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Items: 1 to 50 of 82

1.

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1.

Kasurinen A, Gramolelli S, Hagström J, Laitinen A, Kokkola A, Miki Y, Lehti K, Yashiro M, Ojala PM, Böckelman C, Haglund C.

Cancer Med. 2019 Nov;8(16):6995-7005. doi: 10.1002/cam4.2576. Epub 2019 Sep 27.

2.

MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues.

Gonzalez-Molina J, Gramolelli S, Liao Z, Carlson JW, Ojala PM, Lehti K.

Cells. 2019 Aug 28;8(9). pii: E991. doi: 10.3390/cells8090991. Review.

3.

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo.

Gungor B, Vanharanta L, Hölttä-Vuori M, Pirhonen J, Petersen NHT, Gramolelli S, Ojala PM, Kirkegaard T, Ikonen E.

Mol Metab. 2019 Oct;28:135-143. doi: 10.1016/j.molmet.2019.07.005. Epub 2019 Jul 6.

4.

PROX1 is a transcriptional regulator of MMP14.

Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM.

Sci Rep. 2018 Jun 22;8(1):9531. doi: 10.1038/s41598-018-27739-w.

5.

Access to radical resections of pancreatic cancer is region-dependent despite the public healthcare system in Finland.

Ahola R, Hölsä H, Kiskola S, Ojala P, Pirttilä A, Sand J, Laukkarinen J.

J Epidemiol Community Health. 2018 Sep;72(9):803-808. doi: 10.1136/jech-2017-210187. Epub 2018 May 2.

PMID:
29720389
6.

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.

Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM.

Elife. 2018 May 1;7. pii: e32490. doi: 10.7554/eLife.32490.

7.

Kaposi's sarcoma herpesvirus-induced endothelial cell reprogramming supports viral persistence and contributes to Kaposi's sarcoma tumorigenesis.

Gramolelli S, Ojala PM.

Curr Opin Virol. 2017 Oct;26:156-162. doi: 10.1016/j.coviro.2017.09.002. Epub 2017 Oct 12. Review.

8.

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.

Wang J, Okkeri J, Pavic K, Wang Z, Kauko O, Halonen T, Sarek G, Ojala PM, Rao Z, Xu W, Westermarck J.

EMBO Rep. 2017 Mar;18(3):437-450. doi: 10.15252/embr.201642788. Epub 2017 Feb 7.

9.

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

Balistreri G, Viiliäinen J, Turunen M, Diaz R, Lyly L, Pekkonen P, Rantala J, Ojala K, Sarek G, Teesalu M, Denisova O, Peltonen K, Julkunen I, Varjosalo M, Kainov D, Kallioniemi O, Laiho M, Taipale J, Hautaniemi S, Ojala PM.

PLoS Pathog. 2016 Feb 18;12(2):e1005424. doi: 10.1371/journal.ppat.1005424. eCollection 2016 Feb.

10.

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, Maliniemi P, Lohi J, Rantanen V, Hautaniemi S, Alitalo K, Ranki A, Ojala PM, Keski-Oja J, Lehti K.

Cancer Res. 2015 May 15;75(10):2083-94. doi: 10.1158/0008-5472.CAN-14-1923. Epub 2015 Mar 25.

11.

Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma.

Aavikko M, Kaasinen E, Nieminen JK, Byun M, Donner I, Mancuso R, Ferrante P, Clerici M, Brambilla L, Tourlaki A, Sarid R, Guttman-Yassky E, Taipale M, Morgunova E, Pekkonen P, Ojala PM, Pukkala E, Casanova JL, Vaarala O, Vahteristo P, Aaltonen LA.

J Infect Dis. 2015 Jun 1;211(11):1842-51. doi: 10.1093/infdis/jiu667. Epub 2014 Dec 9.

PMID:
25492914
12.

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo.

Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM.

Cell Cycle. 2014;13(23):3670-84. doi: 10.4161/15384101.2014.964118.

13.

Manipulation of endothelial cells by KSHV: implications for angiogenesis and aberrant vascular differentiation.

Ojala PM, Schulz TF.

Semin Cancer Biol. 2014 Jun;26:69-77. doi: 10.1016/j.semcancer.2014.01.008. Epub 2014 Jan 28. Review.

PMID:
24486643
14.

Enhanced development of auditory change detection in musically trained school-aged children: a longitudinal event-related potential study.

Putkinen V, Tervaniemi M, Saarikivi K, Ojala P, Huotilainen M.

Dev Sci. 2014 Mar;17(2):282-97. doi: 10.1111/desc.12109. Epub 2013 Nov 28.

PMID:
24283257
15.

[Viral infection--a diverse causative agent of cancer].

Pekkonen P, Ojala PM.

Duodecim. 2013;129(15):1545-51. Review. Finnish.

PMID:
24163972
16.

Naughty chaperone as a target for viral cancer.

Ojala PM.

Blood. 2013 Oct 17;122(16):2767-8. doi: 10.1182/blood-2013-08-522425. No abstract available.

PMID:
24136075
17.

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.

Kakkola L, Denisova OV, Tynell J, Viiliäinen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE.

Cell Death Dis. 2013 Jul 25;4:e742. doi: 10.1038/cddis.2013.267.

18.

Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.

Turpeinen H, Ojala PJ, Ojala K, Miettinen M, Volin L, Partanen J.

Int J Immunogenet. 2013 Dec;40(6):495-501. doi: 10.1111/iji.12051. Epub 2013 Mar 11.

PMID:
23480177
19.

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

Buss H, Handschick K, Jurrmann N, Pekkonen P, Beuerlein K, Müller H, Wait R, Saklatvala J, Ojala PM, Schmitz ML, Naumann M, Kracht M.

PLoS One. 2012;7(12):e51847. doi: 10.1371/journal.pone.0051847. Epub 2012 Dec 26.

20.

Instigation of Notch signaling in the pathogenesis of Kaposi's sarcoma-associated herpesvirus and other human tumor viruses.

Cheng F, Pekkonen P, Ojala PM.

Future Microbiol. 2012 Oct;7(10):1191-205. doi: 10.2217/fmb.12.95. Review.

PMID:
23030424
21.

Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells.

Santag S, Jäger W, Karsten CB, Kati S, Pietrek M, Steinemann D, Sarek G, Ojala PM, Schulz TF.

Oncogene. 2013 Aug 8;32(32):3676-85. doi: 10.1038/onc.2012.385. Epub 2012 Sep 10.

PMID:
22964633
22.

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.

Sarek G, Ma L, Enbäck J, Järviluoma A, Moreau P, Haas J, Gessain A, Koskinen PJ, Laakkonen P, Ojala PM.

Oncogene. 2013 Feb 28;32(9):1091-8. doi: 10.1038/onc.2012.118. Epub 2012 Apr 2.

PMID:
22469985
23.

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions.

Paudel N, Sadagopan S, Chakraborty S, Sarek G, Ojala PM, Chandran B.

J Virol. 2012 Jun;86(11):5974-91. doi: 10.1128/JVI.00070-12. Epub 2012 Mar 21.

24.

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, Alitalo K, Lehti K, Ojala PM.

Cell Host Microbe. 2011 Dec 15;10(6):577-90. doi: 10.1016/j.chom.2011.10.011.

25.

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.

Suffert G, Malterer G, Hausser J, Viiliäinen J, Fender A, Contrant M, Ivacevic T, Benes V, Gros F, Voinnet O, Zavolan M, Ojala PM, Haas JG, Pfeffer S.

PLoS Pathog. 2011 Dec;7(12):e1002405. doi: 10.1371/journal.ppat.1002405. Epub 2011 Dec 8.

26.

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K.

Cancer Cell. 2010 Dec 14;18(6):630-40. doi: 10.1016/j.ccr.2010.11.001. Epub 2010 Dec 2.

27.

Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production.

Riederer M, Ojala PJ, Hrzenjak A, Graier WF, Malli R, Tritscher M, Hermansson M, Watzer B, Schweer H, Desoye G, Heinemann A, Frank S.

J Lipid Res. 2010 Oct;51(10):2957-66. doi: 10.1194/jlr.M006536. Epub 2010 Jul 7. Erratum in: J Lipid Res. 2011 Jan;52(1):185. Graier, Wolfgang F [added]; Malli, Roland [added].

28.

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

Sarek G, Järviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P, Laiho M, Ojala PM.

PLoS Pathog. 2010 Mar 19;6(3):e1000818. doi: 10.1371/journal.ppat.1000818.

29.

[Encouraging experiences of interactive lectures].

Lehtonen S, Linden AM, Ojala PM, Polvi A, Sallinen V, Viranta S.

Duodecim. 2009;125(20):2199-205. Finnish.

PMID:
19998758
30.

Robust extraction of functional signals from gene set analysis using a generalized threshold free scoring function.

Törönen P, Ojala PJ, Marttinen P, Holm L.

BMC Bioinformatics. 2009 Sep 23;10:307. doi: 10.1186/1471-2105-10-307.

31.

Genetic similarity of chromosome 6 between patients receiving hematopoietic stem cell transplantation and HLA matched sibling donors.

Turpeinen H, Volin L, Nikkinen L, Ojala P, Palotie A, Saarela J, Partanen J.

Haematologica. 2009 Apr;94(4):528-35. doi: 10.3324/haematol.2008.000919. Epub 2009 Mar 10.

32.

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J, Ojala PM.

PLoS Pathog. 2009 Mar;5(3):e1000324. doi: 10.1371/journal.ppat.1000324. Epub 2009 Mar 6.

33.

Interspliced transcription chimeras: neglected pathological mechanism infiltrating gene accession queries?

Tolvanen M, Ojala PJ, Törönen P, Anderson H, Partanen J, Turpeinen H.

J Biomed Inform. 2009 Apr;42(2):382-9. doi: 10.1016/j.jbi.2008.11.002. Epub 2008 Nov 13.

34.

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling.

Varjosalo M, Björklund M, Cheng F, Syvänen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J.

Cell. 2008 May 2;133(3):537-48. doi: 10.1016/j.cell.2008.02.047.

35.

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.

Koopal S, Furuhjelm JH, Järviluoma A, Jäämaa S, Pyakurel P, Pussinen C, Wirzenius M, Biberfeld P, Alitalo K, Laiho M, Ojala PM.

PLoS Pathog. 2007 Sep 7;3(9):1348-60.

36.

p53 reactivation kills KSHV lymphomas efficiently in vitro and in vivo: new hope for treating aggressive viral lymphomas.

Sarek G, Ojala PM.

Cell Cycle. 2007 Sep 15;6(18):2205-9. Epub 2007 Jul 10. Review.

PMID:
17890905
37.

Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophils.

Ojala PJ, Hirvonen TE, Hermansson M, Somerharju P, Parkkinen J.

J Leukoc Biol. 2007 Dec;82(6):1501-9. Epub 2007 Sep 20.

PMID:
17884992
38.

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

Sarek G, Kurki S, Enbäck J, Iotzova G, Haas J, Laakkonen P, Laiho M, Ojala PM.

J Clin Invest. 2007 Apr;117(4):1019-28. Epub 2007 Mar 15.

39.

Computer-assisted identification of multitrace electrophoretic patterns in differential display experiments.

Vähämaa H, Ojala P, Pahikkala T, Nevalainen OS, Lahesmaa R, Aittokallio T.

Electrophoresis. 2007 Mar;28(6):879-93.

PMID:
17309051
40.

Large-scale differential display analysis of T helper cell differentiation.

Ojala P, Virtanen E, Chen Z.

Electrophoresis. 2007 Mar;28(6):903-17.

PMID:
17309050
41.

Molecular mechanisms underlying neuroprotective effects of albumin after ischemic stroke.

Parkkinen J, Ojala P, Niiranen J, Jolkkonen J.

Stroke. 2007 Feb;38(2):255; author reply 256. Epub 2006 Dec 14. No abstract available.

PMID:
17170360
42.

Identification of alpha-1 acid glycoprotein as a lysophospholipid binding protein: a complementary role to albumin in the scavenging of lysophosphatidylcholine.

Ojala PJ, Hermansson M, Tolvanen M, Polvinen K, Hirvonen T, Impola U, Jauhiainen M, Somerharju P, Parkkinen J.

Biochemistry. 2006 Nov 28;45(47):14021-31.

PMID:
17115697
43.

Integration of electrokinetics and chemical oxidation for the remediation of creosote-contaminated clay.

Isosaari P, Piskonen R, Ojala P, Voipio S, Eilola K, Lehmus E, Itävaara M.

J Hazard Mater. 2007 Jun 1;144(1-2):538-48. Epub 2006 Oct 29.

PMID:
17112659
44.

Herpesvirukset ja immuunijärjestelmä--virusperäisen syövän alkulähhteillä.

Lehtonen A, Ojala PM.

Duodecim. 2006;122(14):1759-66. Finnish. No abstract available.

PMID:
17091710
45.

Cell signaling pathways engaged by KSHV.

Järviluoma A, Ojala PM.

Biochim Biophys Acta. 2006 Aug;1766(1):140-58. Epub 2006 May 19. Review.

PMID:
16828973
46.

Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest.

Järviluoma A, Child ES, Sarek G, Sirimongkolkasem P, Peters G, Ojala PM, Mann DJ.

Mol Cell Biol. 2006 Mar;26(6):2430-40.

47.

Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians.

Rontu R, Ojala P, Hervonen A, Goebeler S, Karhunen PJ, Nikkilä M, Kunnas T, Jylhä M, Eklund C, Hurme M, Lehtimäki T.

Clin Endocrinol (Oxf). 2006 Mar;64(3):265-70.

PMID:
16487435
48.

Automated pattern ranking in differential display data analysis.

Aittokallio T, Ojala P, Nevalainen TJ, Nevalainen OS.

Methods Mol Biol. 2006;317:111-22.

PMID:
16264225
49.

KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas.

Sarek G, Järviluoma A, Ojala PM.

Blood. 2006 Jan 15;107(2):725-32. Epub 2005 Sep 13.

PMID:
16160006
50.

Interleukin-6 modulates plasma cholesterol and C-reactive protein concentrations in nonagenarians.

Lehtimäki T, Ojala P, Rontu R, Goebeler S, Karhunen PJ, Jylhä M, Mattila K, Metso S, Jokela H, Nikkilä M, Wuolijoki E, Hervonen A, Hurme M.

J Am Geriatr Soc. 2005 Sep;53(9):1552-8.

PMID:
16137286

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