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Items: 1 to 50 of 65

1.

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.

Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A.

Nat Chem Biol. 2019 Mar;15(3):250-258. doi: 10.1038/s41589-018-0204-3. Epub 2019 Jan 14.

PMID:
30643284
2.

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.

Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.

Sci Signal. 2018 Nov 13;11(556). pii: eaat5185. doi: 10.1126/scisignal.aat5185.

PMID:
30425165
3.

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly.

Usui K, Yamamoto K, Ueno Y, Igawa K, Hagihara R, Masuda T, Ojida A, Karasawa S, Tomooka K, Hirai G, Suemune H.

Chemistry. 2018 Oct 1;24(55):14617-14621. doi: 10.1002/chem.201803270. Epub 2018 Sep 6.

PMID:
30062767
4.

A host-guest system based on collagen-like triple-helix hybridization.

Delsuc N, Uchinomiya S, Ojida A, Hamachi I.

Chem Commun (Camb). 2017 Jun 22;53(51):6856-6859. doi: 10.1039/c7cc03055j.

PMID:
28604910
5.

Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation.

Kurashige N, Fuchida H, Tabata S, Uchinomiya S, Ojida A.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3486-3489. doi: 10.1016/j.bmcl.2017.05.069. Epub 2017 May 24.

PMID:
28576616
6.

Reversible ratiometric detection of highly reactive hydropersulfides using a FRET-based dual emission fluorescent probe.

Kawagoe R, Takashima I, Uchinomiya S, Ojida A.

Chem Sci. 2017 Feb 1;8(2):1134-1140. doi: 10.1039/c6sc03856e. Epub 2016 Sep 26.

7.

Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications.

Wongkongkatep J, Ojida A, Hamachi I.

Top Curr Chem (Cham). 2017 Apr;375(2):30. doi: 10.1007/s41061-017-0120-0. Epub 2017 Mar 1. Review.

PMID:
28251566
8.

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S.

EBioMedicine. 2016 Nov;13:262-273. doi: 10.1016/j.ebiom.2016.10.008. Epub 2016 Oct 6.

9.

Intracellular delivery of chemical probes using a glutathione-responsive traceless tag.

Aoyama E, Fuchida H, Oshikawa Y, Uchinomiya S, Ojida A.

Chem Commun (Camb). 2016 Jun 8;52(49):7715-8. doi: 10.1039/c6cc03336a.

PMID:
27229298
10.

Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement.

Oshikawa Y, Furuta K, Tanaka S, Ojida A.

Anal Chem. 2016 Feb 2;88(3):1526-9. doi: 10.1021/acs.analchem.5b04758. Epub 2016 Jan 22.

PMID:
26790581
11.

[Development of Fluorescence Sensing Mechanism for Cell Functional Analysis].

Ojida A, Takashima I.

Yakugaku Zasshi. 2016;136(1):3-7. doi: 10.1248/yakushi.15-00225-1. Review. Japanese.

12.

[Chamical Biology for Pharmaceutical Sciences-Novel Approaches for Exploring Cellular Functions with Non-drug Chemicals].

Ojida A, Nakagawa H.

Yakugaku Zasshi. 2016;136(1):1. doi: 10.1248/yakushi.15-00225-F. Japanese. No abstract available.

13.

Quantification of Amino Groups on Solid Surfaces Using Cleavable Fluorescent Compounds.

Shiota S, Yamamoto S, Shimomura A, Ojida A, Nishino T, Maruyama T.

Langmuir. 2015 Aug 18;31(32):8824-9. doi: 10.1021/acs.langmuir.5b02548. Epub 2015 Aug 7.

PMID:
26223292
14.

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis.

Oyama T, Negishi E, Onigahara H, Kusano N, Miyoshi Y, Mita M, Nakazono M, Ohtsuki S, Ojida A, Lindner W, Hamase K.

J Pharm Biomed Anal. 2015 Dec 10;116:71-9. doi: 10.1016/j.jpba.2015.05.039. Epub 2015 Jun 17.

PMID:
26166005
15.

Rational Design of a Ratiometric Fluorescent Probe Based on Arene-Metal-Ion Contact for Endogenous Hydrogen Sulfide Detection in Living Cells.

Kawagoe R, Takashima I, Usui K, Kanegae A, Ozawa Y, Ojida A.

Chembiochem. 2015 Jul 27;16(11):1608-15. doi: 10.1002/cbic.201500249. Epub 2015 Jun 26.

PMID:
26033276
16.

Development of an AND logic-gate-type fluorescent probe for ratiometric imaging of autolysosome in cell autophagy.

Takashima I, Kawagoe R, Hamachi I, Ojida A.

Chemistry. 2015 Jan 26;21(5):2038-44. doi: 10.1002/chem.201405686. Epub 2014 Dec 2.

PMID:
25470007
17.

Aza-crown-ether-appended xanthene: selective ratiometric fluorescent probe for silver(I) ion based on arene-metal ion interaction.

Takashima I, Kanegae A, Sugimoto M, Ojida A.

Inorg Chem. 2014 Jul 21;53(14):7080-2. doi: 10.1021/ic500980j. Epub 2014 Jul 9.

PMID:
25007117
18.

Design of a binuclear Ni(II)-iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins.

Takahira I, Fuchida H, Tabata S, Shindo N, Uchinomiya S, Hamachi I, Ojida A.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2855-8. doi: 10.1016/j.bmcl.2014.04.096. Epub 2014 May 4.

PMID:
24835629
19.

Design of ratiometric fluorescent probes based on arene-metal-ion interactions and their application to Cd(II) and hydrogen sulfide imaging in living cells.

Takashima I, Kinoshita M, Kawagoe R, Nakagawa S, Sugimoto M, Hamachi I, Ojida A.

Chemistry. 2014 Feb 17;20(8):2184-92. doi: 10.1002/chem.201304181. Epub 2014 Jan 23.

PMID:
24458536
20.

Coordination ligand exchange of a xanthene probe-Ce(III) complex for selective fluorescence sensing of inorganic pyrophosphate.

Kittiloespaisan E, Takashima I, Kiatpathomchai W, Wongkongkatep J, Ojida A.

Chem Commun (Camb). 2014 Feb 28;50(17):2126-8. doi: 10.1039/c3cc48101h. Epub 2014 Jan 14.

PMID:
24419249
21.

PET-dependent fluorescence sensing of enzyme reactions using the large and tunable pKa shift of aliphatic amines.

Oshikawa Y, Ojida A.

Chem Commun (Camb). 2013 Dec 18;49(97):11373-5. doi: 10.1039/c3cc46824k.

PMID:
24162888
22.

Peptide tag/probe pairs based on the coordination chemistry for protein labeling.

Uchinomiya S, Ojida A, Hamachi I.

Inorg Chem. 2014 Feb 17;53(4):1816-23. doi: 10.1021/ic401612z. Epub 2013 Oct 16. Review.

PMID:
24131471
23.

In-cell covalent labeling of reactive His-tag fused proteins.

Uchinomiya S, Nonaka H, Wakayama S, Ojida A, Hamachi I.

Chem Commun (Camb). 2013 Jun 4;49(44):5022-4. doi: 10.1039/c3cc41979g. Epub 2013 Apr 24.

PMID:
23612601
24.

Protein organic chemistry and applications for labeling and engineering in live-cell systems.

Takaoka Y, Ojida A, Hamachi I.

Angew Chem Int Ed Engl. 2013 Apr 8;52(15):4088-106. doi: 10.1002/anie.201207089. Epub 2013 Feb 20. Review.

PMID:
23426903
25.

Organelle-localizable fluorescent chemosensors for site-specific multicolor imaging of nucleoside polyphosphate dynamics in living cells.

Kurishita Y, Kohira T, Ojida A, Hamachi I.

J Am Chem Soc. 2012 Nov 14;134(45):18779-89. doi: 10.1021/ja308754g. Epub 2012 Nov 5.

PMID:
23098271
26.

Ligand-directed acyl imidazole chemistry for labeling of membrane-bound proteins on live cells.

Fujishima SH, Yasui R, Miki T, Ojida A, Hamachi I.

J Am Chem Soc. 2012 Mar 7;134(9):3961-4. doi: 10.1021/ja2108855. Epub 2012 Feb 24.

PMID:
22352855
27.

[Development of specific protein labeling method by using small molecular probes].

Ojida A.

Yakugaku Zasshi. 2012;132(2):195-9. Review. Japanese.

28.

[Challenges for futuristic nanomedical detection, diagnosis and treatment].

Ojida A, Kato M.

Yakugaku Zasshi. 2012;132(2):183. Japanese. No abstract available.

29.

Design of a multinuclear Zn(II) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins.

Fujishima SH, Nonaka H, Uchinomiya SH, Kawase YA, Ojida A, Hamachi I.

Chem Commun (Camb). 2012 Jan 14;48(4):594-6. doi: 10.1039/c1cc16263b. Epub 2011 Nov 24.

PMID:
22113378
30.

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

Kaku T, Hitaka T, Ojida A, Matsunaga N, Adachi M, Tanaka T, Hara T, Yamaoka M, Kusaka M, Okuda T, Asahi S, Furuya S, Tasaka A.

Bioorg Med Chem. 2011 Nov 1;19(21):6383-99. doi: 10.1016/j.bmc.2011.08.066. Epub 2011 Sep 1.

PMID:
21978946
31.

17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.

Kaku T, Matsunaga N, Ojida A, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A.

Bioorg Med Chem. 2011 Mar 1;19(5):1751-70. doi: 10.1016/j.bmc.2011.01.017. Epub 2011 Jan 15.

PMID:
21316976
32.

Rational design of FRET-based ratiometric chemosensors for in vitro and in cell fluorescence analyses of nucleoside polyphosphates.

Kurishita Y, Kohira T, Ojida A, Hamachi I.

J Am Chem Soc. 2010 Sep 29;132(38):13290-9. doi: 10.1021/ja103615z.

PMID:
20812684
33.

Selective covalent labeling of tag-fused GPCR proteins on live cell surface with a synthetic probe for their functional analysis.

Nonaka H, Fujishima SH, Uchinomiya SH, Ojida A, Hamachi I.

J Am Chem Soc. 2010 Jul 14;132(27):9301-9. doi: 10.1021/ja910703v.

PMID:
20568758
34.

Development of highly sensitive fluorescent probes for detection of intracellular copper(I) in living systems.

Taki M, Iyoshi S, Ojida A, Hamachi I, Yamamoto Y.

J Am Chem Soc. 2010 May 5;132(17):5938-9. doi: 10.1021/ja100714p.

PMID:
20377254
35.

Binuclear Ni(II)-DpaTyr complex as a high affinity probe for an oligo-aspartate Tag tethered to proteins.

Ojida A, Fujishima SH, Honda K, Nonaka H, Uchinomiya SH, Hamachi I.

Chem Asian J. 2010 Apr 1;5(4):877-86. doi: 10.1002/asia.200900362.

PMID:
20143369
36.

FLAG-tag selective covalent protein labeling via a binding-induced acyl-transfer reaction.

Nonaka H, Fujishima SH, Uchinomiya SH, Ojida A, Hamachi I.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6696-9. doi: 10.1016/j.bmcl.2009.09.122. Epub 2009 Oct 3.

PMID:
19837586
37.

Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(II)-NTA probe.

Uchinomiya SH, Nonaka H, Fujishima SH, Tsukiji S, Ojida A, Hamachi I.

Chem Commun (Camb). 2009 Oct 21;(39):5880-2. doi: 10.1039/b912025d. Epub 2009 Aug 13.

PMID:
19787128
38.

Real-time fluorescence monitoring of GSK3beta-catalyzed phosphoryation by use of a BODIPY-based Zn(II)-Dpa chemosensor.

Sakamoto T, Inoue MA, Ojida A, Hamachi I.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4175-7. doi: 10.1016/j.bmcl.2009.05.121. Epub 2009 Jun 21.

PMID:
19546004
39.

Sequence selective dual-emission detection of (i, i + 1) bis-phosphorylated peptide using diazastilbene-type Zn(II)-Dpa chemosensor.

Ishida Y, Inoue MA, Inoue T, Ojida A, Hamachi I.

Chem Commun (Camb). 2009 May 28;(20):2848-50. doi: 10.1039/b905814a. Epub 2009 Apr 24.

PMID:
19436886
40.

Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy.

Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N.

Adv Exp Med Biol. 2009;611:145-6. No abstract available.

PMID:
19400132
41.

Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients.

Ojida A, Sakamoto T, Inoue MA, Fujishima SH, Lippens G, Hamachi I.

J Am Chem Soc. 2009 May 13;131(18):6543-8. doi: 10.1021/ja9008369.

PMID:
19368380
42.

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.

Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, Mori Y.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5. doi: 10.1073/pnas.0808793106. Epub 2009 Mar 16.

43.

Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn(II)-Dpa complexes.

Sakamoto T, Ojida A, Hamachi I.

Chem Commun (Camb). 2009 Jan 8;(2):141-52. doi: 10.1039/b812374h. Epub 2008 Oct 29.

PMID:
19099054
44.

Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor.

Taki M, Desaki M, Ojida A, Iyoshi S, Hirayama T, Hamachi I, Yamamoto Y.

J Am Chem Soc. 2008 Sep 24;130(38):12564-5. doi: 10.1021/ja803429z. Epub 2008 Aug 30.

PMID:
18761452
45.

Turn-on fluorescence sensing of nucleoside polyphosphates using a xanthene-based Zn(II) complex chemosensor.

Ojida A, Takashima I, Kohira T, Nonaka H, Hamachi I.

J Am Chem Soc. 2008 Sep 10;130(36):12095-101. doi: 10.1021/ja803262w. Epub 2008 Aug 14.

PMID:
18700758
46.

Artificial receptors designed for intracellular delivery of anionic phosphate derivatives.

Kohira T, Honda K, Ojida A, Hamachi I.

Chembiochem. 2008 Mar 25;9(5):698-701. doi: 10.1002/cbic.200700627. No abstract available.

PMID:
18253939
47.

Non-enzymatic covalent protein labeling using a reactive tag.

Nonaka H, Tsukiji S, Ojida A, Hamachi I.

J Am Chem Soc. 2007 Dec 26;129(51):15777-9. Epub 2007 Dec 5.

PMID:
18052248
48.

[Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype].

Ojida A.

Tanpakushitsu Kakusan Koso. 2007 Oct;52(13 Suppl):1806-7. Review. Japanese. No abstract available.

PMID:
18051435
49.

Pyrene excimer-based dual-emission detection of a oligoaspartate tag-fused protein by using a Zn(II)-DpaTyr probe.

Honda K, Fujishima SH, Ojida A, Hamachi I.

Chembiochem. 2007 Aug 13;8(12):1370-2. No abstract available.

PMID:
17590878
50.

Design of a hybrid biosensor for enhanced phosphopeptide recognition based on a phosphoprotein binding domain coupled with a fluorescent chemosensor.

Anai T, Nakata E, Koshi Y, Ojida A, Hamachi I.

J Am Chem Soc. 2007 May 16;129(19):6232-9. Epub 2007 Apr 19.

PMID:
17441721

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