y.

Gan To Kagaku Ryoho. 2018 Apr;45(4):593-596. Japanese.

PMID:
29650810
40.

Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway.

Okuno Y, Fukuhara A, Hashimoto E, Kobayashi H, Kobayashi S, Otsuki M, Shimomura I.

Diabetes. 2018 Jun;67(6):1113-1127. doi: 10.2337/db17-1032. Epub 2018 Apr 4.

41.

Bufalin induces DNA damage response under hypoxic condition in myeloma cells.

Fujii E, Inada Y, Kakoki M, Nishimura N, Endo S, Fujiwara S, Wada N, Kawano Y, Okuno Y, Sugimoto T, Hata H.

Oncol Lett. 2018 May;15(5):6443-6449. doi: 10.3892/ol.2018.8091. Epub 2018 Feb 21.

42.

[A nationwide multi-center questionnaire survey on the management and treatment of post-stroke seizure and epilepsy in Japan].

Higashida K, Tanaka T, Yamagami H, Tomari S, Fukuma K, Okuno Y, Abe S, Nagatsuka K, Toyoda K, Ihara M.

Rinsho Shinkeigaku. 2018 Apr 25;58(4):217-222. doi: 10.5692/clinicalneurol.cn-001126. Epub 2018 Mar 31. Japanese.

PMID:
29607916
43.

Novel inhibitor candidates of TRPV2 prevent damage of dystrophic myocytes and ameliorate against dilated cardiomyopathy in a hamster model.

Iwata Y, Katayama Y, Okuno Y, Wakabayashi S.

Oncotarget. 2018 Feb 8;9(18):14042-14057. doi: 10.18632/oncotarget.24449. eCollection 2018 Mar 6.

44.

Oxygen cost of thoracic and diaphragmatic breathing during hyperventilation in healthy males.

Ishii N, Tomita K, Suetake S, Okuno Y, Kawamura K, Takeshima R, Ohse H, Imura S.

J Phys Ther Sci. 2018 Feb;30(2):238-241. doi: 10.1589/jpts.30.238. Epub 2018 Feb 20.

45.

Li deposition and desolvation with electron transfer at a silicon/propylene-carbonate interface: transition-state and free-energy profiles by large-scale first-principles molecular dynamics.

Ohwaki T, Ozaki T, Okuno Y, Ikeshoji T, Imai H, Otani M.

Phys Chem Chem Phys. 2018 May 3;20(17):11586-11591. doi: 10.1039/c7cp08569a.

PMID:
29537050
46.

Comprehensive detection of pathogens in immunocompromised children with bloodstream infections by next-generation sequencing.

Horiba K, Kawada JI, Okuno Y, Tetsuka N, Suzuki T, Ando S, Kamiya Y, Torii Y, Yagi T, Takahashi Y, Ito Y.

Sci Rep. 2018 Feb 28;8(1):3784. doi: 10.1038/s41598-018-22133-y.

47.

An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency.

Oi R, Takeichi T, Okuno Y, Kojima D, Sugawara K, Kono M, Muramatsu H, Akiyama M.

J Dermatol Sci. 2018 May;90(2):216-218. doi: 10.1016/j.jdermsci.2018.01.017. Epub 2018 Feb 6. No abstract available.

PMID:
29454537
48.

Integrated molecular profiling of juvenile myelomonocytic leukemia.

Murakami N, Okuno Y, Yoshida K, Shiraishi Y, Nagae G, Suzuki K, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Ito M, Hirayama M, Watanabe A, Ueno T, Kojima S, Aburatani H, Mano H, Miyano S, Ogawa S, Takahashi Y, Muramatsu H.

Blood. 2018 Apr 5;131(14):1576-1586. doi: 10.1182/blood-2017-07-798157. Epub 2018 Feb 2.

PMID:
29437595
49.

A secondary RET mutation in the activation loop conferring resistance to vandetanib.

Nakaoku T, Kohno T, Araki M, Niho S, Chauhan R, Knowles PP, Tsuchihara K, Matsumoto S, Shimada Y, Mimaki S, Ishii G, Ichikawa H, Nagatoishi S, Tsumoto K, Okuno Y, Yoh K, McDonald NQ, Goto K.

Nat Commun. 2018 Feb 12;9(1):625. doi: 10.1038/s41467-018-02994-7.

50.

Rapid recovery of vision following early intervention with fractionated stereotactic radiotherapy for optic nerve sheath meningioma.

Inoue T, Okuno Y, Nishiguchi I, Ikenaga K, Mimura O.

Int Med Case Rep J. 2018 Jan 30;11:17-22. doi: 10.2147/IMCRJ.S149592. eCollection 2018.

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