Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 36

1.

Pharmacokinetics and Organ Distribution of C-3 Alkyl Esters as Potential Antimycobacterial Prodrugs of Fusidic Acid.

Strydom N, Kaur G, Dziwornu GA, Okombo J, Wiesner L, Chibale K.

ACS Infect Dis. 2020 Mar 13;6(3):459-466. doi: 10.1021/acsinfecdis.9b00405. Epub 2020 Feb 3.

PMID:
32011859
2.

Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).

Cheuka PM, Dziwornu G, Okombo J, Chibale K.

J Med Chem. 2020 Jan 23. doi: 10.1021/acs.jmedchem.9b01622. [Epub ahead of print]

PMID:
31913032
3.

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.

Kim J, Tan YZ, Wicht KJ, Erramilli SK, Dhingra SK, Okombo J, Vendome J, Hagenah LM, Giacometti SI, Warren AL, Nosol K, Roepe PD, Potter CS, Carragher B, Kossiakoff AA, Quick M, Fidock DA, Mancia F.

Nature. 2019 Dec;576(7786):315-320. doi: 10.1038/s41586-019-1795-x. Epub 2019 Nov 27.

PMID:
31776516
4.

Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture.

Njoroge M, Kaur G, Espinoza-Moraga M, Wasuna A, Dziwornu GA, Seldon R, Taylor D, Okombo J, Warner DF, Chibale K.

ACS Infect Dis. 2019 Sep 13;5(9):1634-1644. doi: 10.1021/acsinfecdis.9b00208. Epub 2019 Jul 29.

PMID:
31309823
5.

Pyronaridine-Artesunate Shows Promise as an Effective and Well-Tolerated Treatment for Artemisinin-Resistant Plasmodium falciparum Malaria.

Okombo J, Fidock DA.

Clin Infect Dis. 2019 Jun 28. pii: ciz583. doi: 10.1093/cid/ciz583. [Epub ahead of print] No abstract available.

PMID:
31251323
6.

Antimalarial Pyrido[1,2- a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies.

Okombo J, Brunschwig C, Singh K, Dziwornu GA, Barnard L, Njoroge M, Wittlin S, Chibale K.

ACS Infect Dis. 2019 Mar 8;5(3):372-384. doi: 10.1021/acsinfecdis.8b00279. Epub 2019 Jan 17.

PMID:
30608648
7.

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.

Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates C, Wittlin S, Prudêncio M, Chibale K.

J Med Chem. 2019 Jan 24;62(2):1022-1035. doi: 10.1021/acs.jmedchem.8b01769. Epub 2018 Dec 24.

PMID:
30562027
8.

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.

Kumar M, Okombo J, Mambwe D, Taylor D, Lawrence N, Reader J, van der Watt M, Fontinha D, Sanches-Vaz M, Bezuidenhout BC, Lauterbach SB, Liebenberg D, Birkholtz LM, Coetzer TL, Prudêncio M, Egan TJ, Wittlin S, Chibale K.

ACS Infect Dis. 2019 Feb 8;5(2):303-315. doi: 10.1021/acsinfecdis.8b00272. Epub 2019 Jan 7.

PMID:
30525439
9.

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates.

Okombo J, Chibale K.

Medchemcomm. 2018 Mar 2;9(3):590. doi: 10.1039/c8md90009d. eCollection 2018 Mar 1.

10.

Recent updates in the discovery and development of novel antimalarial drug candidates.

Okombo J, Chibale K.

Medchemcomm. 2018 Feb 2;9(3):437-453. doi: 10.1039/c7md00637c. eCollection 2018 Mar 1. Review. Erratum in: Medchemcomm. 2018 Mar 2;9(3):590.

11.

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.

Joshi MC, Okombo J, Nsumiwa S, Ndove J, Taylor D, Wiesner L, Hunter R, Chibale K, Egan TJ.

J Med Chem. 2017 Dec 28;60(24):10245-10256. doi: 10.1021/acs.jmedchem.7b01537. Epub 2017 Dec 7.

PMID:
29185748
12.

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.

Okombo J, Chibale K.

Acc Chem Res. 2017 Jul 18;50(7):1606-1616. doi: 10.1021/acs.accounts.6b00631. Epub 2017 Jun 21.

13.

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine.

Dhingra SK, Redhi D, Combrinck JM, Yeo T, Okombo J, Henrich PP, Cowell AN, Gupta P, Stegman ML, Hoke JM, Cooper RA, Winzeler E, Mok S, Egan TJ, Fidock DA.

mBio. 2017 May 9;8(3). pii: e00303-17. doi: 10.1128/mBio.00303-17.

14.

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

Okombo J, Singh K, Mayoka G, Ndubi F, Barnard L, Njogu PM, Njoroge M, Gibhard L, Brunschwig C, Vargas M, Keiser J, Egan TJ, Chibale K.

ACS Infect Dis. 2017 Jun 9;3(6):411-420. doi: 10.1021/acsinfecdis.6b00205. Epub 2017 May 3.

PMID:
28440625
15.

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K.

J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7.

PMID:
28094524
16.

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.

Espinoza-Moraga M, Singh K, Njoroge M, Kaur G, Okombo J, De Kock C, Smith PJ, Wittlin S, Chibale K.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):658-661. doi: 10.1016/j.bmcl.2016.11.077. Epub 2016 Nov 25.

PMID:
28012840
17.

Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics.

Stringer T, De Kock C, Guzgay H, Okombo J, Liu J, Kanetake S, Kim J, Tam C, Cheng LW, Smith PJ, Hendricks DT, Land KM, Egan TJ, Smith GS.

Dalton Trans. 2016 Sep 14;45(34):13415-26. doi: 10.1039/c6dt02685k. Epub 2016 Aug 3.

PMID:
27485032
18.

Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population.

Ochola-Oyier LI, Okombo J, Wagatua N, Ochieng J, Tetteh KK, Fegan G, Bejon P, Marsh K.

Malar J. 2016 May 6;15(1):261. doi: 10.1186/s12936-016-1304-8.

19.

Malaria in the Era of Food Fortification With Folic Acid.

Nzila A, Okombo J, Hyde J.

Food Nutr Bull. 2016 Jun;37(2):153-63. doi: 10.1177/0379572116634511. Epub 2016 Mar 4. Review.

PMID:
26944505
20.

Antiplasmodial drug targets: a patent review (2000 - 2013).

Okombo J, Chibale K.

Expert Opin Ther Pat. 2016;26(1):107-30. doi: 10.1517/13543776.2016.1113258. Epub 2015 Nov 13. Review.

PMID:
26566576
21.

Chloroquine-containing compounds: a patent review (2010 - 2014).

Njaria PM, Okombo J, Njuguna NM, Chibale K.

Expert Opin Ther Pat. 2015;25(9):1003-24. doi: 10.1517/13543776.2015.1050791. Epub 2015 Jun 1. Review.

22.

The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya.

Ochola-Oyier LI, Okombo J, Mwai L, Kiara SM, Pole L, Tetteh KK, Nzila A, Marsh K.

Antimicrob Agents Chemother. 2015 Mar;59(3):1770-5. doi: 10.1128/AAC.03522-14. Epub 2014 Dec 22.

23.

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya.

Okombo J, Kamau AW, Marsh K, Sutherland CJ, Ochola-Oyier LI.

Int J Parasitol Drugs Drug Resist. 2014 Aug 7;4(3):152-63. doi: 10.1016/j.ijpddr.2014.07.003. eCollection 2014 Dec.

24.

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.

Wendler JP, Okombo J, Amato R, Miotto O, Kiara SM, Mwai L, Pole L, O'Brien J, Manske M, Alcock D, Drury E, Sanders M, Oyola SO, Malangone C, Jyothi D, Miles A, Rockett KA, MacInnis BL, Marsh K, Bejon P, Nzila A, Kwiatkowski DP.

PLoS One. 2014 May 8;9(5):e96486. doi: 10.1371/journal.pone.0096486. eCollection 2014.

25.

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya.

Borrmann S, Straimer J, Mwai L, Abdi A, Rippert A, Okombo J, Muriithi S, Sasi P, Kortok MM, Lowe B, Campino S, Assefa S, Auburn S, Manske M, Maslen G, Peshu N, Kwiatkowski DP, Marsh K, Nzila A, Clark TG.

Sci Rep. 2013 Nov 25;3:3318. doi: 10.1038/srep03318.

26.

Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.

Nzila A, Okombo J, Molloy AM.

J Antimicrob Chemother. 2014 Feb;69(2):323-30. doi: 10.1093/jac/dkt394. Epub 2013 Oct 14. Review.

PMID:
24126794
27.

Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.

Okombo J, Abdi AI, Kiara SM, Mwai L, Pole L, Sutherland CJ, Nzila A, Ochola-Oyier LI.

Antimicrob Agents Chemother. 2013 Dec;57(12):6196-204. doi: 10.1128/AAC.01465-13. Epub 2013 Sep 30.

28.

The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa.

Okombo J, Zongo I, Gadalla N, Bousema T, Beshir KB, Roper C, Hallett R, Ochola-Oyier LI, Sutherland CJ.

Antimicrob Agents Chemother. 2013 Sep;57(9):4595-8. doi: 10.1128/AAC.00455-13. Epub 2013 Jul 8.

29.

Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes.

Okombo J, Kiara SM, Abdirahman A, Mwai L, Ohuma E, Borrmann S, Nzila A, Ward S.

J Antimicrob Chemother. 2013 Apr;68(4):786-8. doi: 10.1093/jac/dks471. Epub 2012 Nov 20.

PMID:
23169890
30.

Update on the in vivo tolerance and in vitro reduced susceptibility to the antimalarial lumefantrine.

Nzila A, Okombo J, Ohuma E, Al-Thukair A.

J Antimicrob Chemother. 2012 Oct;67(10):2309-15. doi: 10.1093/jac/dks252. Epub 2012 Jul 2. Review.

PMID:
22761327
31.

Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.

Okombo J, Kiara SM, Mwai L, Pole L, Ohuma E, Ochola LI, Nzila A.

Antimicrob Agents Chemother. 2012 Feb;56(2):1105-7. doi: 10.1128/AAC.05454-11. Epub 2011 Nov 28.

32.

Update on genetic markers of quinine resistance in Plasmodium falciparum.

Okombo J, Ohuma E, Picot S, Nzila A.

Mol Biochem Parasitol. 2011 Jun;177(2):77-82. doi: 10.1016/j.molbiopara.2011.01.012. Epub 2011 Feb 1. Review.

PMID:
21295079
33.

In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.

Okombo J, Kiara SM, Rono J, Mwai L, Pole L, Ohuma E, Borrmann S, Ochola LI, Nzila A.

Antimicrob Agents Chemother. 2010 Aug;54(8):3302-7. doi: 10.1128/AAC.00325-10. Epub 2010 Jun 1.

34.

Probiotic-induced reduction of gastrointestinal oxalate absorption in healthy subjects.

Okombo J, Liebman M.

Urol Res. 2010 Jun;38(3):169-78. doi: 10.1007/s00240-010-0262-9. Epub 2010 Mar 12.

PMID:
20224931
35.

Anticancer agents against malaria: time to revisit?

Nzila A, Okombo J, Becker RP, Chilengi R, Lang T, Niehues T.

Trends Parasitol. 2010 Mar;26(3):125-9. doi: 10.1016/j.pt.2009.12.002. Epub 2010 Jan 6.

36.

In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.

Kiara SM, Okombo J, Masseno V, Mwai L, Ochola I, Borrmann S, Nzila A.

Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. doi: 10.1128/AAC.00308-09. Epub 2009 Jun 15.

Supplemental Content

Loading ...
Support Center