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Treatment strategy and decision-making for elderly surgical candidates with early lung cancer.

Okami J.

J Thorac Dis. 2019 Apr;11(Suppl 7):S987-S997. doi: 10.21037/jtd.2019.04.01. Review.


Pulmonary carcinosarcoma characterized by small round cells with neuroendocrine, myogenic, and chondrogenic differentiation: An extremely rare case.

Nakamura H, Tamiya M, Sato Y, Tsuta K, Okami J, Nakatsuka SI.

Pathol Int. 2019 Mar 12. doi: 10.1111/pin.12780. [Epub ahead of print]


Upfront surgery in patients with clinical skip N2 lung cancer based on results of modern radiological examinations.

Maniwa T, Shintani Y, Okami J, Kadota Y, Takeuchi Y, Takami K, Yokouchi H, Kurokawa E, Kanzaki R, Sakamaki Y, Shiono H, Iwasaki T, Nishioka K, Kodama K, Okumura M; Thoracic Surgery Study Group of Osaka University (TSSGO).

J Thorac Dis. 2018 Dec;10(12):6828-6837. doi: 10.21037/jtd.2018.10.115.


High-throughput screening in colorectal cancer tissue-originated spheroids.

Kondo J, Ekawa T, Endo H, Yamazaki K, Tanaka N, Kukita Y, Okuyama H, Okami J, Imamura F, Ohue M, Kato K, Nomura T, Kohara A, Mori S, Dan S, Inoue M.

Cancer Sci. 2019 Jan;110(1):345-355. doi: 10.1111/cas.13843. Epub 2018 Nov 20.


Demographics, Safety and Quality, and Prognostic Information in Both the Seventh and Eighth Editions of the TNM Classification in 18,973 Surgical Cases of the Japanese Joint Committee of Lung Cancer Registry Database in 2010.

Okami J, Shintani Y, Okumura M, Ito H, Ohtsuka T, Toyooka S, Mori T, Watanabe SI, Date H, Yokoi K, Asamura H, Nagayasu T, Miyaoka E, Yoshino I; Japanese Joint Committee of Lung Cancer Registry.

J Thorac Oncol. 2019 Feb;14(2):212-222. doi: 10.1016/j.jtho.2018.10.002. Epub 2018 Oct 10.


Post-operative AICS status in completely resected lung cancer patients with pre-operative AICS abnormalities: predictive significance of disease recurrence.

Anayama T, Higashiyama M, Yamamoto H, Kikuchi S, Ikeda A, Okami J, Tokunaga T, Hirohashi K, Miyazaki R, Orihashi K.

Sci Rep. 2018 Aug 17;8(1):12378. doi: 10.1038/s41598-018-30685-2.


Surgical Treatment following Chemo-Targeted Therapy with Bevacizumab for Lung Metastasis from Colorectal Carcinoma: Analysis of Safety and Histological Therapeutic Effects in Patients Treated at a Single Institution.

Nakagiri T, Tokunaga T, Kunoh H, Noura S, Ishida H, Miyoshi N, Ohue M, Okami J, Higashiyama M.

Case Rep Oncol. 2018 Feb 9;11(1):98-108. doi: 10.1159/000486825. eCollection 2018 Jan-Apr.


HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1.

Kumagai T, Tomita Y, Nakatsuka SI, Kimura M, Kunimasa K, Inoue T, Tamiya M, Nishino K, Susaki Y, Kusu T, Tokunaga T, Okami J, Higashiyama M, Imamura F.

Thorac Cancer. 2018 Apr;9(4):466-471. doi: 10.1111/1759-7714.12609. Epub 2018 Feb 23.


Neoadjuvant and adjuvant therapy for Stage III non-small cell lung cancer.

Watanabe SI, Nakagawa K, Suzuki K, Takamochi K, Ito H, Okami J, Aokage K, Saji H, Yoshioka H, Zenke Y, Aoki T, Tsutani Y, Okada M; Lung Cancer Surgical Study Group (LCSSG) of the Japan Clinical Oncology Group (JCOG).

Jpn J Clin Oncol. 2017 Dec 1;47(12):1112-1118. doi: 10.1093/jjco/hyx147. Review.


Impact of in vitro chemosensitivity test-guided platinum-based adjuvant chemotherapy on the surgical outcomes of patients with p-stage IIIA non-small cell lung cancer that underwent complete resection.

Akazawa Y, Higashiyama M, Nishino K, Uchida J, Kumagai T, Inoue T, Fujiwara A, Tokunaga T, Okami J, Imamura F, Kodama K, Kobayashi H.

Mol Clin Oncol. 2017 Sep;7(3):327-335. doi: 10.3892/mco.2017.1340. Epub 2017 Jul 24.


Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer.

Kimura M, Imamura F, Inoue T, Nishino K, Uchida J, Kumagai T, Okami J, Higasiyama M, Kamoshida S.

Mol Clin Oncol. 2017 Jul;7(1):15-23. doi: 10.3892/mco.2017.1262. Epub 2017 May 16.


Randomized Study Comparing Equal Height Staples With Graduated Height Staples in Bronchial Closure.

Okami J, Tokunaga T, Kanou T, Kunou H, Ishida D, Fujiwara A, Ito Y, Higashiyama M.

Ann Thorac Surg. 2017 Sep;104(3):1012-1019. doi: 10.1016/j.athoracsur.2017.02.070. Epub 2017 May 24.


A prospective, multi-institutional phase II study of induction chemoradiotherapy followed by surgery in patients with non-small cell lung cancer involving the chest wall (CJLSG0801).

Kawaguchi K, Yokoi K, Niwa H, Ohde Y, Mori S, Okumura S, Shiono S, Ito H, Yano M, Shigemitsu K, Hiramatsu Y, Okami J, Saka H; Central Japan Lung Study Group.

Lung Cancer. 2017 Feb;104:79-84. doi: 10.1016/j.lungcan.2016.12.011. Epub 2016 Dec 21.


Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs.

Kukita Y, Okami J, Yoneda-Kato N, Nakamae I, Kawabata T, Higashiyama M, Kato J, Kodama K, Kato K.

Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001032.


Prophylactic middle lobe fixation for postoperative pulmonary torsion.

Higashiyama M, Tokunaga T, Kusu T, Ishida H, Okami J, Kodama K.

Asian Cardiovasc Thorac Ann. 2017 Jan;25(1):41-46. doi: 10.1177/0218492316682669. Epub 2016 Dec 5.


The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations.

Endo H, Okami J, Okuyama H, Nishizawa Y, Imamura F, Inoue M.

Oncogene. 2017 May 18;36(20):2824-2834. doi: 10.1038/onc.2016.431. Epub 2016 Nov 28.


Novel prognostic prediction models for patients with stage IV colorectal cancer after concurrent curative resection.

Miyoshi N, Ohue M, Yasui M, Noura S, Shingai T, Sugimura K, Akita H, Gotoh K, Marubashi S, Takahashi H, Okami J, Fujiwara Y, Higashiyama M, Yano M.

ESMO Open. 2016 May 23;1(3):e000052. eCollection 2016.


A phase II trial evaluating the efficacy and safety of perioperative pirfenidone for prevention of acute exacerbation of idiopathic pulmonary fibrosis in lung cancer patients undergoing pulmonary resection: West Japan Oncology Group 6711 L (PEOPLE Study).

Iwata T, Yoshino I, Yoshida S, Ikeda N, Tsuboi M, Asato Y, Katakami N, Sakamoto K, Yamashita Y, Okami J, Mitsudomi T, Yamashita M, Yokouchi H, Okubo K, Okada M, Takenoyama M, Chida M, Tomii K, Matsuura M, Azuma A, Iwasawa T, Kuwano K, Sakai S, Hiroshima K, Fukuoka J, Yoshimura K, Tada H, Nakagawa K, Nakanishi Y; West Japan Oncology Group.

Respir Res. 2016 Jul 22;17(1):90. doi: 10.1186/s12931-016-0398-4.


Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study.

Kakinuma R, Noguchi M, Ashizawa K, Kuriyama K, Maeshima AM, Koizumi N, Kondo T, Matsuguma H, Nitta N, Ohmatsu H, Okami J, Suehisa H, Yamaji T, Kodama K, Mori K, Yamada K, Matsuno Y, Murayama S, Murata K.

J Thorac Oncol. 2016 Jul;11(7):1012-28. doi: 10.1016/j.jtho.2016.04.006. Epub 2016 Apr 16.


Surgical resection of solitary omental metastasis from non-small cell lung cancer: Report of three cases.

Matsuda Y, Fujiwara Y, Kishi K, Okami J, Sugimura K, Motoori M, Miyoshi N, Noura S, Ohue M, Gotoh K, Marubashi S, Akita H, Takahashi H, Sakon M, Yano M.

Oncol Lett. 2016 Jan;11(1):563-567. Epub 2015 Nov 18.


[A Patient with Rectal Cancer and Multiple Lung Metastases Treated with XELOX plus Bevacizumab (Bev) Therapy].

Noura S, Ohue M, Miyoshi N, Yasui M, Sugimoto N, Okami J, Higashiyama M, Fujiwara Y, Yano M, Sakon M.

Gan To Kagaku Ryoho. 2015 Nov;42(12):2097-9. Japanese.


Clinicopathological characteristics and prognosis of stage IV colorectal cancer.

Miyoshi N, Ohue M, Shingai T, Noura S, Sugimura K, Akita H, Gotoh K, Motoori M, Takahashi H, Kishi K, Okami J, Marubashi S, Fujiwara Y, Higashiyama M, Yano M.

Mol Clin Oncol. 2015 Sep;3(5):1093-1098. Epub 2015 Jul 8.


Oncologic Outcomes of Segmentectomy Versus Lobectomy for Clinical T1a N0 M0 Non-Small Cell Lung Cancer.

Kodama K, Higashiyama M, Okami J, Tokunaga T, Imamura F, Nakayama T, Inoue A, Kuriyama K.

Ann Thorac Surg. 2016 Feb;101(2):504-11. doi: 10.1016/j.athoracsur.2015.08.063. Epub 2015 Nov 3.


Different spatial distributions of brain metastases from lung cancer by histological subtype and mutation status of epidermal growth factor receptor.

Takano K, Kinoshita M, Takagaki M, Sakai M, Tateishi S, Achiha T, Hirayama R, Nishino K, Uchida J, Kumagai T, Okami J, Kawaguchi A, Hashimoto N, Nakanishi K, Imamura F, Higashiyama M, Yoshimine T.

Neuro Oncol. 2016 May;18(5):716-24. doi: 10.1093/neuonc/nov266. Epub 2015 Oct 31.


Granulocyte-colony stimulating factor (G-CSF) producing malignant pleural mesothelioma: Report of a case.

Fujiwara A, Higashiyama M, Kanou T, Okami J, Tokunaga T, Tomita Y, Kodama K.

Thorac Cancer. 2015 Jan;6(1):105-9. doi: 10.1111/1759-7714.12140. Epub 2015 Jan 7.


Prognostic factors in patients with postoperative brain recurrence from completely resected non-small cell lung cancer.

Kanou T, Okami J, Tokunaga T, Ishida D, Kuno H, Higashiyama M.

Thorac Cancer. 2015 Jan;6(1):38-42. doi: 10.1111/1759-7714.12137. Epub 2015 Jan 7.


Pneumothorax triggered by the combination of gefitinib and amrubicin and treated with endobronchial silicone spigots.

Imamura F, Okamoto N, Inoue T, Uchida J, Nishino K, Kimura M, Kumagai T, Okami J.

Respir Med Case Rep. 2015 May 7;15:42-4. doi: 10.1016/j.rmcr.2015.02.007. eCollection 2015.


Pulmonary metastasectomy: outcomes and issues according to the type of surgical resection.

Higashiyama M, Tokunaga T, Nakagiri T, Ishida D, Kuno H, Okami J.

Gen Thorac Cardiovasc Surg. 2015 Jun;63(6):320-30. doi: 10.1007/s11748-015-0544-9. Epub 2015 Apr 3. Review.


Clinicopathological characteristics and lymph node metastasis pathway of non-small-cell lung cancer located in the left lingular division.

Shien K, Toyooka S, Soh J, Okami J, Higashiyama M, Kadota Y, Maeda H, Hayama M, Chida M, Funaki S, Okumura M, Miyoshi S.

Interact Cardiovasc Thorac Surg. 2015 Jun;20(6):791-6. doi: 10.1093/icvts/ivv062. Epub 2015 Mar 24.


A simple risk scoring system for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer patients.

Sato T, Kondo H, Watanabe A, Nakajima J, Niwa H, Horio H, Okami J, Okumura N, Sugio K, Teramukai S, Kishi K, Ebina M, Sugiyama Y, Kondo T, Date H.

Gen Thorac Cardiovasc Surg. 2015 Mar;63(3):164-72. doi: 10.1007/s11748-014-0487-6. Epub 2014 Oct 30.


Trimodality therapy for lung cancer with chest wall invasion: initial results of a phase II study.

Kawaguchi K, Yokoi K, Niwa H, Ohde Y, Mori S, Okumura S, Shiono S, Ito H, Yano M, Shigemitsu K, Hiramatsu Y, Okami J, Saito H.

Ann Thorac Surg. 2014 Oct;98(4):1184-91. doi: 10.1016/j.athoracsur.2014.05.022. Epub 2014 Aug 7.


Primary papillary carcinoma of the thymus with invasion into subcutaneous tissue through the sternum.

Ibuki Y, Okami J, Tomita Y, Fujiwara A, Kanou T, Tokunaga T, Higashiyama M.

J Cardiothorac Surg. 2014 May 2;9:77. doi: 10.1186/1749-8090-9-77.


Prognosis associated with surgery for non-small cell lung cancer and synchronous brain metastasis.

Kanou T, Okami J, Tokunaga T, Fujiwara A, Ishida D, Kuno H, Higashiyama M.

Surg Today. 2014 Jul;44(7):1321-7. doi: 10.1007/s00595-014-0895-3. Epub 2014 Apr 20.


Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement.

Fujiwara A, Higashiyama M, Kanou T, Tokunaga T, Okami J, Kodama K, Nishino K, Tomita Y, Okamoto I.

Lung Cancer. 2014 Feb;83(2):302-4. doi: 10.1016/j.lungcan.2013.11.022. Epub 2013 Dec 1.


Radiotherapy for postoperative thoracic lymph node recurrence of non-small-cell lung cancer provides better outcomes if the disease is asymptomatic and a single-station involvement.

Okami J, Nishiyama K, Fujiwara A, Konishi K, Kanou T, Tokunaga T, Teshima T, Higashiyama M.

J Thorac Oncol. 2013 Nov;8(11):1417-24. doi: 10.1097/JTO.0b013e3182a5097b.


Cytoreductive surgery and post-operative heated pleural chemotherapy for the management of pleural surface malignancy.

Kodama K, Higashiyama M, Okami J, Tokunaga T, Fujiwara A, Imamura F, Nakayama T.

Int J Hyperthermia. 2013 Nov;29(7):653-62. doi: 10.3109/02656736.2013.829247. Epub 2013 Sep 12.


Role of combined 18F-FDG-PET/CT for predicting the WHO malignancy grade of thymic epithelial tumors: a multicenter analysis.

Lococo F, Cesario A, Okami J, Cardillo G, Cavuto S, Tokunaga T, Apolone G, Margaritora S, Granone P.

Lung Cancer. 2013 Nov;82(2):245-51. doi: 10.1016/j.lungcan.2013.08.003. Epub 2013 Aug 13.


Pleural recurrence after surgery for pleomorphic adenoma arising from peripheral lung: computed tomography-guided percutaneous needle biopsy as a possible mechanism of local failure.

Tokunaga T, Kunou H, Ishida D, Kanou T, Okami J, Tomita Y, Higashiyama M.

Gen Thorac Cardiovasc Surg. 2015 Aug;63(8):478-82. doi: 10.1007/s11748-013-0310-9. Epub 2013 Aug 21.


[Exploratory thoracotomy (open lung biopsy) for peripheral lung nodule].

Higashiyama M, Tokunaga T, Kanou T, Fujiwara A, Ishida D, Okami J.

Nihon Geka Gakkai Zasshi. 2012 Nov;113(6):519-24. Japanese. No abstract available.


Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation.

Endo H, Okami J, Okuyama H, Kumagai T, Uchida J, Kondo J, Takehara T, Nishizawa Y, Imamura F, Higashiyama M, Inoue M.

J Thorac Oncol. 2013 Feb;8(2):131-9. doi: 10.1097/JTO.0b013e3182779ccf.


An accurate and rapid detection of lymph node metastasis in non-small cell lung cancer patients based on one-step nucleic acid amplification assay.

Inoue M, Hiyama K, Nakabayashi K, Morii E, Minami M, Sawabata N, Shintani Y, Nakagiri T, Susaki Y, Maeda J, Higashiyama M, Okami J, Yoshida Y, Ding J, Otomo Y, Okumura M.

Lung Cancer. 2012 Dec;78(3):212-8. doi: 10.1016/j.lungcan.2012.08.018. Epub 2012 Sep 29.


Surgical management of primary intrathoracic goiters.

Kanzaki R, Higashiyama M, Oda K, Okami J, Maeda J, Takenaka A, Tomita Y, Kodama K.

Gen Thorac Cardiovasc Surg. 2012 Mar;60(3):171-4. doi: 10.1007/s11748-011-0801-5. Epub 2012 Mar 15.


Differences in chemosensitivity between primary and paired metastatic lung cancer tissues: In vitro analysis based on the collagen gel droplet embedded culture drug test (CD-DST).

Higashiyama M, Okami J, Maeda J, Tokunaga T, Fujiwara A, Kodama K, Imamura F, Kobayashi H.

J Thorac Dis. 2012 Feb;4(1):40-7. doi: 10.3978/j.issn.2072-1439.2011.05.02.


Surgical treatment for gastrointestinal metastasis of non-small-cell lung cancer after pulmonary resection.

Fujiwara A, Okami J, Tokunaga T, Maeda J, Higashiyama M, Kodama K.

Gen Thorac Cardiovasc Surg. 2011 Nov;59(11):748-52. doi: 10.1007/s11748-011-0811-3. Epub 2011 Nov 15.


Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas.

Taniguchi K, Uchida J, Nishino K, Kumagai T, Okuyama T, Okami J, Higashiyama M, Kodama K, Imamura F, Kato K.

Clin Cancer Res. 2011 Dec 15;17(24):7808-15. doi: 10.1158/1078-0432.CCR-11-1712. Epub 2011 Oct 5.


Outcome of surgical resection for recurrent pulmonary metastasis from colorectal carcinoma.

Kanzaki R, Higashiyama M, Oda K, Fujiwara A, Tokunaga T, Maeda J, Okami J, Tanaka K, Shingai T, Noura S, Ohue M, Kodama K.

Am J Surg. 2011 Oct;202(4):419-26. doi: 10.1016/j.amjsurg.2010.08.016. Epub 2011 Aug 6.


Surgical resection of pulmonary metastases from meningioma: report of a case.

Kanzaki R, Higashiyama M, Fujiwara A, Tokunaga T, Maeda J, Okami J, Tomita Y, Kodama K.

Surg Today. 2011 Jul;41(7):995-8. doi: 10.1007/s00595-010-4409-7. Epub 2011 Jul 12.


Intrathoracic chemo-thermotherapy with radiofrequency waves after extrapleural pneumonectomy for malignant pleural mesothelioma.

Tokunaga T, Higashiyama M, Okami J, Maeda J, Fujiwara A, Kodama K.

Interact Cardiovasc Thorac Surg. 2011 Sep;13(3):267-70. doi: 10.1510/icvts.2011.270561. Epub 2011 Jun 15. Erratum in: Interact Cardiovasc Thorac Surg. 2011 Oct;13(4):460-1.


Indications and clinical benefits of mini-invasive parenchymal-sparing bronchoplastic procedures.

Lococo F, Okami J, Higashiyama M, Kodama K.

Interact Cardiovasc Thorac Surg. 2011 Apr;12(4):538-9. doi: 10.1510/icvts.2010.258228B. No abstract available.


[Simultaneous surgery for left lung cancer and the aneurysm of an aberrant left subclavian artery in a patient with right aortic arch].

Oda K, Kanzaki R, Fujiwara A, Maeda J, Okami J, Hiraishi T, Takami H, Higashiyama M, Kodama K.

Kyobu Geka. 2011 Mar;64(3):202-5. Japanese.


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