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Items: 1 to 50 of 181

1.

Novel breast cancer screening: combined expression of miR-21 and MMP-1 in urinary exosomes detects 95% of breast cancer without metastasis.

Ando W, Kikuchi K, Uematsu T, Yokomori H, Takaki T, Sogabe M, Kohgo Y, Otori K, Ishikawa S, Okazaki I.

Sci Rep. 2019 Sep 19;9(1):13595. doi: 10.1038/s41598-019-50084-5.

2.

PD-1 aborts the activation trajectory of autoreactive CD8+ T cells to prohibit their acquisition of effector functions.

Okamura H, Okazaki IM, Shimizu K, Maruhashi T, Sugiura D, Mizuno R, Okazaki T.

J Autoimmun. 2019 Jul 2:102296. doi: 10.1016/j.jaut.2019.06.007. [Epub ahead of print]

3.

PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.

Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki IM, Okazaki T.

Front Immunol. 2019 Mar 29;10:630. doi: 10.3389/fimmu.2019.00630. eCollection 2019.

4.

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.

Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, Okazaki T.

Science. 2019 May 10;364(6440):558-566. doi: 10.1126/science.aav7062. Epub 2019 Apr 18.

PMID:
31000591
5.

PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.

Mizuno R, Maruhashi T, Sugiura D, Shimizu K, Watada M, Okazaki IM, Okazaki T.

Biochem Biophys Res Commun. 2019 Apr 9;511(3):491-497. doi: 10.1016/j.bbrc.2019.02.004. Epub 2019 Feb 14.

PMID:
30771904
6.

Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.

Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, Okazaki T.

J Biol Chem. 2019 Apr 12;294(15):6017-6026. doi: 10.1074/jbc.RA119.007455. Epub 2019 Feb 13.

PMID:
30760527
7.

LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.

Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, Okazaki T.

Nat Immunol. 2018 Dec;19(12):1415-1426. doi: 10.1038/s41590-018-0217-9. Epub 2018 Oct 22.

PMID:
30349037
8.

Serum matrix metalloproteinase-1 level represents disease activity as opposed to fibrosis in patients with histologically proven nonalcoholic steatohepatitis.

Ando W, Yokomori H, Tsutsui N, Yamanouchi E, Suzuki Y, Oda M, Inagaki Y, Otori K, Okazaki I.

Clin Mol Hepatol. 2018 Mar;24(1):61-76. doi: 10.3350/cmh.2017.0030. Epub 2017 Nov 20.

9.

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).

Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M.

J Autoimmun. 2018 Jan;86:75-92. doi: 10.1016/j.jaut.2017.09.006. Epub 2017 Sep 18.

10.

Hepatic progenitor cell expansion in early-stage nonalcoholic steatohepatitis: evidence from immunohistochemistry and immunoelectron microscopy of matrix metalloproteinase-1.

Yokomori H, Oda M, Ando W, Inagaki Y, Okazaki I.

Med Mol Morphol. 2017 Dec;50(4):238-242. doi: 10.1007/s00795-017-0162-y. Epub 2017 Jun 2. No abstract available.

PMID:
28577062
11.

Lung Adenocarcinoma in Never Smokers: Problems of Primary Prevention from Aspects of Susceptible Genes and Carcinogens.

Okazaki I, Ishikawa S, Ando W, Sohara Y.

Anticancer Res. 2016 Dec;36(12):6207-6224. Review.

PMID:
27919939
12.

Thrombophilia testing has limited usefulness in clinical decision-making and should be used selectively.

Masuda EM, Lee RW, Okazaki IJ, Benyamini P, Kistner RL.

J Vasc Surg Venous Lymphat Disord. 2015 Apr;3(2):228-35. doi: 10.1016/j.jvsv.2015.01.001. Epub 2015 Mar 13.

PMID:
26993845
13.

[Regulation of autoimmunity and tumor immunity by immunoinhibitory co-receptor, PD-1].

Okazaki T, Okazaki IM.

Seikagaku. 2015 Dec;87(6):693-704. Review. Japanese. No abstract available.

PMID:
26863747
14.

Primary rhabdomyosarcoma of the pineal gland.

Lau SK, Cykowski MD, Desai S, Cao Y, Fuller GN, Bruner J, Okazaki I.

Am J Clin Pathol. 2015 May;143(5):728-33. doi: 10.1309/AJCP9ZON4ZIHODIG. Review.

PMID:
25873508
15.

Genes associated with succeptibility to lung adenocarcinoma among never smokers suggest the mechanism of disease.

Okazaki I, Ishikawa S, Sohara Y.

Anticancer Res. 2014 Oct;34(10):5229-40. Review. Erratum in: Anticancer Res. 2015 Apr;35(4):2477.

PMID:
25275015
16.

Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs).

Okazaki I, Noro T, Tsutsui N, Yamanouchi E, Kuroda H, Nakano M, Yokomori H, Inagaki Y.

Cancers (Basel). 2014 Jun 27;6(3):1220-55. doi: 10.3390/cancers6031220.

17.

TRIM28 prevents autoinflammatory T cell development in vivo.

Chikuma S, Suita N, Okazaki IM, Shibayama S, Honjo T.

Nat Immunol. 2012 Apr 29;13(6):596-603. doi: 10.1038/ni.2293.

PMID:
22544392
18.

Novel Cancer-targeting Agents/Application Strategies Developed from MMP Science.

Okazaki I.

Anticancer Agents Med Chem. 2012 Jan 31. [Epub ahead of print] No abstract available.

PMID:
22292755
19.

Introduction: MMPs, ADAMs/ADAMTSs research products to achieve big dream.

Okazaki I, Nabeshima K.

Anticancer Agents Med Chem. 2012 Sep;12(7):688-706. Review.

PMID:
22292751
20.

Novel strategies for hepatocellular carcinoma based on MMPs science.

Okazaki I, Inagaki Y.

Anticancer Agents Med Chem. 2012 Sep;12(7):753-63. Review.

PMID:
22292750
21.

Matrix metalloproteinase-13 promotes recovery from experimental liver cirrhosis in rats.

Endo H, Niioka M, Sugioka Y, Itoh J, Kameyama K, Okazaki I, Ala-Aho R, Kähäri VM, Watanabe T.

Pathobiology. 2011;78(5):239-52. doi: 10.1159/000328841. Epub 2011 Aug 17.

22.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7920-5. doi: 10.1073/pnas.1104423108. Epub 2011 Apr 25.

23.

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.

Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F, Yoshida T, Kato Y, Fagarasan S, Muramatsu M, Eto T, Hioki K, Honjo T.

J Exp Med. 2011 Feb 14;208(2):395-407. doi: 10.1084/jem.20100466. Epub 2011 Feb 7.

24.

Additional candidates to conventional genes susceptible for lung cancer and changing trend in Japan.

Okazaki I, Sugita M, Matsuki H, Billah SM, Watanabe T.

Oncol Rep. 2010 Jun;23(6):1493-500. Review.

PMID:
20428802
25.

PD-1 deficiency results in the development of fatal myocarditis in MRL mice.

Wang J, Okazaki IM, Yoshida T, Chikuma S, Kato Y, Nakaki F, Hiai H, Honjo T, Okazaki T.

Int Immunol. 2010 Jun;22(6):443-52. doi: 10.1093/intimm/dxq026. Epub 2010 Apr 21.

PMID:
20410257
26.

ELISA measurement for urinary 3-hydroxyproline-containing peptides and its preliminary application to healthy persons and cancer patients.

Saito J, Imamura Y, Itoh J, Matsuyama S, Maruta A, Hayashi T, Sato A, Wada N, Kashiwazaki K, Inagaki Y, Watanabe T, Kitagawa Y, Okazaki I.

Anticancer Res. 2010 Mar;30(3):1007-14.

PMID:
20393028
27.

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.

Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22375-80. doi: 10.1073/pnas.0911879106. Epub 2009 Dec 11.

28.

Activation of two distinct MAPK pathways governs constitutive expression of matrix metalloproteinase-1 in human pancreatic cancer cell lines.

Endo H, Watanabe T, Sugioka Y, Niioka M, Inagaki Y, Okazaki I.

Int J Oncol. 2009 Dec;35(6):1237-45.

PMID:
19885545
29.

De novo synthesis, uptake and proteolytic processing of lipocalin-type prostaglandin D synthase, beta-trace, in the kidneys.

Nagata N, Fujimori K, Okazaki I, Oda H, Eguchi N, Uehara Y, Urade Y.

FEBS J. 2009 Dec;276(23):7146-58. doi: 10.1111/j.1742-4658.2009.07426.x. Epub 2009 Oct 29.

30.

Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.

Higashiyama R, Moro T, Nakao S, Mikami K, Fukumitsu H, Ueda Y, Ikeda K, Adachi E, Bou-Gharios G, Okazaki I, Inagaki Y.

Gastroenterology. 2009 Oct;137(4):1459-66.e1. doi: 10.1053/j.gastro.2009.07.006. Epub 2009 Jul 29.

PMID:
19596008
31.

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.

Int Immunol. 2009 Aug;21(8):947-55. doi: 10.1093/intimm/dxp061. Epub 2009 Jun 25.

PMID:
19556307
32.

Force-field parameters of the Psi and Phi around glycosidic bonds to oxygen and sulfur atoms.

Saito M, Okazaki I.

J Comput Chem. 2009 Dec;30(16):2656-65. doi: 10.1002/jcc.21245.

PMID:
19396813
33.

Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.

Jiang F, Yoshida T, Nakaki F, Terawaki S, Chikuma S, Kato Y, Okazaki IM, Honjo T, Okazaki T.

Int Immunol. 2009 May;21(5):499-509. doi: 10.1093/intimm/dxp020. Epub 2009 Mar 4.

PMID:
19261693
34.

Molecular mechanism for generation of antibody memory.

Shivarov V, Shinkura R, Doi T, Begum NA, Nagaoka H, Okazaki IM, Ito S, Nonaka T, Kinoshita K, Honjo T.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):569-75. doi: 10.1098/rstb.2008.0183. Review.

35.

A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.

Takai A, Toyoshima T, Uemura M, Kitawaki Y, Marusawa H, Hiai H, Yamada S, Okazaki IM, Honjo T, Chiba T, Kinoshita K.

Oncogene. 2009 Jan 29;28(4):469-78. doi: 10.1038/onc.2008.415. Epub 2008 Nov 10.

PMID:
18997814
36.

Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.

Morisawa T, Marusawa H, Ueda Y, Iwai A, Okazaki IM, Honjo T, Chiba T.

Int J Cancer. 2008 Dec 15;123(12):2735-40. doi: 10.1002/ijc.23853.

37.

Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis.

Moro T, Shimoyama Y, Kushida M, Hong YY, Nakao S, Higashiyama R, Sugioka Y, Inoue H, Okazaki I, Inagaki Y.

Life Sci. 2008 Oct 10;83(15-16):531-9. doi: 10.1016/j.lfs.2008.07.023. Epub 2008 Aug 16.

PMID:
18771671
38.

Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.

Inagaki Y, Higashi K, Kushida M, Hong YY, Nakao S, Higashiyama R, Moro T, Itoh J, Mikami T, Kimura T, Shiota G, Kuwabara I, Okazaki I.

Gastroenterology. 2008 Apr;134(4):1180-90. doi: 10.1053/j.gastro.2008.01.014. Epub 2008 Jan 11.

PMID:
18395096
39.

Autologous large multivalent immunogen vaccine in patients with metastatic melanoma and renal cell carcinoma.

Dudek AZ, Mescher MF, Okazaki I, Math VT, Luo X, Curtsinger JM, Miller JS.

Am J Clin Oncol. 2008 Apr;31(2):173-81. doi: 10.1097/COC.0b013e3181573e6b.

PMID:
18391603
40.

Treatment strategy for liver fibrosis through recruitment and differentiation of bone marrow stem/progenitor cells.

Inagaki Y, Higashiyama R, Okazaki I.

Hepatol Res. 2007 Dec;37(12):991-3. No abstract available.

PMID:
17976135
41.

Role of AID in tumorigenesis.

Okazaki IM, Kotani A, Honjo T.

Adv Immunol. 2007;94:245-73. Review.

PMID:
17560277
42.

Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling.

Endo Y, Marusawa H, Kinoshita K, Morisawa T, Sakurai T, Okazaki IM, Watashi K, Shimotohno K, Honjo T, Chiba T.

Oncogene. 2007 Aug 16;26(38):5587-95. Epub 2007 Apr 2.

PMID:
17404578
43.

Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.

Kanekiyo T, Ban T, Aritake K, Huang ZL, Qu WM, Okazaki I, Mohri I, Murayama S, Ozono K, Taniike M, Goto Y, Urade Y.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6412-7. Epub 2007 Apr 2.

44.

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.

Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, Azuma T, Okazaki IM, Honjo T, Chiba T.

Nat Med. 2007 Apr;13(4):470-6. Epub 2007 Apr 1.

PMID:
17401375
45.

Regulation of AID function in vivo.

Shinkura R, Okazaki IM, Muto T, Begum NA, Honjo T.

Adv Exp Med Biol. 2007;596:71-81. Review. No abstract available.

PMID:
17338177
46.

Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis.

Inagaki Y, Okazaki I.

Gut. 2007 Feb;56(2):284-92. Review. No abstract available.

48.

Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.

Kotani A, Kakazu N, Tsuruyama T, Okazaki IM, Muramatsu M, Kinoshita K, Nagaoka H, Yabe D, Honjo T.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1616-20. Epub 2007 Jan 24.

49.

Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice.

Higashiyama R, Inagaki Y, Hong YY, Kushida M, Nakao S, Niioka M, Watanabe T, Okano H, Matsuzaki Y, Shiota G, Okazaki I.

Hepatology. 2007 Jan;45(1):213-22.

PMID:
17187438
50.

Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.

Kou T, Marusawa H, Kinoshita K, Endo Y, Okazaki IM, Ueda Y, Kodama Y, Haga H, Ikai I, Chiba T.

Int J Cancer. 2007 Feb 1;120(3):469-76.

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