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Items: 1 to 50 of 95

1.

Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle-Aged Adults.

O'Grady JP, Dean DC 3rd, Yang KL, Canda CM, Hoscheidt SM, Starks EJ, Merluzzi A, Hurley S, Davenport NJ, Okonkwo OC, Anderson RM, Asthana S, Johnson SC, Alexander AL, Bendlin BB.

Obesity (Silver Spring). 2019 Sep;27(9):1464-1471. doi: 10.1002/oby.22558. Epub 2019 Jul 17.

PMID:
31314172
2.

Cardiorespiratory Fitness Modifies Influence of Sleep Problems on Cerebrospinal Fluid Biomarkers in an At-Risk Cohort.

Law LL, Sprecher KE, Dougherty RJ, Edwards DF, Koscik RL, Gallagher CL, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Hermann BP, Johnson SC, Cook DB, Bendlin BB, Okonkwo OC.

J Alzheimers Dis. 2019;69(1):111-121. doi: 10.3233/JAD-180291.

PMID:
30958346
3.

Leisure Activity, Brain β-amyloid, and Episodic Memory in Adults with Down Syndrome.

Mihaila I, Handen BL, Christian BT, Lao PJ, Cody KA, Klunk WE, Tudorascu DL, Cohen AD, Okonkwo OC, Hartley SL.

Dev Neurobiol. 2019 Mar 26. doi: 10.1002/dneu.22677. [Epub ahead of print]

PMID:
30912871
4.

KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD.

Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC.

Neurology. 2019 Apr 16;92(16):e1878-e1889. doi: 10.1212/WNL.0000000000007323. Epub 2019 Mar 13.

PMID:
30867273
5.

Fitness, independent of physical activity is associated with cerebral blood flow in adults at risk for Alzheimer's disease.

Dougherty RJ, Boots EA, Lindheimer JB, Stegner AJ, Van Riper S, Edwards DF, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Johnson SC, Okonkwo OC, Cook DB.

Brain Imaging Behav. 2019 Mar 9. doi: 10.1007/s11682-019-00068-w. [Epub ahead of print]

PMID:
30852709
6.

Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort.

Vesperman CJ, Pozorski V, Dougherty RJ, Law LL, Boots E, Oh JM, Gallagher CL, Carlsson CM, Rowley HA, Ma Y, Bendlin BB, Asthana S, Sager MA, Hermann BP, Johnson SC, Cook DB, Okonkwo OC.

Alzheimers Res Ther. 2018 Sep 24;10(1):97. doi: 10.1186/s13195-018-0429-0.

7.

Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer's Disease.

Hao L, Wang J, Page D, Asthana S, Zetterberg H, Carlsson C, Okonkwo OC, Li L.

Sci Rep. 2018 Jun 18;8(1):9291. doi: 10.1038/s41598-018-27031-x.

8.

Arterial spin labeling reveals relationships between resting cerebral perfusion and motor learning in Parkinson's disease.

Barzgari A, Sojkova J, Maritza Dowling N, Pozorski V, Okonkwo OC, Starks EJ, Oh J, Thiesen F, Wey A, Nicholas CR, Johnson S, Gallagher CL.

Brain Imaging Behav. 2019 Jun;13(3):577-587. doi: 10.1007/s11682-018-9877-1.

PMID:
29744796
9.

Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease.

Law LL, Rol RN, Schultz SA, Dougherty RJ, Edwards DF, Koscik RL, Gallagher CL, Carlsson CM, Bendlin BB, Zetterberg H, Blennow K, Asthana S, Sager MA, Hermann BP, Johnson SC, Cook DB, Okonkwo OC.

Alzheimers Dement (Amst). 2018 Feb 6;10:188-195. doi: 10.1016/j.dadm.2018.01.001. eCollection 2018.

10.

The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions.

Johnson SC, Koscik RL, Jonaitis EM, Clark LR, Mueller KD, Berman SE, Bendlin BB, Engelman CD, Okonkwo OC, Hogan KJ, Asthana S, Carlsson CM, Hermann BP, Sager MA.

Alzheimers Dement (Amst). 2017 Dec 8;10:130-142. doi: 10.1016/j.dadm.2017.11.007. eCollection 2018. Review.

11.

Social support and verbal interaction are differentially associated with cognitive function in midlife and older age.

Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2019 Mar;26(2):144-160. doi: 10.1080/13825585.2017.1414769. Epub 2017 Dec 15.

12.

An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria.

Dougherty RJ, Lindheimer JB, Stegner AJ, Van Riper S, Okonkwo OC, Cook DB.

J Alzheimers Dis. 2018;61(2):601-611. doi: 10.3233/JAD-170576.

13.

Pediatric advance care planning (pACP) for teens with cancer and their families: Design of a dyadic, longitudinal RCCT.

Curtin KB, Watson AE, Wang J, Okonkwo OC, Lyon ME.

Contemp Clin Trials. 2017 Nov;62:121-129. doi: 10.1016/j.cct.2017.08.016. Epub 2017 Aug 24.

14.

Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults.

Sprecher KE, Koscik RL, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Sager MA, Asthana S, Johnson SC, Benca RM, Bendlin BB.

Neurology. 2017 Aug 1;89(5):445-453. doi: 10.1212/WNL.0000000000004171. Epub 2017 Jul 5.

15.

Reliability of a Novel Social Activity Questionnaire: Perceived Social Support and Verbal Interaction in the Wisconsin Registry for Alzheimer's Prevention.

Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD.

J Aging Health. 2018 Feb;30(2):305-320. doi: 10.1177/0898264316674812. Epub 2016 Oct 24.

16.

Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer's Disease.

Dougherty RJ, Schultz SA, Kirby TK, Boots EA, Oh JM, Edwards D, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Johnson SC, Cook DB, Okonkwo OC.

J Alzheimers Dis. 2017;58(4):1089-1097. doi: 10.3233/JAD-161067.

17.

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC.

Neurology. 2017 May 30;88(22):2098-2106. doi: 10.1212/WNL.0000000000003980. Epub 2017 May 3.

18.

Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD.

Schultz SA, Boots EA, Darst BF, Zetterberg H, Blennow K, Edwards DF, Koscik RL, Carlsson CM, Gallagher CL, Bendlin BB, Asthana S, Sager MA, Hogan KJ, Hermann BP, Cook DB, Johnson SC, Engelman CD, Okonkwo OC.

Neurology. 2017 Apr 25;88(17):1650-1658. doi: 10.1212/WNL.0000000000003862. Epub 2017 Mar 24.

19.

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease.

Dougherty RJ, Schultz SA, Boots EA, Ellingson LD, Meyer JD, Van Riper S, Stegner AJ, Edwards DF, Oh JM, Einerson J, Korcarz CE, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Stein JH, Johnson SC, Okonkwo OC, Cook DB.

Brain Behav. 2017 Feb 17;7(3):e00625. doi: 10.1002/brb3.625. eCollection 2017 Mar.

20.

Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging.

Hoy AR, Ly M, Carlsson CM, Okonkwo OC, Zetterberg H, Blennow K, Sager MA, Asthana S, Johnson SC, Alexander AL, Bendlin BB.

PLoS One. 2017 Mar 14;12(3):e0173982. doi: 10.1371/journal.pone.0173982. eCollection 2017.

21.

Stemming the Alzheimer tsunami: introduction to the special issue on reserve and resilience in Alzheimer's disease.

Okonkwo OC, Vemuri P.

Brain Imaging Behav. 2017 Apr;11(2):301-303. doi: 10.1007/s11682-017-9677-z. No abstract available.

22.

Chronotropic Response and Cognitive Function in a Cohort at Risk for Alzheimer's Disease.

Law LL, Schultz SA, Boots EA, Einerson JA, Dougherty RJ, Oh JM, Korcarz CE, Edwards DF, Koscik RL, Dowling NM, Gallagher CL, Bendlin BB, Carlsson CM, Asthana S, Hermann BP, Sager MA, Johnson SC, Cook DB, Stein JH, Okonkwo OC.

J Alzheimers Dis. 2017;56(1):351-359. doi: 10.3233/JAD-160642.

23.

Intraindividual Cognitive Variability in Middle Age Predicts Cognitive Impairment 8-10 Years Later: Results from the Wisconsin Registry for Alzheimer's Prevention.

Koscik RL, Berman SE, Clark LR, Mueller KD, Okonkwo OC, Gleason CE, Hermann BP, Sager MA, Johnson SC.

J Int Neuropsychol Soc. 2016 Nov;22(10):1016-1025.

24.

Dementia Trends in the United States: Read Up and Weigh In.

Okonkwo OC, Asthana S.

JAMA Intern Med. 2017 Jan 1;177(1):58-60. doi: 10.1001/jamainternmed.2016.7073. No abstract available.

PMID:
27893015
25.

Paediatric airway foreign body - The human factors influencing patient safety in our hospitals.

Okonkwo OC, Simons A, Nichani J; North West ENT Research Collaborative.

Int J Pediatr Otorhinolaryngol. 2016 Dec;91:100-104. doi: 10.1016/j.ijporl.2016.10.016. Epub 2016 Oct 14.

PMID:
27863620
26.

Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD.

J Alzheimers Dis. 2017;55(2):473-484.

27.

Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease.

Dougherty RJ, Ellingson LD, Schultz SA, Boots EA, Meyer JD, Lindheimer JB, Van Riper S, Stegner AJ, Edwards DF, Oh JM, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Johnson SC, Okonkwo OC, Cook DB.

Alzheimers Dement (Amst). 2016 Apr 9;4:14-7. doi: 10.1016/j.dadm.2016.03.005. eCollection 2016.

28.

Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife.

Racine AM, Koscik RL, Berman SE, Nicholas CR, Clark LR, Okonkwo OC, Rowley HA, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Gleason CE, Carlsson CM, Johnson SC.

Brain. 2016 Aug;139(Pt 8):2261-74. doi: 10.1093/brain/aww142. Epub 2016 Jun 20.

29.

Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging.

Merluzzi AP, Dean DC 3rd, Adluru N, Suryawanshi GS, Okonkwo OC, Oh JM, Hermann BP, Sager MA, Asthana S, Zhang H, Johnson SC, Alexander AL, Bendlin BB.

Neurobiol Aging. 2016 Jul;43:79-88. doi: 10.1016/j.neurobiolaging.2016.03.026. Epub 2016 Apr 6.

30.

Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer's Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data.

Clark LR, Koscik RL, Nicholas CR, Okonkwo OC, Engelman CD, Bratzke LC, Hogan KJ, Mueller KD, Bendlin BB, Carlsson CM, Asthana S, Sager MA, Hermann BP, Johnson SC.

Arch Clin Neuropsychol. 2016 May 8. pii: acw024. [Epub ahead of print]

31.

On Statistical Analysis of Neuroimages with Imperfect Registration.

Kim WH, Ravi SN, Johnson SC, Okonkwo OC, Singh V.

Proc IEEE Int Conf Comput Vis. 2015 Dec;2015:666-674.

32.

Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation.

Racine AM, Koscik RL, Nicholas CR, Clark LR, Okonkwo OC, Oh JM, Hillmer AT, Murali D, Barnhart TE, Betthauser TJ, Gallagher CL, Rowley HA, Dowling NM, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Carlsson CM, Christian BT, Johnson SC.

Alzheimers Dement (Amst). 2016;2:27-38.

33.

Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition.

Ly M, Adluru N, Destiche DJ, Lu SY, Oh JM, Hoscheidt SM, Alexander AL, Okonkwo OC, Rowley HA, Sager MA, Johnson SC, Bendlin BB.

J Int Neuropsychol Soc. 2016 Feb;22(2):191-204. doi: 10.1017/S1355617715001216.

34.

Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease.

Melah KE, Lu SY, Hoscheidt SM, Alexander AL, Adluru N, Destiche DJ, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Gleason CE, Dowling NM, Bratzke LC, Rowley HA, Sager MA, Asthana S, Johnson SC, Bendlin BB.

J Alzheimers Dis. 2016;50(3):873-86. doi: 10.3233/JAD-150897.

35.

Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study.

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC.

Alzheimers Dement. 2016 Jul;12(7):805-14. doi: 10.1016/j.jalz.2015.12.009. Epub 2016 Jan 21.

36.

Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition.

Schultz SA, Boots EA, Almeida RP, Oh JM, Einerson J, Korcarz CE, Edwards DF, Koscik RL, Dowling MN, Gallagher CL, Bendlin BB, Christian BT, Zetterberg H, Blennow K, Carlsson CM, Asthana S, Hermann BP, Sager MA, Johnson SC, Stein JH, Okonkwo OC.

J Int Neuropsychol Soc. 2015 Nov;21(10):841-50. doi: 10.1017/S1355617715000843.

37.

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease.

Willette AA, Bendlin BB, Starks EJ, Birdsill AC, Johnson SC, Christian BT, Okonkwo OC, La Rue A, Hermann BP, Koscik RL, Jonaitis EM, Sager MA, Asthana S.

JAMA Neurol. 2015 Sep;72(9):1013-20. doi: 10.1001/jamaneurol.2015.0613. Erratum in: JAMA Neurol. 2015 Dec;72(12):1537. Erratum in: JAMA Neurol. 2017 Jul 1;74(7):873.

38.

Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Doherty BM, Schultz SA, Oh JM, Koscik RL, Dowling NM, Barnhart TE, Murali D, Gallagher CL, Carlsson CM, Bendlin BB, LaRue A, Hermann BP, Rowley HA, Asthana S, Sager MA, Christian BT, Johnson SC, Okonkwo OC.

Alzheimers Dement (Amst). 2015 Jun 1;1(2):160-169.

39.

Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease.

Boots EA, Schultz SA, Almeida RP, Oh JM, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Sager MA, Hermann BP, Johnson SC, Okonkwo OC.

Arch Clin Neuropsychol. 2015 Nov;30(7):634-42. doi: 10.1093/arclin/acv041. Epub 2015 Jul 8.

40.

Imaging-based enrichment criteria using deep learning algorithms for efficient clinical trials in mild cognitive impairment.

Ithapu VK, Singh V, Okonkwo OC, Chappell RJ, Dowling NM, Johnson SC; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2015 Dec;11(12):1489-1499. doi: 10.1016/j.jalz.2015.01.010. Epub 2015 Jun 18.

41.

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults.

Sprecher KE, Bendlin BB, Racine AM, Okonkwo OC, Christian BT, Koscik RL, Sager MA, Asthana S, Johnson SC, Benca RM.

Neurobiol Aging. 2015 Sep;36(9):2568-76. doi: 10.1016/j.neurobiolaging.2015.05.004. Epub 2015 May 14.

42.

Multi-resolution statistical analysis of brain connectivity graphs in preclinical Alzheimer's disease.

Kim WH, Adluru N, Chung MK, Okonkwo OC, Johnson SC, B Bendlin B, Singh V.

Neuroimage. 2015 Sep;118:103-17. doi: 10.1016/j.neuroimage.2015.05.050. Epub 2015 May 27.

43.

Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD.

Schultz SA, Oh JM, Koscik RL, Dowling NM, Gallagher CL, Carlsson CM, Bendlin BB, LaRue A, Hermann BP, Rowley HA, Asthana S, Sager MA, Johnson SC, Okonkwo OC.

Alzheimers Dement (Amst). 2015 Mar 1;1(1):33-40.

44.

Effect of Cognitive Reserve on Age-Related Changes in Cerebrospinal Fluid Biomarkers of Alzheimer Disease.

Almeida RP, Schultz SA, Austin BP, Boots EA, Dowling NM, Gleason CE, Bendlin BB, Sager MA, Hermann BP, Zetterberg H, Carlsson CM, Johnson SC, Asthana S, Okonkwo OC.

JAMA Neurol. 2015 Jun;72(6):699-706. doi: 10.1001/jamaneurol.2015.0098.

45.

Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOEɛ4 Carriers.

Starks EJ, Patrick O'Grady J, Hoscheidt SM, Racine AM, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Puglielli L, Asthana S, Dowling NM, Gleason CE, Anderson RM, Davenport-Sis NJ, DeRungs LM, Sager MA, Johnson SC, Bendlin BB.

J Alzheimers Dis. 2015;46(2):525-33. doi: 10.3233/JAD-150072.

46.

Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease.

Schultz SA, Larson J, Oh J, Koscik R, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Johnson SC, Sager M, LaRue A, Okonkwo OC.

Brain Imaging Behav. 2015 Dec;9(4):729-36. doi: 10.1007/s11682-014-9329-5.

47.

Posteromedial hyperactivation during episodic recognition among people with memory decline: findings from the WRAP study.

Nicholas CR, Okonkwo OC, Bendlin BB, Oh JM, Asthana S, Rowley HA, Hermann B, Sager MA, Johnson SC.

Brain Imaging Behav. 2015 Dec;9(4):690-702. doi: 10.1007/s11682-014-9322-z.

48.

Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease.

Boots EA, Schultz SA, Oh JM, Larson J, Edwards D, Cook D, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, LaRue A, Asthana S, Hermann BP, Sager MA, Johnson SC, Okonkwo OC.

Brain Imaging Behav. 2015 Sep;9(3):639-49. doi: 10.1007/s11682-014-9325-9.

49.

Physical activity attenuates age-related biomarker alterations in preclinical AD.

Okonkwo OC, Schultz SA, Oh JM, Larson J, Edwards D, Cook D, Koscik R, Gallagher CL, Dowling NM, Carlsson CM, Bendlin BB, LaRue A, Rowley HA, Christian BT, Asthana S, Hermann BP, Johnson SC, Sager MA.

Neurology. 2014 Nov 4;83(19):1753-60. doi: 10.1212/WNL.0000000000000964. Epub 2014 Oct 8. Erratum in: Neurology. 2015 Mar 3;84(9):963.

50.

At the crossroads of preclinical AD and normal brain ageing.

Okonkwo OC.

Lancet Neurol. 2014 Oct;13(10):965-6. doi: 10.1016/S1474-4422(14)70207-8. Epub 2014 Sep 4. No abstract available.

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