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Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.

McMahon KA, Wu Y, Gambin Y, Sierecki E, Tillu VA, Hall T, Martel N, Okano S, Moradi SV, Ruelcke JE, Ferguson C, Yap AS, Alexandrov K, Hill MM, Parton RG.

Nat Commun. 2019 Jul 22;10(1):3279. doi: 10.1038/s41467-019-11111-1.


A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition).

Head and Neck Cancer Study Group (HNCSG), Monden N, Asakage T, Kiyota N, Homma A, Matsuura K, Hanai N, Kodaira T, Zenda S, Fujii H, Tahara M, Yokota T, Akimoto T, Iwae S, Onitsuka T, Ogawa T, Okano S, Takahashi S, Shimizu Y, Yonezawa K, Hayashi R.

Jpn J Clin Oncol. 2019 Jun 13. pii: hyz052. doi: 10.1093/jjco/hyz052. [Epub ahead of print]


Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice.

Okano S, Yasui A, Kanno SI, Satoh K, Igarashi M, Nakajima O.

J Diabetes Res. 2019 Apr 24;2019:7234549. doi: 10.1155/2019/7234549. eCollection 2019.


Pilot prescription survey of antineoplastic agents: real-world data from veterinary teaching hospitals in Japan.

Tanaka N, Takizawa T, Tanaka R, Okano S, Funayama S, Iwasaki T.

Vet Med Sci. 2019 Aug;5(3):297-306. doi: 10.1002/vms3.173. Epub 2019 May 17.


Diabetes care - addressing psychological wellbeing in young adults with a newly developed assessment tooll.

Bachmeier CAE, O'Moore-Sullivan T, Barrett HL, D'Silva N, Vitanza M, Bowden T, d'Emden H, Waugh C, Okano S, Hurst C.

Intern Med J. 2019 May 13. doi: 10.1111/imj.14355. [Epub ahead of print]


The effect of a low carbohydrate formula on glycaemia in critically ill enterally-fed adult patients with hyperglycaemia: A blinded randomised feasibility trial.

Doola R, Deane AM, Tolcher DM, Presneill JJ, Barrett HL, Forbes JM, Todd AS, Okano S, Sturgess DJ.

Clin Nutr ESPEN. 2019 Jun;31:80-87. doi: 10.1016/j.clnesp.2019.02.013. Epub 2019 Mar 11.


Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers.

Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Okano S, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Kito M, Aoki K, Uemura T, Haniu H, Kato H, Saito N.

Onco Targets Ther. 2019 Apr 3;12:2513-2518. doi: 10.2147/OTT.S198421. eCollection 2019.


Therapeutic Potential of Pluripotent Stem Cells for Cardiac Repair after Myocardial Infarction.

Okano S, Shiba Y.

Biol Pharm Bull. 2019;42(4):524-530. doi: 10.1248/bpb.b18-00257. Review.


IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer.

Imai D, Yoshizumi T, Okano S, Itoh S, Ikegami T, Harada N, Aishima S, Oda Y, Maehara Y.

J Surg Res. 2019 Aug;240:115-123. doi: 10.1016/j.jss.2019.02.038. Epub 2019 Mar 27.


Biocompatibility of new low-cost (α + β)-type Ti-Mo-Fe alloys for long-term implantation.

Abdelrhman Y, Gepreel MA, Kobayashi S, Okano S, Okamoto T.

Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:552-562. doi: 10.1016/j.msec.2019.01.133. Epub 2019 Jan 31.


Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer.

Okano S, Enokida T, Onoe T, Ota Y, Motegi A, Zenda S, Akimoto T, Tahara M.

Int J Clin Oncol. 2019 Jul;24(7):789-797. doi: 10.1007/s10147-019-01418-w. Epub 2019 Feb 22.


Novel compound heterozygous CDH23 variants in a patient with Usher syndrome type I.

Okano S, Makita Y, Katada A, Harabuchi Y, Kohmoto T, Naruto T, Masuda K, Imoto I.

Hum Genome Var. 2019 Jan 28;6:8. doi: 10.1038/s41439-019-0037-y. eCollection 2019.


A Multicenter Phase II Trial of Docetaxel, Cisplatin, and Cetuximab (TPEx) Followed by Cetuximab and Concurrent Radiotherapy for Patients With Local Advanced Squamous Cell Carcinoma of the Head and Neck (CSPOR HN01: ECRIPS Study).

Zenda S, Ota Y, Kiyota N, Okano S, Fujii M, Kitamura M, Takahashi S, Ueda T, Monden N, Yamanaka T, Tahara M.

Front Oncol. 2019 Jan 22;9:6. doi: 10.3389/fonc.2019.00006. eCollection 2019.


Predictive Value of Cetuximab-Induced Skin Toxicity in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and NECK.

Uozumi S, Enokida T, Suzuki S, Nishizawa A, Kamata H, Okano T, Fujisawa T, Ueda Y, Okano S, Tahara M, Yamaguchi M.

Front Oncol. 2018 Dec 13;8:616. doi: 10.3389/fonc.2018.00616. eCollection 2018.


Antithrombotic properties of hemofilter coated with polymer having a hydrophilic blood-contacting layer.

Tagaya M, Hara K, Takahashi S, Nagoshi S, Handa H, Okano S, Murataka T.

Int J Artif Organs. 2019 Feb;42(2):88-94. doi: 10.1177/0391398818815480. Epub 2018 Nov 29.


Evaluation of fetal fibronectin for threatened preterm labour in reducing inappropriate interventions.

Mahomed K, Anwar S, Geer JE, Ballard E, Okano S.

Aust N Z J Obstet Gynaecol. 2019 Aug;59(4):523-527. doi: 10.1111/ajo.12914. Epub 2018 Nov 4.


Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells.

Kuroda C, Ueda K, Haniu H, Ishida H, Okano S, Takizawa T, Sobajima A, Kamanaka T, Yoshida K, Okamoto M, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.

Int J Nanomedicine. 2018 Oct 5;13:6079-6088. doi: 10.2147/IJN.S172493. eCollection 2018.


Paclitaxel Plus Cetuximab as 1st Line Chemotherapy in Platinum-Based Chemoradiotherapy-Refractory Patients With Squamous Cell Carcinoma of the Head and Neck.

Enokida T, Okano S, Fujisawa T, Ueda Y, Uozumi S, Tahara M.

Front Oncol. 2018 Aug 27;8:339. doi: 10.3389/fonc.2018.00339. eCollection 2018.


Introduction of a mandatory pre-block safety checklist into a regional anaesthesia block room service: a quality improvement project.

McLellan EJ, Hade AD, Pelecanos A, Okano S.

Anaesth Intensive Care. 2018 Sep;46(5):504-509.


What are the factors that contribute to the development of sexual dysfunction in breastfeeding women? A systematic scoping review protocol.

Fuentealba-Torres M, Cartagena-Ramos D, Sierra JC, Lara LA, Okano SP, Berra TZ, Alves LS, Leite ACAB, Yamamura M, Silva IA, Nascimento LC, Arcêncio RA.

BMJ Open. 2018 Aug 30;8(8):e022863. doi: 10.1136/bmjopen-2018-022863.


[IV. The Current State and Prospect of Drug Therapy - Treatment Development of Recent Years].

Fujisawa T, Okano S.

Gan To Kagaku Ryoho. 2018 Jul;45(7):1056-1060. Japanese. No abstract available.


Genitopatellar syndrome: the first reported case in Japan.

Okano S, Miyamoto A, Fukuda I, Tanaka H, Hata K, Kaname T, Matsubara Y, Makita Y.

Hum Genome Var. 2018 May 28;5:8. doi: 10.1038/s41439-018-0010-1. eCollection 2018.


Effect of Propofol Continuous-Rate Infusion on Intravenous Glucose Tolerance Test in Dogs.

Maeda K, Iwasaki M, Itou Y, Iwai S, Okano S.

Vet Sci. 2018 Apr 20;5(2). pii: E43. doi: 10.3390/vetsci5020043.


Influence of Trendelenburg position and pneumoperitoneum treatment on gastroesophageal reflux in dogs.

Park YT, Nogami M, Okano S.

Pol J Vet Sci. 2017 Dec;20(4):823-826. doi: 10.1515/pjvs-2017-0104.


Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab.

He X, Cruz JL, Joseph S, Pett N, Chew HY, Tuong ZK, Okano S, Kelly G, Veitch M, Simpson F, Wells JW.

Oncotarget. 2018 Jan 13;9(15):12250-12260. doi: 10.18632/oncotarget.24242. eCollection 2018 Feb 23.


Childhood leptospirosis in an industrialized country: Population-based study in Okinawa, Japan.

Tomari K, Toyokawa T, Takahashi T, Kakita T, Okano S, Kyan H, Tonegawa N, Okawa T, Matsuoka T, Matsumora T.

PLoS Negl Trop Dis. 2018 Mar 8;12(3):e0006294. doi: 10.1371/journal.pntd.0006294. eCollection 2018 Mar.


Myeloid-derived suppressor cells increase and inhibit donor-reactive T cell responses to graft intestinal epithelium in intestinal transplant patients.

Okano S, Abu-Elmagd K, Kish DD, Keslar K, Baldwin WM 3rd, Fairchild RL, Fujiki M, Khanna A, Osman M, Costa G, Fung J, Miller C, Kayashima H, Hashimoto K.

Am J Transplant. 2018 Oct;18(10):2544-2558. doi: 10.1111/ajt.14718. Epub 2018 Apr 17.


[A Case of Perforation Peritonitis with Multiple Duodenal and Intestinal Malignant Lymphomas].

Hatakeyama T, Sakai K, Matsumura A, Ogino S, Akami T, Okano S, Ueda Y, Mazak T.

Gan To Kagaku Ryoho. 2017 Nov;44(12):2023-2025. Japanese.


[Long-Term Disease-Free Survival by Curative Resection in a Case of Remnant Gastric Cancer with Peritoneal Recurrence].

Matsumura A, Hatakeyama T, Sakai K, Ogino S, Akami T, Okano S, Ueda Y, Mazaki T.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1967-1969. Japanese.


[A Case of Stage IV Breast Cancer with Extensive Metastasis Successfully Treated with S-1 plus Anastrozole Therapy].

Mugitani T, Hatakeyama T, Sakai T, Matsumura A, Ogino S, Akami T, Okano S.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1479-1481. Japanese.


5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice.

Saitoh S, Okano S, Nohara H, Nakano H, Shirasawa N, Naito A, Yamamoto M, Kelly VP, Takahashi K, Tanaka T, Nakajima M, Nakajima O.

PLoS One. 2018 Jan 24;13(1):e0189593. doi: 10.1371/journal.pone.0189593. eCollection 2018.


Congenital basal meningoceles with different outcomes: a case series.

Okano S, Tanaka R, Okayama A, Tsuchida E, Nohara F, Suzuki N, Okamoto T, Nagaya K, Takahashi S, Azuma H.

J Med Case Rep. 2017 Dec 27;11(1):359. doi: 10.1186/s13256-017-1497-7.


Evolution into moyamoya disease in an infant with internal carotid artery aneurysms.

Tanaka R, Takahashi S, Okano S, Okayama A, Suzuki N, Kure S, Azuma H.

eNeurologicalSci. 2017 Jan 31;6:80-82. doi: 10.1016/j.ensci.2017.01.002. eCollection 2017 Mar.


Titanium Fiber Plates for Bone Tissue Repair.

Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, Saito N.

Adv Mater. 2018 Jan;30(4). doi: 10.1002/adma.201703608. Epub 2017 Dec 7.


Immunochromatography test for rapid diagnosis of Mycoplasma pneumoniae infection.

Onari S, Okada T, Okada T, Okano S, Kakuta O, Kutsuma H, Kobayashi M, Kondo Y, Sakaguchi N, Tajima T, Nagao M, Nakayama E, Niimi R, Nishimura S, Higashidate Y, Hikita T, Meguro H, Mori T, Yoto Y, Tsutsumi H.

Pediatr Int. 2017 Oct;59(10):1123-1125. doi: 10.1111/ped.13383. Erratum in: Pediatr Int. 2018 Feb;60(2):206.


New Technology Mimics Physiologic Pulsatile Flow During Cardiopulmonary Bypass.

Sunagawa G, Karimov JH, Dessoffy R, Byram N, Grady P, Sinkewich M, Naber JP, Vincent D, Okano S, Stewart RD, Sale SM, Moazami N, Fukamachi K.

Artif Organs. 2018 Feb;42(2):231-235. doi: 10.1111/aor.12986. Epub 2017 Oct 27.


Feasibility of a Miniature Esophageal Heat Exchange Device for Rapid Therapeutic Cooling in Newborns: Preliminary Investigations in a Piglet Model.

Dingley J, Okano S, Planas S, Chakkarapani E.

Ther Hypothermia Temp Manag. 2018 Mar;8(1):36-44. doi: 10.1089/ther.2017.0028. Epub 2017 Oct 23.


Clinical significance of programmed cell death-ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high microsatellite instability.

Korehisa S, Oki E, Iimori M, Nakaji Y, Shimokawa M, Saeki H, Okano S, Oda Y, Maehara Y.

Int J Cancer. 2018 Feb 15;142(4):822-832. doi: 10.1002/ijc.31107. Epub 2017 Oct 31.


Real world data of a veterinary teaching hospital in Japan: a pilot survey of prescribed medicines.

Tanaka N, Takizawa T, Miyamoto N, Funayama S, Tanaka R, Okano S, Iwasaki T.

Vet Rec Open. 2017 Sep 26;4(1):e000218. doi: 10.1136/vetreco-2016-000218. eCollection 2017.


A novel histological examination with dynamic three-dimensional reconstruction from multiple immunohistochemically stained sections of a PD-L1-positive colon cancer.

Korehisa S, Ikeda T, Okano S, Saeki H, Oki E, Oda Y, Hashizume M, Maehara Y.

Histopathology. 2018 Mar;72(4):697-703. doi: 10.1111/his.13400. Epub 2017 Dec 13.


Protein Expression of Programmed Death 1 Ligand 1 and HER2 in Gastric Carcinoma.

Oki E, Okano S, Saeki H, Umemoto Y, Teraishi K, Nakaji Y, Ando K, Zaitsu Y, Yamashita N, Sugiyama M, Nakashima Y, Ohgaki K, Oda Y, Maehara Y.

Oncology. 2017;93(6):387-394. doi: 10.1159/000479231. Epub 2017 Sep 15.


Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model.

Ogasawara T, Okano S, Ichimura H, Kadota S, Tanaka Y, Minami I, Uesugi M, Wada Y, Saito N, Okada K, Kuwahara K, Shiba Y.

Sci Rep. 2017 Aug 17;7(1):8630. doi: 10.1038/s41598-017-09217-x.


Hemodialysis membrane coated with a polymer having a hydrophilic blood-contacting layer can enhance diffusional performance.

Tagaya M, Nagoshi S, Matsuda M, Takahashi S, Okano S, Hara K.

Int J Artif Organs. 2017 Nov 24;40(12):665-669. doi: 10.5301/ijao.5000631. Epub 2017 Aug 2.


Gemcitabine monotherapy in patients with heavily treated nasopharyngeal cancer: a case series.

Enokida T, Uozumi S, Fujisawa T, Ueda Y, Okano S, Tahara M.

Int J Clin Oncol. 2017 Dec;22(6):1009-1014. doi: 10.1007/s10147-017-1152-8. Epub 2017 Jun 14.


Retrospective analysis of premedication, glucocorticosteroids, and H1-antihistamines for preventing infusion reactions associated with cetuximab treatment of patients with head and neck cancer.

Ikegawa K, Suzuki S, Nomura H, Enokida T, Yamazaki T, Okano S, Endo K, Saito S, Yamaguchi M, Tahara M.

J Int Med Res. 2017 Aug;45(4):1378-1385. doi: 10.1177/0300060517713531. Epub 2017 Jun 12.


The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer.

Imai D, Yoshizumi T, Okano S, Uchiyama H, Ikegami T, Harimoto N, Itoh S, Soejima Y, Aishima S, Oda Y, Maehara Y.

Cancer Med. 2017 Jul;6(7):1614-1626. doi: 10.1002/cam4.1087. Epub 2017 Jun 10.


Association between preoperative characteristics and risk of anaesthesia-related death in dogs in small-animal referral hospitals in Japan.

Itami T, Aida H, Asakawa M, Fujii Y, Iizuka T, Imai A, Iseri T, Ishizuka T, Kakishima K, Kamata M, Miyabe-Nishiwaki T, Nagahama S, Naganobu K, Nishimura R, Okano S, Sano T, Yamashita K, Yamaya Y, Yanagawa M.

Vet Anaesth Analg. 2017 May;44(3):461-472. doi: 10.1016/j.vaa.2016.08.007. Epub 2017 Jan 11.


Programmed death-ligand 1 expression at tumor invasive front is associated with epithelial-mesenchymal transition and poor prognosis in esophageal squamous cell carcinoma.

Tsutsumi S, Saeki H, Nakashima Y, Ito S, Oki E, Morita M, Oda Y, Okano S, Maehara Y.

Cancer Sci. 2017 Jun;108(6):1119-1127. doi: 10.1111/cas.13237. Epub 2017 May 25.


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