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Items: 1 to 50 of 751

1.

A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production.

Seo H, Chen SJ, Hashimoto K, Endo H, Nishi Y, Ohta A, Yamamoto T, Hotta A, Sawaguchi A, Hayashi H, Koseki N, Murphy GJ, Fukuda K, Sugimoto N, Eto K.

Blood Adv. 2018 Sep 11;2(17):2262-2272. doi: 10.1182/bloodadvances.2018019547.

2.

Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans.

Ujisawa T, Ohta A, Ii T, Minakuchi Y, Toyoda A, Ii M, Kuhara A.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8823-8828. doi: 10.1073/pnas.1808634115. Epub 2018 Aug 13.

PMID:
30104389
3.

A Case of Anticentromere Antibody-positive Scleroderma Renal Crisis Requiring Dialysis.

Ubukata M, Mitsuhashi A, Nishizawa Y, Fujii T, Hara M, Ohta A, Nitta K.

Intern Med. 2018 Aug 10. doi: 10.2169/internalmedicine.0980-18. [Epub ahead of print]

4.

Aggregation Behavior and Thiol-Thioester Exchange for Cationic Surfactants with Propylthioacetate Side Chain.

Asakawa T, Arai N, Fujii A, Takahashi K, Takakuwa K, Honda M, Ohta A, Asakawa H.

J Oleo Sci. 2018 Aug 1;67(8):969-976. doi: 10.5650/jos.ess18032. Epub 2018 Jul 17.

5.

Efficacy and Safety of Oral Budesonide in Patients with Active Crohn's Disease in Japan: A Multicenter, Double-Blind, Randomized, Parallel-Group Phase 3 Study.

Yokoyama T, Ohta A, Motoya S, Takazoe M, Yajima T, Date M, Nii M, Nagy P, Suzuki Y, Hibi T.

Inflamm Intest Dis. 2018 Mar;2(3):154-162. doi: 10.1159/000484047. Epub 2017 Nov 22.

6.

Interobserver concordance of assessments of dysplasia and blast counts for the diagnosis of patients with cytopenia: From the Japanese central review study.

Matsuda A, Kawabata H, Tohyama K, Maeda T, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Usuki K, Chiba S, Ishikawa T, Arima N, Nohgawa M, Ohta A, Miyazaki Y, Nakao S, Ozawa K, Arai S, Kurokawa M, Mitani K, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Leuk Res. 2018 Jun 7. pii: S0145-2126(18)30124-3. doi: 10.1016/j.leukres.2018.06.003. [Epub ahead of print]

PMID:
29914726
7.

Oxygen-dependent regulation of immune checkpoint mechanisms.

Ohta A.

Int Immunol. 2018 Jul 24;30(8):335-343. doi: 10.1093/intimm/dxy038.

PMID:
29846615
8.

Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial.

Nakajima A, Seki M, Taniguchi S, Ohta A, Gillberg PG, Mattsson JP, Camilleri M.

Lancet Gastroenterol Hepatol. 2018 Aug;3(8):537-547. doi: 10.1016/S2468-1253(18)30123-7. Epub 2018 May 25.

PMID:
29805116
9.

A2A Adenosine Receptor Gene Deletion or Synthetic A2A Antagonist Liberate Tumor-Reactive CD8+ T Cells from Tumor-Induced Immunosuppression.

Kjaergaard J, Hatfield S, Jones G, Ohta A, Sitkovsky M.

J Immunol. 2018 Jul 15;201(2):782-791. doi: 10.4049/jimmunol.1700850. Epub 2018 May 25.

PMID:
29802128
10.

Synthesis of 2-Methyl-1-azulenyl Tetracyanobutadienes and Dicyanoquinodimethanes: Substituent Effect of 2-Methyl Moiety on the Azulene Ring toward the Optical and Electrochemical Properties.

Shoji T, Miura K, Araki T, Maruyama A, Ohta A, Sekiguchi R, Ito S, Okujima T.

J Org Chem. 2018 Jun 15;83(12):6690-6705. doi: 10.1021/acs.joc.8b01067. Epub 2018 Jun 4.

PMID:
29799742
11.

The membrane-bound O-acyltransferase Ale1 transfers an acyl moiety to newly synthesized 2-alkyl-sn-glycero-3-phosphocholine in yeast.

Morisada S, Ono Y, Kodaira T, Kishino H, Ninomiya R, Mori N, Watanabe H, Ohta A, Horiuchi H, Fukuda R.

FEBS Lett. 2018 Jun;592(11):1829-1836. doi: 10.1002/1873-3468.13103. Epub 2018 May 28.

PMID:
29782033
12.

Evidence-based clinical practice guideline for adult Still's disease.

Mimura T, Kondo Y, Ohta A, Iwamoto M, Ota A, Okamoto N, Kawaguchi Y, Kono H, Takasaki Y, Takei S, Nishimoto N, Fujimoto M, Asanuma YF, Mimori A, Okiyama N, Kaneko S, Takahashi H, Yokosawa M, Sumida T.

Mod Rheumatol. 2018 Sep;28(5):736-757. doi: 10.1080/14397595.2018.1465633. Epub 2018 May 9.

PMID:
29651907
13.

Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients.

Saito H, Ohta A, Abe E, Kaidu M, Shioi M, Nakano T, Oshikane T, Tanaka K, Maruyama K, Kushima N, Tanabe S, Utsunomiya S, Sasamoto R, Aoyama H.

Clin Transl Radiat Oncol. 2017 Dec 24;9:12-17. doi: 10.1016/j.ctro.2017.12.003. eCollection 2018 Feb.

14.

Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast.

Tian S, Ohta A, Horiuchi H, Fukuda R.

J Biol Chem. 2018 Apr 13;293(15):5636-5648. doi: 10.1074/jbc.RA117.000596. Epub 2018 Feb 27.

PMID:
29487131
15.

Prevalence and mortality of chronic kidney disease in lymphoma patients: A large retrospective cohort study.

Ubukata M, Hara M, Nishizawa Y, Fujii T, Nitta K, Ohta A.

Medicine (Baltimore). 2018 Jan;97(2):e9615. doi: 10.1097/MD.0000000000009615.

16.

Clinical practice guideline for Sjögren's syndrome 2017.

Sumida T, Azuma N, Moriyama M, Takahashi H, Asashima H, Honda F, Abe S, Ono Y, Hirota T, Hirata S, Tanaka Y, Shimizu T, Nakamura H, Kawakami A, Sano H, Ogawa Y, Tsubota K, Ryo K, Saito I, Tanaka A, Nakamura S, Takamura E, Tanaka M, Suzuki K, Takeuchi T, Yamakawa N, Mimori T, Ohta A, Nishiyama S, Yoshihara T, Suzuki Y, Kawano M, Tomiita M, Tsuboi H.

Mod Rheumatol. 2018 May;28(3):383-408. doi: 10.1080/14397595.2018.1438093. Epub 2018 Mar 13. Review.

PMID:
29409370
17.

Aggregation and pH Responsive Behavior of Thioester Surfactants and Formation of Disulfide Linkages in Aqueous Solutions.

Asakawa T, Takano Y, Ohta A, Asakawa H.

J Oleo Sci. 2018 Feb 1;67(2):199-206. doi: 10.5650/jos.ess17192. Epub 2018 Jan 23.

18.

Localized Single-Cell Lysis and Manipulation Using Optothermally-Induced Bubbles.

Fan Q, Hu W, Ohta AT.

Micromachines (Basel). 2017 Apr;8(4). pii: 121. doi: 10.3390/mi8040121. Epub 2017 Apr 11.

19.

Difference in Uptake of Tetrodotoxin and Saxitoxins into Liver Tissue Slices among Pufferfish, Boxfish and Porcupinefish.

Nagashima Y, Ohta A, Yin X, Ishizaki S, Matsumoto T, Doi H, Ishibashi T.

Mar Drugs. 2018 Jan 8;16(1). pii: E17. doi: 10.3390/md16010017.

20.

Beneficial use of serum ferritin and heme oxygenase-1 as biomarkers in adult-onset Still's disease: A multicenter retrospective study.

Kirino Y, Kawaguchi Y, Tada Y, Tsukamoto H, Ota T, Iwamoto M, Takahashi H, Nagasawa K, Takei S, Horiuchi T, Ichida H, Minota S, Ueda A, Ohta A, Ishigatsubo Y.

Mod Rheumatol. 2018 Sep;28(5):858-864. doi: 10.1080/14397595.2017.1422231. Epub 2018 Jan 11.

PMID:
29278009
21.

Synthesis of azulene-substituted benzofurans and isocoumarins via intramolecular cyclization of 1-ethynylazulenes, and their structural and optical properties.

Shoji T, Tanaka M, Takagaki S, Miura K, Ohta A, Sekiguchi R, Ito S, Mori S, Okujima T.

Org Biomol Chem. 2018 Jan 17;16(3):480-489. doi: 10.1039/c7ob02861j.

PMID:
29270584
22.

Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells.

Kotaka M, Toyoda T, Yasuda K, Kitano Y, Okada C, Ohta A, Watanabe A, Uesugi M, Osafune K.

Sci Rep. 2017 Dec 1;7(1):16734. doi: 10.1038/s41598-017-16858-5.

23.

Development of effective tumor immunotherapy using a novel dendritic cell-targeting Toll-like receptor ligand.

De Silva NH, Akazawa T, Wijewardana V, Inoue N, Oyamada M, Ohta A, Tachibana Y, Wijesekera DPH, Kuwamura M, Nishizawa Y, Itoh K, Izawa T, Hatoya S, Hasegawa T, Yamate J, Inaba T, Sugiura K.

PLoS One. 2017 Nov 30;12(11):e0188738. doi: 10.1371/journal.pone.0188738. eCollection 2017.

24.

iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease.

Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T, Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H.

Cell Rep. 2017 Nov 21;21(8):2304-2312. doi: 10.1016/j.celrep.2017.10.109.

25.

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells.

Sethumadhavan S, Silva M, Philbrook P, Nguyen T, Hatfield SM, Ohta A, Sitkovsky MV.

PLoS One. 2017 Nov 20;12(11):e0187314. doi: 10.1371/journal.pone.0187314. eCollection 2017.

26.

Vision-assisted micromanipulation using closed-loop actuation of multiple microrobots.

Rahman MA, Takahashi N, Siliga KF, Ng NK, Wang Z, Ohta AT.

Robotics Biomim. 2017;4(1):7. doi: 10.1186/s40638-017-0064-4. Epub 2017 Oct 30.

27.

Aggregation Behavior of Disulfide Linked Gemini Surfactants Compared to that of Double Tailed Surfactants.

Takano Y, Asakawa T, Inai M, Ohta A, Asakawa H.

J Oleo Sci. 2017 Dec 1;66(12):1321-1328. doi: 10.5650/jos.ess17083. Epub 2017 Nov 13.

28.

Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells.

Matsuo K, Sone M, Honda-Kohmo K, Toyohara T, Sonoyama T, Taura D, Kojima K, Fukuda Y, Ohno Y, Inoue M, Ohta A, Osafune K, Nakao K, Inagaki N.

Sci Rep. 2017 Nov 9;7(1):15120. doi: 10.1038/s41598-017-15485-4.

29.

Construction and expression of vectors encoding biologically active rodent gonadotropins.

Ohta A, Tsunoda Y, Tamura Y, Iino K, Nishimura N, Nishihara H, Takanashi H, Yoshida S, Kato T, Kato Y.

J Reprod Dev. 2017 Dec 15;63(6):605-609. doi: 10.1262/jrd.2017-091. Epub 2017 Oct 13.

30.

Secondary Syphilis with Pulmonary Involvement.

Ohta A, Furusyo N, Kishihara Y, Eiraku K, Murata M, Kainuma M, Toyoda K, Ogawa E, Hayashi T, Koga T.

Intern Med. 2018 Jan 1;57(1):121-126. doi: 10.2169/internalmedicine.8439-16. Epub 2017 Oct 11.

31.

Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells.

Kimura A, Toyoda T, Nishi Y, Nasu M, Ohta A, Osafune K.

Stem Cell Res. 2017 Oct;24:61-68. doi: 10.1016/j.scr.2017.08.010. Epub 2017 Aug 17.

32.

Ipragliflozin, a sodium glucose co-transporter 2 inhibitor, reduces intrahepatic lipid content and abdominal visceral fat volume in patients with type 2 diabetes.

Ohta A, Kato H, Ishii S, Sasaki Y, Nakamura Y, Nakagawa T, Nagai Y, Tanaka Y.

Expert Opin Pharmacother. 2017 Oct;18(14):1433-1438. doi: 10.1080/14656566.2017.1363888. Epub 2017 Aug 11.

PMID:
28770629
33.

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.

Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J, Ikeya M.

J Clin Invest. 2017 Sep 1;127(9):3339-3352. doi: 10.1172/JCI93521. Epub 2017 Jul 31.

34.

A novel function of vitellogenin subdomain, vWF type D, as a toxin-binding protein in the pufferfish Takifugu pardalis ovary.

Yin X, Kiriake A, Ohta A, Kitani Y, Ishizaki S, Nagashima Y.

Toxicon. 2017 Sep 15;136:56-66. doi: 10.1016/j.toxicon.2017.06.006. Epub 2017 Jun 23.

PMID:
28651990
35.

Cooperative Micromanipulation Using the Independent Actuation of Fifty Microrobots in Parallel.

Rahman MA, Cheng J, Wang Z, Ohta AT.

Sci Rep. 2017 Jun 12;7(1):3278. doi: 10.1038/s41598-017-03525-y.

36.

The renal pathological findings in Japanese HIV-infected individuals with CKD: a clinical case series from a single center.

Hara M, Momoki K, Ubukata M, Ohta A, Tonooka A, Ando M.

Clin Exp Nephrol. 2018 Feb;22(1):68-77. doi: 10.1007/s10157-017-1425-6. Epub 2017 Jun 8.

PMID:
28597149
37.

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H.

Sci Transl Med. 2017 May 24;9(391). pii: eaaf3962. doi: 10.1126/scitranslmed.aaf3962.

PMID:
28539470
38.

Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells.

Kondo Y, Toyoda T, Ito R, Funato M, Hosokawa Y, Matsui S, Sudo T, Nakamura M, Okada C, Zhuang X, Watanabe A, Ohta A, Inagaki N, Osafune K.

Diabetologia. 2017 Aug;60(8):1454-1466. doi: 10.1007/s00125-017-4302-7. Epub 2017 May 22.

PMID:
28534195
39.

Significance of Psychological Stress Response and Health-related Quality of Life in Spouses of Cancer Patients When Given Bad News.

Kugimoto T, Katsuki R, Kosugi T, Ohta A, Sato H.

Asia Pac J Oncol Nurs. 2017 Apr-Jun;4(2):147-154. doi: 10.4103/2347-5625.204494.

40.

Validation of the revised International Prognostic Scoring System in patients with myelodysplastic syndrome in Japan: results from a prospective multicenter registry.

Kawabata H, Tohyama K, Matsuda A, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Zaike Y, Usuki K, Chiba S, Ishikawa T, Arima N, Nogawa M, Ohta A, Miyazaki Y, Mitani K, Ozawa K, Arai S, Kurokawa M, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Int J Hematol. 2017 Sep;106(3):375-384. doi: 10.1007/s12185-017-2250-0. Epub 2017 May 11.

PMID:
28497239
41.

Effect of Ezetimibe Monotherapy on Low-Density Lipoprotein Cholesterol and on Markers of Cholesterol Synthesis and Absorption in Japanese Patients With Hypercholesterolemia.

Ohta A, Kato H, Ishii S, Nagai Y, Tanaka Y.

J Clin Med Res. 2017 Jun;9(6):476-481. doi: 10.14740/jocmr2782w. Epub 2017 Apr 26.

42.

Δ12-fatty acid desaturase is involved in growth at low temperature in yeast Yarrowia lipolytica.

Tezaki S, Iwama R, Kobayashi S, Shiwa Y, Yoshikawa H, Ohta A, Horiuchi H, Fukuda R.

Biochem Biophys Res Commun. 2017 Jun 17;488(1):165-170. doi: 10.1016/j.bbrc.2017.05.028. Epub 2017 May 5.

PMID:
28483524
43.

Eating glutinous brown rice for one day improves glycemic control in Japanese patients with type 2 diabetes assessed by continuous glucose monitoring.

Terashima Y, Nagai Y, Kato H, Ohta A, Tanaka Y.

Asia Pac J Clin Nutr. 2017 May;26(3):421-426. doi: 10.6133/apjcn.042016.07.

44.

Synthesis of 2-amino- and 2-arylazoazulenes via nucleophilic aromatic substitution of 2-chloroazulenes with amines and arylhydrazines.

Shoji T, Sugiyama S, Araki T, Ohta A, Sekiguchi R, Ito S, Mori S, Okujima T, Yasunami M.

Org Biomol Chem. 2017 May 10;15(18):3917-3923. doi: 10.1039/c7ob00691h.

PMID:
28426084
45.

Synthesis of 2-Aminofurans by Sequential [2+2] Cycloaddition-Nucleophilic Addition of 2-Propyn-1-ols with Tetracyanoethylene and Amine-Induced Transformation into 6-Aminopentafulvenes.

Shoji T, Nagai D, Tanaka M, Araki T, Ohta A, Sekiguchi R, Ito S, Mori S, Okujima T.

Chemistry. 2017 Apr 11;23(21):5126-5136. doi: 10.1002/chem.201700121. Epub 2017 Mar 23.

PMID:
28191692
46.

Respiratory gating and multifield technique radiotherapy for esophageal cancer.

Ohta A, Kaidu M, Tanabe S, Utsunomiya S, Sasamoto R, Maruyama K, Tanaka K, Saito H, Nakano T, Shioi M, Takahashi H, Kushima N, Abe E, Aoyama H.

Jpn J Radiol. 2017 Mar;35(3):95-100. doi: 10.1007/s11604-016-0606-7. Epub 2017 Feb 3.

PMID:
28160228
47.

Synthesis of 2-Azulenyltetrathiafulvalenes by Palladium-Catalyzed Direct Arylation of 2-Chloroazulenes with Tetrathiafulvalene and Their Optical and Electrochemical Properties.

Shoji T, Araki T, Sugiyama S, Ohta A, Sekiguchi R, Ito S, Okujima T, Toyota K.

J Org Chem. 2017 Feb 3;82(3):1657-1665. doi: 10.1021/acs.joc.6b02818. Epub 2017 Jan 26.

PMID:
28094947
48.

Micropore Formation of [Zn2(Oxac) (Taz)2]·(H2O)2.5 via CO2 Adsorption.

Zubir M, Hamasaki A, Iiyama T, Ohta A, Ohki H, Ozeki S.

Langmuir. 2017 Jan 24;33(3):680-684. doi: 10.1021/acs.langmuir.6b03456. Epub 2017 Jan 12.

PMID:
28045538
49.

The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.

Abbott RK, Silva M, Labuda J, Thayer M, Cain DW, Philbrook P, Sethumadhavan S, Hatfield S, Ohta A, Sitkovsky M.

J Biol Chem. 2017 Jan 27;292(4):1211-1217. doi: 10.1074/jbc.C116.764043. Epub 2016 Dec 14.

50.

Effect of 24-week treatment with ipragliflozin on proinsulin/C-peptide ratio in Japanese patients with type 2 diabetes.

Nagai Y, Ohta A, Sada Y, Kato H, Tanaka Y.

Expert Opin Pharmacother. 2017 Jan;18(1):13-17. doi: 10.1080/14656566.2016.1261110. Epub 2016 Nov 21.

PMID:
27841020

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