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Items: 1 to 50 of 122

1.

Time-resolved analysis of short term metabolic adaptation at dark transition in Synechocystis sp. PCC 6803.

Maruyama M, Nishiguchi H, Toyoshima M, Okahashi N, Matsuda F, Shimizu H.

J Biosci Bioeng. 2019 Apr 10. pii: S1389-1723(19)30167-7. doi: 10.1016/j.jbiosc.2019.03.016. [Epub ahead of print]

PMID:
30979614
2.

Sugar phosphate analysis with baseline separation and soft ionization by gas chromatography-negative chemical ionization-mass spectrometry improves flux estimation of bidirectional reactions in cancer cells.

Okahashi N, Maeda K, Kawana S, Iida J, Shimizu H, Matsuda F.

Metab Eng. 2019 Jan;51:43-49. doi: 10.1016/j.ymben.2018.08.011. Epub 2018 Sep 1.

PMID:
30176394
3.

Mass Spectrometry-Based Method to Study Inhibitor-Induced Metabolic Redirection in the Central Metabolism of Cancer Cells.

Araki C, Okahashi N, Maeda K, Shimizu H, Matsuda F.

Mass Spectrom (Tokyo). 2018;7(1):A0067. doi: 10.5702/massspectrometry.A0067. Epub 2018 Jun 14.

4.

Streptococcus sanguinis Noncoding cia-Dependent Small RNAs Negatively Regulate Expression of Type IV Pilus Retraction ATPase PilT and Biofilm Formation.

Ota C, Morisaki H, Nakata M, Arimoto T, Fukamachi H, Kataoka H, Masuda Y, Suzuki N, Miyazaki T, Okahashi N, Kuwata H.

Infect Immun. 2018 Feb 20;86(3). pii: e00894-17. doi: 10.1128/IAI.00894-17. Print 2018 Mar.

5.

Metabolic engineering of isopropyl alcohol-producing Escherichia coli strains with 13 C-metabolic flux analysis.

Okahashi N, Matsuda F, Yoshikawa K, Shirai T, Matsumoto Y, Wada M, Shimizu H.

Biotechnol Bioeng. 2017 Dec;114(12):2782-2793. doi: 10.1002/bit.26390. Epub 2017 Aug 17.

PMID:
28755490
6.

The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.

Kitajima S, Yoshida A, Kohno S, Li F, Suzuki S, Nagatani N, Nishimoto Y, Sasaki N, Muranaka H, Wan Y, Thai TC, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen ME, Barbie DA, Hirose O, Tanaka T, Takahashi C.

Oncogene. 2017 Sep 7;36(36):5145-5157. doi: 10.1038/onc.2017.124. Epub 2017 May 8.

PMID:
28481867
7.

Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide.

Sumioka R, Nakata M, Okahashi N, Li Y, Wada S, Yamaguchi M, Sumitomo T, Hayashi M, Kawabata S.

PLoS One. 2017 Feb 21;12(2):e0172223. doi: 10.1371/journal.pone.0172223. eCollection 2017.

8.

Microarray analysis of macrophage response to infection with Streptococcus oralis reveals the immunosuppressive effect of hydrogen peroxide.

Matsushima H, Kumagai Y, Vandenbon A, Kataoka H, Kadena M, Fukamachi H, Arimoto T, Morisaki H, Fujiwara N, Okahashi N, Kuwata H.

Biochem Biophys Res Commun. 2017 Apr 1;485(2):461-467. doi: 10.1016/j.bbrc.2017.02.048. Epub 2017 Feb 13.

9.

Possible assessment of coagulation function and haemostasis therapy using comprehensive coagulation assays in a patient with acquired haemophilia A.

Takeyama M, Nogami K, Matsumoto T, Taguchi M, Yada K, Okahashi N, Amano I, Kimura H, Shima M.

Haemophilia. 2017 Jan;23(1):e46-e50. doi: 10.1111/hae.13134. Epub 2016 Dec 8. No abstract available.

PMID:
27928869
10.

GC-MS/MS survey of collision-induced dissociation of tert-butyldimethylsilyl-derivatized amino acids and its application to (13)C-metabolic flux analysis of Escherichia coli central metabolism.

Okahashi N, Kawana S, Iida J, Shimizu H, Matsuda F.

Anal Bioanal Chem. 2016 Sep;408(22):6133-40. doi: 10.1007/s00216-016-9724-4. Epub 2016 Jun 24.

PMID:
27342798
11.

Investigation of useful carbon tracers for 13C-metabolic flux analysis of Escherichia coli by considering five experimentally determined flux distributions.

Maeda K, Okahashi N, Toya Y, Matsuda F, Shimizu H.

Metab Eng Commun. 2016 Jun 7;3:187-195. doi: 10.1016/j.meteno.2016.06.001. eCollection 2016 Dec.

12.

Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide.

Okahashi N, Nakata M, Kuwata H, Kawabata S.

Infect Immun. 2016 Jun 23;84(7):2042-2050. doi: 10.1128/IAI.00134-16. Print 2016 Jul.

13.

Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations.

Okahashi N, Kohno S, Kitajima S, Matsuda F, Takahashi C, Shimizu H.

J Biosci Bioeng. 2015 Dec;120(6):725-31. doi: 10.1016/j.jbiosc.2015.04.003. Epub 2015 Apr 27.

PMID:
25936961
14.

Absolute quantitation of glycolytic intermediates reveals thermodynamic shifts in Saccharomyces cerevisiae strains lacking PFK1 or ZWF1 genes.

Nishino S, Okahashi N, Matsuda F, Shimizu H.

J Biosci Bioeng. 2015 Sep;120(3):280-6. doi: 10.1016/j.jbiosc.2015.01.012. Epub 2015 Mar 16.

PMID:
25792186
15.

Cell wall-anchored nuclease of Streptococcus sanguinis contributes to escape from neutrophil extracellular trap-mediated bacteriocidal activity.

Morita C, Sumioka R, Nakata M, Okahashi N, Wada S, Yamashiro T, Hayashi M, Hamada S, Sumitomo T, Kawabata S.

PLoS One. 2014 Aug 1;9(8):e103125. doi: 10.1371/journal.pone.0103125. eCollection 2014.

16.

Reliable Metabolic Flux Estimation in Escherichia coli Central Carbon Metabolism Using Intracellular Free Amino Acids.

Okahashi N, Kajihata S, Furusawa C, Shimizu H.

Metabolites. 2014 May 30;4(2):408-20. doi: 10.3390/metabo4020408.

17.

Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028--for human safety in clinical study.

Nishizato Y, Imai S, Okahashi N, Yabunaka A, Kunimatsu T, Kikuchi K, Yabuki M.

Toxicol Appl Pharmacol. 2014 May 1;276(3):213-9. doi: 10.1016/j.taap.2014.02.016. Epub 2014 Mar 1.

PMID:
24593921
18.

Hydrogen peroxide contributes to the epithelial cell death induced by the oral mitis group of streptococci.

Okahashi N, Sumitomo T, Nakata M, Sakurai A, Kuwata H, Kawabata S.

PLoS One. 2014 Jan 31;9(1):e88136. doi: 10.1371/journal.pone.0088136. eCollection 2014.

19.

Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats.

Nishizato Y, Imai S, Yabunaka A, Okahashi N, Kunimatsu T, Yabuki M.

Toxicol In Vitro. 2014 Apr;28(3):397-402. doi: 10.1016/j.tiv.2013.12.005. Epub 2013 Dec 21.

PMID:
24362046
20.

Hydrogen peroxide produced by oral Streptococci induces macrophage cell death.

Okahashi N, Nakata M, Sumitomo T, Terao Y, Kawabata S.

PLoS One. 2013 May 3;8(5):e62563. doi: 10.1371/journal.pone.0062563. Print 2013.

21.

Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: comparison with RANKL-overexpressing transgenic male mice.

Koide M, Kobayashi Y, Ninomiya T, Nakamura M, Yasuda H, Arai Y, Okahashi N, Yoshinari N, Takahashi N, Udagawa N.

Endocrinology. 2013 Feb;154(2):773-82. doi: 10.1210/en.2012-1928. Epub 2013 Jan 4.

PMID:
23291450
22.

[Right ventricular myocardial infarction: feature of diagnosis and prognosis].

Okahashi N, Okura H.

Nihon Rinsho. 2011 Nov;69 Suppl 9:121-5. Japanese. No abstract available.

PMID:
22724188
23.

Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species.

Okahashi N, Okinaga T, Sakurai A, Terao Y, Nakata M, Nakashima K, Shintani S, Kawabata S, Ooshima T, Nishihara T.

FEMS Microbiol Lett. 2011 Oct;323(2):164-70. doi: 10.1111/j.1574-6968.2011.02375.x. Epub 2011 Sep 1.

24.

Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes.

Nakata M, Kimura KR, Sumitomo T, Wada S, Sugauchi A, Oiki E, Higashino M, Kreikemeyer B, Podbielski A, Okahashi N, Hamada S, Isoda R, Terao Y, Kawabata S.

J Biol Chem. 2011 Oct 28;286(43):37566-77. doi: 10.1074/jbc.M111.239780. Epub 2011 Aug 31.

25.

Novel epitopic region of glucosyltransferase B from Streptococcus mutans.

Hoshino T, Kondo Y, Saito K, Terao Y, Okahashi N, Kawabata S, Fujiwara T.

Clin Vaccine Immunol. 2011 Sep;18(9):1552-61. doi: 10.1128/CVI.05041-11. Epub 2011 Jul 27.

26.

Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation.

Okahashi N, Nakata M, Terao Y, Isoda R, Sakurai A, Sumitomo T, Yamaguchi M, Kimura RK, Oiki E, Kawabata S, Ooshima T.

Microb Pathog. 2011 Mar-Apr;50(3-4):148-54. doi: 10.1016/j.micpath.2011.01.005. Epub 2011 Jan 14.

PMID:
21238567
27.

Relationship between arterial and fibrous cap remodeling: a serial three-vessel intravascular ultrasound and optical coherence tomography study.

Yamada R, Okura H, Kume T, Saito K, Miyamoto Y, Imai K, Tsuchiya T, Maehama T, Okahashi N, Obase K, Hayashida A, Neishi Y, Kawamoto T, Yoshida K.

Circ Cardiovasc Interv. 2010 Oct;3(5):484-90. doi: 10.1161/CIRCINTERVENTIONS.109.928911. Epub 2010 Aug 24.

PMID:
20736445
28.

Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7.

Sakurai A, Maruyama F, Funao J, Nozawa T, Aikawa C, Okahashi N, Shintani S, Hamada S, Ooshima T, Nakagawa I.

J Biol Chem. 2010 Jul 16;285(29):22666-75. doi: 10.1074/jbc.M109.100131. Epub 2010 May 14.

29.

The predictivity of preliminary embryo-fetal development (EFD) studies: results of a retrospective survey in Japanese pharmaceutical companies.

Okahashi N, Ikeda T, Kai S, Komatsu S, Matsui H, Yamashita Y, Yamamoto K, Sagami F.

J Toxicol Sci. 2010 Feb;35(1):21-31.

30.

Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.

Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.

Biochem Biophys Res Commun. 2010 Jan 8;391(2):1192-6. doi: 10.1016/j.bbrc.2009.12.029. Epub 2009 Dec 14.

PMID:
20004645
31.

Portopulmonary hypertension associated with congenital absence of the portal vein treated with bosentan.

Hino T, Hayashida A, Okahashi N, Wada N, Watanabe N, Obase K, Neishi Y, Kawamoto T, Okura H, Yoshida K.

Intern Med. 2009;48(8):597-600. Epub 2009 Apr 15.

32.

Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13.

Sakurai A, Okahashi N, Maruyama F, Ooshima T, Hamada S, Nakagawa I.

Biochem Biophys Res Commun. 2008 Aug 29;373(3):450-4. doi: 10.1016/j.bbrc.2008.06.061. Epub 2008 Jun 27.

PMID:
18586009
33.

Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment.

Makiura N, Ojima M, Kou Y, Furuta N, Okahashi N, Shizukuishi S, Amano A.

Oral Microbiol Immunol. 2008 Aug;23(4):348-51. doi: 10.1111/j.1399-302X.2007.00426.x.

PMID:
18582336
34.

Porphyromonas gingivalis gingipains cause G(1) arrest in osteoblastic/stromal cells.

Kato T, Tsuda T, Inaba H, Kawai S, Okahashi N, Shibata Y, Abiko Y, Amano A.

Oral Microbiol Immunol. 2008 Apr;23(2):158-64. doi: 10.1111/j.1399-302X.2007.00405.x. Erratum in: Oral Microbiol Immunol. 2008 Oct;23(5):440.

PMID:
18279184
35.

Signaling pathways in osteoblast proinflammatory responses to infection by Porphyromonas gingivalis.

Ohno T, Okahashi N, Morisaki I, Amano A.

Oral Microbiol Immunol. 2008 Apr;23(2):96-104. doi: 10.1111/j.1399-302X.2007.00393.x.

PMID:
18279176
36.

Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction.

Kume T, Kawamoto T, Okura H, Toyota E, Neishi Y, Watanabe N, Hayashida A, Okahashi N, Yoshimura Y, Saito K, Nezuo S, Yamada R, Yoshida K.

Circ J. 2008 Jan;72(1):106-8.

37.

Three-dimensional quantitation of mitral valve coaptation by a novel software system with transthoracic real-time three-dimensional echocardiography.

Tsukiji M, Watanabe N, Yamaura Y, Okahashi N, Obase K, Neishi Y, Toyota E, Kawamoto T, Okura H, Ogasawara Y, Yoshida K.

J Am Soc Echocardiogr. 2008 Jan;21(1):43-6. Epub 2007 Jul 12.

PMID:
17628419
38.

Rapid progression of mild to moderate aortic stenosis in patients older than 80 years.

Kume T, Kawamoto T, Okura H, Watanabe N, Toyota E, Neishi Y, Okahashi N, Yamada R, Yoshida K.

J Am Soc Echocardiogr. 2007 Nov;20(11):1243-6. Epub 2007 Jun 25.

PMID:
17588711
39.

Rate of progression of valvular aortic stenosis in patients undergoing dialysis.

Kume T, Kawamoto T, Akasaka T, Watanabe N, Toyota E, Neishi Y, Wada N, Okahashi N, Yoshida K.

J Am Soc Echocardiogr. 2006 Jul;19(7):914-8.

PMID:
16825002
40.

Implantable cardioverter defibrillator therapy in a patient with cardiac amyloidosis.

Itoh M, Ohmori K, Yata K, Wada H, Tsuchiya T, Okahashi N, Hamanaka S, Yoshida K, Tanemoto K, Sugihara T.

Am J Hematol. 2006 Jul;81(7):560-1. No abstract available.

41.

Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis.

Ohno T, Okahashi N, Kawai S, Kato T, Inaba H, Shibata Y, Morisaki I, Abiko Y, Amano A.

Microbes Infect. 2006 Apr;8(4):1025-34. Epub 2006 Jan 18.

PMID:
16476562
42.

Effect of phenytoin on collagen accumulation by human gingival fibroblasts exposed to TNF-alpha in vitro.

Kato T, Okahashi N, Ohno T, Inaba H, Kawai S, Amano A.

Oral Dis. 2006 Mar;12(2):156-62.

PMID:
16476037
43.

Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin.

Kato T, Okahashi N, Kawai S, Kato T, Inaba H, Morisaki I, Amano A.

J Periodontol. 2005 Jun;76(6):941-50.

PMID:
15948689
44.

[A 54-year-old woman with general fatigue].

Okahashi N, Watanabe N, Kawamoto T, Akasaka T, Yoshida K.

J Cardiol. 2005 Jan;45(1):41-2. Japanese. No abstract available.

PMID:
15700929
45.

Odd-skipped related 2 splicing variants show opposite transcriptional activity.

Kawai S, Kato T, Inaba H, Okahashi N, Amano A.

Biochem Biophys Res Commun. 2005 Mar 4;328(1):306-11.

PMID:
15670784
46.

Lack of evidence for endocrine disrupting effects in rats exposed to fenitrothion in utero and from weaning to maturation.

Okahashi N, Sano M, Miyata K, Tamano S, Higuchi H, Kamita Y, Seki T.

Toxicology. 2005 Jan 5;206(1):17-31.

PMID:
15590106
47.

[Bilateral coronary ostial stenosis after aortic valve replacement with freestyle stentless bioprosthesis: a case report].

Tsukiji M, Akasaka T, Wada N, Okahashi N, Kume T, Yoshitani H, Neishi Y, Watanabe N, Yoshida K.

J Cardiol. 2004 Nov;44(5):207-13. Japanese.

PMID:
15584253
48.

Effect of enamel matrix derivative on periodontal ligament cells in vitro is diminished by Porphyromonas gingivalis.

Inaba H, Kawai S, Nakayama K, Okahashi N, Amano A.

J Periodontol. 2004 Jun;75(6):858-65.

PMID:
15295953
49.

Comparison of inflammatory changes caused by Porphyromonas gingivalis with distinct fimA genotypes in a mouse abscess model.

Nakano K, Kuboniwa M, Nakagawa I, Yamamura T, Nomura R, Okahashi N, Ooshima T, Amano A.

Oral Microbiol Immunol. 2004 Jun;19(3):205-9.

PMID:
15107074
50.

Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes.

Kuboniwa M, Amano A, Kimura KR, Sekine S, Kato S, Yamamoto Y, Okahashi N, Iida T, Shizukuishi S.

Oral Microbiol Immunol. 2004 Jun;19(3):168-76.

PMID:
15107068

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