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EFLA 945 restricts AIM2 inflammasome activation by preventing DNA entry for psoriasis treatment.

Chung IC, Yuan SN, OuYang CN, Hu SI, Lin HC, Huang KY, Lin WN, Chuang YT, Chen YJ, Ojcius DM, Chang YS, Chen LC.

Cytokine. 2019 Dec 11;127:154951. doi: 10.1016/j.cyto.2019.154951. [Epub ahead of print]


Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.

Chung IC, Chen LC, Tsang NM, Chuang WY, Liao TC, Yuan SN, OuYang CN, Ojcius DM, Wu CC, Chang YS.

Mol Cell Proteomics. 2020 Jan;19(1):142-154. doi: 10.1074/mcp.RA119.001808. Epub 2019 Nov 13.


Development of humoral immunity.

Kanellopoulos JM, Ojcius DM.

Biomed J. 2019 Aug;42(4):207-208. doi: 10.1016/ Epub 2019 Sep 17. No abstract available.


HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry.

Paoletti A, Allouch A, Caillet M, Saïdi H, Subra F, Nardacci R, Wu Q, Muradova Z, Voisin L, Raza SQ, Law F, Thoreau M, Dakhli H, Delelis O, Poirier-Beaudouin B, Dereuddre-Bosquet N, Le Grand R, Lambotte O, Saez-Cirion A, Pancino G, Ojcius DM, Solary E, Deutsch E, Piacentini M, Gougeon ML, Kroemer G, Perfettini JL.

Cell Rep. 2019 Sep 24;28(13):3381-3394.e7. doi: 10.1016/j.celrep.2019.02.095.


CD73-dependent adenosine dampens interleukin 1β-induced CXCL8 production in gingival fibroblasts: Association with heme oxygenase-1 and adenosine monophosphate-activated protein kinase.

Ramos-Junior ES, Pedram M, Lee RE, Exstrom D, Yilmaz Ö, Coutinho-Silva R, Ojcius DM, Morandini AC.

J Periodontol. 2019 Jul 25. doi: 10.1002/JPER.19-0137. [Epub ahead of print]


Investigation of foreign materials in gingival lesions: a clinicopathologic, energy-dispersive microanalysis of the lesions and in vitro confirmation of pro-inflammatory effects of the foreign materials.

Ferreira L, Peng HH, Cox DP, Chambers DW, Bhula A, Young JD, Ojcius DM, Ramos-Junior ES, Morandini AC.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Sep;128(3):250-267. doi: 10.1016/j.oooo.2019.04.009. Epub 2019 Apr 20.


130th anniversary of Institut Pasteur: celebrating science.

Gougeon ML, Schwartz M, Brunner T, Ojcius DM.

Microbes Infect. 2019 Jun - Jul;21(5-6):190-191. doi: 10.1016/j.micinf.2019.06.010. Epub 2019 Jun 25. No abstract available.


Hormetic Effects of Phytochemicals on Health and Longevity.

Martel J, Ojcius DM, Ko YF, Ke PY, Wu CY, Peng HH, Young JD.

Trends Endocrinol Metab. 2019 Jun;30(6):335-346. doi: 10.1016/j.tem.2019.04.001. Epub 2019 May 3. Review.


130th anniversary of Institut Pasteur: celebrating science.

Gougeon ML, Schwartz M, Brunner T, Ojcius DM.

Genes Immun. 2019 May;20(5):342-343. doi: 10.1038/s41435-019-0070-3. Epub 2019 Apr 25. No abstract available.


Dicer regulates activation of the NLRP3 inflammasome.

Ojcius DM, Jafari A, Yeruva L, Schindler CW, Abdul-Sater AA.

PLoS One. 2019 Apr 23;14(4):e0215689. doi: 10.1371/journal.pone.0215689. eCollection 2019.


Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer.

Li Y, Li KX, Hu WL, Ojcius DM, Fang JQ, Li SJ, Lin X, Yan J.

Elife. 2019 Apr 23;8. pii: e44594. doi: 10.7554/eLife.44594.


Association between periodontal pathogens and systemic disease.

Bui FQ, Almeida-da-Silva CLC, Huynh B, Trinh A, Liu J, Woodward J, Asadi H, Ojcius DM.

Biomed J. 2019 Feb;42(1):27-35. doi: 10.1016/ Epub 2019 Mar 2. Review.


Chlamydia pneumoniae is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells.

Almeida-da-Silva CLC, Alpagot T, Zhu Y, Lee SS, Roberts BP, Hung SC, Tang N, Ojcius DM.

Microb Cell. 2019 Mar 11;6(4):197-208. doi: 10.15698/mic2019.04.674.


Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells.

Huang TT, Lan YW, Chen CM, Ko YF, Ojcius DM, Martel J, Young JD, Chong KY.

Sci Rep. 2019 Mar 26;9(1):5145. doi: 10.1038/s41598-019-41653-9.


Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice.

Chung IC, OuYang CN, Yuan SN, Lin HC, Huang KY, Wu PS, Liu CY, Tsai KJ, Loi LK, Chen YJ, Chung AK, Ojcius DM, Chang YS, Chen LC.

Nutrients. 2019 Feb 28;11(3). pii: E516. doi: 10.3390/nu11030516.


Antiaging effects of bioactive molecules isolated from plants and fungi.

Martel J, Ojcius DM, Ko YF, Chang CJ, Young JD.

Med Res Rev. 2019 Sep;39(5):1515-1552. doi: 10.1002/med.21559. Epub 2019 Jan 15. Review.


Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients.

Davini D, Naeem F, Phong A, Al-Kuhlani M, Valentine KM, McCarty J, Ojcius DM, Gravano DM, Hoyer KK.

J Allergy Clin Immunol. 2018 Dec;142(6):1971-1974.e7. doi: 10.1016/j.jaci.2018.10.022. Epub 2018 Oct 26. No abstract available.


P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation.

Almeida-da-Silva CLC, Ramos-Junior ES, Morandini AC, Rocha GDC, Marinho Y, Tamura AS, de Andrade KQ, Bellio M, Savio LEB, Scharfstein J, Ojcius DM, Coutinho-Silva R.

Immunobiology. 2019 Jan;224(1):50-59. doi: 10.1016/j.imbio.2018.10.008. Epub 2018 Nov 2.


Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation.

Chung IC, Yuan SN, OuYang CN, Lin HC, Huang KY, Chen YJ, Chung AK, Chu CL, Ojcius DM, Chang YS, Chen LC.

Cell Death Dis. 2018 Oct 31;9(11):1109. doi: 10.1038/s41419-018-1163-z.


vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation.

Fang JQ, Imran M, Hu WL, Ojcius DM, Li Y, Ge YM, Li KX, Lin X, Yan J.

EBioMedicine. 2018 Nov;37:428-441. doi: 10.1016/j.ebiom.2018.10.033. Epub 2018 Oct 15.


Oral infection of mice with Fusobacterium nucleatum results in macrophage recruitment to the dental pulp and bone resorption.

Johnson L, Almeida-da-Silva CLC, Takiya CM, Figliuolo V, Rocha GM, Weissmüller G, Scharfstein J, Coutinho-Silva R, Ojcius DM.

Biomed J. 2018 Jun;41(3):184-193. doi: 10.1016/ Epub 2018 Jul 2.


A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway.

Du P, Li SJ, Ojcius DM, Li KX, Hu WL, Lin X, Sun AH, Yan J.

Emerg Microbes Infect. 2018 Jul 31;7(1):135. doi: 10.1038/s41426-018-0135-9.


NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection.

Lai HC, Chang CJ, Lin CS, Wu TR, Hsu YJ, Wu TS, Lu JJ, Martel J, Ojcius DM, Ku CL, Young JD, Lu CC.

J Immunol. 2018 Sep 1;201(5):1478-1490. doi: 10.4049/jimmunol.1800123. Epub 2018 Jul 30.


Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis.

Wu TR, Lin CS, Chang CJ, Lin TL, Martel J, Ko YF, Ojcius DM, Lu CC, Young JD, Lai HC.

Gut. 2019 Feb;68(2):248-262. doi: 10.1136/gutjnl-2017-315458. Epub 2018 Jul 14.


Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death.

Martins I, Raza SQ, Voisin L, Dakhli H, Allouch A, Law F, Sabino D, De Jong D, Thoreau M, Mintet E, Dugué D, Piacentini M, Gougeon ML, Jaulin F, Bertrand P, Brenner C, Ojcius DM, Kroemer G, Modjtahedi N, Deutsch E, Perfettini JL.

Cell Death Dis. 2018 Jun 18;9(7):716. doi: 10.1038/s41419-018-0747-y.


Salivary biomarkers for the diagnosis and monitoring of neurological diseases.

Farah R, Haraty H, Salame Z, Fares Y, Ojcius DM, Said Sadier N.

Biomed J. 2018 Apr;41(2):63-87. doi: 10.1016/ Epub 2018 May 10. Review.


Microbes and Infection turns 20.

Häfner SJ, Ojcius DM.

Microbes Infect. 2018 Oct - Nov;20(9-10):451-454. doi: 10.1016/j.micinf.2018.05.002. Epub 2018 May 30.


Antrodia cinnamomea produces anti-angiogenic effects by inhibiting the VEGFR2 signaling pathway.

Huang TT, Lan YW, Ko YF, Chen CM, Lai HC, Ojcius DM, Martel J, Young JD, Chong KY.

J Ethnopharmacol. 2018 Jun 28;220:239-249. doi: 10.1016/j.jep.2018.03.041. Epub 2018 Mar 30.


Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation.

Li S, Wang M, Ojcius DM, Zhou B, Hu W, Liu Y, Ma Q, Tang G, Wang D, Yan J.

Microbes Infect. 2018 Apr;20(4):254-260. doi: 10.1016/j.micinf.2018.01.010. Epub 2018 Feb 9.


Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1.

Peng HH, Liu YJ, Ojcius DM, Lee CM, Chen RH, Huang PR, Martel J, Young JD.

Sci Rep. 2017 Nov 30;7(1):16628. doi: 10.1038/s41598-017-16778-4.


Bid-Induced Release of AIF/EndoG from Mitochondria Causes Apoptosis of Macrophages during Infection with Leptospira interrogans.

Hu WL, Dong HY, Li Y, Ojcius DM, Li SJ, Yan J.

Front Cell Infect Microbiol. 2017 Nov 14;7:471. doi: 10.3389/fcimb.2017.00471. eCollection 2017.


NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4.

Singh A, Koduru B, Carlisle C, Akhter H, Liu RM, Schroder K, Brandes RP, Ojcius DM.

Sci Rep. 2017 Oct 30;7(1):14346. doi: 10.1038/s41598-017-14574-8.


Myths and Realities Surrounding the Mysterious Caterpillar Fungus.

Martel J, Ko YF, Liau JC, Lee CS, Ojcius DM, Lai HC, Young JD.

Trends Biotechnol. 2017 Nov;35(11):1017-1021. doi: 10.1016/j.tibtech.2017.06.011.


NLRX1 modulates differentially NLRP3 inflammasome activation and NF-κB signaling during Fusobacterium nucleatum infection.

Hung SC, Huang PR, Almeida-da-Silva CLC, Atanasova KR, Yilmaz O, Ojcius DM.

Microbes Infect. 2018 Oct - Nov;20(9-10):615-625. doi: 10.1016/j.micinf.2017.09.014. Epub 2017 Oct 9.


Combating flu in China.

Jiang S, Ojcius DM.

Microbes Infect. 2017 Dec;19(12):567-569. doi: 10.1016/j.micinf.2017.09.013. Epub 2017 Oct 6.


Sulphate-reducing bacteria from ulcerative colitis patients induce apoptosis of gastrointestinal epithelial cells.

Coutinho CMLM, Coutinho-Silva R, Zinkevich V, Pearce CB, Ojcius DM, Beech I.

Microb Pathog. 2017 Nov;112:126-134. doi: 10.1016/j.micpath.2017.09.054. Epub 2017 Sep 28.


Effects of obesity on depression: A role for inflammation and the gut microbiota.

Schachter J, Martel J, Lin CS, Chang CJ, Wu TR, Lu CC, Ko YF, Lai HC, Ojcius DM, Young JD.

Brain Behav Immun. 2018 Mar;69:1-8. doi: 10.1016/j.bbi.2017.08.026. Epub 2017 Sep 6. Review.


Immunomodulatory Properties of Plants and Mushrooms.

Martel J, Ko YF, Ojcius DM, Lu CC, Chang CJ, Lin CS, Lai HC, Young JD.

Trends Pharmacol Sci. 2017 Nov;38(11):967-981. doi: 10.1016/ Epub 2017 Aug 30.


Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.


Mononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis.

Chen X, Li SJ, Ojcius DM, Sun AH, Hu WL, Lin X, Yan J.

PLoS One. 2017 Jul 11;12(7):e0181014. doi: 10.1371/journal.pone.0181014. eCollection 2017.


Corrigendum: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.

Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YM, Young JD, Lai HC.

Nat Commun. 2017 Jul 11;8:16130. doi: 10.1038/ncomms16130.


Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.

Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, Young JD.

Int J Obes (Lond). 2018 Feb;42(2):231-243. doi: 10.1038/ijo.2017.149. Epub 2017 Jun 20.


NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.

Wu Q, Allouch A, Paoletti A, Leteur C, Mirjolet C, Martins I, Voisin L, Law F, Dakhli H, Mintet E, Thoreau M, Muradova Z, Gauthier M, Caron O, Milliat F, Ojcius DM, Rosselli F, Solary E, Modjtahedi N, Deutsch E, Perfettini JL.

Cell Death Differ. 2017 Sep;24(9):1632-1644. doi: 10.1038/cdd.2017.91. Epub 2017 Jun 2.


Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells.

Zeng Y, Liu B, Rubio MT, Wang X, Ojcius DM, Tang R, Durrbach A, Ru Z, Zhou Y, Lone YC.

PLoS One. 2017 Apr 11;12(4):e0173754. doi: 10.1371/journal.pone.0173754. eCollection 2017.


Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells.

Wu TR, Huang TT, Martel J, Liau JC, Chiu CY, Leu YL, Jian WT, Chang IT, Lu CC, Ojcius DM, Ko YF, Lai HC, Young JD.

J Ethnopharmacol. 2017 Apr 6;201:117-122. doi: 10.1016/j.jep.2017.02.008. Epub 2017 Feb 4.


Isolation, Culture and Characterization of Hirsutella sinensis Mycelium from Caterpillar Fungus Fruiting Body.

Ko YF, Liau JC, Lee CS, Chiu CY, Martel J, Lin CS, Tseng SF, Ojcius DM, Lu CC, Lai HC, Young JD.

PLoS One. 2017 Jan 3;12(1):e0168734. doi: 10.1371/journal.pone.0168734. eCollection 2017.


Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae.

Pettengill MA, Abdul-Sater A, Coutinho-Silva R, Ojcius DM.

Biomed J. 2016 Oct;39(5):306-315. doi: 10.1016/ Epub 2016 Oct 27. Review.


Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome.

Atanasova K, Lee J, Roberts J, Lee K, Ojcius DM, Yilmaz Ö.

Sci Rep. 2016 Nov 24;6:37643. doi: 10.1038/srep37643.


An iron detection system determines bacterial swarming initiation and biofilm formation.

Lin CS, Tsai YH, Chang CJ, Tseng SF, Wu TR, Lu CC, Wu TS, Lu JJ, Horng JT, Martel J, Ojcius DM, Lai HC, Young JD.

Sci Rep. 2016 Nov 15;6:36747. doi: 10.1038/srep36747.

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