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Items: 1 to 50 of 314

1.

EAP1 regulation of GnRH promoter activity is important for human pubertal timing.

Mancini A, Howard SR, Cabrera CP, Barnes MR, David A, Wehkalampi K, Heger S, Lomniczi A, Guasti L, Ojeda SR, Dunkel L.

Hum Mol Genet. 2019 Apr 15;28(8):1357-1368. doi: 10.1093/hmg/ddy451.

2.

Methylome profiling of healthy and central precocious puberty girls.

Bessa DS, Maschietto M, Aylwin CF, Canton APM, Brito VN, Macedo DB, Cunha-Silva M, Palhares HMC, de Resende EAMR, Borges MF, Mendonca BB, Netchine I, Krepischi ACV, Lomniczi A, Ojeda SR, Latronico AC.

Clin Epigenetics. 2018 Nov 22;10(1):146. doi: 10.1186/s13148-018-0581-1.

3.

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.

Vazquez MJ, Toro CA, Castellano JM, Ruiz-Pino F, Roa J, Beiroa D, Heras V, Velasco I, Dieguez C, Pinilla L, Gaytan F, Nogueiras R, Bosch MA, Rønnekleiv OK, Lomniczi A, Ojeda SR, Tena-Sempere M.

Nat Commun. 2018 Oct 10;9(1):4194. doi: 10.1038/s41467-018-06459-9.

4.

Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice.

Matagne V, Wondolowski J, Frerking M, Shahidullah M, Delamere NA, Sandau US, Budden S, Ojeda SR.

Brain Res. 2018 Oct 15;1697:45-52. doi: 10.1016/j.brainres.2018.06.013. Epub 2018 Jun 12.

PMID:
29902467
5.

Elucidating the genetic architecture of reproductive ageing in the Japanese population.

Horikoshi M, Day FR, Akiyama M, Hirata M, Kamatani Y, Matsuda K, Ishigaki K, Kanai M, Wright H, Toro CA, Ojeda SR, Lomniczi A, Kubo M, Ong KK, Perry JRB.

Nat Commun. 2018 May 17;9(1):1977. doi: 10.1038/s41467-018-04398-z.

6.

Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty.

Toro CA, Wright H, Aylwin CF, Ojeda SR, Lomniczi A.

Nat Commun. 2018 Jan 4;9(1):57. doi: 10.1038/s41467-017-02512-1.

7.

Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update.

Dissen GA, Adachi K, Lomniczi A, Chatkupt T, Davidson BL, Nakai H, Ojeda SR.

Reprod Domest Anim. 2017 Apr;52 Suppl 2:354-358. doi: 10.1111/rda.12834. Epub 2016 Nov 17.

8.

Seminal Plasma Induces Ovulation in Llamas in the Absence of a Copulatory Stimulus: Role of Nerve Growth Factor as an Ovulation-Inducing Factor.

Berland MA, Ulloa-Leal C, Barría M, Wright H, Dissen GA, Silva ME, Ojeda SR, Ratto MH.

Endocrinology. 2016 Aug;157(8):3224-32. doi: 10.1210/en.2016-1310. Epub 2016 Jun 29.

9.

The Emerging Role of Epigenetics in the Regulation of Female Puberty.

Lomniczi A, Ojeda SR.

Endocr Dev. 2016;29:1-16. doi: 10.1159/000438840. Epub 2015 Dec 17. Review.

10.

Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression.

Lomniczi A, Wright H, Castellano JM, Matagne V, Toro CA, Ramaswamy S, Plant TM, Ojeda SR.

Nat Commun. 2015 Dec 16;6:10195. doi: 10.1038/ncomms10195.

11.

FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer.

De La Chesnaye E, Méndez JP, López-Romero R, De Los Angeles Romero-Tlalolini M, Vergara MD, Salcedo M, Ojeda SR.

Int J Clin Exp Pathol. 2015 Sep 1;8(9):10192-203. eCollection 2015.

12.

Pro-nerve growth factor in the ovary and human granulosa cells.

Meinel S, Blohberger J, Berg D, Berg U, Dissen GA, Ojeda SR, Mayerhofer A.

Horm Mol Biol Clin Investig. 2015 Nov;24(2):91-9. doi: 10.1515/hmbci-2015-0028.

13.

Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles: a marker of growing follicles?

Merz C, Saller S, Kunz L, Xu J, Yeoman RR, Ting AY, Lawson MS, Stouffer RL, Hennebold JD, Pau F, Dissen GA, Ojeda SR, Zelinski MB, Mayerhofer A.

J Ovarian Res. 2015 Mar 7;8:8. doi: 10.1186/s13048-015-0136-4.

14.

Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?

Blohberger J, Kunz L, Einwang D, Berg U, Berg D, Ojeda SR, Dissen GA, Fröhlich T, Arnold GJ, Soreq H, Lara H, Mayerhofer A.

Cell Death Dis. 2015 Mar 12;6:e1685. doi: 10.1038/cddis.2015.51.

15.

Excess of nerve growth factor in the ovary causes a polycystic ovary-like syndrome in mice, which closely resembles both reproductive and metabolic aspects of the human syndrome.

Wilson JL, Chen W, Dissen GA, Ojeda SR, Cowley MA, Garcia-Rudaz C, Enriori PJ.

Endocrinology. 2014 Nov;155(11):4494-506. doi: 10.1210/en.2014-1368. Epub 2014 Sep 11.

16.

Epigenetic regulation of female puberty.

Lomniczi A, Wright H, Ojeda SR.

Front Neuroendocrinol. 2015 Jan;36:90-107. doi: 10.1016/j.yfrne.2014.08.003. Epub 2014 Aug 27. Review.

PMID:
25171849
17.

Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome.

Topaloglu AK, Lomniczi A, Kretzschmar D, Dissen GA, Kotan LD, McArdle CA, Koc AF, Hamel BC, Guclu M, Papatya ED, Eren E, Mengen E, Gurbuz F, Cook M, Castellano JM, Kekil MB, Mungan NO, Yuksel B, Ojeda SR.

J Clin Endocrinol Metab. 2014 Oct;99(10):E2067-75. doi: 10.1210/jc.2014-1836. Epub 2014 Jul 17.

18.

Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion.

Gaytan F, Garcia-Galiano D, Dorfman MD, Manfredi-Lozano M, Castellano JM, Dissen GA, Ojeda SR, Tena-Sempere M.

Endocrinology. 2014 Aug;155(8):3088-97. doi: 10.1210/en.2014-1110. Epub 2014 Jun 2. Erratum in: Endocrinology. 2015 Sep;156(9):3402.

19.

Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure.

Dorfman MD, Garcia-Rudaz C, Alderman Z, Kerr B, Lomniczi A, Dissen GA, Castellano JM, Garcia-Galiano D, Gaytan F, Xu B, Tena-Sempere M, Ojeda SR.

Endocrinology. 2014 Aug;155(8):3098-111. doi: 10.1210/en.2014-1111. Epub 2014 May 30.

20.

An alternative transcription start site yields estrogen-unresponsive Kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats.

Castellano JM, Wright H, Ojeda SR, Lomniczi A.

Neuroendocrinology. 2014;99(2):94-107. doi: 10.1159/000362280. Epub 2014 Mar 28.

21.

Puberty in 2013: Unravelling the mystery of puberty.

Ojeda SR, Lomniczi A.

Nat Rev Endocrinol. 2014 Feb;10(2):67-9. doi: 10.1038/nrendo.2013.233. Epub 2013 Nov 26. Review.

PMID:
24275741
22.

Molecular and gene network analysis of thyroid transcription factor 1 (TTF1) and enhanced at puberty (EAP1) genes in patients with GnRH-dependent pubertal disorders.

Cukier P, Wright H, Rulfs T, Silveira LF, Teles MG, Mendonca BB, Arnhold IJ, Heger S, Latronico AC, Ojeda SR, Brito VN.

Horm Res Paediatr. 2013;80(4):257-66. doi: 10.1159/000354643. Epub 2013 Sep 18.

23.

A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates.

Lomniczi A, Wright H, Castellano JM, Sonmez K, Ojeda SR.

Horm Behav. 2013 Jul;64(2):175-86. doi: 10.1016/j.yhbeh.2012.09.013. Review.

24.

Applying gene silencing technology to contraception.

Dissen GA, Lomniczi A, Boudreau RL, Chen YH, Davidson BL, Ojeda SR.

Reprod Domest Anim. 2012 Dec;47 Suppl 6:381-6. doi: 10.1111/rda.12016.

25.

Epigenetic control of female puberty.

Lomniczi A, Loche A, Castellano JM, Ronnekleiv OK, Bosch M, Kaidar G, Knoll JG, Wright H, Pfeifer GP, Ojeda SR.

Nat Neurosci. 2013 Mar;16(3):281-9. doi: 10.1038/nn.3319. Epub 2013 Jan 27.

26.

Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty.

Sangiao-Alvarellos S, Manfredi-Lozano M, Ruiz-Pino F, Navarro VM, Sánchez-Garrido MA, Leon S, Dieguez C, Cordido F, Matagne V, Dissen GA, Ojeda SR, Pinilla L, Tena-Sempere M.

Endocrinology. 2013 Feb;154(2):942-55. doi: 10.1210/en.2012-2006. Epub 2013 Jan 4.

27.

Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome.

Matagne V, Budden S, Ojeda SR, Raber J.

Brain Res. 2013 Feb 16;1496:104-14. doi: 10.1016/j.brainres.2012.12.009. Epub 2012 Dec 14.

28.

Targeted gene silencing to induce permanent sterility.

Dissen GA, Lomniczi A, Boudreau RL, Chen YH, Davidson BL, Ojeda SR.

Reprod Domest Anim. 2012 Aug;47 Suppl 4:228-32. doi: 10.1111/j.1439-0531.2012.02080.x.

29.

Decorin is a part of the ovarian extracellular matrix in primates and may act as a signaling molecule.

Adam M, Saller S, Ströbl S, Hennebold JD, Dissen GA, Ojeda SR, Stouffer RL, Berg D, Berg U, Mayerhofer A.

Hum Reprod. 2012 Nov;27(11):3249-58. doi: 10.1093/humrep/des297. Epub 2012 Aug 11.

30.

Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations.

Sandau US, Alderman Z, Corfas G, Ojeda SR, Raber J.

PLoS One. 2012;7(4):e36424. doi: 10.1371/journal.pone.0036424. Epub 2012 Apr 30.

31.

Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression.

Matagne V, Kim JG, Ryu BJ, Hur MK, Kim MS, Kim K, Park BS, Damante G, Smiley G, Lee BJ, Ojeda SR.

J Neuroendocrinol. 2012 Jun;24(6):916-29. doi: 10.1111/j.1365-2826.2012.02302.x.

32.

Hypothalamic EAP1 (enhanced at puberty 1) is required for menstrual cyclicity in nonhuman primates.

Dissen GA, Lomniczi A, Heger S, Neff TL, Ojeda SR.

Endocrinology. 2012 Jan;153(1):350-61. doi: 10.1210/en.2011-1541. Epub 2011 Nov 29.

33.

A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates.

Lomniczi A, Garcia-Rudaz C, Ramakrishnan R, Wilmot B, Khouangsathiene S, Ferguson B, Dissen GA, Ojeda SR.

Endocrinology. 2012 Jan;153(1):339-49. doi: 10.1210/en.2011-1540. Epub 2011 Nov 29.

34.

Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease.

McBride JL, Pitzer MR, Boudreau RL, Dufour B, Hobbs T, Ojeda SR, Davidson BL.

Mol Ther. 2011 Dec;19(12):2152-62. doi: 10.1038/mt.2011.219. Epub 2011 Oct 25.

35.

Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development.

Dorfman MD, Kerr B, Garcia-Rudaz C, Paredes AH, Dissen GA, Ojeda SR.

Endocrinology. 2011 Dec;152(12):5005-16. doi: 10.1210/en.2011-1465. Epub 2011 Oct 25.

36.

Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.

Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, Prevot V.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16104-9. doi: 10.1073/pnas.1107533108. Epub 2011 Sep 6.

37.

Transcriptional regulation of the human KiSS1 gene.

Mueller JK, Dietzel A, Lomniczi A, Loche A, Tefs K, Kiess W, Danne T, Ojeda SR, Heger S.

Mol Cell Endocrinol. 2011 Aug 6;342(1-2):8-19. doi: 10.1016/j.mce.2011.04.025. Epub 2011 Jun 6.

38.

Excessive ovarian production of nerve growth factor elicits granulosa cell apoptosis by setting in motion a tumor necrosis factor α/stathmin-mediated death signaling pathway.

Garcia-Rudaz C, Dorfman M, Nagalla S, Svechnikov K, Söder O, Ojeda SR, Dissen GA.

Reproduction. 2011 Aug;142(2):319-31. doi: 10.1530/REP-11-0134. Epub 2011 Jun 6.

39.

Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates.

Gray SJ, Matagne V, Bachaboina L, Yadav S, Ojeda SR, Samulski RJ.

Mol Ther. 2011 Jun;19(6):1058-69. doi: 10.1038/mt.2011.72. Epub 2011 Apr 12.

40.

SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development.

Sandau US, Mungenast AE, Alderman Z, Sardi SP, Fogel AI, Taylor B, Parent AS, Biederer T, Corfas G, Ojeda SR.

Endocrinology. 2011 Jun;152(6):2364-76. doi: 10.1210/en.2010-1435. Epub 2011 Apr 12.

41.

The synaptic cell adhesion molecule, SynCAM1, mediates astrocyte-to-astrocyte and astrocyte-to-GnRH neuron adhesiveness in the mouse hypothalamus.

Sandau US, Mungenast AE, McCarthy J, Biederer T, Corfas G, Ojeda SR.

Endocrinology. 2011 Jun;152(6):2353-63. doi: 10.1210/en.2010-1434. Epub 2011 Apr 12.

42.

A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.

Yeung KT, Das S, Zhang J, Lomniczi A, Ojeda SR, Xu CF, Neubert TA, Samuels HH.

Mol Cell Biol. 2011 Jun;31(11):2287-98. doi: 10.1128/MCB.01381-10. Epub 2011 Mar 28.

43.

Brain region-specific expression of Fxyd1, an Mecp2 target gene, is regulated by epigenetic mechanisms.

Banine F, Matagne V, Sherman LS, Ojeda SR.

J Neurosci Res. 2011 Jun;89(6):840-51. doi: 10.1002/jnr.22608. Epub 2011 Mar 10.

44.

Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty.

Ojeda SR, Lomniczi A, Sandau U.

Eur J Neurosci. 2010 Dec;32(12):2003-10. doi: 10.1111/j.1460-9568.2010.07515.x. Review.

45.

The transcriptional control of female puberty.

Ojeda SR, Lomniczi A, Loche A, Matagne V, Kaidar G, Sandau US, Dissen GA.

Brain Res. 2010 Dec 10;1364:164-74. doi: 10.1016/j.brainres.2010.09.039. Epub 2010 Sep 17. Review.

46.

Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death.

Choi EJ, Kim DH, Kim JG, Kim DY, Kim JD, Seol OJ, Jeong CS, Park JW, Choi MY, Kang SG, Costa ME, Ojeda SR, Lee BJ.

J Biol Chem. 2010 Aug 6;285(32):25074-84. doi: 10.1074/jbc.M110.100545. Epub 2010 Jun 10.

47.

Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence.

de Seranno S, d'Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V.

Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870. Epub 2010 Feb 4.

48.

Oxytocin receptors in the primate ovary: molecular identity and link to apoptosis in human granulosa cells.

Saller S, Kunz L, Dissen GA, Stouffer R, Ojeda SR, Berg D, Berg U, Mayerhofer A.

Hum Reprod. 2010 Apr;25(4):969-76. doi: 10.1093/humrep/dep467. Epub 2010 Jan 23.

49.

Gene networks and the neuroendocrine regulation of puberty.

Ojeda SR, Dubay C, Lomniczi A, Kaidar G, Matagne V, Sandau US, Dissen GA.

Mol Cell Endocrinol. 2010 Aug 5;324(1-2):3-11. doi: 10.1016/j.mce.2009.12.003. Epub 2009 Dec 22.

50.

New concepts on the control of the onset of puberty.

Ojeda SR, Lomniczi A, Sandau U, Matagne V.

Endocr Dev. 2010;17:44-51. doi: 10.1159/000262527. Epub 2009 Nov 24. Review.

PMID:
19955755

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