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Aberrant Methylation of Tumor Suppressive miRNAs in Bile from Patients With Pancreaticobiliary Diseases.

Ohtsubo K, Miyake K, Arai S, Fukuda K, Yanagimura N, Suzuki C, Otani S, Adachi Y, Tanimoto A, Nishiyama A, Yamashita K, Takeuchi S, Notohara K, Yoshimura K, Yano S.

Anticancer Res. 2019 Oct;39(10):5449-5459. doi: 10.21873/anticanres.13738.


Patient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance.

Kita K, Fukuda K, Takahashi H, Tanimoto A, Nishiyama A, Arai S, Takeuchi S, Yamashita K, Ohtsubo K, Otani S, Yanagimura N, Suzuki C, Ikeda H, Tamura M, Matsumoto I, Yano S.

Cancer Sci. 2019 Oct;110(10):3215-3224. doi: 10.1111/cas.14171.


A case of advanced pancreatic neuroendocrine tumor in which octreotide long-acting repeatable was effective after failure of everolimus and sunitinib.

Kitade H, Ohtsubo K, Hokkoku K, Mori M, Osamura RY, Sakuma H, Nakai M, Yano S.

Int Cancer Conf J. 2018 Nov 7;8(1):24-28. doi: 10.1007/s13691-018-0348-8. eCollection 2019 Jan.


Distribution and Activity of Lenvatinib in Brain Tumor Models of Human Anaplastic Thyroid Cancer Cells in Severe Combined Immune Deficient Mice.

Wang R, Yamada T, Arai S, Fukuda K, Taniguchi H, Tanimoto A, Nishiyama A, Takeuchi S, Yamashita K, Ohtsubo K, Matsui J, Onoda N, Hirata E, Taira S, Yano S.

Mol Cancer Ther. 2019 May;18(5):947-956. doi: 10.1158/1535-7163.MCT-18-0695. Epub 2019 Mar 29.


The effect of electroconvulsive seizure on survival, neuronal differentiation, and expression of the maturation marker in the adult mouse hippocampus.

Ueno M, Sugimoto M, Ohtsubo K, Sakai N, Endo A, Shikano K, Imoto Y, Segi-Nishida E.

J Neurochem. 2019 May;149(4):488-498. doi: 10.1111/jnc.14691. Epub 2019 Apr 2.


Physicochemical measurements of Japonica rice cultivars in Heilongjiang Province.

Nakamura S, Li H, Dai CJ, Zhang RY, Kawano M, Ohtsubo K.

Biosci Biotechnol Biochem. 2019 May;83(5):970-973. doi: 10.1080/09168451.2019.1576499. Epub 2019 Feb 6.


Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report.

Tanimoto A, Takeuchi S, Kotani H, Yamashita K, Yamada T, Ohtsubo K, Ebi H, Ikeda H, Yano S.

BMC Pulm Med. 2018 Dec 12;18(1):193. doi: 10.1186/s12890-018-0757-7.


Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.

Yabe M, Koike T, Ohtsubo K, Imai E, Morimoto T, Takakura H, Koh K, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Mori M, Hira A, Takata M, Yabe H.

Ann Hematol. 2019 Feb;98(2):271-280. doi: 10.1007/s00277-018-3517-0. Epub 2018 Oct 27.


Development and characterization of a new rice cultivar, 'Chikushi-kona 85', derived from a starch-branching enzyme IIb-deficient mutant line.

Wada T, Yamaguchi O, Miyazaki M, Miyahara K, Ishibashi M, Aihara T, Shibuta T, Inoue T, Tsubone M, Toyosawa Y, Satoh H, Akaishi R, Yoshii Y, Ohtsubo K.

Breed Sci. 2018 Mar;68(2):278-283. doi: 10.1270/jsbbs.17069. Epub 2018 Apr 12.


Effects of different heat-moisture treatments on the physicochemical properties of brown rice flour.

Nakamura S, Okumura H, Sugawara M, Noro W, Homma N, Ohtsubo K.

Biosci Biotechnol Biochem. 2017 Dec;81(12):2370-2385. doi: 10.1080/09168451.2017.1387047. Epub 2017 Oct 20.


Androgen replacement therapy for cancer-related symptoms in male advanced cancer patients: study protocol for a randomised prospective trial (ARTFORM study).

Izumi K, Shigehara K, Nohara T, Narimoto K, Kadono Y, Nanjo S, Yamada T, Ohtsubo K, Yano S, Mizokami A.

J Med Invest. 2017;64(3.4):202-204. doi: 10.2152/jmi.64.202.


Resection of carcinoma in situ and minimally invasive carcinoma of the pancreas in a patient presenting with stenosis and post-stenotic dilatation of the main pancreatic duct on endoscopic ultrasonography and positive serial pancreatic juice aspiration cytology.

Ohtsubo K, Mouri H, Yamashita K, Makino I, Tajima H, Ohta T, Inoue D, Gabata T, Ikeda H, Zen Y, Watanabe H.

Nihon Shokakibyo Gakkai Zasshi. 2017;114(4):700-709. doi: 10.11405/nisshoshi.114.700. Japanese.


A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models.

Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N.

Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L268-L276. doi: 10.1152/ajplung.00151.2016. Epub 2016 Dec 23.


Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.

Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, ParÉ PD, Lomas DA, Silverman EK, Taniguchi N, Kida K.

Respirology. 2017 May;22(4):684-690. doi: 10.1111/resp.12952. Epub 2016 Nov 22.


The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.

Yabe M, Yabe H, Morimoto T, Fukumura A, Ohtsubo K, Koike T, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Hira A, Takata M.

Br J Haematol. 2016 Nov;175(3):457-461. doi: 10.1111/bjh.14243. Epub 2016 Jul 5.


Effects of super-hard rice bread blended with black rice bran on amyloid β peptide production and abrupt increase in postprandial blood glucose levels in mice.

Nakamura S, Hara T, Joh T, Kobayashi A, Yamazaki A, Kasuga K, Ikeuchi T, Ohtsubo K.

Biosci Biotechnol Biochem. 2017 Feb;81(2):323-334. doi: 10.1080/09168451.2016.1240605. Epub 2016 Oct 4.


Comparison of eating quality and physicochemical properties between Japanese and Chinese rice cultivars.

Nakamura S, Cui J, Zhang X, Yang F, Xu X, Sheng H, Ohtsubo K.

Biosci Biotechnol Biochem. 2016 Dec;80(12):2437-2449. Epub 2016 Aug 30.


Disease-associated glycans on cell surface proteins.

Takahashi M, Kizuka Y, Ohtsubo K, Gu J, Taniguchi N.

Mol Aspects Med. 2016 Oct;51:56-70. doi: 10.1016/j.mam.2016.04.008. Epub 2016 Apr 27. Review.


Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology.

Taniguchi N, Kizuka Y, Takamatsu S, Miyoshi E, Gao C, Suzuki K, Kitazume S, Ohtsubo K.

Arch Biochem Biophys. 2016 Apr 1;595:72-80. doi: 10.1016/


Recurrence of renal cell carcinoma diagnosed using contralateral adrenal biopsy with endoscopic ultrasound-guided fine-needle aspiration.

Tanimoto A, Takeuchi S, Yaegashi H, Kotani H, Kitai H, Nanjo S, Ebi H, Yamashita K, Mouri H, Ohtsubo K, Ikeda H, Yano S.

Mol Clin Oncol. 2016 Apr;4(4):537-540. Epub 2016 Jan 25.


Multi-platform metabolomics analyses of a broad collection of fragrant and non-fragrant rice varieties reveals the high complexity of grain quality characteristics.

Mumm R, Hageman JA, Calingacion MN, de Vos RCH, Jonker HH, Erban A, Kopka J, Hansen TH, Laursen KH, Schjoerring JK, Ward JL, Beale MH, Jongee S, Rauf A, Habibi F, Indrasari SD, Sakhan S, Ramli A, Romero M, Reinke RF, Ohtsubo K, Boualaphanh C, Fitzgerald MA, Hall RD.

Metabolomics. 2016;12:38. doi: 10.1007/s11306-015-0925-1. Epub 2016 Jan 23.


An inverting β-1,2-mannosidase belonging to glycoside hydrolase family 130 from Dyadobacter fermentans.

Nihira T, Chiku K, Suzuki E, Nishimoto M, Fushinobu S, Kitaoka M, Ohtsubo K, Nakai H.

FEBS Lett. 2015 Nov 30;589(23):3604-10. doi: 10.1016/j.febslet.2015.10.008. Epub 2015 Oct 20.


Development of formulae for estimating amylose content and resistant starch content based on the pasting properties measured by RVA of Japonica polished rice and starch.

Nakamura S, Katsura J, Kato K, Ohtsubo K.

Biosci Biotechnol Biochem. 2016;80(2):329-40. doi: 10.1080/09168451.2015.1088373. Epub 2015 Sep 23.


Measurement of resistant starch content in cooked rice and analysis of gelatinization and retrogradation characteristics.

Nakayoshi Y, Nakamura S, Kameo Y, Shiiba D, Katsuragi Y, Ohtsubo K.

Biosci Biotechnol Biochem. 2015;79(11):1860-6. doi: 10.1080/09168451.2015.1044934. Epub 2015 May 21.


Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways.

Wang Y, Fukuda T, Isaji T, Lu J, Im S, Hang Q, Gu W, Hou S, Ohtsubo K, Gu J.

FASEB J. 2015 Aug;29(8):3217-27. doi: 10.1096/fj.15-270710. Epub 2015 Apr 14.


Organ-level analysis of idioblast patterning in Egeria densa Planch. leaves.

Hara T, Kobayashi E, Ohtsubo K, Kumada S, Kanazawa M, Abe T, Itoh RD, Fujiwara MT.

PLoS One. 2015 Mar 5;10(3):e0118965. doi: 10.1371/journal.pone.0118965. eCollection 2015.


Discovery of two β-1,2-mannoside phosphorylases showing different chain-length specificities from Thermoanaerobacter sp. X-514.

Chiku K, Nihira T, Suzuki E, Nishimoto M, Kitaoka M, Ohtsubo K, Nakai H.

PLoS One. 2014 Dec 12;9(12):e114882. doi: 10.1371/journal.pone.0114882. eCollection 2014.


Development of formulae for estimating amylose content, amylopectin chain length distribution, and resistant starch content based on the iodine absorption curve of rice starch.

Nakamura S, Satoh H, Ohtsubo K.

Biosci Biotechnol Biochem. 2015;79(3):443-55. doi: 10.1080/09168451.2014.978257. Epub 2014 Nov 11.


Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer.

Ohtsubo K, Yamada T, Zhao L, Jin TF, Takeuchi S, Mouri H, Yamashita K, Yasumoto K, Fujita N, Kitagawa H, Ohta T, Ikeda H, Yano S.

Pancreas. 2014 Oct;43(7):1093-100. doi: 10.1097/MPA.0000000000000168.


Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease.

Angata T, Ishii T, Gao C, Ohtsubo K, Kitazume S, Gemma A, Kida K, Taniguchi N.

Physiol Rep. 2014 Jul 3;2(7). pii: e12069. doi: 10.14814/phy2.12069. Print 2014 Jul 1.


Feasibility of marrow harvesting from pediatric sibling donors without hematopoietic growth factors and allotransfusion.

Yabe M, Morimoto T, Shimizu T, Koike T, Takakura H, Ohtsubo K, Fukumura A, Kato S, Yabe H.

Bone Marrow Transplant. 2014 Jul;49(7):921-6. doi: 10.1038/bmt.2014.73. Epub 2014 Apr 28.


P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma.

Terashima T, Mizukoshi E, Arai K, Yamashita T, Yoshida M, Ota H, Onishi I, Kayahara M, Ohtsubo K, Kagaya T, Honda M, Kaneko S.

Cancer Immunol Immunother. 2014 May;63(5):479-89. doi: 10.1007/s00262-014-1529-8. Epub 2014 Mar 16.


2-O-α-D-glucosylglycerol phosphorylase from Bacillus selenitireducens MLS10 possessing hydrolytic activity on β-D-glucose 1-phosphate.

Nihira T, Saito Y, Ohtsubo K, Nakai H, Kitaoka M.

PLoS One. 2014 Jan 22;9(1):e86548. doi: 10.1371/journal.pone.0086548. eCollection 2014.


Improved palatability and bio-functionality of super-hard rice by soaking in a barley-koji miso suspension.

Nakamura S, Nakano Y, Satoh H, Ohtsubo K.

Biosci Biotechnol Biochem. 2013;77(12):2419-29. Epub 2013 Dec 7.


Discovery of cellobionic acid phosphorylase in cellulolytic bacteria and fungi.

Nihira T, Saito Y, Nishimoto M, Kitaoka M, Igarashi K, Ohtsubo K, Nakai H.

FEBS Lett. 2013 Nov 1;587(21):3556-61. doi: 10.1016/j.febslet.2013.09.014. Epub 2013 Sep 19.


Potassium ion-dependent trehalose phosphorylase from halophilic Bacillus selenitireducens MLS10.

Nihira T, Saito Y, Chiku K, Kitaoka M, Ohtsubo K, Nakai H.

FEBS Lett. 2013 Nov 1;587(21):3382-6. doi: 10.1016/j.febslet.2013.08.038. Epub 2013 Sep 8.


Synchronous triple cancers of the pancreas, stomach, and cecum treated with S-1 followed by pancrelipase treatment of pancreatic exocrine insufficiency.

Ohtsubo K, Ishikawa D, Nanjo S, Takeuchi S, Yamada T, Mouri H, Yamashita K, Yasumoto K, Gabata T, Matsui O, Ikeda H, Takamatsu Y, Iwakami S, Yano S.

JOP. 2013 Sep 10;14(5):515-20. doi: 10.6092/1590-8577/1719.


Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb).

Korekane H, Park JY, Matsumoto A, Nakajima K, Takamatsu S, Ohtsubo K, Miyamoto Y, Hanashima S, Kanekiyo K, Kitazume S, Yamaguchi Y, Matsuo I, Taniguchi N.

J Biol Chem. 2013 Sep 27;288(39):27912-26. doi: 10.1074/jbc.M113.474304. Epub 2013 Aug 19.


Discovery of β-1,4-D-mannosyl-N-acetyl-D-glucosamine phosphorylase involved in the metabolism of N-glycans.

Nihira T, Suzuki E, Kitaoka M, Nishimoto M, Ohtsubo K, Nakai H.

J Biol Chem. 2013 Sep 20;288(38):27366-74. doi: 10.1074/jbc.M113.469080. Epub 2013 Aug 13.


A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography.

Kobayashi S, Fujinawa R, Ota F, Kobayashi S, Angata T, Ueno M, Maeno T, Kitazume S, Yoshida K, Ishii T, Gao C, Ohtsubo K, Yamaguchi Y, Betsuyaku T, Kida K, Taniguchi N.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):971-7. doi: 10.1165/rcmb.2013-0074OC.


N-acetylglucosaminyltransferase (GnT) assays using fluorescent oligosaccharide acceptor substrates: GnT-III, IV, V, and IX (GnT-Vb).

Takamatsu S, Korekane H, Ohtsubo K, Oguri S, Park JY, Matsumoto A, Taniguchi N.

Methods Mol Biol. 2013;1022:283-98. doi: 10.1007/978-1-62703-465-4_21.


Mass isotopomer analysis of metabolically labeled nucleotide sugars and N- and O-glycans for tracing nucleotide sugar metabolisms.

Nakajima K, Ito E, Ohtsubo K, Shirato K, Takamiya R, Kitazume S, Angata T, Taniguchi N.

Mol Cell Proteomics. 2013 Sep;12(9):2468-80. doi: 10.1074/mcp.M112.027151. Epub 2013 May 29.


Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells.

Shirato K, Gao C, Ota F, Angata T, Shogomori H, Ohtsubo K, Yoshida K, Lepenies B, Taniguchi N.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):460-5. doi: 10.1016/j.bbrc.2013.05.009. Epub 2013 May 14.


N-Glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells.

Ohtsubo K, Takamatsu S, Gao C, Korekane H, Kurosawa TM, Taniguchi N.

Biochem Biophys Res Commun. 2013 May 3;434(2):346-51. doi: 10.1016/j.bbrc.2013.03.076. Epub 2013 Mar 30.


Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.

Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N.

Cell Mol Life Sci. 2013 Sep;70(17):3199-210. doi: 10.1007/s00018-013-1311-7. Epub 2013 Mar 22.


Recent development of phosphorylases possessing large potential for oligosaccharide synthesis.

Nakai H, Kitaoka M, Svensson B, Ohtsubo K.

Curr Opin Chem Biol. 2013 Apr;17(2):301-9. doi: 10.1016/j.cbpa.2013.01.006. Epub 2013 Feb 8. Review.


Successful treatment of unresectable gallbladder cancer with low-dose paclitaxel as palliative chemotherapy after failure of gemcitabine and oral S-1: A case report.

Tajima H, Ohta T, Shinbashi H, Hirose A, Tsukada T, Okamoto K, Nakanuma S, Sakai S, Furukawa H, Makino I, Nakamura K, Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Miyashita T, Fujita H, Takamura H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Mouri H, Ohtsubo K.

Oncol Lett. 2012 Dec;4(6):1281-1284. Epub 2012 Sep 12.


The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.

Takamiya R, Ohtsubo K, Takamatsu S, Taniguchi N, Angata T.

Glycobiology. 2013 Feb;23(2):178-87. doi: 10.1093/glycob/cws139. Epub 2012 Oct 3.


[A case of poorly-differentiated neuroendocrine carcinoma of the ascending colon with multiple liver metastases successfully treated with cisplatin and irinotecan].

Yamashita K, Ishikawa D, Nanjo S, Takeuchi S, Yamada T, Mouri H, Ohtsubo K, Yasumoto K, Kumagai M, Ueda Y, Yano S.

Gan To Kagaku Ryoho. 2012 Sep;39(9):1427-30. Japanese.


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