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Improving the estimation of the global burden of antimicrobial resistant infections.

Limmathurotsakul D, Dunachie S, Fukuda K, Feasey NA, Okeke IN, Holmes AH, Moore CE, Dolecek C, van Doorn HR, Shetty N, Lopez AD, Peacock SJ; Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC).

Lancet Infect Dis. 2019 Aug 16. pii: S1473-3099(19)30276-2. doi: 10.1016/S1473-3099(19)30276-2. [Epub ahead of print] Review.


Antimicrobial resistance of Vibrio cholerae from sub-Saharan Africa: A systematic review.

Mohammed Y, Aboderin AO, Okeke IN, Olayinka AT.

Afr J Lab Med. 2018 Dec 6;7(2):778. doi: 10.4102/ajlm.v7i2.778. eCollection 2018. Review.


The HPAfrica protocol: Assessment of health behaviour and population-based socioeconomic, hygiene behavioural factors - a standardised repeated cross-sectional study in multiple cohorts in sub-Saharan Africa.

Pak GD, Haselbeck AH, Seo HW, Osei I, Amuasi J, Breiman RF, Cruz Espinosa LM, Holm M, Im J, Jang GH, Jeon HJ, Luby SP, Lunguya-Metila O, MacWright W, Mogeni OD, Okeke IN, Owusu-Dabo E, Park JK, Park SE, Popoola O, Seo HJ, Soura AB, Teferi M, Toy T, Chon Y, Rafindrakalia M, Rakotozandrindrainy R, Meyer CG, Marks F, Panzner U.

BMJ Open. 2018 Dec 19;8(12):e021438. doi: 10.1136/bmjopen-2017-021438.


Antimicrobial resistance surveillance in Africa: Successes, gaps and a roadmap for the future.

Kariuki S, Keddy KH, Antonio M, Okeke IN.

Afr J Lab Med. 2018 Dec 6;7(2):924. doi: 10.4102/ajlm.v7i2.924. eCollection 2018. No abstract available.


Building resources to meet evolving laboratory medicine challenges in Africa.

Okeke IN.

Afr J Lab Med. 2018 Nov 29;7(1):915. doi: 10.4102/ajlm.v7i1.915. eCollection 2018. No abstract available.


Harnessing alternative sources of antimicrobial resistance data to support surveillance in low-resource settings.

Ashley EA, Shetty N, Patel J, van Doorn R, Limmathurotsakul D, Feasey NA, Okeke IN, Peacock SJ.

J Antimicrob Chemother. 2019 Mar 1;74(3):541-546. doi: 10.1093/jac/dky487.


Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC): Supporting the transition from strategy to action.

Fukuda K, Limmathurotsakul D, Okeke IN, Shetty N, van Doorn R, Feasey NA, Chiara F, Zoubiane G, Jinks T, Parkhill J, Patel J, Reid SWJ, Holmes AH, Peacock SJ; Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC).

Wellcome Open Res. 2018 May 16;3:59. doi: 10.12688/wellcomeopenres.14586.2. eCollection 2018.


Correction: Classes 1 and 2 integrons in faecal Escherichia coli strains isolated from mother-child pairs in Nigeria.

Odetoyin BW, Labar AS, Lamikanra A, Aboderin AO, Okeke IN.

PLoS One. 2018 May 7;13(5):e0197202. doi: 10.1371/journal.pone.0197202. eCollection 2018.


Aggregative Adherence and Intestinal Colonization by Enteroaggregative Escherichia coli Are Produced by Interactions among Multiple Surface Factors.

Blanton LV, Wang LT, Hofmann J, DuBow J, Lafrance A, Kwak S, Bowers L, Levine MA, Hale CO, Meneely PM, Okeke IN.

mSphere. 2018 Mar 21;3(2). pii: e00078-18. doi: 10.1128/mSphere.00078-18. eCollection 2018 Mar-Apr.


Honing in on disease etiology.

Okeke IN.

Afr J Lab Med. 2017 Dec 8;6(1):679. doi: 10.4102/ajlm.v6i1.679. eCollection 2017. No abstract available.


Laboratory systems as an antibacterial resistance containment tool in Africa.

Okeke IN.

Afr J Lab Med. 2016 Oct 31;5(3):497. doi: 10.4102/ajlm.v5i3.497. eCollection 2016. Review.


Classes 1 and 2 integrons in faecal Escherichia coli strains isolated from mother-child pairs in Nigeria.

Odetoyin BW, Labar AS, Lamikanra A, Aboderin AO, Okeke IN.

PLoS One. 2017 Aug 22;12(8):e0183383. doi: 10.1371/journal.pone.0183383. eCollection 2017. Erratum in: PLoS One. 2018 May 7;13(5):e0197202.


Characterization of a Large Antibiotic Resistance Plasmid Found in Enteropathogenic Escherichia coli Strain B171 and Its Relatedness to Plasmids of Diverse E. coli and Shigella Strains.

Hazen TH, Michalski J, Nagaraj S, Okeke IN, Rasko DA.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00995-17. doi: 10.1128/AAC.00995-17. Print 2017 Sep.


Broadening Participation in the Sciences within and from Africa: Purpose, Challenges, and Prospects.

Okeke IN, Babalola CP, Byarugaba DK, Djimde A, Osoniyi OR.

CBE Life Sci Educ. 2017 Summer;16(2). pii: es2. doi: 10.1187/cbe.15-12-0265.


Self-association motifs in the enteroaggregative Escherichia coli heat-resistant agglutinin 1.

Glaubman J, Hofmann J, Bonney ME, Park S, Thomas JM, Kokona B, Ramos Falcón LI, Chung YK, Fairman R, Okeke IN.

Microbiology. 2016 Jul;162(7):1091-102. doi: 10.1099/mic.0.000303. Epub 2016 May 10.


Fluoroquinolone-Resistant Enteric Bacteria in Sub-Saharan Africa: Clones, Implications and Research Needs.

Chattaway MA, Aboderin AO, Fashae K, Okoro CK, Opintan JA, Okeke IN.

Front Microbiol. 2016 Apr 22;7:558. doi: 10.3389/fmicb.2016.00558. eCollection 2016. Review.


Enteroinvasive Escherichia coli May Account for Uncultured Shigella.

Okeke IN, Aboderin AO, Opintan JA.

Am J Trop Med Hyg. 2016 Feb;94(2):480-481. doi: 10.4269/ajtmh.15-0777a. No abstract available.


Diarrhoeagenic Escherichia coli in mother-child Pairs in Ile-Ife, South Western Nigeria.

Odetoyin BW, Hofmann J, Aboderin AO, Okeke IN.

BMC Infect Dis. 2016 Jan 25;16:28. doi: 10.1186/s12879-016-1365-x.


Enteroaggregative Escherichia coli have evolved independently as distinct complexes within the E. coli population with varying ability to cause disease.

Chattaway MA, Jenkins C, Rajendram D, Cravioto A, Talukder KA, Dallman T, Underwood A, Platt S, Okeke IN, Wain J.

PLoS One. 2014 Nov 21;9(11):e112967. doi: 10.1371/journal.pone.0112967. eCollection 2014.


Dissemination of the transmissible quinolone-resistance gene qnrS1 by IncX plasmids in Nigeria.

Sumrall ET, Gallo EB, Aboderin AO, Lamikanra A, Okeke IN.

PLoS One. 2014 Oct 23;9(10):e110279. doi: 10.1371/journal.pone.0110279. eCollection 2014.


Diagnostic schemes for reducing epidemic size of African viral hemorrhagic fever outbreaks.

Okeke IN, Manning RS, Pfeiffer T.

J Infect Dev Ctries. 2014 Sep 12;8(9):1148-59. doi: 10.3855/jidc.4636.


Comparative genomics of 274 Vibrio cholerae genomes reveals mobile functions structuring three niche dimensions.

Dutilh BE, Thompson CC, Vicente AC, Marin MA, Lee C, Silva GG, Schmieder R, Andrade BG, Chimetto L, Cuevas D, Garza DR, Okeke IN, Aboderin AO, Spangler J, Ross T, Dinsdale EA, Thompson FL, Harkins TT, Edwards RA.

BMC Genomics. 2014 Aug 5;15:654. doi: 10.1186/1471-2164-15-654.


Antibiotics for uncomplicated severe malnutrition.

Okeke IN, Cruz JR, Keusch GT; Alliance for the Prudent Use of Antibiotics–Nutrition Group.

N Engl J Med. 2013 Jun 20;368(25):2435-6. doi: 10.1056/NEJMc1304407. No abstract available.


Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.

Marin MA, Thompson CC, Freitas FS, Fonseca EL, Aboderin AO, Zailani SB, Quartey NK, Okeke IN, Vicente AC.

PLoS Negl Trop Dis. 2013;7(2):e2049. doi: 10.1371/journal.pntd.0002049. Epub 2013 Feb 14.


Regional dissemination of a trimethoprim-resistance gene cassette via a successful transposable element.

Labar AS, Millman JS, Ruebush E, Opintan JA, Bishar RA, Aboderin AO, Newman MJ, Lamikanra A, Okeke IN.

PLoS One. 2012;7(5):e38142. doi: 10.1371/journal.pone.0038142. Epub 2012 May 30.


Prolonged febrile illness due to CTX-M-15 extended-spectrum β-lactamase-producing Klebsiella pneumoniae infection in Nigeria.

Aboderin OA, Adefehinti O, Odetoyin BW, Olotu AA, Okeke IN, Adeodu OO.

Afr J Lab Med. 2012 Jun 4;1(1):16. doi: 10.4102/ajlm.v1i1.16. eCollection 2012.


Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use.

Lamikanra A, Crowe JL, Lijek RS, Odetoyin BW, Wain J, Aboderin AO, Okeke IN.

BMC Infect Dis. 2011 Nov 7;11:312. doi: 10.1186/1471-2334-11-312.


Vibrio cholerae O1 lineages driving cholera outbreaks during seventh cholera pandemic in Ghana.

Thompson CC, Freitas FS, Marin MA, Fonseca EL, Okeke IN, Vicente AC.

Infect Genet Evol. 2011 Dec;11(8):1951-6. doi: 10.1016/j.meegid.2011.08.020. Epub 2011 Aug 30.


The heat-resistant agglutinin family includes a novel adhesin from enteroaggregative Escherichia coli strain 60A.

Mancini J, Weckselblatt B, Chung YK, Durante JC, Andelman S, Glaubman J, Dorff JD, Bhargava S, Lijek RS, Unger KP, Okeke IN.

J Bacteriol. 2011 Sep;193(18):4813-20. doi: 10.1128/JB.05142-11. Epub 2011 Jul 15.


Biomedical loopholes, distrusted state, and the politics of HIV/AIDS "cure" in Nigeria.

Obadare E, Okeke IN.

Afr Aff (Lond). 2011;110(439):191-211.


Enteroaggregative E. coli O104 from an outbreak of HUS in Germany 2011, could it happen again?

Chattaway MA, Dallman T, Okeke IN, Wain J.

J Infect Dev Ctries. 2011 Jul 4;5(6):425-36. Review.


Non-prescription antimicrobial use worldwide: a systematic review.

Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S.

Lancet Infect Dis. 2011 Sep;11(9):692-701. doi: 10.1016/S1473-3099(11)70054-8. Epub 2011 Jun 12. Review.


IS3 profiling identifies the enterohaemorrhagic Escherichia coli O-island 62 in a distinct enteroaggregative E. coli lineage.

Okeke IN, Macfarlane-Smith LR, Fletcher JN, Snelling AM.

Gut Pathog. 2011 Mar 30;3:4. doi: 10.1186/1757-4749-3-4.


Diagnostics as essential tools for containing antibacterial resistance.

Okeke IN, Peeling RW, Goossens H, Auckenthaler R, Olmsted SS, de Lavison JF, Zimmer BL, Perkins MD, Nordqvist K.

Drug Resist Updat. 2011 Apr;14(2):95-106. doi: 10.1016/j.drup.2011.02.002. Epub 2011 Mar 12. Review.


Quinolone resistance in Escherichia coli from Accra, Ghana.

Namboodiri SS, Opintan JA, Lijek RS, Newman MJ, Okeke IN.

BMC Microbiol. 2011 Feb 27;11:44. doi: 10.1186/1471-2180-11-44.


Drug Resistance.

Laxminarayan R, Bhutta Z, Duse A, Jenkins P, O'Brien T, Okeke IN, Pablo-Mendez A, Klugman KP.

In: Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P, editors. Disease Control Priorities in Developing Countries. 2nd edition. Washington (DC): World Bank; 2006. Chapter 55.


Multi-locus sequence typing of enteroaggregative Escherichia coli isolates from Nigerian children uncovers multiple lineages.

Okeke IN, Wallace-Gadsden F, Simons HR, Matthews N, Labar AS, Hwang J, Wain J.

PLoS One. 2010 Nov 23;5(11):e14093. doi: 10.1371/journal.pone.0014093.


When medicines fail: recommendations for curbing antibiotic resistance.

Nugent R, Okeke IN.

J Infect Dev Ctries. 2010 Jun 30;4(6):355-6. No abstract available.


A pathoadaptive deletion in an enteroaggregative Escherichia coli outbreak strain enhances virulence in a Caenorhabditis elegans model.

Hwang J, Mattei LM, VanArendonk LG, Meneely PM, Okeke IN.

Infect Immun. 2010 Sep;78(9):4068-76. doi: 10.1128/IAI.00014-10. Epub 2010 Jun 28.


African researchers underrepresented.

Okeke IN.

Science. 2010 May 28;328(5982):1103. doi: 10.1126/science.328.5982.1103-b. No abstract available.


Carriage of diarrhoeagenic Escherichia coli by older children and adults in Accra, Ghana.

Opintan JA, Bishar RA, Newman MJ, Okeke IN.

Trans R Soc Trop Med Hyg. 2010 Jul;104(7):504-6. doi: 10.1016/j.trstmh.2010.02.011. Epub 2010 Mar 21.


Genetic elements associated with antimicrobial resistance in enteropathogenic Escherichia coli (EPEC) from Brazil.

Scaletsky IC, Souza TB, Aranda KR, Okeke IN.

BMC Microbiol. 2010 Jan 27;10:25. doi: 10.1186/1471-2180-10-25.


The commonly-used DNA probe for diffusely-adherent Escherichia coli cross-reacts with a subset of enteroaggregative E. coli.

Snelling AM, Macfarlane-Smith LR, Fletcher JN, Okeke IN.

BMC Microbiol. 2009 Dec 21;9:269. doi: 10.1186/1471-2180-9-269.


Cholera vaccine will reduce antibiotic use.

Okeke IN.

Science. 2009 Aug 7;325(5941):674. doi: 10.1126/science.325_674b. No abstract available.


Heat-resistant agglutinin 1 is an accessory enteroaggregative Escherichia coli colonization factor.

Bhargava S, Johnson BB, Hwang J, Harris TA, George AS, Muir A, Dorff J, Okeke IN.

J Bacteriol. 2009 Aug;191(15):4934-42. doi: 10.1128/JB.01831-08. Epub 2009 May 29.


The Escherichia coli common pilus and the bundle-forming pilus act in concert during the formation of localized adherence by enteropathogenic E. coli.

Saldaña Z, Erdem AL, Schüller S, Okeke IN, Lucas M, Sivananthan A, Phillips AD, Kaper JB, Puente JL, Girón JA.

J Bacteriol. 2009 Jun;191(11):3451-61. doi: 10.1128/JB.01539-08. Epub 2009 Feb 13.


The plasmid-encoded regulator activates factors conferring lysozyme resistance on enteropathogenic Escherichia coli strains.

Salinger N, Kokona B, Fairman R, Okeke IN.

Appl Environ Microbiol. 2009 Jan;75(1):275-80. doi: 10.1128/AEM.01734-08. Epub 2008 Nov 7.


Vibrio cholerae O1 from Accra, Ghana carrying a class 2 integron and the SXT element.

Opintan JA, Newman MJ, Nsiah-Poodoh OA, Okeke IN.

J Antimicrob Chemother. 2008 Nov;62(5):929-33. doi: 10.1093/jac/dkn334. Epub 2008 Aug 27.


Post-genomic challenges for collaborative research in infectious diseases.

Okeke IN, Wain J.

Nat Rev Microbiol. 2008 Nov;6(11):858-64. doi: 10.1038/nrmicro1989. Epub 2008 Aug 19. Review.


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