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Items: 1 to 50 of 139

1.

Effect of Calcium on the Hydrolysis Activity of Human Butyrylcholinesterase.

Imai T, Bahar FG, Ohura K, Toda A.

J Pharm Sci. 2019 Dec 12. pii: S0022-3549(19)30812-3. doi: 10.1016/j.xphs.2019.12.006. [Epub ahead of print]

PMID:
31837977
2.

Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys.

Ohura K, Igawa Y, Tanaka M, Matsumoto K, Kasahara A, Wada N, Kubota K, Uno Y, Imai T.

Drug Metab Dispos. 2019 Dec 13. pii: dmd.119.089011. doi: 10.1124/dmd.119.089011. [Epub ahead of print]

3.

Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model.

Chiyo T, Fujita K, Iwama H, Fujihara S, Tadokoro T, Ohura K, Matsui T, Goda Y, Kobayashi N, Nishiyama N, Yachida T, Morishita A, Kobara H, Mori H, Niki T, Hirashima M, Himoto T, Masaki T.

Int J Mol Sci. 2019 May 29;20(11). pii: E2634. doi: 10.3390/ijms20112634.

4.
5.

Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3'R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues.

Samir A, Ohura K, Bodor N, Imai T.

J Pharm Sci. 2019 Aug;108(8):2791-2797. doi: 10.1016/j.xphs.2019.03.030. Epub 2019 Apr 5.

PMID:
30954525
6.

Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones.

Kawai M, Herrmann D, Fuchs A, Cheng S, Ferrer-Vaquer A, Götz R, Driller K, Neubüser A, Ohura K.

Med Mol Morphol. 2019 Sep;52(3):156-163. doi: 10.1007/s00795-018-0213-z. Epub 2018 Nov 29.

PMID:
30499042
7.

Analysis of mineral apposition rates during alveolar bone regeneration over three weeks following transfer of BMP-2/7 gene via in vivo electroporation

Kawai M, Kataoka Y, Sonobe J, Yamamoto H, Maruyama H, Yamamoto T, Bessho K, Ohura K.

Eur J Histochem. 2018 Aug 9;62(3). doi: 10.4081/ejh.2018.2947.

8.

Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat.

Samir A, Kage A, Ohura K, Imai T.

Xenobiotica. 2019 May;49(5):569-576. doi: 10.1080/00498254.2018.1479803. Epub 2018 Jul 5.

PMID:
29781759
9.

Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies.

Ishizaki Y, Furihata T, Oyama Y, Ohura K, Imai T, Hosokawa M, Akita H, Chiba K.

Biol Pharm Bull. 2018;41(5):697-706. doi: 10.1248/bpb.b17-00880.

10.

Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques.

Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T.

J Med Primatol. 2018 Jun;47(3):185-191. doi: 10.1111/jmp.12342. Epub 2018 Mar 24.

PMID:
29573432
11.

Targeted sequencing of cancer-associated genes in hepatocellular carcinoma using next-generation sequencing.

Morishita A, Iwama H, Fujihara S, Watanabe M, Fujita K, Tadokoro T, Ohura K, Chiyo T, Sakamoto T, Mimura S, Nomura T, Tani J, Yoneyama H, Okano K, Suzuki Y, Himoto T, Masaki T.

Oncol Lett. 2018 Jan;15(1):528-532. doi: 10.3892/ol.2017.7334. Epub 2017 Nov 2.

12.

Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver.

Uno Y, Igawa Y, Tanaka M, Ohura K, Hosokawa M, Imai T.

Xenobiotica. 2019 Feb;49(2):247-255. doi: 10.1080/00498254.2018.1435927. Epub 2018 Apr 27.

PMID:
29384423
13.

A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate-biotin probe.

Abdel-Daim A, Ohura K, Imai T.

Eur J Pharm Sci. 2018 Mar 1;114:267-274. doi: 10.1016/j.ejps.2017.12.016. Epub 2017 Dec 28.

PMID:
29289670
14.

Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions.

Notomi T, Kuno M, Hiyama A, Nozaki T, Ohura K, Ezura Y, Noda M.

J Biol Chem. 2017 Dec 22;292(51):20998-21010. doi: 10.1074/jbc.M117.780072. Epub 2017 Oct 30.

15.

All-solid-state ion-selective electrodes with redox-active lithium, sodium, and potassium insertion materials as the inner solid-contact layer.

Komaba S, Akatsuka T, Ohura K, Suzuki C, Yabuuchi N, Kanazawa S, Tsuchiya K, Hasegawa T.

Analyst. 2017 Oct 9;142(20):3857-3866. doi: 10.1039/c7an01068k.

PMID:
28901351
16.

Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in Yucatan micropig skin.

Fujii M, Ohara R, Matsumi A, Ohura K, Koizumi N, Imai T, Watanabe Y.

Eur J Pharm Sci. 2017 Nov 15;109:280-287. doi: 10.1016/j.ejps.2017.08.012. Epub 2017 Aug 15.

PMID:
28821439
17.

Non-surgical model for alveolar bone regeneration by bone morphogenetic protein-2/7 gene therapy.

Kawai M, Kataoka YH, Sonobe J, Yamamoto H, Inubushi M, Ishimoto T, Nakano T, Maruyama H, Miyazaki JI, Yamamoto T, Bessho K, Ohura K.

J Periodontol. 2018 Jan;89(1):85-92. doi: 10.1902/jop.2017.170328.

PMID:
28820323
18.

Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation.

Kawai M, Ohmori YK, Nishino M, Yoshida M, Tabata K, Hirota DS, Ryu-Mon A, Yamamoto H, Sonobe J, Kataoka YH, Shiotsu N, Ikegame M, Maruyama H, Yamamoto T, Bessho K, Ohura K.

Eur J Histochem. 2017 May 5;61(2):2772. doi: 10.4081/ejh.2017.2772.

19.

Elucidation of the Intestinal Absorption of para-Aminobenzoic Acid, a Marker for Dietary Intake.

Imai T, Tanaka K, Yonemitsu T, Yakushiji Y, Ohura K.

J Pharm Sci. 2017 Sep;106(9):2881-2888. doi: 10.1016/j.xphs.2017.04.070. Epub 2017 May 24.

PMID:
28549908
20.

Therapeutic potential of the antidiabetic drug metformin in small bowel adenocarcinoma.

Chiyo T, Kato K, Iwama H, Fujihara S, Fujita K, Tadokoro T, Ohura K, Samukawa E, Yamana Y, Kobayashi N, Matsunaga T, Nishiyama N, Ayaki M, Yachida T, Morishita A, Kobara H, Mori H, Masaki T.

Int J Oncol. 2017 Jun;50(6):2145-2153. doi: 10.3892/ijo.2017.3971. Epub 2017 Apr 20.

PMID:
28440424
21.

Nicorandil inhibits osteoclast differentiation in vitro.

Iwaki F, Amano H, Ohura K.

Eur J Pharmacol. 2016 Dec 15;793:14-20. doi: 10.1016/j.ejphar.2016.10.034. Epub 2016 Nov 1.

22.

Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine.

Ohura K, Nishiyama H, Saco S, Kurokawa K, Imai T.

Drug Metab Dispos. 2016 Dec;44(12):1890-1898. Epub 2016 Sep 16.

PMID:
27638507
23.

Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes.

Igawa Y, Fujiwara S, Ohura K, Hirokawa T, Nishizawa Y, Uehara S, Uno Y, Imai T.

Mol Pharm. 2016 Sep 6;13(9):3176-86. doi: 10.1021/acs.molpharmaceut.6b00394. Epub 2016 Aug 8.

PMID:
27454346
24.

Evaluation of in vivo efficacy of radiofrequency ablation with D-sorbitol in animal liver.

Morishita A, Sakamoto T, Kobara H, Tadokoro T, Ohura K, Fujita K, Tani J, Miyoshi H, Yoneyama H, Himoto T, Masaki T.

Mol Clin Oncol. 2016 Feb;4(2):183-186. Epub 2015 Nov 16.

25.

Expression of Carboxylesterase Isozymes and Their Role in the Behavior of a Fexofenadine Prodrug in Rat Skin.

Imai T, Ariyoshi S, Ohura K, Sawada T, Nakada Y.

J Pharm Sci. 2016 Feb;105(2):714-721. doi: 10.1002/jps.24648. Epub 2016 Jan 12.

PMID:
26444870
26.

Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts.

Notomi T, Kuno M, Hiyama A, Ezura Y, Honma M, Ishizuka T, Ohura K, Yawo H, Noda M.

Bone. 2015 Dec;81:306-314. doi: 10.1016/j.bone.2015.07.031. Epub 2015 Jul 23.

PMID:
26211991
27.

A new method for measuring osteoclast formation by electrical impedance.

Emori H, Iwai S, Ryu K, Amano H, Sambe T, Kobayashi T, Oguchi T, Ohura K, Oguchi K.

J Pharmacol Sci. 2015 Jun;128(2):87-91. doi: 10.1016/j.jphs.2015.05.002. Epub 2015 May 15.

28.

Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.

Ohura K, Nakada Y, Kotani S, Imai T.

J Pharm Sci. 2015 Sep;104(9):3076-83. doi: 10.1002/jps.24467. Epub 2015 May 7.

PMID:
25953731
29.

Zinc-Induced Effects on Osteoclastogenesis Involves Activation of Hyperpolarization-Activated Cyclic Nucleotide Modulated Channels via Changes in Membrane Potential.

Notomi T, Kuno M, Hiyama A, Ohura K, Noda M, Skerry TM.

J Bone Miner Res. 2015 Sep;30(9):1618-26. doi: 10.1002/jbmr.2507. Epub 2015 May 31.

30.

Establishment of a novel dwarf rat strain: cartilage calcification insufficient (CCI) rats.

Tanaka M, Watanabe M, Yokomi I, Matsumoto N, Sudo K, Satoh H, Igarashi T, Seki A, Amano H, Ohura K, Ryu K, Shibata S, Nagayama M, Tanuma J.

Exp Anim. 2015;64(2):121-8. doi: 10.1538/expanim.14-0072. Epub 2014 Dec 20.

31.

3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells.

Matsusaki M, Hikimoto D, Nishiguchi A, Kadowaki K, Ohura K, Imai T, Akashi M.

Biochem Biophys Res Commun. 2015 Feb 13;457(3):363-9. doi: 10.1016/j.bbrc.2014.12.118. Epub 2015 Jan 8.

PMID:
25576862
32.

Insulinogenic sucrose+amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose+amino acid mixture in growing rats.

Notomi T, Karasaki I, Okazaki Y, Okimoto N, Kato Y, Ohura K, Noda M, Nakamura T, Suzuki M.

Bone. 2014 Aug;65:42-8. doi: 10.1016/j.bone.2014.05.002. Epub 2014 May 9.

PMID:
24815919
33.

Regulation of miRNA during direct reprogramming of dental pulp cells to insulin-producing cells.

Nozaki T, Ohura K.

Biochem Biophys Res Commun. 2014 Feb 7;444(2):195-8. doi: 10.1016/j.bbrc.2014.01.030. Epub 2014 Jan 16.

PMID:
24440707
34.

Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine.

Ohura K, Tasaka K, Hashimoto M, Imai T.

Drug Metab Dispos. 2014 Feb;42(2):264-73. doi: 10.1124/dmd.113.054551. Epub 2013 Nov 22.

PMID:
24271336
35.

Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment.

Nozaki T, Fujimori H, Wang J, Suzuki H, Imai H, Watanabe M, Ohura K, Masutani M.

Pathol Int. 2013 Aug;63(8):408-14. doi: 10.1111/pin.12086.

PMID:
23957916
36.

Monitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV.

Ustün-Aytekin O, Gürhan ID, Ohura K, Imai T, Ongen G.

Cytotechnology. 2014 Jan;66(1):159-68. doi: 10.1007/s10616-013-9549-3. Epub 2013 May 29.

37.

Possible involvement of A₂A and A₃ receptors in modulation of insulin secretion and β-cell survival in mouse pancreatic islets.

Ohtani M, Oka T, Ohura K.

Gen Comp Endocrinol. 2013 Jun 15;187:86-94. doi: 10.1016/j.ygcen.2013.02.011. Epub 2013 Feb 27.

PMID:
23453966
38.

Prediction of carotid plaque characteristics using non-gated MR imaging: correlation with endarterectomy specimens.

Narumi S, Sasaki M, Ohba H, Ogasawara K, Kobayashi M, Hitomi J, Mori K, Ohura K, Yamaguchi M, Kudo K, Terayama Y.

AJNR Am J Neuroradiol. 2013 Jan;34(1):191-7. doi: 10.3174/ajnr.A3249. Epub 2012 Jul 26.

39.

Species difference of esterase expression and hydrolase activity in plasma.

Bahar FG, Ohura K, Ogihara T, Imai T.

J Pharm Sci. 2012 Oct;101(10):3979-88. doi: 10.1002/jps.23258. Epub 2012 Jul 25.

PMID:
22833171
40.

[Initial clinical experience of early cardiac rehabilitation for very elderly patients over 85 years old following open heart surgery].

Furukawa H, Kangai K, Minami K, Ohura K, Ochi Y, Ikumoto H, Fujimoto M, Aono H, Samukawa M.

Kyobu Geka. 2012 Jun;65(6):440-5. Japanese.

PMID:
22647324
41.

Effect of intestinal first-pass hydrolysis on the oral bioavailability of an ester prodrug of fexofenadine.

Ohura K, Soejima T, Nogata R, Adachi Y, Ninomiya S, Imai T.

J Pharm Sci. 2012 Sep;101(9):3264-74. doi: 10.1002/jps.23182. Epub 2012 May 24.

PMID:
22628163
42.

Quantitative assessment of changes in carotid plaques during cilostazol administration using three-dimensional ultrasonography and non-gated magnetic resonance plaque imaging.

Yamaguchi M, Sasaki M, Ohba H, Mori K, Narumi S, Katsura N, Ohura K, Kudo K, Terayama Y.

Neuroradiology. 2012 Sep;54(9):939-45. doi: 10.1007/s00234-012-1011-2. Epub 2012 Jan 21.

PMID:
22271319
43.

Involvement of P2X receptors in the regulation of insulin secretion, proliferation and survival in mouse pancreatic β-cells.

Ohtani M, Ohura K, Oka T.

Cell Physiol Biochem. 2011;28(2):355-66. doi: 10.1159/000331752. Epub 2011 Aug 16.

44.

Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case.

Ohura K, Nozawa T, Murakami K, Imai T.

J Pharm Sci. 2011 Sep;100(9):3985-94. doi: 10.1002/jps.22628. Epub 2011 May 26.

PMID:
21618543
45.

Gene expression profile of dental pulp cells during differentiation into an adipocyte lineage.

Nozaki T, Ohura K.

J Pharmacol Sci. 2011;115(3):354-63. Epub 2011 Feb 22.

46.

The role of intestinal carboxylesterase in the oral absorption of prodrugs.

Imai T, Ohura K.

Curr Drug Metab. 2010 Nov;11(9):793-805. Review.

PMID:
21189138
47.

A novel chemoattractant lectin, karatoxin, from the dorsal spines of the small scorpionfish Hypodytes rubripinnis.

Shinohara M, Nagasaka K, Nakagawa H, Edo K, Sakai H, Kato K, Iwaki F, Ohura K, Sakuraba H.

J Pharmacol Sci. 2010;113(4):414-7. Epub 2010 Jul 16.

48.

Dilazep decreases lipopolysaccharide-induced nitric oxide and TNF-alpha synthesis in RAW 264 cells.

Nakatsuka R, Nozaki T, Shinohara M, Ohura K.

J Pharmacol Sci. 2010;113(3):271-5.

49.

5-Aza-2'-deoxycytidine treatment induces skeletal myogenic differentiation of mouse dental pulp stem cells.

Nakatsuka R, Nozaki T, Uemura Y, Matsuoka Y, Sasaki Y, Shinohara M, Ohura K, Sonoda Y.

Arch Oral Biol. 2010 May;55(5):350-7. doi: 10.1016/j.archoralbio.2010.03.003. Epub 2010 Apr 1.

PMID:
20362276
50.

Altered carotid plaque signal among different repetition times on T1-weighted magnetic resonance plaque imaging with self-navigated radial-scan technique.

Narumi S, Sasaki M, Ohba H, Ogasawara K, Hitomi J, Mori K, Ohura K, Ono A, Terayama Y.

Neuroradiology. 2010 Apr;52(4):285-90. doi: 10.1007/s00234-009-0642-4. Epub 2009 Dec 18.

PMID:
20020115

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