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Items: 1 to 50 of 78

1.

Safety and pharmacokinetics of quizartinib in Japanese patients with relapsed or refractory acute myeloid leukemia in a phase 1 study.

Usuki K, Handa H, Choi I, Yamauchi T, Iida H, Hata T, Ohwada S, Okudaira N, Nakamura K, Sakajiri S.

Int J Hematol. 2019 Jul 29. doi: 10.1007/s12185-019-02709-8. [Epub ahead of print]

PMID:
31359361
2.

Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.

Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.

Anticancer Res. 2019 Jul;39(7):3507-3518. doi: 10.21873/anticanres.13497.

PMID:
31262875
3.

Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.

Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.

Anticancer Res. 2018 Aug;38(8):4459-4467. doi: 10.21873/anticanres.12748.

PMID:
30061210
4.

Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.

Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.

Anticancer Res. 2018 Aug;38(8):4449-4457. doi: 10.21873/anticanres.12747.

PMID:
30061209
5.

Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.

Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.

Anticancer Res. 2018 Jul;38(7):3897-3906. doi: 10.21873/anticanres.12674.

PMID:
29970510
6.

In Vitro Antitumor Activity of Alkylaminoguaiazulenes.

Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.

In Vivo. 2018 May-Jun;32(3):541-547.

7.

In Vitro Anti-tumor Activity of Azulene Amide Derivatives.

Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.

In Vivo. 2018 May-Jun;32(3):479-486.

8.

Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.

Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.

Anticancer Res. 2018 Feb;38(2):817-823.

PMID:
29374707
9.

Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.

Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y.

Anticancer Res. 2018 Feb;38(2):763-770.

PMID:
29374700
10.

Evaluation of New Chemical Entities as Substrates of Liver Transporters in the Pharmaceutical Industry: Response to Regulatory Requirements and Future Steps.

Okudaira N.

J Pharm Sci. 2017 Sep;106(9):2251-2256. doi: 10.1016/j.xphs.2017.05.009. Epub 2017 May 19. Review.

PMID:
28533120
11.

Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.

Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.

Anticancer Res. 2017 Mar;37(3):1023-1029.

PMID:
28314260
12.

Antiviral and Antitumor Activity of Licorice Root Extracts.

Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.

In Vivo. 2016 11-12;30(6):777-785.

PMID:
27815461
13.

Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.

Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.

Anticancer Res. 2016 Nov;36(11):5931-5935.

PMID:
27793918
14.

Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.

Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.

In Vivo. 2016 09-10;30(5):645-50.

PMID:
27566085
15.

Prominent Anti-UV Activity and Possible Cosmetic Potential of Lignin-carbohydrate Complex.

Sakagami H, Sheng H, Okudaira N, Yasui T, Wakabayashi H, Jia J, Natori T, Suguro-Kitajima M, Oizumi H, Oizumi T.

In Vivo. 2016 Jul-Aug;30(4):331-9. Review.

PMID:
27381594
16.

Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1.

Okudaira N, Ishizaka Y, Nishio H, Sakagami H.

In Vivo. 2016 Mar-Apr;30(2):113-8.

PMID:
26912821
17.

Liver-selective distribution in rats supports the importance of active uptake into the liver via organic anion transporting polypeptides (OATPs) in humans.

Mikkaichi T, Nakai D, Yoshigae Y, Imaoka T, Okudaira N, Izumi T.

Drug Metab Pharmacokinet. 2015 Oct;30(5):334-40. doi: 10.1016/j.dmpk.2015.06.003. Epub 2015 Jun 24.

PMID:
26403085
18.

The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01.

Hirasawa M, Hagihara K, Okudaira N, Izumi T.

PLoS One. 2015 Jun 22;10(6):e0130928. doi: 10.1371/journal.pone.0130928. eCollection 2015.

19.

Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.

Karibe T, Hagihara-Nakagomi R, Abe K, Imaoka T, Mikkaichi T, Yasuda S, Hirouchi M, Watanabe N, Okudaira N, Izumi T.

Pharm Res. 2015 May;32(5):1634-47. doi: 10.1007/s11095-014-1563-4. Epub 2014 Nov 8.

PMID:
25380981
20.

A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes.

Okudaira N, Kuwahara M, Hirata Y, Oku Y, Nishio H.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):665-8. doi: 10.1016/j.bbrc.2014.08.132. Epub 2014 Sep 1.

PMID:
25193700
21.

Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: a study using a knock-in mouse model.

Nishio H, Okudaira N, Matsushita K, Yoshimoto T, Sato T, Suzuki K.

Leg Med (Tokyo). 2014 Nov;16(6):326-32. doi: 10.1016/j.legalmed.2014.06.008. Epub 2014 Jul 10.

PMID:
25087098
22.

Retrotransposition of long interspersed element 1 induced by methamphetamine or cocaine.

Okudaira N, Ishizaka Y, Nishio H.

J Biol Chem. 2014 Sep 12;289(37):25476-85. doi: 10.1074/jbc.M114.559419. Epub 2014 Jul 22.

23.

6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.

Imamura Y, Tsuruya Y, Damme K, Heer D, Kumagai Y, Maeda K, Murayama N, Okudaira N, Kurihara A, Izumi T, Sugiyama Y, Kusuhara H.

Drug Metab Dispos. 2014 Apr;42(4):685-94. doi: 10.1124/dmd.113.055475. Epub 2014 Jan 31.

PMID:
24487120
24.

Edoxaban transport via P-glycoprotein is a key factor for the drug's disposition.

Mikkaichi T, Yoshigae Y, Masumoto H, Imaoka T, Rozehnal V, Fischer T, Okudaira N, Izumi T.

Drug Metab Dispos. 2014 Apr;42(4):520-8. doi: 10.1124/dmd.113.054866. Epub 2014 Jan 23.

PMID:
24459178
25.

Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1.

Iijima K, Okudaira N, Tamura M, Doi A, Saito Y, Shimura M, Goto M, Matsunaga A, Kawamura YI, Otsubo T, Dohi T, Hoshino S, Kano S, Hagiwara S, Tanuma J, Gatanaga H, Baba M, Iguchi T, Yanagita M, Oka S, Okamura T, Ishizaka Y.

Retrovirology. 2013 Aug 5;10:83. doi: 10.1186/1742-4690-10-83.

26.

Integrated approach of in vivo and in vitro evaluation of the involvement of hepatic uptake organic anion transporters in the drug disposition in rats using rifampicin as an inhibitor.

Imaoka T, Mikkaichi T, Abe K, Hirouchi M, Okudaira N, Izumi T.

Drug Metab Dispos. 2013 Jul;41(7):1442-9. doi: 10.1124/dmd.113.051052. Epub 2013 May 2.

PMID:
23640987
27.

[Activation and mechanism of endogenous retroelement in intractable diseases].

Okudaira N, Ishizaka Y.

Seikagaku. 2012 Oct;84(10):870-4. Review. Japanese. No abstract available.

PMID:
23240544
28.

Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.

Okudaira N, Okamura T, Tamura M, Iijma K, Goto M, Matsunaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y.

Oncogene. 2013 Oct 10;32(41):4903-12. doi: 10.1038/onc.2012.516. Epub 2012 Dec 3.

29.

Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6β-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.

Imamura Y, Murayama N, Okudaira N, Kurihara A, Inoue K, Yuasa H, Izumi T, Kusuhara H, Sugiyama Y.

Pharm Res. 2013 Feb;30(2):447-57. doi: 10.1007/s11095-012-0890-6. Epub 2012 Oct 17.

PMID:
23073666
30.

Modes of retrotransposition of long interspersed element-1 by environmental factors.

Ishizaka Y, Okudaira N, Tamura M, Iijima K, Shimura M, Goto M, Okamura T.

Front Microbiol. 2012 May 31;3:191. doi: 10.3389/fmicb.2012.00191. eCollection 2012.

31.

Prediction of human plasma concentration-time profiles of monoclonal antibodies from monkey data by a species-invariant time method.

Oitate M, Nakayama S, Ito T, Kurihara A, Okudaira N, Izumi T.

Drug Metab Pharmacokinet. 2012;27(3):354-9. Epub 2011 Dec 6.

32.

Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate.

Okudaira N, Goto M, Yanobu-Takanashi R, Tamura M, An A, Abe Y, Kano S, Hagiwara S, Ishizaka Y, Okamura T.

Cancer Sci. 2011 Nov;102(11):2000-6. doi: 10.1111/j.1349-7006.2011.02060.x. Epub 2011 Sep 19.

33.

Prediction of human pharmacokinetics of therapeutic monoclonal antibodies from simple allometry of monkey data.

Oitate M, Masubuchi N, Ito T, Yabe Y, Karibe T, Aoki T, Murayama N, Kurihara A, Okudaira N, Izumi T.

Drug Metab Pharmacokinet. 2011;26(4):423-30. Epub 2011 May 24.

34.

Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.

Nakayama S, Takakusa H, Watanabe A, Miyaji Y, Suzuki W, Sugiyama D, Shiosakai K, Honda K, Okudaira N, Izumi T, Okazaki O.

Drug Metab Dispos. 2011 Jul;39(7):1247-54. doi: 10.1124/dmd.111.039180. Epub 2011 Apr 5.

PMID:
21467212
35.

Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion.

Imamura Y, Murayama N, Okudaira N, Kurihara A, Okazaki O, Izumi T, Inoue K, Yuasa H, Kusuhara H, Sugiyama Y.

Clin Pharmacol Ther. 2011 Jan;89(1):81-8. doi: 10.1038/clpt.2010.232. Epub 2010 Dec 1.

PMID:
21124314
36.

Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct.

Okudaira N, Iijima K, Koyama T, Minemoto Y, Kano S, Mimori A, Ishizaka Y.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18487-92. doi: 10.1073/pnas.1001252107. Epub 2010 Sep 17.

37.

Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide.

Sawamura R, Okudaira N, Watanabe K, Murai T, Kobayashi Y, Tachibana M, Ohnuki T, Masuda K, Honma H, Kurihara A, Okazaki O.

Drug Metab Dispos. 2010 Oct;38(10):1857-64. doi: 10.1124/dmd.110.034173. Epub 2010 Jul 6. Erratum in: Drug Metab Dispos. 2010 Dec;38(12):2347.

PMID:
20606003
38.

Radiation dose-rate effect on mutation induction in spleen and liver of gpt delta mice.

Okudaira N, Uehara Y, Fujikawa K, Kagawa N, Ootsuyama A, Norimura T, Saeki K, Nohmi T, Masumura K, Matsumoto T, Oghiso Y, Tanaka K, Ichinohe K, Nakamura S, Tanaka S, Ono T.

Radiat Res. 2010 Feb;173(2):138-47. doi: 10.1667/RR1932.1.

PMID:
20095845
39.

Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.

Kamiyama E, Nakai D, Mikkaichi T, Okudaira N, Okazaki O.

Life Sci. 2010 Jan 2;86(1-2):52-8. doi: 10.1016/j.lfs.2009.11.006. Epub 2009 Nov 13.

PMID:
19914261
40.

Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam.

Nishiya Y, Nakamura K, Okudaira N, Abe K, Kobayashi N, Okazaki O.

Xenobiotica. 2010 Jan;40(1):1-8. doi: 10.3109/00498250903337392.

PMID:
19905875
41.

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.

Nishiya Y, Hagihara K, Kurihara A, Okudaira N, Farid NA, Okazaki O, Ikeda T.

Xenobiotica. 2009 Nov;39(11):836-43. doi: 10.3109/00498250903191427.

PMID:
19845434
42.

Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones.

Ohta KY, Imamura Y, Okudaira N, Atsumi R, Inoue K, Yuasa H.

J Pharmacol Exp Ther. 2009 Feb;328(2):628-34. doi: 10.1124/jpet.108.142257. Epub 2008 Nov 12.

PMID:
19004926
43.

Comparison of the antioxidant activity of albumin from various animal species.

Okazaki T, Okudaira N, Ishii N, Yotsuyanagi H, Nagai T, Tokudome S, Fujioka T, Takahashi S.

Zoolog Sci. 2008 Feb;25(2):172-7. doi: 10.2108/zsj.25.172.

PMID:
18533748
45.
46.

Apoptosis and adhesion of hemocytes during molting stage of silkworm, Bombyx mori.

Okazaki T, Okudaira N, Iwabuchi K, Fugo H, Nagai T.

Zoolog Sci. 2006 Mar;23(3):299-304.

PMID:
16603823
47.

Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).

Kondo C, Onuki R, Kusuhara H, Suzuki H, Suzuki M, Okudaira N, Kojima M, Ishiwata K, Jonker JW, Sugiyama Y.

Pharm Res. 2005 Apr;22(4):613-8. Epub 2005 Apr 7.

PMID:
15846469
48.

Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, prulifloxacin.

Yagi Y, Shibutani S, Hodoshima N, Ishiwata K, Okudaira N, Li Q, Sai Y, Kato Y, Tsuji A.

Drug Metab Pharmacokinet. 2003;18(6):381-9.

49.

Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid.

Okudaira N, Fujigaki M, Nakayoshi T, Komiya I, Sugiyama Y.

Pharm Res. 2001 Apr;18(4):439-45.

PMID:
11451029
50.

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