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Role of irisin in androgen-deficient muscle wasting and osteopenia in mice.

Iemura S, Kawao N, Okumoto K, Akagi M, Kaji H.

J Bone Miner Metab. 2019 Sep 7. doi: 10.1007/s00774-019-01043-7. [Epub ahead of print]


Incidence of development of hepatocellular carcinoma in Japanese patients infected with hepatitis B virus is equivalent between genotype B and C in long term.

Haga H, Saito T, Okumoto K, Tomita K, Katsumi T, Mizuno K, Nishina T, Watanabe H, Ueno Y.

J Viral Hepat. 2019 Jul;26(7):866-872. doi: 10.1111/jvh.13099. Epub 2019 Apr 23.


Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of Cyanidioschyzon merolae.

Imoto Y, Abe Y, Okumoto K, Ohnuma M, Kuroiwa H, Kuroiwa T, Fujiki Y.

Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(2):75-85. doi: 10.2183/pjab.95.007.


A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder.

Tanaka AJ, Okumoto K, Tamura S, Abe Y, Hirsch Y, Deng L, Ekstein J, Chung WK, Fujiki Y.

Cold Spring Harb Mol Case Stud. 2019 Feb 1;5(1). pii: a003483. doi: 10.1101/mcs.a003483. Print 2019 Feb.


Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes.

Imoto Y, Abe Y, Honsho M, Okumoto K, Ohnuma M, Kuroiwa H, Kuroiwa T, Fujiki Y.

Nat Commun. 2018 Nov 6;9(1):4634. doi: 10.1038/s41467-018-07009-z.


Cell Death or Survival Against Oxidative Stress.

Miyata N, Okumoto K, Fujiki Y.

Subcell Biochem. 2018;89:463-471. doi: 10.1007/978-981-13-2233-4_20. Review.


Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.

Okumoto K, Miyata N, Fujiki Y.

Subcell Biochem. 2018;89:287-298. doi: 10.1007/978-981-13-2233-4_12.


A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein.

Niwa H, Miyauchi-Nanri Y, Okumoto K, Mukai S, Noi K, Ogura T, Fujiki Y.

J Biochem. 2018 Dec 1;164(6):437-447. doi: 10.1093/jb/mvy073.


Clinical features of stroke mimics in the emergency department.

Okano Y, Ishimatsu K, Kato Y, Yamaga J, Kuwahara K, Okumoto K, Wada K.

Acute Med Surg. 2018 Apr 10;5(3):241-248. doi: 10.1002/ams2.338. eCollection 2018 Jul.


Roles of plasminogen in the alterations in bone marrow hematopoietic stem cells during bone repair.

Okada K, Kawao N, Tatsumi K, Ishida M, Takafuji Y, Kurashimo S, Okumoto K, Kojima K, Matsuo O, Kaji H.

Bone Rep. 2018 Apr 27;8:195-203. doi: 10.1016/j.bonr.2018.04.005. eCollection 2018 Jun.


Suicide by plastic bag suffocation combined with the mixture of citric acid and baking soda in an adolescent.

Murakami K, Kawaguchi T, Hashizume Y, Kitamura K, Okada M, Okumoto K, Sakamoto S, Ishida Y, Nosaka M, Kimura A, Takatsu A, Kondo T.

Int J Legal Med. 2019 Jan;133(1):177-180. doi: 10.1007/s00414-018-1856-y. Epub 2018 May 22.


Role of Macrophages and Plasminogen Activator Inhibitor-1 in Delayed Bone Repair in Diabetic Female Mice.

Shimoide T, Kawao N, Tamura Y, Okada K, Horiuchi Y, Okumoto K, Kurashimo S, Ishida M, Tatsumi K, Matsuo O, Kaji H.

Endocrinology. 2018 Apr 1;159(4):1875-1885. doi: 10.1210/en.2018-00085.


New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes.

Okumoto K, Ono T, Toyama R, Shimomura A, Nagata A, Fujiki Y.

J Cell Biol. 2018 Feb 5;217(2):619-633. doi: 10.1083/jcb.201708122. Epub 2017 Dec 8.


Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice.

Moritake A, Kawao N, Okada K, Tatsumi K, Ishida M, Okumoto K, Matsuo O, Akagi M, Kaji H.

BMC Musculoskelet Disord. 2017 Sep 11;18(1):392. doi: 10.1186/s12891-017-1752-5.


A synthetic peptide derived from staphylokinase enhances FGF-2-induced skin wound healing in mice.

Okada K, Kojima K, Okumoto K, Kawao N, Matsuo O, Kaji H.

Thromb Res. 2017 Sep;157:7-8. doi: 10.1016/j.thromres.2017.06.032. Epub 2017 Jun 27. No abstract available.


BAK regulates catalase release from peroxisomes.

Fujiki Y, Miyata N, Mukai S, Okumoto K, Cheng EH.

Mol Cell Oncol. 2017 Mar 17;4(3):e1306610. doi: 10.1080/23723556.2017.1306610. eCollection 2017.


Generation of Peroxisome-Deficient Somatic Animal Cell Mutants.

Okumoto K, Fujiki Y.

Methods Mol Biol. 2017;1595:319-327. doi: 10.1007/978-1-4939-6937-1_29.


Peroxisomal Membrane and Matrix Protein Import Using a Semi-Intact Mammalian Cell System.

Okumoto K, Honsho M, Liu Y, Fujiki Y.

Methods Mol Biol. 2017;1595:213-219. doi: 10.1007/978-1-4939-6937-1_20.


Blue Native PAGE: Applications to Study Peroxisome Biogenesis.

Okumoto K, Tamura S, Fujiki Y.

Methods Mol Biol. 2017;1595:197-205. doi: 10.1007/978-1-4939-6937-1_18.


The VDAC2-BAK axis regulates peroxisomal membrane permeability.

Hosoi KI, Miyata N, Mukai S, Furuki S, Okumoto K, Cheng EH, Fujiki Y.

J Cell Biol. 2017 Mar 6;216(3):709-722. doi: 10.1083/jcb.201605002. Epub 2017 Feb 7.


Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis.

Abe S, Nagai T, Masukawa M, Okumoto K, Homma Y, Fujiki Y, Mizuno K.

J Biol Chem. 2017 Mar 10;292(10):4089-4098. doi: 10.1074/jbc.M117.775916. Epub 2017 Jan 25.


Defining the dynamin-based ring organizing center on the peroxisome-dividing machinery isolated from Cyanidioschyzon merolae.

Imoto Y, Abe Y, Okumoto K, Honsho M, Kuroiwa H, Kuroiwa T, Fujiki Y.

J Cell Sci. 2017 Mar 1;130(5):853-867. doi: 10.1242/jcs.199182. Epub 2017 Jan 23.


MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis.

Katsumi T, Ninomiya M, Nishina T, Mizuno K, Tomita K, Haga H, Okumoto K, Saito T, Shimosegawa T, Ueno Y.

Lab Invest. 2016 Nov;96(11):1165-1177. doi: 10.1038/labinvest.2016.95. Epub 2016 Sep 26.


The vestibular system is critical for the changes in muscle and bone induced by hypergravity in mice.

Kawao N, Morita H, Obata K, Tamura Y, Okumoto K, Kaji H.

Physiol Rep. 2016 Oct;4(19). pii: e12979.


Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C.

Saito T, Sugimoto M, Okumoto K, Haga H, Katsumi T, Mizuno K, Nishina T, Sato S, Igarashi K, Maki H, Tomita M, Ueno Y, Soga T.

World J Gastroenterol. 2016 Jul 21;22(27):6224-34. doi: 10.3748/wjg.v22.i27.6224.


[Report from the 10th Tohoku Chapter Educational Seminar: A case of intractable ascites with mediastinal lymphadenopathy].

Yamaguchi H, Okumoto K, Omoto E, Konta T.

Nihon Naika Gakkai Zasshi. 2015 Jun 10;104(6):1213-22. Japanese. No abstract available.


Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during the bone repair process.

Okada K, Kawao N, Yano M, Tamura Y, Kurashimo S, Okumoto K, Kojima K, Kaji H.

Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E15-23. doi: 10.1152/ajpendo.00253.2015. Epub 2015 Nov 3.


Role of osteoclasts in heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice.

Kawao N, Yano M, Tamura Y, Okumoto K, Okada K, Kaji H.

J Bone Miner Metab. 2016 Sep;34(5):517-25. doi: 10.1007/s00774-015-0701-3. Epub 2015 Jul 24.


α₂-Antiplasmin is involved in bone loss induced by ovariectomy in mice.

Shiomi A, Kawao N, Yano M, Okada K, Tamura Y, Okumoto K, Matsuo O, Akagi M, Kaji H.

Bone. 2015 Oct;79:233-41. doi: 10.1016/j.bone.2015.06.009. Epub 2015 Jun 18.


The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice.

Kawao N, Tamura Y, Horiuchi Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H.

PLoS One. 2015 Apr 20;10(4):e0123982. doi: 10.1371/journal.pone.0123982. eCollection 2015.


Erythropoietin Receptor Antagonist Suppressed Ectopic Hemoglobin Synthesis in Xenografts of HeLa Cells to Promote Their Destruction.

Yasuda Y, Fujita M, Koike E, Obata K, Shiota M, Kotani Y, Musha T, Tsuji-Kawahara S, Satou T, Masuda S, Okano J, Yamasaki H, Okumoto K, Uesugi T, Nakao S, Hoshiai H, Mandai M.

PLoS One. 2015 Apr 15;10(4):e0122458. doi: 10.1371/journal.pone.0122458. eCollection 2015.


Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice.

Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H.

Diabetes. 2015 Jun;64(6):2194-206. doi: 10.2337/db14-1192. Epub 2014 Dec 31.


Bone marrow cell-based regenerative therapy for liver cirrhosis.

Saito T, Tomita K, Haga H, Okumoto K, Ueno Y.

World J Methodol. 2013 Dec 26;3(4):65-9. doi: 10.5662/wjm.v3.i4.65. eCollection 2013 Dec 26. Review.


Mechanochromic luminescence characteristics of pyridine-terminated chromophores in the solid state and in a poly(vinyl alcohol) matrix.

Kondo M, Miura S, Okumoto K, Hashimoto M, Kawatsuki N.

Chem Asian J. 2014 Nov;9(11):3188-95. doi: 10.1002/asia.201402739. Epub 2014 Sep 5.


Peroxisome biogenesis in mammalian cells.

Fujiki Y, Okumoto K, Mukai S, Honsho M, Tamura S.

Front Physiol. 2014 Aug 15;5:307. doi: 10.3389/fphys.2014.00307. eCollection 2014. Review.


Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor.

Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E278-88. doi: 10.1152/ajpendo.00129.2014. Epub 2014 Jun 10.


Epiregulin promotes the emergence and proliferation of adult liver progenitor cells.

Tomita K, Haga H, Mizuno K, Katsumi T, Sato C, Okumoto K, Nishise Y, Watanabe H, Saito T, Ueno Y.

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G50-7. doi: 10.1152/ajpgi.00434.2013. Epub 2014 May 8.


Fibrodysplasia ossificans progressiva-related activated activin-like kinase signaling enhances osteoclast formation during heterotopic ossification in muscle tissues.

Yano M, Kawao N, Okumoto K, Tamura Y, Okada K, Kaji H.

J Biol Chem. 2014 Jun 13;289(24):16966-77. doi: 10.1074/jbc.M113.526038. Epub 2014 May 5.


Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import.

Okumoto K, Noda H, Fujiki Y.

J Biol Chem. 2014 May 16;289(20):14089-108. doi: 10.1074/jbc.M113.527937. Epub 2014 Mar 24.


Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice.

Mao L, Kawao N, Tamura Y, Okumoto K, Okada K, Yano M, Matsuo O, Kaji H.

PLoS One. 2014 Mar 20;9(3):e92686. doi: 10.1371/journal.pone.0092686. eCollection 2014.


Possible autoimmune hepatitis induced after chronic active Epstein-Barr virus infection.

Wada Y, Sato C, Tomita K, Ishii-Aso R, Haga H, Okumoto K, Nishise Y, Watanabe H, Saito T, Ueno Y.

Clin J Gastroenterol. 2014 Feb;7(1):58-61. doi: 10.1007/s12328-013-0438-2. Epub 2013 Nov 23.


Influence of diabetic state and vitamin D deficiency on bone repair in female mice.

Mao L, Tamura Y, Kawao N, Okada K, Yano M, Okumoto K, Kaji H.

Bone. 2014 Apr;61:102-8. doi: 10.1016/j.bone.2013.12.024. Epub 2013 Dec 28.


A case of adult type 1 Gaucher disease complicated by temporal intestinal hemorrhage.

Ito J, Saito T, Numakura C, Iwaba A, Sugahara S, Ishii R, Sato C, Haga H, Okumoto K, Nishise Y, Watanabe H, Ida H, Hayasaka K, Togashi H, Kawata S, Ueno Y.

Case Rep Gastroenterol. 2013 Aug 16;7(2):340-6. doi: 10.1159/000354725. eCollection 2013.


Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: a metabolomics analysis.

Saito T, Sugimoto M, Igarashi K, Saito K, Shao L, Katsumi T, Tomita K, Sato C, Okumoto K, Nishise Y, Watanabe H, Tomita M, Ueno Y, Soga T.

Metabolism. 2013 Nov;62(11):1577-86. doi: 10.1016/j.metabol.2013.07.002. Epub 2013 Aug 15.


Serum prolactin levels and prolactin mRNA expression in peripheral blood mononuclear cells in hepatitis C virus infection.

Ishii R, Saito T, Shao L, Okumoto K, Nishise Y, Watanabe H, Makino N, Fukao A, Kitanaka C, Kayama T, Ueno Y, Kawata S.

J Med Virol. 2013 Jul;85(7):1199-205. doi: 10.1002/jmv.23599.


Impaired mitochondrial β-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance.

Sato C, Saito T, Misawa K, Katsumi T, Tomita K, Ishii R, Haga H, Okumoto K, Nishise Y, Watanabe H, Ueno Y, Kawata S.

BMC Gastroenterol. 2013 Jul 10;13:112. doi: 10.1186/1471-230X-13-112.


Clinical manifestations of liver injury in patients with anorexia nervosa.

Tomita K, Haga H, Ishii G, Katsumi T, Sato C, Aso R, Okumoto K, Nishise Y, Watanabe H, Saito T, Otani K, Ueno Y.

Hepatol Res. 2014 Oct;44(10):E26-31. doi: 10.1111/hepr.12202. Epub 2013 Aug 7.


Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice.

Tamura Y, Kawao N, Okada K, Yano M, Okumoto K, Matsuo O, Kaji H.

Diabetes. 2013 Sep;62(9):3170-9. doi: 10.2337/db12-1552. Epub 2013 May 28.


System to quantify the import of peroxisomal matrix proteins by fluorescence intensity.

Noguchi M, Okumoto K, Fujiki Y.

Genes Cells. 2013 Jun;18(6):476-92. doi: 10.1111/gtc.12051. Epub 2013 Apr 11.


Erythropoietin is involved in hemoprotein syntheses in developing human decidua.

Shiota M, Yasuda Y, Shimaoka M, Tsuritani M, Koike E, Oiki M, Matsubara J, Taketani S, Murakami H, Yamasaki H, Okumoto K, Hoshiai H.

Congenit Anom (Kyoto). 2013 Mar;53(1):18-26. doi: 10.1111/j.1741-4520.2012.00382.x.


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