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Items: 1 to 50 of 498

1.

Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA.

Okamoto A, Koide H, Morita N, Hirai Y, Kawato Y, Egami H, Hamashima Y, Asai T, Dewa T, Oku N.

J Control Release. 2019 Feb 10;295:87-92. doi: 10.1016/j.jconrel.2018.12.044. Epub 2018 Dec 26.

PMID:
30593831
2.

Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle.

Koide H, Yoshimatsu K, Hoshino Y, Ariizumi S, Okishima A, Ide T, Egami H, Hamashima Y, Nishimura Y, Kanazawa H, Miura Y, Asai T, Oku N, Shea KJ.

J Control Release. 2019 Feb 10;295:13-20. doi: 10.1016/j.jconrel.2018.12.033. Epub 2018 Dec 20.

PMID:
30578808
3.

Kidney and Thyroid Cancer-Specific Treatment Algorithm for Spinal Metastases: A Validation Study.

Kato S, Murakami H, Demura S, Yoshioka K, Yokogawa N, Yonezawa N, Shimizu T, Oku N, Kitagawa R, Tsuchiya H.

World Neurosurg. 2019 Feb;122:e1305-e1311. doi: 10.1016/j.wneu.2018.11.040. Epub 2018 Nov 15.

PMID:
30448587
4.

Prediction of the Oral Pharmacokinetics and Food Effects of Gabapentin Enacarbil Extended-Release Tablets Using Biorelevant Dissolution Tests.

Yamaguchi Ikeuchi S, Kambayashi A, Kojima H, Oku N, Asai T.

Biol Pharm Bull. 2018;41(11):1708-1715. doi: 10.1248/bpb.b18-00456.

5.

En bloc corpectomy for late gastrointestinal stromal tumor metastasis: a case report and review of the literature.

Shimizu T, Murakami H, Sangsin A, Demura S, Kato S, Shinmura K, Yokogawa N, Oku N, Kitagawa R, Tsuchiya H.

J Med Case Rep. 2018 Oct 16;12(1):300. doi: 10.1186/s13256-018-1844-3. Review.

6.

Total spondylectomy for Enneking stage III giant cell tumor of the mobile spine.

Yokogawa N, Murakami H, Demura S, Kato S, Yoshioka K, Shimizu T, Oku N, Kitagawa R, Tsuchiya H.

Eur Spine J. 2018 Sep 12. doi: 10.1007/s00586-018-5761-3. [Epub ahead of print]

PMID:
30209582
7.

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp.

Li D, Oku N, Hasada A, Shimizu M, Igarashi Y.

Beilstein J Org Chem. 2018 Jun 14;14:1446-1451. doi: 10.3762/bjoc.14.122. eCollection 2018.

8.

Anticancer Efficacy of the Combination of Berberine and PEGylated Liposomal Doxorubicin in Meth A Sarcoma-Bearing Mice.

Yahuafai J, Asai T, Oku N, Siripong P.

Biol Pharm Bull. 2018;41(7):1103-1106. doi: 10.1248/bpb.b17-00989.

9.

Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila.

Akiyama H, Indananda C, Thamchaipenet A, Motojima A, Oikawa T, Komaki H, Hosoyama A, Kimura A, Oku N, Igarashi Y.

J Nat Prod. 2018 Jul 27;81(7):1561-1569. doi: 10.1021/acs.jnatprod.8b00071. Epub 2018 Jun 25.

PMID:
29939741
10.

Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box.

Milanowski DJ, Oku N, Cartner LK, Bokesch HR, Williamson RT, Saurí J, Liu Y, Blinov KA, Ding Y, Li XC, Ferreira D, Walker LA, Khan S, Davies-Coleman MT, Kelley JA, McMahon JB, Martin GE, Gustafson KR.

Chem Sci. 2017 Nov 6;9(2):307-314. doi: 10.1039/c7sc01996c. eCollection 2018 Jan 14.

11.

Involvement of Tumor Lymphatic System in Translocation of Intratumorally Injected Liposomes.

Shimizu K, Ikeuchi SY, Okajima A, Nakamura G, Muraoka E, Oku N.

Biol Pharm Bull. 2018;41(4):652-656. doi: 10.1248/bpb.b17-00730.

12.

Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.

Kimura J, Shimizu K, Kajima K, Yokosuka A, Mimaki Y, Oku N, Ohizumi Y.

Biol Pharm Bull. 2018;41(4):451-457. doi: 10.1248/bpb.b17-00364.

13.

Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer.

Okamoto A, Asai T, Hirai Y, Shimizu K, Koide H, Minamino T, Oku N.

Mol Pharm. 2018 Apr 2;15(4):1495-1504. doi: 10.1021/acs.molpharmaceut.7b01055. Epub 2018 Mar 12.

PMID:
29502423
14.

Food-dependent exercise-induced anaphylaxis in Japanese elementary school children.

Manabe T, Oku N, Aihara Y.

Pediatr Int. 2018 Apr;60(4):329-333. doi: 10.1111/ped.13520. Epub 2018 Mar 23.

PMID:
29341364
15.

Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.

Fukuta T, Yanagida Y, Asai T, Oku N.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):873-877. doi: 10.1016/j.bbrc.2017.11.107. Epub 2017 Nov 21.

PMID:
29162447
16.

Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins.

Koide H, Tsuchida H, Nakamoto M, Okishima A, Ariizumi S, Kiyokawa C, Asai T, Hoshino Y, Oku N.

J Control Release. 2017 Dec 28;268:335-342. doi: 10.1016/j.jconrel.2017.10.028. Epub 2017 Oct 20.

PMID:
29061513
17.

Self-assembled monolayers of sulfonate-terminated alkanethiols investigated by frequency modulation atomic force microscopy in liquid.

Asakawa H, Inada N, Hirata K, Matsui S, Igarashi T, Oku N, Yoshikawa N, Fukuma T.

Nanotechnology. 2017 Nov 10;28(45):455603. doi: 10.1088/1361-6528/aa8aa7.

PMID:
28876225
18.

Topics of nuclear medicine research in Europe.

Inubushi M, Kaneta T, Ishimori T, Imabayashi E, Okizaki A, Oku N.

Ann Nucl Med. 2017 Oct;31(8):571-574. doi: 10.1007/s12149-017-1198-8. Epub 2017 Jul 25. Review.

19.

A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF165).

Koide H, Yoshimatsu K, Hoshino Y, Lee SH, Okajima A, Ariizumi S, Narita Y, Yonamine Y, Weisman AC, Nishimura Y, Oku N, Miura Y, Shea KJ.

Nat Chem. 2017 Jul;9(7):715-722. doi: 10.1038/nchem.2749. Epub 2017 Mar 27.

PMID:
28644480
20.

Targeted delivery of anticancer drugs to tumor vessels by use of liposomes modified with a peptide identified by phage biopanning with human endothelial progenitor cells.

Fukuta T, Asai T, Kiyokawa Y, Nakada T, Bessyo-Hirashima K, Fukaya N, Hyodo K, Takase K, Kikuchi H, Oku N.

Int J Pharm. 2017 May 30;524(1-2):364-372. doi: 10.1016/j.ijpharm.2017.03.059. Epub 2017 Mar 27.

PMID:
28359814
21.

Process optimization by use of design of experiments: Application for liposomalization of FK506.

Toyota H, Asai T, Oku N.

Eur J Pharm Sci. 2017 May 1;102:196-202. doi: 10.1016/j.ejps.2017.03.007. Epub 2017 Mar 7.

PMID:
28279762
22.

Two new sacrolide-class oxylipins from the edible cyanobacterium Aphanothece sacrum.

Oku N, Hana S, Matsumoto M, Yonejima K, Tansei K, Isogai Y, Igarashi Y.

J Antibiot (Tokyo). 2017 May;70(5):708-709. doi: 10.1038/ja.2017.32. Epub 2017 Mar 8. No abstract available.

PMID:
28270686
23.

Innovations in Liposomal DDS Technology and Its Application for the Treatment of Various Diseases.

Oku N.

Biol Pharm Bull. 2017;40(2):119-127. doi: 10.1248/bpb.b16-00857. Review.

24.

Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke.

Fukuta T, Asai T, Yanagida Y, Namba M, Koide H, Shimizu K, Oku N.

FASEB J. 2017 May;31(5):1879-1890. doi: 10.1096/fj.201601209R. Epub 2017 Jan 12.

PMID:
28082354
25.

Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats.

Okuda K, Fu HY, Matsuzaki T, Araki R, Tsuchida S, Thanikachalam PV, Fukuta T, Asai T, Yamato M, Sanada S, Asanuma H, Asano Y, Asakura M, Hanawa H, Hao H, Oku N, Takashima S, Kitakaze M, Sakata Y, Minamino T.

PLoS One. 2016 Aug 8;11(8):e0160944. doi: 10.1371/journal.pone.0160944. eCollection 2016.

26.

Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity.

Fukuta T, Asai T, Ishii T, Koide H, Kiyokawa C, Hashimoto M, Kikuchi T, Shimizu K, Harada N, Tsukada H, Oku N.

Sci Rep. 2016 Jul 21;6:30127. doi: 10.1038/srep30127.

27.

[Basic Evaluation of Microsemi LC-767CRP as POCT Model for Simultaneous Measurement of CBC and CRP].

Inaba T, Ikeda M, Saitoh K, Yuasa S, Mishima N, Ogura K, Oku N, Kodama M, Fujitomo Y, Nakanishi M, Fujita N.

Rinsho Byori. 2016 Feb;64(2):152-6. Japanese.

PMID:
27311278
29.

Ameliorating Effects of Sphingomyelin-Based Liposomes on Sarcopenia in Senescence-Accelerated Mice.

Ishida Y, Kiyokawa Y, Asai T, Oku N.

Biol Pharm Bull. 2016;39(5):786-93. doi: 10.1248/bpb.b15-00915.

30.

Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil.

Fukuta T, Asai T, Sato A, Namba M, Yanagida Y, Kikuchi T, Koide H, Shimizu K, Oku N.

Int J Pharm. 2016 Jun 15;506(1-2):129-37. doi: 10.1016/j.ijpharm.2016.04.046. Epub 2016 Apr 20.

PMID:
27107903
31.

Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect.

Shimizu K, Miyauchi H, Urakami T, Yamamura-Ichikawa K, Yonezawa S, Asai T, Oku N.

J Drug Target. 2016 Nov;24(9):890-895. Epub 2016 May 25.

PMID:
27030163
32.

One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing.

Koide H, Okamoto A, Tsuchida H, Ando H, Ariizumi S, Kiyokawa C, Hashimoto M, Asai T, Dewa T, Oku N.

J Control Release. 2016 Apr 28;228:1-8. doi: 10.1016/j.jconrel.2016.01.032. Epub 2016 Jan 28.

PMID:
26826309
33.

Ascidiimonas aurantiaca gen. nov., sp. nov., a member of Flavobacteriaceae isolated from a sea squirt.

Yoon J, Oku N, Kasai H.

Antonie Van Leeuwenhoek. 2016 Apr;109(4):501-8. doi: 10.1007/s10482-016-0655-z. Epub 2016 Jan 22.

PMID:
26800666
34.

Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow.

Okamoto A, Asai T, Ryu S, Ando H, Maeda N, Dewa T, Oku N.

J Clin Med. 2016 Jan 19;5(1). pii: E10. doi: 10.3390/jcm5010010.

35.

Amelioration of Citrobacter rodentium proliferation in early stage of infection in mice by pretreatment with Lactobacillus brevis KB290 and verification using in vivo bioluminescence imaging.

Waki N, Kuwabara Y, Yoshikawa Y, Suganuma H, Koide H, Oku N, Ohashi N.

FEMS Microbiol Lett. 2017 Mar 1;364(6). doi: 10.1093/femsle/fnw254.

PMID:
28333177
36.

Insights into the Biosynthesis of Dehydroalanines in Goadsporin.

Ozaki T, Kurokawa Y, Hayashi S, Oku N, Asamizu S, Igarashi Y, Onaka H.

Chembiochem. 2016 Feb 2;17(3):218-23. doi: 10.1002/cbic.201500541. Epub 2016 Jan 8.

PMID:
26630235
37.

Bauhinia purprea agglutinin-modified liposomes for human prostate cancer treatment.

Ikemoto K, Shimizu K, Ohashi K, Takeuchi Y, Shimizu M, Oku N.

Cancer Sci. 2016 Jan;107(1):53-9. doi: 10.1111/cas.12839. Epub 2015 Dec 11.

38.

Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions.

Fukuta T, Ishii T, Asai T, Sato A, Kikuchi T, Shimizu K, Minamino T, Oku N.

Eur J Pharm Biopharm. 2015 Nov;97(Pt A):1-7. doi: 10.1016/j.ejpb.2015.09.020. Epub 2015 Oct 9.

PMID:
26455340
39.

Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes.

Yang Y, Yu L, Komaki H, Oku N, Igarashi Y.

J Antibiot (Tokyo). 2016 Jan;69(1):69-71. doi: 10.1038/ja.2015.80. Epub 2015 Aug 19. No abstract available.

PMID:
26285791
40.

Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model.

Kojima R, Yoshida T, Tasaki H, Umejima H, Maeda M, Higashi Y, Watanabe S, Oku N.

Int J Pharm. 2015 Aug 15;492(1-2):20-7. doi: 10.1016/j.ijpharm.2015.07.004. Epub 2015 Jul 6.

PMID:
26160668
41.

Food-dependent exercise-induced anaphylaxis among junior high school students: a 14-year epidemiological comparison.

Manabe T, Oku N, Aihara Y.

Allergol Int. 2015 Jul;64(3):285-6. doi: 10.1016/j.alit.2015.01.007. Epub 2015 Mar 4. No abstract available.

42.

Wenyingzhuangia gracilariae sp. nov., a novel marine bacterium of the phylum Bacteroidetes isolated from the red alga Gracilaria vermiculophylla.

Yoon J, Oku N, Kasai H.

Antonie Van Leeuwenhoek. 2015 Jun;107(6):1607-13. doi: 10.1007/s10482-015-0456-9. Epub 2015 Apr 21.

PMID:
25896307
43.

Correction to Complete Stereochemistry and Preliminary Structure-Activity Relationship of Rakicidin A, a Hypoxia-Selective Cytotoxin from Micromonospora sp.

Oku N, Matoba S, Yamazaki YM, Shimasaki R, Miyanaga S, Igarashi Y.

J Nat Prod. 2015 Apr 24;78(4):969. doi: 10.1021/acs.jnatprod.5b00167. Epub 2015 Feb 27. No abstract available.

PMID:
25723086
44.

Complete stereochemistry and preliminary structure-activity relationship of rakicidin A, a hypoxia-selective cytotoxin from Micromonospora sp.

Oku N, Matoba S, Yamazaki YM, Shimasaki R, Miyanaga S, Igarashi Y.

J Nat Prod. 2014 Nov 26;77(11):2561-5. doi: 10.1021/np500276c. Epub 2014 Nov 6. Erratum in: J Nat Prod. 2015 Apr 24;78(4):969.

PMID:
25375258
45.

Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography.

Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Akai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N.

Artif Organs. 2014 Aug;38(8):662-6. doi: 10.1111/aor.12350.

PMID:
25295359
46.

Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin.

Koide H, Asai T, Kato H, Yonenaga N, Yokota M, Ando H, Dewa T, Nango M, Maeda N, Oku N.

Nanomedicine. 2015 Jan;11(1):185-94. doi: 10.1016/j.nano.2014.09.003. Epub 2014 Sep 18.

PMID:
25240598
47.

Identification of the n-1 fatty acid as an antibacterial constituent from the edible freshwater cyanobacterium Nostoc verrucosum.

Oku N, Yonejima K, Sugawa T, Igarashi Y.

Biosci Biotechnol Biochem. 2014;78(7):1147-50. doi: 10.1080/09168451.2014.918484. Epub 2014 Jun 17.

PMID:
25229849
48.

Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum.

Oku N, Matsumoto M, Yonejima K, Tansei K, Igarashi Y.

Beilstein J Org Chem. 2014 Aug 7;10:1808-16. doi: 10.3762/bjoc.10.190. eCollection 2014.

49.

Suppression in mice of immunosurveillance against PEGylated liposomes by encapsulated doxorubicin.

Yahuafai J, Asai T, Nakamura G, Fukuta T, Siripong P, Hyodo K, Ishihara H, Kikuchi H, Oku N.

J Control Release. 2014 Oct 28;192:167-73. doi: 10.1016/j.jconrel.2014.07.010. Epub 2014 Jul 17.

PMID:
25041998
50.

Formulation design and evaluation of liposomal sepantronium bromide (YM155), a small-molecule survivin suppressant, based on pharmacokinetic modeling and simulation.

Shakushiro K, Kawano H, Nakata M, Kita A, Maeda A, Watanabe S, Sako K, Oku N.

Pharm Res. 2015 Jan;32(1):238-47. doi: 10.1007/s11095-014-1458-4. Epub 2014 Jul 18.

PMID:
25033765

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