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Items: 1 to 50 of 72

1.

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells.

Häkkinen ST, Nygren H, Maiorova N, Haavikko R, Alakurtti S, Yli-Kauhaluoma J, Rischer H, Oksman-Caldentey KM.

Planta Med. 2018 Jul;84(9-10):743-748. doi: 10.1055/a-0585-6081. Epub 2018 Mar 8.

PMID:
29518814
2.

Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus: ploidy as a promising parameter in the metabolic engineering of tropane alkaloids.

Dehghan E, Reed DW, Covello PS, Hasanpour Z, Palazon J, Oksman-Caldentey KM, Ahmadi FS.

Plant Cell Rep. 2017 Oct;36(10):1615-1626. doi: 10.1007/s00299-017-2178-0. Epub 2017 Jul 13.

PMID:
28707113
3.

Biotechnology of the medicinal plant Rhazya stricta: a little investigated member of the Apocynaceae family.

Akhgari A, Oksman-Caldentey KM, Rischer H.

Biotechnol Lett. 2017 Jun;39(6):829-840. doi: 10.1007/s10529-017-2320-7. Epub 2017 Mar 15. Review.

PMID:
28299544
4.

Exploring the Metabolic Stability of Engineered Hairy Roots after 16 Years Maintenance.

Häkkinen ST, Moyano E, Cusidó RM, Oksman-Caldentey KM.

Front Plant Sci. 2016 Sep 30;7:1486. eCollection 2016.

5.

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.

Pirttimaa M, Nasereddin A, Kopelyanskiy D, Kaiser M, Yli-Kauhaluoma J, Oksman-Caldentey KM, Brun R, Jaffe CL, Moreira VM, Alakurtti S.

J Nat Prod. 2016 Feb 26;79(2):362-8. doi: 10.1021/acs.jnatprod.5b00990. Epub 2016 Feb 5.

PMID:
26849852
6.

Analysis of Indole Alkaloids from Rhazya stricta Hairy Roots by Ultra-Performance Liquid Chromatography-Mass Spectrometry.

Akhgari A, Laakso I, Seppänen-Laakso T, Yrjönen T, Vuorela H, Oksman-Caldentey KM, Rischer H.

Molecules. 2015 Dec 17;20(12):22621-34. doi: 10.3390/molecules201219873.

7.

Bioconversion to Raspberry Ketone is Achieved by Several Non-related Plant Cell Cultures.

Häkkinen ST, Seppänen-Laakso T, Oksman-Caldentey KM, Rischer H.

Front Plant Sci. 2015 Nov 24;6:1035. doi: 10.3389/fpls.2015.01035. eCollection 2015.

8.

Fermentation and dry fractionation increase bioactivity of cloudberry (Rubus chamaemorus).

Puupponen-Pimiä R, Nohynek L, Juvonen R, Kössö T, Truchado P, Westerlund-Wikström B, Leppänen T, Moilanen E, Oksman-Caldentey KM.

Food Chem. 2016 Apr 15;197(Pt A):950-8. doi: 10.1016/j.foodchem.2015.11.061. Epub 2015 Nov 14.

PMID:
26617039
9.

Establishment of transgenic Rhazya stricta hairy roots to modulate terpenoid indole alkaloid production.

Akhgari A, Yrjönen T, Laakso I, Vuorela H, Oksman-Caldentey KM, Rischer H.

Plant Cell Rep. 2015 Nov;34(11):1939-52. doi: 10.1007/s00299-015-1841-6. Epub 2015 Aug 6.

PMID:
26245531
10.

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS.

Akhgari A, Laakso I, Seppänen-Laakso T, Yrjönen T, Vuorela H, Oksman-Caldentey KM, Rischer H.

Phytochem Anal. 2015 Sep-Oct;26(5):331-8. doi: 10.1002/pca.2567. Epub 2015 Jun 11.

PMID:
26095837
11.

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.

Härmä V, Haavikko R, Virtanen J, Ahonen I, Schukov HP, Alakurtti S, Purev E, Rischer H, Yli-Kauhaluoma J, Moreira VM, Nees M, Oksman-Caldentey KM.

PLoS One. 2015 May 12;10(5):e0126111. doi: 10.1371/journal.pone.0126111. eCollection 2015.

12.

The seco-iridoid pathway from Catharanthus roseus.

Miettinen K, Dong L, Navrot N, Schneider T, Burlat V, Pollier J, Woittiez L, van der Krol S, Lugan R, Ilc T, Verpoorte R, Oksman-Caldentey KM, Martinoia E, Bouwmeester H, Goossens A, Memelink J, Werck-Reichhart D.

Nat Commun. 2014 Apr 7;5:3606. doi: 10.1038/ncomms4606. Erratum in: Nat Commun. 2014;5:4175.

13.

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway.

Ritala A, Dong L, Imseng N, Seppänen-Laakso T, Vasilev N, van der Krol S, Rischer H, Maaheimo H, Virkki A, Brändli J, Schillberg S, Eibl R, Bouwmeester H, Oksman-Caldentey KM.

J Biotechnol. 2014 Apr 20;176:20-8. doi: 10.1016/j.jbiotec.2014.01.031. Epub 2014 Feb 14.

PMID:
24530945
14.

Recombinant barley-produced antibody for detection and immunoprecipitation of the major bovine milk allergen, β-lactoglobulin.

Ritala A, Leelavathi S, Oksman-Caldentey KM, Reddy VS, Laukkanen ML.

Transgenic Res. 2014 Jun;23(3):477-87. doi: 10.1007/s11248-014-9783-2. Epub 2014 Feb 5.

PMID:
24497085
15.

Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production.

Masakapalli SK, Ritala A, Dong L, van der Krol AR, Oksman-Caldentey KM, Ratcliffe RG, Sweetlove LJ.

Phytochemistry. 2014 Mar;99:73-85. doi: 10.1016/j.phytochem.2013.12.007. Epub 2014 Jan 25.

PMID:
24472392
16.

Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody.

Häkkinen ST, Raven N, Henquet M, Laukkanen ML, Anderlei T, Pitkänen JP, Twyman RM, Bosch D, Oksman-Caldentey KM, Schillberg S, Ritala A.

Biotechnol Bioeng. 2014 Feb;111(2):336-46. doi: 10.1002/bit.25113. Epub 2013 Sep 24.

PMID:
24030771
17.

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome.

Puupponen-Pimiä R, Seppänen-Laakso T, Kankainen M, Maukonen J, Törrönen R, Kolehmainen M, Leppänen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tómas-Barberán FA, Espín JC, Oksman-Caldentey KM.

Mol Nutr Food Res. 2013 Dec;57(12):2258-63. doi: 10.1002/mnfr.201300280. Epub 2013 Aug 12.

PMID:
23934737
18.

CathaCyc, a metabolic pathway database built from Catharanthus roseus RNA-Seq data.

Van Moerkercke A, Fabris M, Pollier J, Baart GJ, Rombauts S, Hasnain G, Rischer H, Memelink J, Oksman-Caldentey KM, Goossens A.

Plant Cell Physiol. 2013 May;54(5):673-85. doi: 10.1093/pcp/pct039. Epub 2013 Mar 14.

PMID:
23493402
19.

Plant cells as pharmaceutical factories.

Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Miralpeix B, Capell T, Christou P, Oksman-Caldentey KM.

Curr Pharm Des. 2013;19(31):5640-60. Review.

PMID:
23394561
20.

Metabolic engineering of plant secondary products: which way forward?

Miralpeix B, Rischer H, Häkkinen ST, Ritala A, Seppänen-Laakso T, Oksman-Caldentey KM, Capell T, Christou P.

Curr Pharm Des. 2013;19(31):5622-39. Review.

PMID:
23394556
21.

Analysis of the interface between primary and secondary metabolism in catharanthus roseus cell cultures using (13)C-stable isotope feeding and coupled mass spectrometry.

Antonio C, Mustafa NR, Osorio S, Tohge T, Giavalisco P, Willmitzer L, Rischer H, Oksman-Caldentey KM, Verpoorte R, Fernie AR.

Mol Plant. 2013 Mar;6(2):581-4. doi: 10.1093/mp/sss156. Epub 2012 Dec 19. No abstract available.

22.

In-depth proteome mining of cultured Catharanthus roseus cells identifies candidate proteins involved in the synthesis and transport of secondary metabolites.

Champagne A, Rischer H, Oksman-Caldentey KM, Boutry M.

Proteomics. 2012 Dec;12(23-24):3536-47. doi: 10.1002/pmic.201200218. Epub 2012 Nov 8.

PMID:
23044725
23.

Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells.

Häkkinen ST, Lackman P, Nygrén H, Oksman-Caldentey KM, Maaheimo H, Rischer H.

J Biotechnol. 2012 Jan 20;157(2):287-94. doi: 10.1016/j.jbiotec.2011.11.008. Epub 2011 Nov 22.

PMID:
22178236
24.

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco.

Lackman P, González-Guzmán M, Tilleman S, Carqueijeiro I, Pérez AC, Moses T, Seo M, Kanno Y, Häkkinen ST, Van Montagu MC, Thevelein JM, Maaheimo H, Oksman-Caldentey KM, Rodriguez PL, Rischer H, Goossens A.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5891-6. doi: 10.1073/pnas.1103010108. Epub 2011 Mar 21.

25.

Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro.

Aura AM, Mattila I, Hyötyläinen T, Gopalacharyulu P, Bounsaythip C, Orešič M, Oksman-Caldentey KM.

Mol Biosyst. 2011 Feb;7(2):437-46. doi: 10.1039/c0mb00023j. Epub 2010 Nov 8.

PMID:
21060933
26.

Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum.

Morita M, Shitan N, Sawada K, Van Montagu MC, Inzé D, Rischer H, Goossens A, Oksman-Caldentey KM, Moriyama Y, Yazaki K.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2447-52. doi: 10.1073/pnas.0812512106. Epub 2009 Jan 23.

27.

Production of recombinant allergens in plants.

Schmidt G, Gadermaier G, Pertl H, Siegert M, Oksman-Caldentey KM, Ritala A, Himly M, Obermeyer G, Ferreira F.

Phytochem Rev. 2008 Oct;7(3):539-552.

28.

Enzyme-assisted processing increases antimicrobial and antioxidant activity of bilberry.

Puupponen-Pimiä R, Nohynek L, Ammann S, Oksman-Caldentey KM, Buchert J.

J Agric Food Chem. 2008 Feb 13;56(3):681-8. doi: 10.1021/jf072001h. Epub 2008 Jan 23.

PMID:
18211029
29.

Functional characterisation of genes involved in pyridine alkaloid biosynthesis in tobacco.

Häkkinen ST, Tilleman S, Swiatek A, De Sutter V, Rischer H, Vanhoutte I, Van Onckelen H, Hilson P, Inzé D, Oksman-Caldentey KM, Goossens A.

Phytochemistry. 2007 Nov-Dec;68(22-24):2773-85. Epub 2007 Nov 14. Erratum in: Phytochemistry. 2008 Jul;69(10):2095.

PMID:
18001808
30.

Effects of processing on availability of total plant sterols, steryl ferulates and steryl glycosides from wheat and rye bran.

Nyström L, Lampi AM, Rita H, Aura AM, Oksman-Caldentey KM, Piironen V.

J Agric Food Chem. 2007 Oct 31;55(22):9059-65. Epub 2007 Oct 2.

PMID:
17907772
31.

Plants utilize isoprene emission as a thermotolerance mechanism.

Sasaki K, Saito T, Lämsä M, Oksman-Caldentey KM, Suzuki M, Ohyama K, Muranaka T, Ohara K, Yazaki K.

Plant Cell Physiol. 2007 Sep;48(9):1254-62. Epub 2007 Aug 21.

PMID:
17711876
32.
33.

Heterologous expression of Vitreoscilla haemoglobin in barley (Hordeum vulgare).

Wilhelmson A, Kallio PT, Oksman-Caldentey KM, Nuutila AM.

Plant Cell Rep. 2007 Oct;26(10):1773-83. Epub 2007 Jun 14.

PMID:
17569049
34.

Weakening of salmonella with selected microbial metabolites of berry-derived phenolic compounds and organic acids.

Alakomi HL, Puupponen-Pimiä R, Aura AM, Helander IM, Nohynek L, Oksman-Caldentey KM, Saarela M.

J Agric Food Chem. 2007 May 16;55(10):3905-12. Epub 2007 Apr 17.

PMID:
17439151
35.

Somaclonal variation in transformed roots and protoplast-derived hairy root clones of Hyoscyamus muticus.

Sevón N, Hiltunen R, Oksman-Caldentey KM.

Planta Med. 1998 Feb;64(1):37-41.

PMID:
17253215
36.

Development of in vitro techniques for the important medicinal plant Veratrum californicum.

Ma R, Ritala A, Oksman-Caldentey KM, Rischer H.

Planta Med. 2006 Oct;72(12):1142-8.

PMID:
17024590
37.

Biotransformation of hyoscyamine into scopolamine in transgenic tobacco cell cultures.

Moyano E, Palazón J, Bonfill M, Osuna L, Cusidó RM, Oksman-Caldentey KM, Piñol MT.

J Plant Physiol. 2007 Apr;164(4):521-4. Epub 2006 Aug 10.

PMID:
16904229
38.

Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens.

Nohynek LJ, Alakomi HL, Kähkönen MP, Heinonen M, Helander IM, Oksman-Caldentey KM, Puupponen-Pimiä RH.

Nutr Cancer. 2006;54(1):18-32.

PMID:
16800770
39.

Glycosylated F4 (K88) fimbrial adhesin FaeG expressed in barley endosperm induces ETEC-neutralizing antibodies in mice.

Joensuu JJ, Kotiaho M, Teeri TH, Valmu L, Nuutila AM, Oksman-Caldentey KM, Niklander-Teeri V.

Transgenic Res. 2006 Jun;15(3):359-73.

PMID:
16779651
40.

Heterologous expression of Vitreoscilla hemoglobin (VHb) and cultivation conditions affect the alkaloid profile of Hyoscyamus muticus hairy roots.

Wilhelmson A, Häkkinen ST, Kallio PT, Oksman-Caldentey KM, Nuutila AM.

Biotechnol Prog. 2006 Mar-Apr;22(2):350-8.

PMID:
16599546
41.

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells.

Rischer H, Oresic M, Seppänen-Laakso T, Katajamaa M, Lammertyn F, Ardiles-Diaz W, Van Montagu MC, Inzé D, Oksman-Caldentey KM, Goossens A.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5614-9. Epub 2006 Mar 24.

42.

The action of berry phenolics against human intestinal pathogens.

Puupponen-Pimiä R, Nohynek L, Alakomi HL, Oksman-Caldentey KM.

Biofactors. 2005;23(4):243-51. Review.

PMID:
16498212
43.

Unintended effects in genetically modified crops: revealed by metabolomics?

Rischer H, Oksman-Caldentey KM.

Trends Biotechnol. 2006 Mar;24(3):102-4. Epub 2006 Feb 7. Review.

PMID:
16460820
44.

F4 (K88) fimbrial adhesin FaeG expressed in alfalfa reduces F4+ enterotoxigenic Escherichia coli excretion in weaned piglets.

Joensuu JJ, Verdonck F, Ehrström A, Peltola M, Siljander-Rasi H, Nuutila AM, Oksman-Caldentey KM, Teeri TH, Cox E, Goddeeris BM, Niklander-Teeri V.

Vaccine. 2006 Mar 20;24(13):2387-94. Epub 2005 Dec 9.

PMID:
16378664
45.

Enhanced secretion of tropane alkaloids in Nicotiana tabacum hairy roots expressing heterologous hyoscyamine-6beta-hydroxylase.

Häkkinen ST, Moyano E, Cusidó RM, Palazón J, Piñol MT, Oksman-Caldentey KM.

J Exp Bot. 2005 Oct;56(420):2611-8. Epub 2005 Aug 16.

PMID:
16105856
46.

Integrating genomics and metabolomics for engineering plant metabolic pathways.

Oksman-Caldentey KM, Saito K.

Curr Opin Biotechnol. 2005 Apr;16(2):174-9. Review.

PMID:
15831383
47.

Berry phenolics selectively inhibit the growth of intestinal pathogens.

Puupponen-Pimiä R, Nohynek L, Hartmann-Schmidlin S, Kähkönen M, Heinonen M, Määttä-Riihinen K, Oksman-Caldentey KM.

J Appl Microbiol. 2005;98(4):991-1000.

48.

Expression of Vitreoscilla hemoglobin enhances growth of Hyoscyamus muticus hairy root cultures.

Wilhelmson A, Kallio PT, Oksman-Caldentey KM, Nuutila AM.

Planta Med. 2005 Jan;71(1):48-53.

PMID:
15678373
49.

Bioactive berry compounds-novel tools against human pathogens.

Puupponen-Pimiä R, Nohynek L, Alakomi HL, Oksman-Caldentey KM.

Appl Microbiol Biotechnol. 2005 Apr;67(1):8-18. Epub 2004 Dec 2. Review.

PMID:
15578177
50.

Anatalline and other methyl jasmonate-inducible nicotine alkaloids from Nicotiana tabacum cv. By-2 cell cultures.

Häkkinen ST, Rischer H, Laakso I, Maaheimo H, Seppänen-Laakso T, Oksman-Caldentey KM.

Planta Med. 2004 Oct;70(10):936-41.

PMID:
15490322

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