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Lipid emulsion attenuates the vasodilation induced by a toxic dose of a calcium channel blocker through its partitioning into the lipid phase.

Ok SH, Lee SH, Kim HJ, Hong JM, Kim JY, Bae SI, Shin Y, Sohn JT.

Gen Physiol Biophys. 2019 May;38(3):227-235. doi: 10.4149/gpb_2019008.


Bupivacaine-induced contraction is attenuated by endothelial nitric oxide release modulated by activation of both stimulatory and inhibitory phosphorylation (Ser1177 and Thr495) of endothelial nitric oxide synthase.

Lee SH, Park CS, Ok SH, Kim D, Kim KN, Hong JM, Kim JY, Bae SI, An S, Sohn JT.

Eur J Pharmacol. 2019 Jun 15;853:121-128. doi: 10.1016/j.ejphar.2019.03.026. Epub 2019 Mar 15.


Levobupivacaine-induced vasoconstriction involves caldesmon phosphorylation mediated by tyrosine kinase-induced ERK phosphorylation.

Lee SH, Kwon SC, Ok SH, Hong JM, Kim JY, Ahn SH, Il Bae S, Shin Y, Sohn JT.

Eur J Pharmacol. 2019 Jan 5;842:167-176. doi: 10.1016/j.ejphar.2018.10.055. Epub 2018 Nov 2.


Lipid Emulsion Inhibits the Late Apoptosis/Cardiotoxicity Induced by Doxorubicin in Rat Cardiomyoblasts.

Subbarao RB, Ok SH, Lee SH, Kang D, Kim EJ, Kim JY, Sohn JT.

Cells. 2018 Sep 20;7(10). pii: E144. doi: 10.3390/cells7100144.


Linoleic Acid Attenuates the Toxic Dose of Bupivacaine-Mediated Reduction of Vasodilation Evoked by the Activation of Adenosine Triphosphate-Sensitive Potassium Channels.

Lee SH, Kang D, Ok SH, Kwon SC, Kim HJ, Kim EJ, Hong JM, Kim JY, Bae SI, An S, Sohn JT.

Int J Mol Sci. 2018 Jun 26;19(7). pii: E1876. doi: 10.3390/ijms19071876.


Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity.

Ok SH, Hong JM, Lee SH, Sohn JT.

Int J Med Sci. 2018 May 14;15(7):713-722. doi: 10.7150/ijms.22643. eCollection 2018. Review.


Amlodipine toxicity and lipid emulsion.

Ok SH, Sohn JT.

Korean J Anesthesiol. 2018 Dec;71(6):491-492. doi: 10.4097/kja.d.18.00126. Epub 2018 May 30. No abstract available.


Chronic Calf Pain Caused by Fibroma-Induced Chronic Inflammation Around the Tibial and Peroneal Nerves that Was Misdiagnosed as Centralized Neuropathic Pain: A Case Report.

Park J, Ok SH, Han JY, Park M, Seo EH, Kim YA.

Pain Pract. 2018 Jul;18(6):810-813. doi: 10.1111/papr.12676. Epub 2018 Feb 12.


Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.

Ok SH, Shin IW, Lee SH, Park J, Woo MS, Hong JM, Kim J, Sohn JT.

Hum Exp Toxicol. 2018 Jun;37(6):636-646. doi: 10.1177/0960327117721963. Epub 2017 Jul 25.


Dexmedetomidine Inhibits Phenylephrine-induced Contractions via Alpha-1 Adrenoceptor Blockade and Nitric Oxide Release in Isolated Rat Aortae.

Byon HJ, Ok SH, Lee SH, Kang S, Cho Y, Han JY, Sohn JT.

Int J Med Sci. 2017 Feb 7;14(2):143-149. doi: 10.7150/ijms.17456. eCollection 2017.


The Impact of 3D Stacking and Technology Scaling on the Power and Area of Stereo Matching Processors.

Ok SH, Lee YH, Shim JH, Lim SK, Moon B.

Sensors (Basel). 2017 Feb 22;17(2). pii: E426. doi: 10.3390/s17020426.


A Lipid Emulsion Reverses Toxic-Dose Bupivacaine-Induced Vasodilation during Tyrosine Phosphorylation-Evoked Contraction in Isolated Rat Aortae.

Ok SH, Lee SH, Kwon SC, Choi MH, Shin IW, Kang S, Park M, Hong JM, Sohn JT.

Int J Mol Sci. 2017 Feb 13;18(2). pii: E394. doi: 10.3390/ijms18020394.


Lipid Emulsion Inhibits Apoptosis Induced by a Toxic Dose of Verapamil via the Delta-Opioid Receptor in H9c2 Rat Cardiomyoblasts.

Ok SH, Choi MH, Shin IW, Lee SH, Kang S, Oh J, Han JY, Sohn JT.

Cardiovasc Toxicol. 2017 Jul;17(3):344-354. doi: 10.1007/s12012-016-9392-9.


Dexmedetomidine-Induced Contraction Involves CPI-17 Phosphorylation in Isolated Rat Aortas.

Ok SH, Kwon SC, Baik J, Hong JM, Oh J, Han JY, Sohn JT.

Int J Mol Sci. 2016 Sep 30;17(10). pii: E1663.


Mepivacaine attenuates vasodilation induced by ATP-sensitive potassium channels in rat aorta.

Baik J, Ok SH, Kim EJ, Kang D, Hong JM, Shin IW, Lee HK, Chung YK, Cho Y, Lee SH, Kang S, Sohn JT.

Can J Physiol Pharmacol. 2016 Nov;94(11):1211-1219. doi: 10.1139/cjpp-2016-0041. Epub 2016 Jul 5.


Effects of Acidification and Alkalinization on the Lipid Emulsion-Mediated Reversal of Toxic Dose Levobupivacaine-Induced Vasodilation in the Isolated Rat Aorta.

Ok SH, Kim WH, Yu J, Lee Y, Choi MJ, Lim DH, Hwang Y, Kim YA, Sohn JT.

Int J Med Sci. 2016 Jan 25;13(1):68-76. doi: 10.7150/ijms.13016. eCollection 2016.


Lipofundin® MCT/LCT 20% increase left ventricular systolic pressure in an ex vivo rat heart model via increase of intracellular calcium level.

Park J, Kim YA, Han JY, Jin S, Ok SH, Sohn JT, Lee HK, Chung YK, Shin IW.

Korean J Anesthesiol. 2016 Feb;69(1):57-62. doi: 10.4097/kjae.2016.69.1.57. Epub 2016 Jan 28.


Lipid Emulsion Inhibits Vasodilation Induced by a Toxic Dose of Bupivacaine via Attenuated Dephosphorylation of Myosin Phosphatase Target Subunit 1 in Isolated Rat Aorta.

Ok SH, Byon HJ, Kwon SC, Park J, Lee Y, Hwang Y, Baik J, Choi MJ, Sohn JT.

Int J Med Sci. 2015 Nov 5;12(12):958-67. doi: 10.7150/ijms.13299. eCollection 2015.


Association Between the Neutrophil/Lymphocyte Ratio and Acute Kidney Injury After Cardiovascular Surgery: A Retrospective Observational Study.

Kim WH, Park JY, Ok SH, Shin IW, Sohn JT.

Medicine (Baltimore). 2015 Oct;94(43):e1867. doi: 10.1097/MD.0000000000001867.


Lipid emulsion attenuates apoptosis induced by a toxic dose of bupivacaine in H9c2 rat cardiomyoblast cells.

Ok SH, Yu J, Lee Y, Cho H, Shin IW, Sohn JT.

Hum Exp Toxicol. 2016 Sep;35(9):929-37. doi: 10.1177/0960327115608930. Epub 2015 Oct 5.


Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation.

Yu J, Ok SH, Kim WH, Cho H, Park J, Shin IW, Lee HK, Chung YK, Choi MJ, Kwon SC, Sohn JT.

Int J Med Sci. 2015 Sep 4;12(9):727-36. doi: 10.7150/ijms.11952. eCollection 2015.


CML10, a variant of calmodulin, modulates ascorbic acid synthesis.

Cho KM, Nguyen HT, Kim SY, Shin JS, Cho DH, Hong SB, Shin JS, Ok SH.

New Phytol. 2016 Jan;209(2):664-78. doi: 10.1111/nph.13612. Epub 2015 Aug 28.


Lipid Emulsion Attenuates Acetylcholine-Induced Relaxation in Isolated Rat Aorta.

Ok SH, Lee SH, Yu J, Park J, Shin IW, Lee Y, Cho H, Choi MJ, Baik J, Hong JM, Han JY, Lee HK, Chung YK, Sohn JT.

Biomed Res Int. 2015;2015:871545. doi: 10.1155/2015/871545. Epub 2015 Jul 27.


Calcineurin B-like 3 calcium sensor associates with and inhibits 5'-methylthioadenosine nucleosidase 2 in Arabidopsis.

Ok SH, Cho JH, Oh SI, Choi MN, Ma JY, Shin JS, Kim KN.

Plant Sci. 2015 Sep;238:228-40. doi: 10.1016/j.plantsci.2015.06.016. Epub 2015 Jun 23.


Anesthetic management for percutaneous computed tomography-guided radiofrequency ablation of reninoma: a case report.

Gil NS, Han JY, Ok SH, Shin IW, Lee HK, Chung YK, Sohn JT.

Korean J Anesthesiol. 2015 Feb;68(1):78-82. doi: 10.4097/kjae.2015.68.1.78. Epub 2015 Jan 28.


Mepivacaine-induced intracellular calcium increase appears to be mediated primarily by calcium influx in rat aorta without endothelium.

Ok SH, Kwon SC, Kang S, Choi MJ, Sohn JT.

Korean J Anesthesiol. 2014 Dec;67(6):404-11. doi: 10.4097/kjae.2014.67.6.404. Epub 2014 Dec 29.


Dexmedetomidine-induced contraction involves phosphorylation of caldesmon by JNK in endothelium-denuded rat aortas.

Baik J, Ok SH, Cho H, Yu J, Kim W, Nam IK, Choi MJ, Lee HK, Sohn JT.

Int J Biol Sci. 2014 Sep 21;10(10):1108-15. doi: 10.7150/ijbs.9797. eCollection 2014.


Dexmedetomidine-induced contraction involves c-Jun NH2 -terminal kinase phosphorylation through activation of the 5-lipoxygenase pathway in the isolated endothelium-denuded rat aorta.

Ok SH, Byon HJ, Jin H, Kim HJ, Kim W, Nam IK, Eun SY, Sohn JT.

Clin Exp Pharmacol Physiol. 2014 Dec;41(12):1014-22. doi: 10.1111/1440-1681.12307.


Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine.

Ok SH, Bae SI, Kwon SC, Park JC, Kim WC, Park KE, Shin IW, Lee HK, Chung YK, Choi MJ, Sohn JT.

Korean J Pain. 2014 Jul;27(3):229-38. doi: 10.3344/kjp.2014.27.3.229. Epub 2014 Jun 30.


Systemic blockage of nitric oxide synthase by L-NAME increases left ventricular systolic pressure, which is not augmented further by Intralipid®.

Shin IW, Hah YS, Kim C, Park J, Shin H, Park KE, Ok SH, Lee HK, Chung YK, Shim HS, Lim DH, Sohn JT.

Int J Biol Sci. 2014 Mar 18;10(4):367-76. doi: 10.7150/ijbs.8048. eCollection 2014.


Delayed recovery from paralysis by succinylcholine in patient with preoperatively unrecognized and inherited pseudocholinesterase deficiency.

Ok SH, Woo MK, Kim CG, Hwang I, Sohn JT.

Korean J Anesthesiol. 2013 Dec;65(6 Suppl):S19-20. doi: 10.4097/kjae.2013.65.6S.S19. No abstract available.


Ropivacaine-induced contraction is attenuated by both endothelial nitric oxide and voltage-dependent potassium channels in isolated rat aortae.

Ok SH, Han JY, Sung HJ, Yang SM, Park J, Kwon SC, Choi MJ, Sohn JT.

Biomed Res Int. 2013;2013:565271. doi: 10.1155/2013/565271. Epub 2013 Nov 20.


Mepivacaine-induced contraction involves increased calcium sensitization mediated via Rho kinase and protein kinase C in endothelium-denuded rat aorta.

Ok SH, Kwon SC, Yeol Han J, Yu J, Shin IW, Lee HK, Chung YK, Choi MJ, Sohn JT.

Eur J Pharmacol. 2014 Jan 15;723:185-93. doi: 10.1016/j.ejphar.2013.11.040. Epub 2013 Dec 12.


Lipid emulsions enhance the norepinephrine-mediated reversal of local anesthetic-induced vasodilation at toxic doses.

Lee SH, Sung HJ, Ok SH, Yu J, Choi MJ, Lim JS, Sohn JT.

Yonsei Med J. 2013 Nov;54(6):1524-32. doi: 10.3349/ymj.2013.54.6.1524.


Effect of two lipid emulsions on reversing high-dose levobupivacaine-induced reduced vasoconstriction in the rat aortas.

Ok SH, Park CS, Kim HJ, Lee SH, Choi BH, Eun SY, Kim KN, Yang SM, Shin IW, Choi MJ, Sohn JT.

Cardiovasc Toxicol. 2013 Dec;13(4):370-80. doi: 10.1007/s12012-013-9218-y.


An Arabidopsis R2R3-MYB transcription factor, AtMYB20, negatively regulates type 2C serine/threonine protein phosphatases to enhance salt tolerance.

Cui MH, Yoo KS, Hyoung S, Nguyen HT, Kim YY, Kim HJ, Ok SH, Yoo SD, Shin JS.

FEBS Lett. 2013 Jun 19;587(12):1773-8. doi: 10.1016/j.febslet.2013.04.028. Epub 2013 May 6.


Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta.

Ok SH, Han JY, Lee SH, Shin IW, Lee HK, Chung YK, Choi MJ, Sohn JT.

Korean J Anesthesiol. 2013 Apr;64(4):353-9. doi: 10.4097/kjae.2013.64.4.353. Epub 2013 Apr 22.


Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle.

Lee HM, Ok SH, Sung HJ, Eun SY, Kim HJ, Lee SH, Kang S, Shin IW, Lee HK, Chung YK, Choi MJ, Bae SI, Sohn JT.

Can J Physiol Pharmacol. 2013 Apr;91(4):285-94. doi: 10.1139/cjpp-2012-0197. Epub 2013 Jan 2.


A cystathionine-β-synthase domain-containing protein, CBSX2, regulates endothecial secondary cell wall thickening in anther development.

Jung KW, Kim YY, Yoo KS, Ok SH, Cui MH, Jeong BC, Yoo SD, Jeung JU, Shin JS.

Plant Cell Physiol. 2013 Feb;54(2):195-208. doi: 10.1093/pcp/pcs166. Epub 2012 Dec 6.


An Arabidopsis cell growth defect factor-related protein, CRS, promotes plant senescence by increasing the production of hydrogen peroxide.

Cui MH, Ok SH, Yoo KS, Jung KW, Yoo SD, Shin JS.

Plant Cell Physiol. 2013 Jan;54(1):155-67. doi: 10.1093/pcp/pcs161. Epub 2012 Dec 4.


Phantom bladder pain.

Park KE, Cheon KS, Ok SH, Jeong YJ, Lee HK.

Korean J Anesthesiol. 2012 Oct;63(4):376-7. doi: 10.4097/kjae.2012.63.4.376. Epub 2012 Oct 12. No abstract available.


Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration.

Ok SH, Bae SI, Shim HS, Sohn JT.

Korean J Anesthesiol. 2012 Sep;63(3):253-9. doi: 10.4097/kjae.2012.63.3.253. Epub 2012 Sep 14.


A Patient with Kikuchi's Disease: What Should Pain Clinicians Do?

Park KE, Kang S, Ok SH, Shin IW, Sohn JT, Chung YK, Lee HK.

Korean J Pain. 2012 Jul;25(3):188-90. doi: 10.3344/kjp.2012.25.3.188. Epub 2012 Jun 28.


Vasoconstriction potency induced by aminoamide local anesthetics correlates with lipid solubility.

Sung HJ, Ok SH, Sohn JY, Son YH, Kim JK, Lee SH, Han JY, Lim DH, Shin IW, Lee HK, Chung YK, Choi MJ, Sohn JT.

J Biomed Biotechnol. 2012;2012:170958. doi: 10.1155/2012/170958. Epub 2012 Jun 17.


Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta.

Sung HJ, Choi MJ, Ok SH, Lee SH, Hwang IJ, Kim HS, Chang KC, Shin IW, Lee HK, Park KE, Chung YK, Sohn JT.

Can J Physiol Pharmacol. 2012 Jul;90(7):863-72. doi: 10.1139/y2012-067. Epub 2012 Jun 15.


CBSXs are sensor relay proteins sensing adenosine-containing ligands in Arabidopsis.

Ok SH, Yoo KS, Shin JS.

Plant Signal Behav. 2012 Jun;7(6):664-7. doi: 10.4161/psb.19945. Epub 2012 May 14.


Protein kinases participate in the contraction in response to levobupivacaine in the rat aorta.

Shim HS, Ok SH, Lee SH, Kwon SC, Sohn JT.

Eur J Pharmacol. 2012 Feb 29;677(1-3):131-7. doi: 10.1016/j.ejphar.2011.12.023. Epub 2011 Dec 27.


Myocardial protective effect by ulinastatin via an anti-inflammatory response after regional ischemia/reperfusion injury in an in vivo rat heart model.

Shin IW, Jang IS, Lee SM, Park KE, Ok SH, Sohn JT, Lee HK, Chung YK.

Korean J Anesthesiol. 2011 Dec;61(6):499-505. doi: 10.4097/kjae.2011.61.6.499. Epub 2011 Dec 20.


Single cystathionine β-synthase domain-containing proteins modulate development by regulating the thioredoxin system in Arabidopsis.

Yoo KS, Ok SH, Jeong BC, Jung KW, Cui MH, Hyoung S, Lee MR, Song HK, Shin JS.

Plant Cell. 2011 Oct;23(10):3577-94. doi: 10.1105/tpc.111.089847. Epub 2011 Oct 21. Erratum in: Plant Cell. 2011 Dec;23(12):4527.

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