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Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis.

Hirose S, Lin Q, Ohtsuji M, Nishimura H, Verbeek JS.

Int Immunol. 2019 Oct 16;31(11):687-696. doi: 10.1093/intimm/dxz036.


FcγRIIb on B Cells and Myeloid Cells Modulates B Cell Activation and Autoantibody Responses via Different but Synergistic Pathways in Lupus-Prone Yaa Mice.

Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek JS, Hirose S.

J Immunol. 2018 Dec 1;201(11):3199-3210. doi: 10.4049/jimmunol.1701487. Epub 2018 Oct 29.


Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice.

Ohtsuji M, Lin Q, Okazaki H, Takahashi K, Amano H, Yagita H, Nishimura H, Hirose S.

Arthritis Res Ther. 2018 Feb 8;20(1):25. doi: 10.1186/s13075-018-1523-1.


IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcγRIIB-deficient rheumatoid arthritis mouse model.

Ohtsuji M, Lin Q, Nishikawa K, Ohtsuji N, Okazaki H, Tsurui H, Amano H, Shirai T, Nishimoto N, Nishimura H, Hirose S.

Mod Rheumatol. 2015 Mar;25(2):270-7. doi: 10.3109/14397595.2014.950035. Epub 2014 Aug 27.


Genome-wide genetic study in autoimmune disease-prone mice.

Obata M, Ohtsuji M, Iida Y, Shirai T, Hirose S, Nishimura H.

Methods Mol Biol. 2014;1142:111-41. doi: 10.1007/978-1-4939-0404-4_13. Review.


TNFα but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model.

Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, Hirose S.

Mod Rheumatol. 2014 Nov;24(6):931-8. doi: 10.3109/14397595.2014.886351. Epub 2014 Mar 4.


Nephrotoxic effect of subchronic exposure to S-(1,2-dichlorovinyl)-L-cysteine in mice.

Shirai N, Ohtsuji M, Hagiwara K, Tomisawa H, Ohtsuji N, Hirose S, Hagiwara H.

J Toxicol Sci. 2012;37(5):871-8.


Transgenic overexpression of G5PR that is normally augmented in centrocytes impairs the enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice.

Kitabatake M, Toda T, Kuwahara K, Igarashi H, Ohtsuji M, Tsurui H, Hirose S, Sakaguchi N.

J Immunol. 2012 Aug 1;189(3):1193-201. doi: 10.4049/jimmunol.1102774. Epub 2012 Jul 2.


Angiotensin II receptor antagonist reduces subsequent uterine arterial dysfunction in pregnant offspring of protein-restricted rat dams.

Saito T, Musha Y, Miyakawa M, Itoh S, Ohtsuji M, Hanson MA, Takeda S.

J Obstet Gynaecol Res. 2012 Mar;38(3):483-9. doi: 10.1111/j.1447-0756.2011.01737.x. Epub 2012 Feb 16.


Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background.

Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S.

Arthritis Rheum. 2011 Oct;63(10):2930-8. doi: 10.1002/art.30485.


Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes.

Fujii T, Hou R, Sato-Hayashizaki A, Obata M, Ohtsuji M, Ikeda K, Mitsui K, Kodera Y, Shirai T, Hirose S, Nishimura H.

Eur J Immunol. 2011 Aug;41(8):2333-40. doi: 10.1002/eji.201141552. Epub 2011 Jul 6.


Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.

Kobayashi A, Tsukide T, Miyasaka T, Morita T, Mizoroki T, Saito Y, Ihara Y, Takashima A, Noguchi N, Fukamizu A, Hirotsu Y, Ohtsuji M, Katsuoka F, Yamamoto M.

Genes Cells. 2011 Jun;16(6):692-703. doi: 10.1111/j.1365-2443.2011.01522.x. Epub 2011 May 10.


Vascular, renal and placental effects on pregnant offspring of protein-restricted rat dams.

Musha Y, Itoh S, Miyakawa M, Ohtsuji M, Hanson MA, Kinoshita K, Takeda S.

J Obstet Gynaecol Res. 2011 Apr;37(4):343-51. doi: 10.1111/j.1447-0756.2010.01351.x. Epub 2011 Jan 27.


FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.

Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):804-10. doi: 10.1016/j.bbrc.2010.03.078. Epub 2010 Mar 15.


Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus.

Lin Q, Hou R, Sato A, Ohtsuji M, Ohtsuji N, Nishikawa K, Tsurui H, Amano H, Amano E, Sudo K, Nishimura H, Shirai T, Hirose S.

J Autoimmun. 2010 Jun;34(4):356-63. doi: 10.1016/j.jaut.2009.08.011. Epub 2009 Sep 15.


Ankylosing enthesitis associated with up-regulated IFN-gamma and IL-17 production in (BXSB x NZB) F(1) male mice: a new mouse model.

Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K, Hirose S.

Mod Rheumatol. 2009;19(3):316-22. doi: 10.1007/s10165-009-0166-0. Epub 2009 Apr 9.


Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice.

Hou R, Ohtsuji M, Ohtsuji N, Zhang L, Adachi T, Hirose S, Tsubata T.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):193-7. doi: 10.1016/j.bbrc.2009.01.072. Epub 2009 Jan 22.


Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.

Ohtsuji M, Katsuoka F, Kobayashi A, Aburatani H, Hayes JD, Yamamoto M.

J Biol Chem. 2008 Nov 28;283(48):33554-62. doi: 10.1074/jbc.M804597200. Epub 2008 Sep 30.


Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains: possible involvement in systemic lupus erythematosus pathogenesis.

Tsukamoto K, Ohtsuji M, Shiroiwa W, Lin Q, Nakamura K, Tsurui H, Jiang Y, Sudo K, Nishimura H, Shirai T, Hirose S.

J Immunol. 2008 Apr 1;180(7):4530-9.


Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T, Shibata T, Yamamoto M, Hirohashi S.

Cancer Res. 2008 Mar 1;68(5):1303-9. doi: 10.1158/0008-5472.CAN-07-5003.


Decreased ADP-ribosyl cyclase activity in peripheral blood mononuclear cells from diabetic patients with nephropathy.

Ohtsuji M, Yagi K, Shintaku-Kubota M, Kojima-Koba Y, Ito N, Sugihara M, Yamaaki N, Chujo D, Nohara A, Takeda Y, Kobayashi J, Yamagishi M, Higashida H.

Exp Diabetes Res. 2008;2008:897508. doi: 10.1155/2008/897508. Epub 2009 Mar 17.


CD3 and immunoglobulin G Fc receptor regulate cerebellar functions.

Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S.

Mol Cell Biol. 2007 Jul;27(14):5128-34. Epub 2007 May 14.


IL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus.

Shiroiwa W, Tsukamoto K, Ohtsuji M, Lin Q, Ida A, Kodera S, Ohtsuji N, Nakamura K, Tsurui H, Kinoshita K, Nishimura H, Shirai T, Hirose S.

Int Immunol. 2007 Feb;19(2):175-83. Epub 2006 Dec 22.


Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating.

Nakamura K, Koyama Y, Takahashi K, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Sugawara Y, Sawabe K, Ohashi A, Ohnuma T, Arai H, Nishimura H, Hasegawa H, Hirose S.

J Mol Biol. 2006 Oct 20;363(2):345-54. Epub 2006 Aug 25.


Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus.

Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, Ohtsuji M, Ohtsuji N, Shiroiwa W, Tsukamoto K, Amano H, Amano E, Kinoshita K, Sudo K, Nishimura H, Izui S, Shirai T, Hirose S.

J Immunol. 2006 Aug 1;177(3):1646-54.


Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.

Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M.

Mol Cell. 2006 Mar 3;21(5):689-700.


Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.

Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S.

J Neurosci. 2006 Jan 11;26(2):530-4.


Frequent down-regulation of HIVEP2 in human breast cancer.

Fujii H, Gabrielson E, Takagaki T, Ohtsuji M, Ohtsuji N, Hino O.

Breast Cancer Res Treat. 2005 May;91(2):103-12.


Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus.

Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S.

Eur J Immunol. 2004 Oct;34(10):2740-9.


Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.

Mol Cell Biol. 2004 Aug;24(16):7130-9.


Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.

Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S.

Hum Mol Genet. 2004 Jan 15;13(2):171-9.


A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model.

Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M, Hirose S, Shirai T.

J Exp Med. 2003 Aug 4;198(3):497-503. Epub 2003 Jul 28.


Genetic dissection of anxiety in autoimmune disease.

Nakamura K, Xiu Y, Ohtsuji M, Sugita G, Abe M, Ohtsuji N, Hamano Y, Jiang Y, Takahashi N, Shirai T, Nishimura H, Hirose S.

Hum Mol Genet. 2003 May 15;12(10):1079-86.


C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis.

Miura-Shimura Y, Nakamura K, Ohtsuji M, Tomita H, Jiang Y, Abe M, Zhang D, Hamano Y, Tsuda H, Hashimoto H, Nishimura H, Taki S, Shirai T, Hirose S.

J Immunol. 2002 Aug 1;169(3):1334-9.


Genetics of synchronous uterine and ovarian endometrioid carcinoma: combined analyses of loss of heterozygosity, PTEN mutation, and microsatellite instability.

Fujii H, Matsumoto T, Yoshida M, Furugen Y, Takagaki T, Iwabuchi K, Nakata Y, Takagi Y, Moriya T, Ohtsuji N, Ohtsuji M, Hirose S, Shirai T.

Hum Pathol. 2002 Apr;33(4):421-8.


Expiratory asynchrony in proportional assist ventilation.

Du HL, Ohtsuji M, Shigeta M, Chao DC, Sasaki K, Usuda Y, Yamada Y.

Am J Respir Crit Care Med. 2002 Apr 1;165(7):972-7.


Polymorphism and chromosomal mapping of the mouse gene for B-cell activating factor belonging to the tumor necrosis factor family (Baff) and association with the autoimmune phenotype.

Jiang Y, Ohtsuji M, Abe M, Li N, Xiu Y, Wen S, Shirai T, Hirose S.

Immunogenetics. 2001 Dec;53(9):810-3. Epub 2001 Dec 13. No abstract available.


A simplified method for detecting isoniazid compliance in patients receiving antituberculosis chemotherapy.

Hashiguchi M, Ohno K, Sakuma A, Hino F, Tanaka T, Ohtsuji M, Matsumoto N, Yanase K, Urae A, Hosogai Y, Sato N, Yazaki A, Matsuda K, Yamazaki K, Rikihisa T.

J Clin Pharmacol. 2002 Feb;42(2):151-6.


[Anesthetic management for neonates with congenital cystic adenomatoid malformation].

Tamai H, Masago K, Chang K, Iwamura N, Ohkado S, Uchida K, Ohtsuji M, Chinzei M, Hanaoka K.

Masui. 2000 Jul;49(7):750-4. Japanese.


Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility.

Jiang Y, Hirose S, Abe M, Sanokawa-Akakura R, Ohtsuji M, Mi X, Li N, Xiu Y, Zhang D, Shirai J, Hamano Y, Fujii H, Shirai T.

Immunogenetics. 2000 May;51(6):429-35.


[Fatal child abuse in Japan and Germany. Comparative retrospective study].

Ohtsuji M, Ohshima T, Kondo T, Godoy MR, Oehmichen M.

Arch Kriminol. 1998 Jul-Aug;202(1-2):8-16. German.


False identification of urinary ephedrine as methamphetamine by gas chromatography/mass spectrometry with a DB-17 column.

Takayasu T, Ohshima T, Ohtsuji M, Takayama N, Kondo T, Lin Z, Sato Y, Minamino T.

Nihon Hoigaku Zasshi. 1997 Jun;51(3):235-40.


An autopsy case of suicidal strangulation with four looped rubber bands.

Lin Z, Kondo T, Sato Y, Ohtsuji M, Takayasu T, Ohshima T.

Nihon Hoigaku Zasshi. 1997 Jun;51(3):231-4.


Use of REMEDi HS in emergency toxicology for a rapid estimate of drug concentrations in urine, serum, and gastric samples.

Ohtsuji M, Lai JS, Binder SR, Kondo T, Takayasu T, Ohshima T.

J Forensic Sci. 1996 Sep;41(5):881-6.


[Death due to cold of a 63-year-old male associated with hepatocellular carcinoma--bibliographic consideration on alcohol metabolism of the patients with liver dysfunction].

Kondo T, Sata Y, Takayasu T, Ohtsuji M, Minamino T, Lin Z, Ohshima T.

Nihon Hoigaku Zasshi. 1996 Aug;50(4):276-80. Japanese.


A case of death due to outbreak of fire during thinner abuse.

Ohshima T, Kondo T, Ohtsuji M, Minamino T, Nishigami J.

Nihon Hoigaku Zasshi. 1996 Feb;50(1):33-6.


Experimental studies on postmortem diffusion of ethanol-d6 using rats.

Takayasu T, Ohshima T, Tanaka N, Maeda H, Kondo T, Nishigami J, Ohtsuji M, Nagano T.

Forensic Sci Int. 1995 Dec 29;76(3):179-88.


Sex determination by polymerase chain reaction on mummies discovered at Taklamakan desert in 1912.

Lin Z, Kondo T, Minamino T, Ohtsuji M, Nishigami J, Takayasu T, Sun R, Ohshima T.

Forensic Sci Int. 1995 Oct 30;75(2-3):197-205.


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