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Items: 1 to 50 of 131

1.

Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4Cdt2 for PCNA and its ubiquitination activity in S phase.

Nukina K, Hayashi A, Shiomi Y, Sugasawa K, Ohtsubo M, Nishitani H.

Genes Cells. 2018 Mar;23(3):200-213. doi: 10.1111/gtc.12563. Epub 2018 Feb 9.

PMID:
29424068
2.

Prevention of Mandible Reconstruction Plate Exposure by Costal Cartilage Wrapping.

Iwasawa M, Mishima Y, Ohtsubo M.

Plast Reconstr Surg Glob Open. 2017 Aug 4;5(8):e1438. doi: 10.1097/GOX.0000000000001438. eCollection 2017 Aug.

3.

CT and MRI findings of thymic carcinoid.

Shimamoto A, Ashizawa K, Kido Y, Hayashi H, Nagayasu T, Kawakami A, Mukae H, Hayashi T, Ohtsubo M, Shigematsu K, Nakazono T, Yabuuchi H, Uetani M.

Br J Radiol. 2017 Mar;90(1071):20150341. doi: 10.1259/bjr.20150341. Epub 2017 Jan 20.

4.

Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs).

Yasunaga S, Ohno Y, Shirasu N, Zhang B, Suzuki-Takedachi K, Ohtsubo M, Takihara Y.

Int J Hematol. 2016 Sep;104(3):324-9. doi: 10.1007/s12185-016-2060-9. Epub 2016 Jul 15. Review.

PMID:
27422432
5.

Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating Geminin.

Ohno Y, Suzuki-Takedachi K, Yasunaga S, Kurogi T, Santo M, Masuhiro Y, Hanazawa S, Ohtsubo M, Naka K, Takihara Y.

PLoS One. 2016 May 19;11(5):e0155558. doi: 10.1371/journal.pone.0155558. eCollection 2016.

6.

Significance of ACADM mutations identified through newborn screening of MCAD deficiency in Japan.

Hara K, Tajima G, Okada S, Tsumura M, Kagawa R, Shirao K, Ohno Y, Yasunaga S, Ohtsubo M, Hata I, Sakura N, Shigematsu Y, Takihara Y, Kobayashi M.

Mol Genet Metab. 2016 May;118(1):9-14. doi: 10.1016/j.ymgme.2015.12.011. Epub 2015 Dec 29.

PMID:
26947917
7.

The KM-parkin-DB: A Sub-set MutationView Database Specialized for PARK2 (PARKIN) Variants.

Mitsuyama S, Ohtsubo M, Minoshima S, Shimizu N.

Hum Mutat. 2015 Aug;36(8):E2430-40. doi: 10.1002/humu.22803. Epub 2015 Jun 3.

PMID:
25907632
8.

The first USH2A mutation analysis of Japanese autosomal recessive retinitis pigmentosa patients: a totally different mutation profile with the lack of frequent mutations found in Caucasian patients.

Zhao Y, Hosono K, Suto K, Ishigami C, Arai Y, Hikoya A, Hirami Y, Ohtsubo M, Ueno S, Terasaki H, Sato M, Nakanishi H, Endo S, Mizuta K, Mineta H, Kondo M, Takahashi M, Minoshima S, Hotta Y.

J Hum Genet. 2014 Sep;59(9):521-8. doi: 10.1038/jhg.2014.65. Epub 2014 Jul 31.

PMID:
25078356
9.

Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.

Gao J, Ohtsubo M, Hotta Y, Minoshima S.

PLoS One. 2014 Jul 1;9(7):e101206. doi: 10.1371/journal.pone.0101206. eCollection 2014.

10.

Effect of post-trochanteric groove support on stance control associated with the pelvic-lumbar system: A preliminary study.

Hama S, Ohtsubo M, Nishiwaki T, Miura A, Sanemasu M, Shimada N, Fujimoto Y, Tao S, Suzuki T, Hara D, Iino E, Kawahama S, Sato D.

Prosthet Orthot Int. 2015 Oct;39(5):405-13. doi: 10.1177/0309364614536763. Epub 2014 Jun 12.

PMID:
24925672
11.

Transcription of the Geminin gene is regulated by a negative-feedback loop.

Ohno Y, Saeki K, Yasunaga S, Kurogi T, Suzuki-Takedachi K, Shirai M, Mihara K, Yoshida K, Voncken JW, Ohtsubo M, Takihara Y.

Mol Biol Cell. 2014 Apr;25(8):1374-83. doi: 10.1091/mbc.E13-09-0534. Epub 2014 Feb 19.

12.

Passive carriage of rabies virus by dendritic cells.

Senba K, Matsumoto T, Yamada K, Shiota S, Iha H, Date Y, Ohtsubo M, Nishizono A.

Springerplus. 2013 Aug 29;2:419. doi: 10.1186/2193-1801-2-419. eCollection 2013.

13.

CASE REPORT Penetrating Injury of the Orbit by a Needlefish.

Ohtsubo M, Fujita K, Tsunekawa K, Yuzuriha S, Matsuo K.

Eplasty. 2013 Aug 6;13:e41. eCollection 2013.

14.

Interaction between optineurin and the bZIP transcription factor NRL.

Wang C, Hosono K, Ohtsubo M, Ohishi K, Gao J, Nakanishi N, Hikoya A, Sato M, Hotta Y, Minoshima S.

Cell Biol Int. 2014 Jan;38(1):16-25. doi: 10.1002/cbin.10174. Epub 2013 Sep 12.

PMID:
23956131
15.

CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo.

Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z, Ohtsubo M, Honda H.

FEBS Lett. 2013 May 21;587(10):1529-35. doi: 10.1016/j.febslet.2013.03.034. Epub 2013 Apr 11.

16.

Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein.

Ohno Y, Yasunaga S, Janmohamed S, Ohtsubo M, Saeki K, Kurogi T, Mihara K, Iscove NN, Takihara Y.

PLoS One. 2013;8(1):e53161. doi: 10.1371/journal.pone.0053161. Epub 2013 Jan 11.

17.

Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.

Yasunaga S, Ohtsubo M, Ohno Y, Saeki K, Kurogi T, Tanaka-Okamoto M, Ishizaki H, Shirai M, Mihara K, Brock HW, Miyoshi J, Takihara Y.

Mol Cell Biol. 2013 Feb;33(4):644-60. doi: 10.1128/MCB.00974-12. Epub 2012 Dec 3.

18.

Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease.

Tsumura M, Okada S, Sakai H, Yasunaga S, Ohtsubo M, Murata T, Obata H, Yasumi T, Kong XF, Abhyankar A, Heike T, Nakahata T, Nishikomori R, Al-Muhsen S, Boisson-Dupuis S, Casanova JL, Alzahrani M, Shehri MA, Elghazali G, Takihara Y, Kobayashi M.

Hum Mutat. 2012 Sep;33(9):1377-87. doi: 10.1002/humu.22113. Epub 2012 Jun 7.

19.

Putty lung: pulmonary parenchymal calcification due to tuberculosis.

Hayashi K, Ashizawa K, Fukuda M, Ohtsubo M.

Jpn J Radiol. 2012 Jan;30(1):92-3. doi: 10.1007/s11604-011-0011-1. Epub 2011 Dec 10. No abstract available.

PMID:
22160608
20.

Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes.

Thanseem I, Anitha A, Nakamura K, Suda S, Iwata K, Matsuzaki H, Ohtsubo M, Ueki T, Katayama T, Iwata Y, Suzuki K, Minoshima S, Mori N.

Biol Psychiatry. 2012 Mar 1;71(5):410-8. doi: 10.1016/j.biopsych.2011.09.020. Epub 2011 Oct 26.

PMID:
22030357
21.

Overexpression of BMI-1 correlates with drug resistance in B-cell lymphoma cells through the stabilization of survivin expression.

Bhattacharyya J, Mihara K, Ohtsubo M, Yasunaga S, Takei Y, Yanagihara K, Sakai A, Hoshi M, Takihara Y, Kimura A.

Cancer Sci. 2012 Jan;103(1):34-41. doi: 10.1111/j.1349-7006.2011.02121.x. Epub 2011 Nov 20.

22.

Decreased expression in nuclear factor-κB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency.

Karakawa S, Okada S, Tsumura M, Mizoguchi Y, Ohno N, Yasunaga S, Ohtsubo M, Kawai T, Nishikomori R, Sakaguchi T, Takihara Y, Kobayashi M.

J Clin Immunol. 2011 Oct;31(5):762-72. doi: 10.1007/s10875-011-9560-4. Epub 2011 Jul 1.

PMID:
21720903
23.

Novel USH2A mutations in Japanese Usher syndrome type 2 patients: marked differences in the mutation spectrum between the Japanese and other populations.

Nakanishi H, Ohtsubo M, Iwasaki S, Hotta Y, Usami S, Mizuta K, Mineta H, Minoshima S.

J Hum Genet. 2011 Jul;56(7):484-90. doi: 10.1038/jhg.2011.45. Epub 2011 May 19.

PMID:
21593743
24.

Case of Japanese patient with x-linked ocular albinism associated with GPR143 gene mutation.

Ohtsubo M, Sato M, Hikoya A, Hosono K, Minoshima S, Hotta Y.

Jpn J Ophthalmol. 2010 Nov;54(6):624-6. No abstract available.

PMID:
21348135
25.

Case of Japanese patient with x-linked ocular albinism associated with GPR143 gene mutation.

Ohtsubo M, Sato M, Hikoya A, Hosono K, Minoshima S, Hotta Y.

Jpn J Ophthalmol. 2010 Nov;54(6):624-6. No abstract available.

PMID:
21274678
26.

Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.

Ohno Y, Yasunaga S, Ohtsubo M, Mori S, Tsumura M, Okada S, Ohta T, Ohtani K, Kobayashi M, Takihara Y.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21529-34. doi: 10.1073/pnas.1011054107. Epub 2010 Nov 22.

27.

[Databases for mutations in human diseases].

Minoshima S, Ohtsubo M, Shimizu N.

Nihon Rinsho. 2010 Aug;68 Suppl 8:150-8. Review. Japanese. No abstract available.

PMID:
20979272
28.

Mutation analysis of the MYO7A and CDH23 genes in Japanese patients with Usher syndrome type 1.

Nakanishi H, Ohtsubo M, Iwasaki S, Hotta Y, Takizawa Y, Hosono K, Mizuta K, Mineta H, Minoshima S.

J Hum Genet. 2010 Dec;55(12):796-800. doi: 10.1038/jhg.2010.115. Epub 2010 Sep 16.

PMID:
20844544
29.
30.

Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein.

Shimada H, Eto M, Ohtaguro M, Ohtsubo M, Mizukami Y, Ide T, Imamura Y.

J Biochem Mol Toxicol. 2010 Jul-Aug;24(4):230-4. doi: 10.1002/jbt.20328.

PMID:
20806393
31.

High-fat diet lowers the nutritional status indicators of pantothenic acid in weaning rats.

Yoshida E, Fukuwatari T, Ohtsubo M, Shibata K.

Biosci Biotechnol Biochem. 2010;74(8):1691-3. Epub 2010 Aug 7.

32.

Small pancreatic cancer with giardiasis: a case report.

Kurita A, Maguchi H, Takahashi K, Katanuma A, Osanai M, Kin T, Yane K, Hashigo S, Ohtsubo M.

Pancreas. 2010 Aug;39(6):943-5. doi: 10.1097/MPA.0b013e3181d7883c. No abstract available.

PMID:
20664486
33.

Hair roots as an mRNA source for mutation analysis of Usher syndrome-causing genes.

Nakanishi H, Ohtsubo M, Iwasaki S, Hotta Y, Mizuta K, Mineta H, Minoshima S.

J Hum Genet. 2010 Oct;55(10):701-3. doi: 10.1038/jhg.2010.83. Epub 2010 Jul 1.

PMID:
20596040
34.

YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.

Hosono K, Noda S, Shimizu A, Nakanishi N, Ohtsubo M, Shimizu N, Minoshima S.

Genomics. 2010 Aug;96(2):102-11. doi: 10.1016/j.ygeno.2010.05.003. Epub 2010 May 24.

35.

Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency.

Shirao K, Okada S, Tajima G, Tsumura M, Hara K, Yasunaga S, Ohtsubo M, Hata I, Sakura N, Shigematsu Y, Takihara Y, Kobayashi M.

Hum Genet. 2010 Jun;127(6):619-28. doi: 10.1007/s00439-010-0822-7. Epub 2010 Apr 8. Review.

PMID:
20376488
36.

KMeyeDB: a graphical database of mutations in genes that cause eye diseases.

Kawamura T, Ohtsubo M, Mitsuyama S, Ohno-Nakamura S, Shimizu N, Minoshima S.

Hum Mutat. 2010 Jun;31(6):667-74. doi: 10.1002/humu.21240.

PMID:
20232414
37.

Identification of 11 novel mutations in USH2A among Japanese patients with Usher syndrome type 2.

Nakanishi H, Ohtsubo M, Iwasaki S, Hotta Y, Mizuta K, Mineta H, Minoshima S.

Clin Genet. 2009 Oct;76(4):383-91. doi: 10.1111/j.1399-0004.2009.01257.x. Epub 2009 Sep 8.

PMID:
19737284
38.

[4+2] cycloaddition of o-xylylenes with imines using palladium catalyst.

Ueno S, Ohtsubo M, Kuwano R.

J Am Chem Soc. 2009 Sep 16;131(36):12904-5. doi: 10.1021/ja905988e.

PMID:
19697911
39.

Lead retention mechanisms and hydraulic conductivity studies of various bentonites for geoenvironment applications.

Nakano A, Li LY, Ohtsubo M, Mishra AK, Higashi T.

Environ Technol. 2008 May;29(5):505-14. doi: 10.1080/09593330801984258.

PMID:
18661734
40.

Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.

Ohtsubo M, Yasunaga S, Ohno Y, Tsumura M, Okada S, Ishikawa N, Shirao K, Kikuchi A, Nishitani H, Kobayashi M, Takihara Y.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10396-401. doi: 10.1073/pnas.0800672105. Epub 2008 Jul 23.

41.

Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene.

Ishikawa N, Okada S, Miki M, Shirao K, Kihara H, Tsumura M, Nakamura K, Kawaguchi H, Ohtsubo M, Yasunaga S, Matsubara K, Sako M, Hara J, Shiohara M, Kojima S, Sato T, Takihara Y, Kobayashi M.

J Med Genet. 2008 Dec;45(12):802-7. doi: 10.1136/jmg.2008.058297. Epub 2008 Jul 8.

PMID:
18611981
42.

The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts.

Genome Information Integration Project And H-Invitational 2, Yamasaki C, Murakami K, Fujii Y, Sato Y, Harada E, Takeda J, Taniya T, Sakate R, Kikugawa S, Shimada M, Tanino M, Koyanagi KO, Barrero RA, Gough C, Chun HW, Habara T, Hanaoka H, Hayakawa Y, Hilton PB, Kaneko Y, Kanno M, Kawahara Y, Kawamura T, Matsuya A, Nagata N, Nishikata K, Noda AO, Nurimoto S, Saichi N, Sakai H, Sanbonmatsu R, Shiba R, Suzuki M, Takabayashi K, Takahashi A, Tamura T, Tanaka M, Tanaka S, Todokoro F, Yamaguchi K, Yamamoto N, Okido T, Mashima J, Hashizume A, Jin L, Lee KB, Lin YC, Nozaki A, Sakai K, Tada M, Miyazaki S, Makino T, Ohyanagi H, Osato N, Tanaka N, Suzuki Y, Ikeo K, Saitou N, Sugawara H, O'Donovan C, Kulikova T, Whitfield E, Halligan B, Shimoyama M, Twigger S, Yura K, Kimura K, Yasuda T, Nishikawa T, Akiyama Y, Motono C, Mukai Y, Nagasaki H, Suwa M, Horton P, Kikuno R, Ohara O, Lancet D, Eveno E, Graudens E, Imbeaud S, Debily MA, Hayashizaki Y, Amid C, Han M, Osanger A, Endo T, Thomas MA, Hirakawa M, Makalowski W, Nakao M, Kim NS, Yoo HS, De Souza SJ, Bonaldo Mde F, Niimura Y, Kuryshev V, Schupp I, Wiemann S, Bellgard M, Shionyu M, Jia L, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Zhang Q, Go M, Minoshima S, Ohtsubo M, Hanada K, Tonellato P, Isogai T, Zhang J, Lenhard B, Kim S, Chen Z, Hinz U, Estreicher A, Nakai K, Makalowska I, Hide W, Tiffin N, Wilming L, Chakraborty R, Soares MB, Chiusano ML, Suzuki Y, Auffray C, Yamaguchi-Kabata Y, Itoh T, Hishiki T, Fukuchi S, Nishikawa K, Sugano S, Nomura N, Tateno Y, Imanishi T, Gojobori T.

Nucleic Acids Res. 2008 Jan;36(Database issue):D793-9. Epub 2007 Dec 18.

43.

[A brainstem variant of reversible posterior leukoencephalopathy syndrome (RPLS) presenting with visual disturbance].

Horioka K, Kinoshita I, Ohtsubo M, Wakiyama H.

Rinsho Shinkeigaku. 2007 Aug;47(8):526-9. Japanese.

PMID:
17882948
44.

A novel mutation (Gln433Glu) in exon 12 combined with the G insertion in exon 13 causes severe factor XI deficiency in Japanese patients.

Ishikawa N, Okada S, Sato T, Yasunaga S, Ohtsubo M, Takihara Y, Kobayashi M.

Blood Coagul Fibrinolysis. 2007 Jul;18(5):519-23.

PMID:
17581330
45.

Three novel mutations of the PAX6 gene in Japanese aniridia patients.

Kawano T, Wang C, Hotta Y, Sato M, Iwata-Amano E, Hikoya A, Fujita N, Koyama N, Shirai S, Azuma N, Ohtsubo M, Shimizu N, Minoshima S.

J Hum Genet. 2007;52(7):571-4. Epub 2007 Jun 14.

PMID:
17568989
46.

The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction.

Okada S, Ishikawa N, Shirao K, Kawaguchi H, Tsumura M, Ohno Y, Yasunaga S, Ohtsubo M, Takihara Y, Kobayashi M.

J Med Genet. 2007 Aug;44(8):485-91. Epub 2007 May 18. Erratum in: J Med Genet. 2007 Oct;44(10):628.

47.

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.

Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N.

Exp Cell Res. 2007 Aug 1;313(13):2858-74. Epub 2007 Apr 20.

PMID:
17512523
48.

Leachability of municipal solid waste ashes in simulated landfill conditions.

Li LY, Ohtsubo M, Higashi T, Yamaoka S, Morishita T.

Waste Manag. 2007;27(7):932-45. Epub 2007 Jan 26.

PMID:
17258447
49.

MutationView/KMcancerDB: a database for cancer gene mutations.

Shimizu N, Ohtsubo M, Minoshima S.

Cancer Sci. 2007 Mar;98(3):259-67. Epub 2007 Jan 12. Review. Erratum in: Cancer Sci. 2007 May;98(5):764-5.

50.

[Atypical takotsubo cardiomyopathy with preservation of apical contraction: a case report including pathological findings].

Ohtsubo M, Sakai H, Takano H, Kon H, Okamoto K, Yoshida N, Fujita M.

J Cardiol. 2005 Dec;46(6):237-42. Japanese.

PMID:
16389743

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