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Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine.

Tateshita N, Miura N, Tanaka H, Masuda T, Ohtsuki S, Tange K, Nakai Y, Yoshioka H, Akita H.

J Control Release. 2019 Aug 3;310:36-46. doi: 10.1016/j.jconrel.2019.08.002. [Epub ahead of print]


Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet.

Ogata S, Ito S, Masuda T, Ohtsuki S.

Pharm Res. 2019 Jul 31;36(10):141. doi: 10.1007/s11095-019-2674-8.


Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Inter-Chain VH-VL Interactions.

Yamauchi S, Kobashigawa Y, Fukuda N, Teramoto M, Toyota Y, Liu C, Ikeguchi Y, Sato T, Sato Y, Kimura H, Masuda T, Ohtsuki S, Noi K, Ogura T, Morioka H.

Molecules. 2019 Jul 18;24(14). pii: E2620. doi: 10.3390/molecules24142620.


Clinical outcomes after the endovascular treatments of pulmonary vein stenosis in patients with congenital heart disease.

Kurita Y, Baba K, Kondo M, Eitoku T, Kasahara S, Iwasaki T, Ohtsuki S, Tsukahara H.

Cardiol Young. 2019 Jul 9:1-9. doi: 10.1017/S1047951119001495. [Epub ahead of print]


Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands.

Takeo E, Sugiura Y, Uemura T, Nishimoto K, Yasuda M, Sugiyama E, Ohtsuki S, Higashi T, Nishikawa T, Suematsu M, Fukusaki E, Shimma S.

Anal Chem. 2019 Jul 16;91(14):8918-8925. doi: 10.1021/acs.analchem.9b00619. Epub 2019 Jun 26.


Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood-Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/ciβ.

Masuda T, Hoshiyama T, Uemura T, Hirayama-Kurogi M, Ogata S, Furukawa A, Couraud PO, Furihata T, Ito S, Ohtsuki S.

Mol Pharm. 2019 May 6;16(5):2162-2171. doi: 10.1021/acs.molpharmaceut.9b00114. Epub 2019 Apr 15.


Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: Changes in drug transporters and metabolizing enzymes.

Kuno T, Hirayama-Kurogi M, Ito S, Ohtsuki S.

Drug Metab Pharmacokinet. 2019 Apr;34(2):159-162. doi: 10.1016/j.dmpk.2019.01.001. Epub 2019 Jan 19.


Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells.

Ito S, Honda G, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S.

Pharm Res. 2019 Jan 11;36(3):39. doi: 10.1007/s11095-018-2565-4.


Oxidative stress-induced activation of Abl and Src kinases rapidly induces P-glycoprotein internalization via phosphorylation of caveolin-1 on tyrosine-14, decreasing cortisol efflux at the blood-brain barrier.

Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T.

J Cereb Blood Flow Metab. 2019 Jan 9:271678X18822801. doi: 10.1177/0271678X18822801. [Epub ahead of print]


Urate Transport via Paracellular Route across Epithelial Cells.

Kimura T, Tsukada A, Fukutomi T, Ichida K, Ohtsuki S, Sakurai H.

Biol Pharm Bull. 2019;42(1):43-49. doi: 10.1248/bpb.b18-00505.


Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA).

Kobayashi D, Tokuda T, Sato K, Okanishi H, Nagayama M, Hirayama-Kurogi M, Ohtsuki S, Araki N.

Mol Cell Proteomics. 2019 Feb;18(2):245-262. doi: 10.1074/mcp.RA118.001014. Epub 2018 Oct 31.


Comparison of venous and fingertip plasma using non-targeted proteomics and metabolomics.

Nishiumi S, Kohata T, Kobayashi T, Kodama Y, Ohtsuki S, Yoshida M.

Talanta. 2019 Jan 15;192:182-188. doi: 10.1016/j.talanta.2018.09.047. Epub 2018 Sep 15.


Influenza virus replication raises the temperature of cells.

Maruyama H, Kimura T, Liu H, Ohtsuki S, Miyake Y, Isogai M, Arai F, Honda A.

Virus Res. 2018 Sep 15;257:94-101. doi: 10.1016/j.virusres.2018.09.011. Epub 2018 Sep 22.


Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells.

Ito S, Fujino Y, Ogata S, Hirayama-Kurogi M, Ohtsuki S.

J Pharm Sci. 2018 Dec;107(12):3163-3170. doi: 10.1016/j.xphs.2018.08.011. Epub 2018 Aug 23.


SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.

Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K.

Nat Commun. 2018 Jul 19;9(1):2833. doi: 10.1038/s41467-018-05187-4.


Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis.

Uchida Y, Sumiya T, Tachikawa M, Yamakawa T, Murata S, Yagi Y, Sato K, Stephan A, Ito K, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T.

Mol Neurobiol. 2019 Mar;56(3):2039-2056. doi: 10.1007/s12035-018-1207-5. Epub 2018 Jul 8.


Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y.

Drug Metab Dispos. 2018 Nov;46(11):1756-1766. doi: 10.1124/dmd.118.081216. Epub 2018 May 18.


Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter.

Nakamura S, Muramatsu SI, Takino N, Ito M, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T, Osaka H.

J Gene Med. 2018 Apr;20(4):e3013. doi: 10.1002/jgm.3013. Epub 2018 Apr 6.


Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.

Miyauchi E, Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi W, Baba T, Watanabe M, Terasaki T, Nakada M.

PLoS One. 2018 Mar 7;13(3):e0193799. doi: 10.1371/journal.pone.0193799. eCollection 2018.


Impact of Cardiac Progenitor Cells on Heart Failure and Survival in Single Ventricle Congenital Heart Disease.

Sano T, Ousaka D, Goto T, Ishigami S, Hirai K, Kasahara S, Ohtsuki S, Sano S, Oh H.

Circ Res. 2018 Mar 30;122(7):994-1005. doi: 10.1161/CIRCRESAHA.117.312311. Epub 2018 Jan 24.


Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels.

Kuno T, Hirayama-Kurogi M, Ito S, Ohtsuki S.

Sci Rep. 2018 Jan 19;8(1):1253. doi: 10.1038/s41598-018-19545-1.


ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver.

Sasaki K, Tachikawa M, Uchida Y, Hirano S, Kadowaki F, Watanabe M, Ohtsuki S, Terasaki T.

Mol Pharm. 2018 Feb 5;15(2):343-355. doi: 10.1021/acs.molpharmaceut.7b00679. Epub 2018 Jan 24.


Formation of the Periotic Space During the Early Fetal Period in Humans.

Ishikawa A, Ohtsuki S, Yamada S, Uwabe C, Imai H, Matsuda T, Takakuwa T.

Anat Rec (Hoboken). 2018 Apr;301(4):563-570. doi: 10.1002/ar.23764. Epub 2018 Jan 18.


Initiation of a lightning search using the lightning and airglow camera onboard the Venus orbiter Akatsuki.

Takahashi Y, Sato M, Imai M, Lorenz R, Yair Y, Aplin K, Fischer G, Nakamura M, Ishii N, Abe T, Satoh T, Imamura T, Hirose C, Suzuki M, Hashimoto GL, Hirata N, Yamazaki A, Sato TM, Yamada M, Murakami SY, Yamamoto Y, Fukuhara T, Ogohara K, Ando H, Sugiyama KI, Kashimura H, Ohtsuki S.

Earth Planets Space. 2018;70(1):88. doi: 10.1186/s40623-018-0836-2. Epub 2018 May 25.


Morphogenesis of the Middle Ear during Fetal Development as Observed Via Magnetic Resonance Imaging.

Ohtsuki S, Ishikawa A, Yamada S, Imai H, Matsuda T, Takakuwa T.

Anat Rec (Hoboken). 2018 May;301(5):757-764. doi: 10.1002/ar.23760. Epub 2018 Jan 23.


Transcoronary cell infusion with the stop-flow technique in children with single-ventricle physiology.

Eitoku T, Baba K, Kondou M, Kurita Y, Fukushima Y, Hirai K, Ohtsuki S, Ishigami S, Sano S, Oh H.

Pediatr Int. 2018 Mar;60(3):240-246. doi: 10.1111/ped.13485.


High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human.

Akazawa T, Uchida Y, Miyauchi E, Tachikawa M, Ohtsuki S, Terasaki T.

Mol Pharm. 2018 Jan 2;15(1):127-140. doi: 10.1021/acs.molpharmaceut.7b00772. Epub 2017 Dec 5.


Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene.

Ohtsuki S, Takahashi Y, Inoue T, Takakura Y, Nishikawa M.

Sci Rep. 2017 Oct 20;7(1):13661. doi: 10.1038/s41598-017-13890-3.


A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs).

Shirotani K, Matsuo K, Ohtsuki S, Masuda T, Asai M, Kutoku Y, Ohsawa Y, Sunada Y, Kondo T, Inoue H, Iwata N.

J Biochem. 2017 Dec 1;162(6):391-394. doi: 10.1093/jb/mvx058.


DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy.

Yata T, Takahashi Y, Tan M, Nakatsuji H, Ohtsuki S, Murakami T, Imahori H, Umeki Y, Shiomi T, Takakura Y, Nishikawa M.

Biomaterials. 2017 Nov;146:136-145. doi: 10.1016/j.biomaterials.2017.09.014. Epub 2017 Sep 9.


Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry.

Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, Chan DW, Gibson BW, Gingras AC, Held JM, Hirayama-Kurogi M, Hou G, Krisp C, Larsen B, Lin L, Liu S, Molloy MP, Moritz RL, Ohtsuki S, Schlapbach R, Selevsek N, Thomas SN, Tzeng SC, Zhang H, Aebersold R.

Nat Commun. 2017 Aug 21;8(1):291. doi: 10.1038/s41467-017-00249-5.


Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile.

Nagahori H, Nakamura K, Sumida K, Ito S, Ohtsuki S.

J Proteome Res. 2017 Oct 6;16(10):3634-3645. doi: 10.1021/acs.jproteome.7b00364. Epub 2017 Sep 6.


Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure.

Mohri K, Nagata K, Ohtsuki S, Toyama S, Nonomura M, Takahashi Y, Takakura Y, Nishikawa M, Sakuma S.

Pharm Res. 2017 Nov;34(11):2362-2370. doi: 10.1007/s11095-017-2243-y. Epub 2017 Aug 8.


Identification of cyclic peptides for facilitation of transcellular transport of phages across intestinal epithelium in vitro and in vivo.

Yamaguchi S, Ito S, Kurogi-Hirayama M, Ohtsuki S.

J Control Release. 2017 Sep 28;262:232-238. doi: 10.1016/j.jconrel.2017.07.037. Epub 2017 Jul 27.


Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood-Brain Barrier.

Ito S, Yanai M, Yamaguchi S, Couraud PO, Ohtsuki S.

J Pharm Sci. 2017 Sep;106(9):2599-2605. doi: 10.1016/j.xphs.2017.04.036. Epub 2017 Apr 26.


Scrambled Internal Standard Method for High-Throughput Protein Quantification by Matrix-Assisted Laser Desorption Ionization Tandem Mass Spectrometry.

Yoneyama T, Ohtsuki S, Tachikawa M, Uchida Y, Terasaki T.

J Proteome Res. 2017 Apr 7;16(4):1556-1565. doi: 10.1021/acs.jproteome.6b00941. Epub 2017 Mar 28.


Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration.

Miura T, Tachikawa M, Ohtsuka H, Fukase K, Nakayama S, Sakata N, Motoi F, Naitoh T, Katayose Y, Uchida Y, Ohtsuki S, Terasaki T, Unno M.

J Pharm Sci. 2017 Sep;106(9):2499-2508. doi: 10.1016/j.xphs.2017.02.018. Epub 2017 Feb 27.


All-trans retinoic acid enhances gemcitabine cytotoxicity in human pancreatic cancer cell line AsPC-1 by up-regulating protein expression of deoxycytidine kinase.

Kuroda H, Tachikawa M, Uchida Y, Inoue K, Ohtsuka H, Ohtsuki S, Unno M, Terasaki T.

Eur J Pharm Sci. 2017 May 30;103:116-121. doi: 10.1016/j.ejps.2017.02.021. Epub 2017 Feb 12.


Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.

Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S.

J Proteomics. 2017 Mar 31;158:31-42. doi: 10.1016/j.jprot.2017.02.009. Epub 2017 Feb 16.


[A Case of a-Fetoprotein Producing Gastric Cancer with Lymph Node Recurrence after Endoscopic Submucosal Dissection].

Gokita K, Inokuchi M, Ohtsuki S, Tanioka T, Okuno K, Tomii C, Murase H, Kojima K.

Gan To Kagaku Ryoho. 2016 Nov;43(12):1872-1874. Japanese.


Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.

Nakamura S, Osaka H, Muramatsu SI, Takino N, Ito M, Aoki S, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T.

Mol Genet Metab Rep. 2017 Jan 15;10:67-74. doi: 10.1016/j.ymgmr.2016.12.008. eCollection 2017 Mar.


Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells.

Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T.

J Neurochem. 2017 Apr;141(2):247-262. doi: 10.1111/jnc.13960. Epub 2017 Mar 6.


Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial.

Ishigami S, Ohtsuki S, Eitoku T, Ousaka D, Kondo M, Kurita Y, Hirai K, Fukushima Y, Baba K, Goto T, Horio N, Kobayashi J, Kuroko Y, Kotani Y, Arai S, Iwasaki T, Sato S, Kasahara S, Sano S, Oh H.

Circ Res. 2017 Mar 31;120(7):1162-1173. doi: 10.1161/CIRCRESAHA.116.310253. Epub 2017 Jan 4.


Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization.

Uemura T, Ito S, Ohta Y, Tachikawa M, Wada T, Terasaki T, Ohtsuki S.

Biol Pharm Bull. 2017;40(1):49-55. doi: 10.1248/bpb.b16-00582.


The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport.

Ochiai Y, Uchida Y, Ohtsuki S, Tachikawa M, Aizawa S, Terasaki T.

J Neurochem. 2017 May;141(3):400-412. doi: 10.1111/jnc.13943. Epub 2017 Mar 30.


Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics.

Yoneyama T, Ohtsuki S, Honda K, Kobayashi M, Iwasaki M, Uchida Y, Okusaka T, Nakamori S, Shimahara M, Ueno T, Tsuchida A, Sata N, Ioka T, Yasunami Y, Kosuge T, Kaneda T, Kato T, Yagihara K, Fujita S, Huang W, Yamada T, Tachikawa M, Terasaki T.

PLoS One. 2016 Aug 31;11(8):e0161009. doi: 10.1371/journal.pone.0161009. eCollection 2016.


Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice.

Kuno T, Hirayama-Kurogi M, Ito S, Ohtsuki S.

Mol Pharm. 2016 Aug 1;13(8):2691-701. doi: 10.1021/acs.molpharmaceut.6b00259. Epub 2016 Jul 20.


Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine.

Akazawa T, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T.

Mol Pharm. 2016 Jul 5;13(7):2443-56. doi: 10.1021/acs.molpharmaceut.6b00196. Epub 2016 Jun 17.


Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.

Nakamura K, Hirayama-Kurogi M, Ito S, Kuno T, Yoneyama T, Obuchi W, Terasaki T, Ohtsuki S.

Proteomics. 2016 Aug;16(15-16):2106-17. doi: 10.1002/pmic.201500433. Epub 2016 Jul 8.


Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney.

Uchida Y, Toyohara T, Ohtsuki S, Moriyama Y, Abe T, Terasaki T.

J Pharm Sci. 2016 Feb;105(2):1011-1016. doi: 10.1002/jps.24645. Epub 2016 Jan 11.


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