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Items: 1 to 50 of 179

1.

SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins.

Yan S, Elmes MW, Tong S, Hu K, Awwa M, Teng GYH, Jing Y, Freitag M, Gan Q, Clement T, Wei L, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Wang L, Bogdan DM, Falcone J, Smietalo N, Zhou Y, Ralph B, Hsu HC, Li H, Rizzo RC, Deutsch DG, Kaczocha M, Ojima I.

Eur J Med Chem. 2018 Jun 25;154:233-252. doi: 10.1016/j.ejmech.2018.04.050. Epub 2018 May 26.

PMID:
29803996
2.

Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery.

Wang T, Zhang Y, Wei L, Teng YG, Honda T, Ojima I.

ACS Omega. 2018 Apr 30;3(4):3717-3736. doi: 10.1021/acsomega.8b00409. Epub 2018 Apr 3.

3.

Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.

Jelínek M, Balušíková K, Daniel P, Němcová-Fürstová V, Kirubakaran P, Jaček M, Wei L, Wang X, Vondrášek J, Ojima I, Kovář J.

Toxicol Appl Pharmacol. 2018 May 15;347:79-91. doi: 10.1016/j.taap.2018.04.002. Epub 2018 Apr 4.

PMID:
29625142
4.

Contribution of diacylglycerol lipase β to pain after surgery.

Luk J, Lu Y, Ackermann A, Peng X, Bogdan D, Puopolo M, Komatsu DE, Tong S, Ojima I, Rebecchi MJ, Kaczocha M.

J Pain Res. 2018 Mar 5;11:473-482. doi: 10.2147/JPR.S157208. eCollection 2018.

5.

Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".

Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, Sallans L, Desai PB, Wiederhold NP, Fothergill AW, Kirkpatrick WR, Patterson T, Wong LH, Sinha S, Giaever G, Nislow C, Flaherty P, Pan X, Cesar GV, de Melo Tavares P, Frases S, Miranda K, Rodrigues ML, Luberto C, Nimrichter L, Del Poeta M.

MBio. 2018 Mar 13;9(2). pii: e00188-18. doi: 10.1128/mBio.00188-18. No abstract available.

6.

Biodistribution and Pharmacokinetic Evaluations of a Novel Taxoid DHA-SBT-1214 in an Oil-in-Water Nanoemulsion Formulation in Naïve and Tumor-Bearing Mice.

Ahmad G, Gattacecca F, El Sadda R, Botchkina G, Ojima I, Egan J, Amiji M.

Pharm Res. 2018 Mar 8;35(4):91. doi: 10.1007/s11095-018-2349-x.

PMID:
29520477
7.

Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.

Yang CH, Wang C, Ojima I, Horwitz SB.

J Nat Prod. 2018 Mar 23;81(3):600-606. doi: 10.1021/acs.jnatprod.7b01047. Epub 2018 Mar 8.

PMID:
29517223
8.

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids.

Lazzarini C, Haranahalli K, Rieger R, Ananthula HK, Desai PB, Ashbaugh A, Linke MJ, Cushion MT, Ruzsicska B, Haley J, Ojima I, Del Poeta M.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e00156-18. doi: 10.1128/AAC.00156-18. Print 2018 May.

9.

Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.

Ojima I, Wang X, Jing Y, Wang C.

J Nat Prod. 2018 Mar 23;81(3):703-721. doi: 10.1021/acs.jnatprod.7b01012. Epub 2018 Feb 22.

10.

Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C-Labeling.

Seitz JD, Wang T, Vineberg JG, Honda T, Ojima I.

J Org Chem. 2018 Mar 2;83(5):2847-2857. doi: 10.1021/acs.joc.7b03284. Epub 2018 Feb 19.

PMID:
29441783
11.

Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation.

Bogdan D, Falcone J, Kanjiya MP, Park SH, Carbonetti G, Studholme K, Gomez M, Lu Y, Elmes MW, Smietalo N, Yan S, Ojima I, Puopolo M, Kaczocha M.

J Biol Chem. 2018 Apr 6;293(14):5295-5306. doi: 10.1074/jbc.RA118.001593. Epub 2018 Feb 13.

PMID:
29440395
12.

Computational Design and Synthesis of Novel Fluoro-Analogs of Combretastatins A-4 and A-1.

Zong Y, Shea C, Maffucci K, Ojima I.

J Fluor Chem. 2017 Nov;203:193-199. doi: 10.1016/j.jfluchem.2017.09.007. Epub 2017 Sep 10.

PMID:
29311752
13.

Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies.

Wang T, Vineberg JG, Honda T, Ojima I.

Bioorg Chem. 2018 Feb;76:458-467. doi: 10.1016/j.bioorg.2017.12.018. Epub 2017 Dec 11.

PMID:
29287255
14.

Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions.

Alford VM, Kamath A, Ren X, Kumar K, Gan Q, Awwa M, Tong M, Seeliger MA, Cao J, Ojima I, Sampson NS.

ACS Chem Biol. 2017 Nov 17;12(11):2788-2803. doi: 10.1021/acschembio.7b00758. Epub 2017 Oct 10.

PMID:
28945333
15.

Strategic Incorporation of Fluorine into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies.

Ojima I.

J Fluor Chem. 2017 Jun;198:10-23. doi: 10.1016/j.jfluchem.2016.12.016. Epub 2017 Jan 3.

16.

Nanoemulsion formulation of a novel taxoid DHA-SBT-1214 inhibits prostate cancer stem cell-induced tumor growth.

Ahmad G, El Sadda R, Botchkina G, Ojima I, Egan J, Amiji M.

Cancer Lett. 2017 Oct 10;406:71-80. doi: 10.1016/j.canlet.2017.08.004. Epub 2017 Aug 11.

PMID:
28803993
17.

Great Challenges in Organic Chemistry.

Ojima I.

Front Chem. 2017 Jul 12;5:52. doi: 10.3389/fchem.2017.00052. eCollection 2017. No abstract available.

18.

The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.

Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H.

Biochemistry. 2017 Jul 11;56(27):3454-3462. doi: 10.1021/acs.biochem.7b00194. Epub 2017 Jun 28.

19.

Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.

Ojima I, Awasthi D, Wei L, Haranahalli K.

J Fluor Chem. 2017 Apr;196:44-56. doi: 10.1016/j.jfluchem.2016.07.020. Epub 2016 Jul 29.

20.

Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells.

Jelinek M, Kabelova A, Sramek J, Seitz J, Ojima I, Kovar J.

Anticancer Res. 2017 Apr;37(4):1581-1590.

PMID:
28373418
21.

Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms.

Peng X, Studholme K, Kanjiya MP, Luk J, Bogdan D, Elmes MW, Carbonetti G, Tong S, Gary Teng YH, Rizzo RC, Li H, Deutsch DG, Ojima I, Rebecchi MJ, Puopolo M, Kaczocha M.

Mol Pain. 2017 Jan;13:1744806917697007. doi: 10.1177/1744806917697007.

22.

SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells.

Zheng X, Wang C, Xing Y, Chen S, Meng T, You H, Ojima I, Dong Y.

Int J Oncol. 2017 Mar;50(3):893-902. doi: 10.3892/ijo.2017.3871. Epub 2017 Feb 10.

23.

Drug resistance mechanisms and novel drug targets for tuberculosis therapy.

Islam MM, Hameed HMA, Mugweru J, Chhotaray C, Wang C, Tan Y, Liu J, Li X, Tan S, Ojima I, Yew WW, Nuermberger E, Lamichhane G, Zhang T.

J Genet Genomics. 2017 Jan 20;44(1):21-37. doi: 10.1016/j.jgg.2016.10.002. Epub 2016 Oct 11. Review.

PMID:
28117224
24.

Trunk deformity evaluation based on 3D measurements of front body surface landmarks in people with severe physical disabilities.

Sato H, Kondo M, Ojima I, Fukasawa H, Higuchi S.

Dev Neurorehabil. 2017 Jul;20(5):280-286. doi: 10.1080/17518423.2016.1211188. Epub 2016 Aug 12.

PMID:
27715377
25.

Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216.

Mohelnikova-Duchonova B, Kocik M, Duchonova B, Brynychova V, Oliverius M, Hlavsa J, Honsova E, Mazanec J, Kala Z, Ojima I, Hughes DJ, Doherty JE, Murray HA, Crockard MA, Lemstrova R, Soucek P.

Pharmacogenomics J. 2017 Oct;17(5):452-460. doi: 10.1038/tpj.2016.55. Epub 2016 Aug 30.

PMID:
27573236
26.

Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity.

Zhou Y, McGillick BE, Teng YG, Haranahalli K, Ojima I, Swaminathan S, Rizzo RC.

Bioorg Med Chem. 2016 Oct 15;24(20):4875-4889. doi: 10.1016/j.bmc.2016.07.031. Epub 2016 Jul 18.

PMID:
27543389
27.

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.

Haranahalli K, Tong S, Ojima I.

Bioorg Med Chem. 2016 Dec 15;24(24):6354-6369. doi: 10.1016/j.bmc.2016.05.003. Epub 2016 May 5. Review.

28.

Hydrogel microstructure live-cell array for multiplexed analyses of cancer stem cells, tumor heterogeneity and differential drug response at single-element resolution.

Afrimzon E, Botchkina G, Zurgil N, Shafran Y, Sobolev M, Moshkov S, Ravid-Hermesh O, Ojima I, Deutsch M.

Lab Chip. 2016 Mar 21;16(6):1047-62. doi: 10.1039/c6lc00014b. Epub 2016 Feb 23.

PMID:
26907542
29.

Taxane anticancer agents: a patent perspective.

Ojima I, Lichtenthal B, Lee S, Wang C, Wang X.

Expert Opin Ther Pat. 2016;26(1):1-20. doi: 10.1517/13543776.2016.1111872. Epub 2015 Dec 10. Review.

30.

Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.

Teng YH, Berger WT, Nesbitt NM, Kumar K, Balius TE, Rizzo RC, Tonge PJ, Ojima I, Swaminathan S.

Bioorg Med Chem. 2015 Sep 1;23(17):5489-95. doi: 10.1016/j.bmc.2015.07.040. Epub 2015 Jul 27.

PMID:
26275678
31.

Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.

Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA.

J Antimicrob Chemother. 2015 Nov;70(11):3070-3. doi: 10.1093/jac/dkv226. Epub 2015 Aug 5.

32.

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.

Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, Sallans L, Desai PB, Wiederhold NP, Fothergill AW, Kirkpatrick WR, Patterson T, Wong LH, Sinha S, Giaever G, Nislow C, Flaherty P, Pan X, Cesar GV, de Melo Tavares P, Frases S, Miranda K, Rodrigues ML, Luberto C, Nimrichter L, Del Poeta M.

MBio. 2015 Jun 23;6(3):e00647. doi: 10.1128/mBio.00647-15. Erratum in: MBio. 2018 Mar 13;9(2):.

33.

New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.

Li W, Zheng S, Higgins M, Morra RP Jr, Mendis AT, Chien CW, Ojima I, Mierke DF, Dinkova-Kostova AT, Honda T.

J Med Chem. 2015 Jun 11;58(11):4738-48. doi: 10.1021/acs.jmedchem.5b00393. Epub 2015 May 20.

PMID:
25965897
34.

Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate.

Seitz JD, Vineberg JG, Herlihy E, Park B, Melief E, Ojima I.

Bioorg Med Chem. 2015 May 1;23(9):2187-94. doi: 10.1016/j.bmc.2015.02.057. Epub 2015 Mar 6.

35.

Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation.

He Z, Schulz A, Wan X, Seitz J, Bludau H, Alakhova DY, Darr DB, Perou CM, Jordan R, Ojima I, Kabanov AV, Luxenhofer R.

J Control Release. 2015 Jun 28;208:67-75. doi: 10.1016/j.jconrel.2015.02.024. Epub 2015 Feb 26.

36.
37.

The role of individual caspases in cell death induction by taxanes in breast cancer cells.

Jelínek M, Balušíková K, Schmiedlová M, Němcová-Fürstová V, Šrámek J, Stančíková J, Zanardi I, Ojima I, Kovář J.

Cancer Cell Int. 2015 Feb 4;15(1):8. doi: 10.1186/s12935-015-0155-7. eCollection 2015.

38.

Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

Elmes MW, Kaczocha M, Berger WT, Leung K, Ralph BP, Wang L, Sweeney JM, Miyauchi JT, Tsirka SE, Ojima I, Deutsch DG.

J Biol Chem. 2015 Apr 3;290(14):8711-21. doi: 10.1074/jbc.M114.618447. Epub 2015 Feb 9.

39.

Design, synthesis, and biological evaluation of theranostic vitamin-linker-taxoid conjugates.

Vineberg JG, Wang T, Zuniga ES, Ojima I.

J Med Chem. 2015 Mar 12;58(5):2406-16. doi: 10.1021/jm5019115. Epub 2015 Feb 18.

40.

Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.

Zheng S, Huang JT, Knatko EV, Sharp S, Higgins M, Ojima I, Dinkova-Kostova AT, Honda T.

J Labelled Comp Radiopharm. 2014 Aug;57(10):606-10. doi: 10.1002/jlcr.3230. Epub 2014 Sep 5.

PMID:
25196444
41.

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

Matesanz R, Trigili C, Rodríguez-Salarichs J, Zanardi I, Pera B, Nogales A, Fang WS, Jímenez-Barbero J, Canales A, Barasoain I, Ojima I, Díaz JF.

Bioorg Med Chem. 2014 Sep 15;22(18):5078-90. doi: 10.1016/j.bmc.2014.05.048. Epub 2014 Jun 19.

42.

Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells.

Rowehl RA, Burke S, Bialkowska AB, Pettet DW 3rd, Rowehl L, Li E, Antoniou E, Zhang Y, Bergamaschi R, Shroyer KR, Ojima I, Botchkina GI.

PLoS One. 2014 Jun 12;9(6):e99091. doi: 10.1371/journal.pone.0099091. eCollection 2014.

43.

Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy.

Vineberg JG, Zuniga ES, Kamath A, Chen YJ, Seitz JD, Ojima I.

J Med Chem. 2014 Jul 10;57(13):5777-91. doi: 10.1021/jm500631u. Epub 2014 Jun 19.

44.

SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly.

Singh D, Bhattacharya A, Rai A, Dhaked HP, Awasthi D, Ojima I, Panda D.

Biochemistry. 2014 May 13;53(18):2979-92. doi: 10.1021/bi401356y. Epub 2014 May 1.

45.

In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis.

Knudson SE, Kumar K, Awasthi D, Ojima I, Slayden RA.

Tuberculosis (Edinb). 2014 May;94(3):271-6. doi: 10.1016/j.tube.2014.03.007. Epub 2014 Apr 1.

46.

A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.

Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA.

PLoS One. 2014 Apr 15;9(4):e93953. doi: 10.1371/journal.pone.0093953. eCollection 2014.

47.

Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.

Park B, Awasthi D, Chowdhury SR, Melief EH, Kumar K, Knudson SE, Slayden RA, Ojima I.

Bioorg Med Chem. 2014 May 1;22(9):2602-12. doi: 10.1016/j.bmc.2014.03.035. Epub 2014 Apr 1.

48.

Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

Kaczocha M, Rebecchi MJ, Ralph BP, Teng YH, Berger WT, Galbavy W, Elmes MW, Glaser ST, Wang L, Rizzo RC, Deutsch DG, Ojima I.

PLoS One. 2014 Apr 4;9(4):e94200. doi: 10.1371/journal.pone.0094200. eCollection 2014.

49.

Drug discovery targeting cell division proteins, microtubules and FtsZ.

Ojima I, Kumar K, Awasthi D, Vineberg JG.

Bioorg Med Chem. 2014 Sep 15;22(18):5060-77. doi: 10.1016/j.bmc.2014.02.036. Epub 2014 Mar 5. Review.

50.

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