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L-Lactate Promotes Adult Hippocampal Neurogenesis.

Lev-Vachnish Y, Cadury S, Rotter-Maskowitz A, Feldman N, Roichman A, Illouz T, Varvak A, Nicola R, Madar R, Okun E.

Front Neurosci. 2019 May 24;13:403. doi: 10.3389/fnins.2019.00403. eCollection 2019.


Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model.

Illouz T, Madar R, Biragyn A, Okun E.

Brain Behav Immun. 2019 Jan;75:163-180. doi: 10.1016/j.bbi.2018.10.004. Epub 2018 Oct 25.


Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair.

De Lorenzo G, Ferrari S, Cervone F, Okun E.

Trends Immunol. 2018 Nov;39(11):937-950. doi: 10.1016/ Epub 2018 Oct 4. Review.


The Toll Pathway in the Central Nervous System of Flies and Mammals.

Shmueli A, Shalit T, Okun E, Shohat-Ophir G.

Neuromolecular Med. 2018 Dec;20(4):419-436. doi: 10.1007/s12017-018-8515-9. Epub 2018 Oct 1. Review.


Dopamine receptors in the rat entopeduncular nucleus.

Lavian H, Loewenstern Y, Madar R, Almog M, Bar-Gad I, Okun E, Korngreen A.

Brain Struct Funct. 2018 Jul;223(6):2673-2684. doi: 10.1007/s00429-018-1657-6. Epub 2018 Mar 22.


Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice.

Griffioen K, Mattson MP, Okun E.

Heliyon. 2018 Jan 18;4(1):e00508. doi: 10.1016/j.heliyon.2018.e00508. eCollection 2018 Jan.


Arabinofuranose 1,2,5-orthobenzoate as a single precursor of linear α(1 → 5)-linked oligoarabinofuranosides.

Panova MV, Podvalnyy NM, Okun EL, Abronina PI, Chizhov AO, Kononov LO.

Carbohydr Res. 2018 Feb 1;456:35-44. doi: 10.1016/j.carres.2017.11.002. Epub 2017 Dec 8.


A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42.

Illouz T, Madar R, Griffioen K, Okun E.

J Neurosci Methods. 2017 Nov 1;291:28-35. doi: 10.1016/j.jneumeth.2017.07.022. Epub 2017 Jul 30.


Dopaminergic Modulation of Synaptic Integration and Firing Patterns in the Rat Entopeduncular Nucleus.

Lavian H, Almog M, Madar R, Loewenstern Y, Bar-Gad I, Okun E, Korngreen A.

J Neurosci. 2017 Jul 26;37(30):7177-7187. doi: 10.1523/JNEUROSCI.0639-17.2017. Epub 2017 Jun 26.


Sirt6 alters adult hippocampal neurogenesis.

Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, Madar R, Cohen HY.

PLoS One. 2017 Jun 23;12(6):e0179681. doi: 10.1371/journal.pone.0179681. eCollection 2017.


The effect of nanoparticle size on the ability to cross the blood-brain barrier: an in vivo study.

Betzer O, Shilo M, Opochinsky R, Barnoy E, Motiei M, Okun E, Yadid G, Popovtzer R.

Nanomedicine (Lond). 2017 Jul;12(13):1533-1546. doi: 10.2217/nnm-2017-0022. Epub 2017 Jun 16.


Corrigendum to "Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm" [Brain Behav. Immun. 52C (2016) 132-144].

Illouz T, Madar R, Louzoun Y, Griffioen KJ, Okun E.

Brain Behav Immun. 2017 Mar;61:386. doi: 10.1016/j.bbi.2016.02.016. Epub 2016 Feb 26. No abstract available.


Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.

Gross A, Benninger F, Madar R, Illouz T, Griffioen K, Steiner I, Offen D, Okun E.

Epilepsia. 2017 Apr;58(4):586-596. doi: 10.1111/epi.13688. Epub 2017 Feb 6.


Unbiased classification of spatial strategies in the Barnes maze.

Illouz T, Madar R, Clague C, Griffioen KJ, Louzoun Y, Okun E.

Bioinformatics. 2016 Nov 1;32(21):3314-3320. Epub 2016 Jul 4.


Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm.

Illouz T, Madar R, Louzoun Y, Griffioen KJ, Okun E.

Brain Behav Immun. 2016 Feb;52:132-144. doi: 10.1016/j.bbi.2015.10.013. Epub 2015 Oct 24. Erratum in: Brain Behav Immun. 2017 Mar;61:386.


Postnatal TLR2 activation impairs learning and memory in adulthood.

Madar R, Rotter A, Waldman Ben-Asher H, Mughal MR, Arumugam TV, Wood WH 3rd, Becker KG, Mattson MP, Okun E.

Brain Behav Immun. 2015 Aug;48:301-12. doi: 10.1016/j.bbi.2015.04.020. Epub 2015 May 27.


DAMPs as mediators of sterile inflammation in aging-related pathologies.

Feldman N, Rotter-Maskowitz A, Okun E.

Ageing Res Rev. 2015 Nov;24(Pt A):29-39. doi: 10.1016/j.arr.2015.01.003. Epub 2015 Jan 29. Review.


No ECSIT-stential evidence for a link with Alzheimer's disease yet (retrospective on DOI 10.1002/bies.201100193).

Illouz T, Okun E.

Bioessays. 2015 Jan;37(1):5. doi: 10.1002/bies.201400179. Epub 2014 Nov 4. No abstract available.


Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans.

Barak B, Feldman N, Okun E.

J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1059-66. doi: 10.1093/gerona/glu162. Epub 2014 Sep 16.


Toll-like receptors as developmental tools that regulate neurogenesis during development: an update.

Barak B, Feldman N, Okun E.

Front Neurosci. 2014 Aug 28;8:272. doi: 10.3389/fnins.2014.00272. eCollection 2014. Review.


Pancreatic polypeptide inhibits somatostatin secretion.

Kim W, Fiori JL, Shin YK, Okun E, Kim JS, Rapp PR, Egan JM.

FEBS Lett. 2014 Aug 25;588(17):3233-9. doi: 10.1016/j.febslet.2014.07.005. Epub 2014 Jul 11.


A heavy toll on the outcome of ischemic brain stroke.

Okun E.

Exp Neurol. 2014 Apr;254:166-7. doi: 10.1016/j.expneurol.2014.02.002. Epub 2014 Feb 7. No abstract available.


Tellurium compound AS101 ameliorates experimental autoimmune encephalomyelitis by VLA-4 inhibition and suppression of monocyte and T cell infiltration into the CNS.

Lee JH, Halperin-Sheinfeld M, Baatar D, Mughal MR, Tae HJ, Kim JW, Carter A, Lustig A, Snir O, Lavie G, Okun E, Mattson MP, Sredni B, Taub DD.

Neuromolecular Med. 2014 Jun;16(2):292-307. doi: 10.1007/s12017-013-8277-3. Epub 2013 Nov 23.


Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.

Okun E, Griffioen KJ, Rothman S, Wan R, Cong WN, De Cabo R, Martin-Montalvo A, Levette A, Maudsley S, Martin B, Arumugam TV, Mattson MP.

Brain Behav Immun. 2014 Feb;36:90-100. doi: 10.1016/j.bbi.2013.10.013. Epub 2013 Oct 18.


Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke.

Cheng YL, Park JS, Manzanero S, Choi Y, Baik SH, Okun E, Gelderblom M, Fann DY, Magnus T, Launikonis BS, Mattson MP, Sobey CG, Jo DG, Arumugam TV.

Neurobiol Dis. 2014 Feb;62:286-95. doi: 10.1016/j.nbd.2013.10.009. Epub 2013 Oct 16.


Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models.

Barak B, Shvarts-Serebro I, Modai S, Gilam A, Okun E, Michaelson DM, Mattson MP, Shomron N, Ashery U.

Transl Psychiatry. 2013 Sep 10;3:e304. doi: 10.1038/tp.2013.77.


Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory.

Barak B, Okun E, Ben-Simon Y, Lavi A, Shapira R, Madar R, Wang Y, Norman E, Sheinin A, Pita MA, Yizhar O, Mughal MR, Stuenkel E, van Praag H, Mattson MP, Ashery U.

Neuromolecular Med. 2013 Jun;15(2):351-63. doi: 10.1007/s12017-013-8223-4. Epub 2013 Mar 22.


A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.

Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL.

Neurobiol Aging. 2013 Jun;34(6):1530-9. doi: 10.1016/j.neurobiolaging.2012.11.023. Epub 2012 Dec 29.


Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing.

Chigurupati S, Mughal MR, Okun E, Das S, Kumar A, McCaffery M, Seal S, Mattson MP.

Biomaterials. 2013 Mar;34(9):2194-201. doi: 10.1016/j.biomaterials.2012.11.061. Epub 2012 Dec 23.


Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines.

Cheng A, Wan R, Yang JL, Kamimura N, Son TG, Ouyang X, Luo Y, Okun E, Mattson MP.

Nat Commun. 2012;3:1250. doi: 10.1038/ncomms2238.


Evidence for a developmental role for TLR4 in learning and memory.

Okun E, Barak B, Saada-Madar R, Rothman SM, Griffioen KJ, Roberts N, Castro K, Mughal MR, Pita MA, Stranahan AM, Arumugam TV, Mattson MP.

PLoS One. 2012;7(10):e47522. doi: 10.1371/journal.pone.0047522. Epub 2012 Oct 11.


Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein.

Griffioen KJ, Rothman SM, Ladenheim B, Wan R, Vranis N, Hutchison E, Okun E, Cadet JL, Mattson MP.

Neurobiol Aging. 2013 Mar;34(3):928-35. doi: 10.1016/j.neurobiolaging.2012.07.008. Epub 2012 Aug 9.


The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.

Halperin-Sheinfeld M, Gertler A, Okun E, Sredni B, Cohen HY.

Aging (Albany NY). 2012 Jun;4(6):436-47.


DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease.

Olkhanud PB, Mughal M, Ayukawa K, Malchinkhuu E, Bodogai M, Feldman N, Rothman S, Lee JH, Chigurupati S, Okun E, Nagashima K, Mattson MP, Biragyn A.

Vaccine. 2012 Feb 21;30(9):1650-8. doi: 10.1016/j.vaccine.2011.12.136. Epub 2012 Jan 14.


Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease.

Griffioen KJ, Wan R, Brown TR, Okun E, Camandola S, Mughal MR, Phillips TM, Mattson MP.

Neurobiol Aging. 2012 Jul;33(7):1481.e1-5. doi: 10.1016/j.neurobiolaging.2011.11.030. Epub 2011 Dec 31.


Toll-like receptor signaling in neural plasticity and disease.

Okun E, Griffioen KJ, Mattson MP.

Trends Neurosci. 2011 May;34(5):269-81. doi: 10.1016/j.tins.2011.02.005. Epub 2011 Mar 16. Review.


Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model.

Chigurupati S, Madan M, Okun E, Wei Z, Pattisapu JV, Mughal MR, Mattson MP, Chan SL.

J Alzheimers Dis. 2011;24(2):349-61. doi: 10.3233/JAD-2011-101797.


Tomosyn expression pattern in the mouse hippocampus suggests both presynaptic and postsynaptic functions.

Barak B, Williams A, Bielopolski N, Gottfried I, Okun E, Brown MA, Matti U, Rettig J, Stuenkel EL, Ashery U.

Front Neuroanat. 2010 Dec 20;4:149. doi: 10.3389/fnana.2010.00149. eCollection 2010.


Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.

Mughal MR, Baharani A, Chigurupati S, Son TG, Chen E, Yang P, Okun E, Arumugam T, Chan SL, Mattson MP.

Hum Mol Genet. 2011 Feb 15;20(4):659-69. doi: 10.1093/hmg/ddq512. Epub 2010 Nov 24. Erratum in: Hum Mol Genet. 2011 May 15;20(10):2078.


GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons.

Griffioen KJ, Wan R, Okun E, Wang X, Lovett-Barr MR, Li Y, Mughal MR, Mendelowitz D, Mattson MP.

Cardiovasc Res. 2011 Jan 1;89(1):72-8. doi: 10.1093/cvr/cvq271. Epub 2010 Aug 24.


Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis.

Okun E, Griffioen K, Barak B, Roberts NJ, Castro K, Pita MA, Cheng A, Mughal MR, Wan R, Ashery U, Mattson MP.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15625-30. doi: 10.1073/pnas.1005807107. Epub 2010 Aug 16.


Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death.

Thundyil J, Tang SC, Okun E, Shah K, Karamyan VT, Li YI, Woodruff TM, Taylor SM, Jo DG, Mattson MP, Arumugam TV.

Exp Transl Stroke Med. 2010 Aug 11;2(1):15. doi: 10.1186/2040-7378-2-15.


TLR2 activation inhibits embryonic neural progenitor cell proliferation.

Okun E, Griffioen KJ, Son TG, Lee JH, Roberts NJ, Mughal MR, Hutchison E, Cheng A, Arumugam TV, Lathia JD, van Praag H, Mattson MP.

J Neurochem. 2010 Jul;114(2):462-74. doi: 10.1111/j.1471-4159.2010.06778.x. Epub 2010 Apr 29.


Involvement of Fc receptors in disorders of the central nervous system.

Okun E, Mattson MP, Arumugam TV.

Neuromolecular Med. 2010 Jun;12(2):164-78. doi: 10.1007/s12017-009-8099-5. Epub 2009 Oct 21. Review.


The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair.

Hutchison ER, Okun E, Mattson MP.

Neuromolecular Med. 2009;11(3):153-61. doi: 10.1007/s12017-009-8086-x.


Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides.

Okun E, Lathia JD, Mattson MP.

Cell Adh Migr. 2009 Jul-Sep;3(3):272-4. Epub 2009 Jul 8.


Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells.

Hayun R, Okun E, Berrebi A, Shvidel L, Bassous L, Sredni B, Nir U.

Leuk Lymphoma. 2009 Apr;50(4):625-32. doi: 10.1080/10428190902789181.


Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression-An Animal Model Study.

Malkesman O, Asaf T, Shbiro L, Goldstein A, Maayan R, Weizman A, Kinor N, Okun E, Sredni B, Yadid G, Weller A.

Adv Pharmacol Sci. 2009;2009:405107. doi: 10.1155/2009/405107. Epub 2009 Oct 18.


Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.

Lathia JD, Okun E, Tang SC, Griffioen K, Cheng A, Mughal MR, Laryea G, Selvaraj PK, ffrench-Constant C, Magnus T, Arumugam TV, Mattson MP.

J Neurosci. 2008 Dec 17;28(51):13978-84. doi: 10.1523/JNEUROSCI.2140-08.2008.

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