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Items: 1 to 50 of 230

1.

Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell.

Sugisawa N, Ohnuma S, Ueda H, Murakami M, Sugiyama K, Ohsawa K, Kano K, Tokuyama H, Doi T, Aoki J, Ishida M, Kudoh K, Naitoh T, Ambudkar SV, Unno M.

Mol Pharm. 2018 Aug 13. doi: 10.1021/acs.molpharmaceut.8b00457. [Epub ahead of print]

PMID:
30052463
2.

Lactobacillus helveticus-fermented milk containing lactononadecapeptide (NIPPLTQTPVVVPPFLQPE) improves cognitive function in healthy middle-aged adults: a randomised, double-blind, placebo-controlled trial.

Ohsawa K, Nakamura F, Uchida N, Mizuno S, Yokogoshi H.

Int J Food Sci Nutr. 2018 May;69(3):369-376. doi: 10.1080/09637486.2017.1365824. Epub 2017 Aug 18.

PMID:
28819993
3.

Identification of peptides present in sour milk whey that ameliorate scopolamine-induced memory impairment in mice.

Ohsawa K, Uchida N, Ohki K, Yokogoshi H.

Int J Food Sci Nutr. 2018 Feb;69(1):33-45. doi: 10.1080/09637486.2017.1324564. Epub 2017 May 23.

PMID:
28535697
4.

Invasive mucinous adenocarcinoma of the lung presenting as a large, thin-walled cyst: A case report and literature review.

Masuzawa K, Minematsu N, Sasaki M, Ohsawa K, Yamamoto T, Iwamaru A, Ogata K, Betsuyaku T, Murakami M.

Mol Clin Oncol. 2017 Mar;6(3):433-437. doi: 10.3892/mco.2017.1143. Epub 2017 Jan 31.

5.

Hemoperitoneum Secondary to Rupture of a Hepatic Metastasis from Small Cell Lung Cancer during Chemotherapy: A Case with a Literature Review.

Mochimaru T, Minematsu N, Ohsawa K, Tomomatsu K, Miura H, Betsuyaku T, Murakami M.

Intern Med. 2017;56(6):695-699. doi: 10.2169/internalmedicine.56.6828. Epub 2017 Mar 17.

6.

Difference of two new LCMV strains in lethality and viral genome load in tissues.

Takagi T, Ohsawa M, Yamanaka H, Matsuda N, Sato H, Ohsawa K.

Exp Anim. 2017 Aug 5;66(3):199-208. doi: 10.1538/expanim.16-0097. Epub 2017 Mar 3.

7.

Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.

Laraia L, Ohsawa K, Konstantinidis G, Robke L, Wu YW, Kumar K, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 13;56(8):2145-2150. doi: 10.1002/anie.201611670. Epub 2017 Jan 18.

PMID:
28097798
8.

A role of nitrite reductase (NirBD) for NO homeostatic regulation in Streptomyces coelicolor A3(2).

Yukioka Y, Tanahashi T, Shida K, Oguchi H, Ogawa S, Saito C, Yajima S, Ito S, Ohsawa K, Shoun H, Sasaki Y.

FEMS Microbiol Lett. 2017 Jan;364(1). pii: fnw241. doi: 10.1093/femsle/fnw241. Epub 2016 Oct 18.

PMID:
27797866
9.

Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway.

Funakoshi-Tago M, Ohsawa K, Ishikawa T, Nakamura F, Ueda F, Narukawa Y, Kiuchi F, Tamura H, Tago K, Kasahara T.

Int Immunopharmacol. 2016 Nov;40:550-560. doi: 10.1016/j.intimp.2016.10.008. Epub 2016 Oct 19.

PMID:
27770720
10.

Pulmonary Mycobacterium avium infection demonstrating unusual lobar caseous pneumonia.

Okuzumi S, Minematsu N, Sasaki M, Ohsawa K, Murakami M.

Respirol Case Rep. 2016 Jul 5;4(5):e00176. doi: 10.1002/rcr2.176. eCollection 2016 Sep.

11.

Microglioma in a child - a further case in support of the microglioma entity and distinction from histiocytic sarcoma.

Mathews A, Ohsawa K, Buckland ME, Kesavadas C, Ratheesan K, Kusumakumary P, Burger PC, Kohsaka S, Graeber MB.

Clin Neuropathol. 2016 Sep-Oct;35(5):302-13. doi: 10.5414/NP300938.

PMID:
27191913
12.

Cell-permeable p38 MAP kinase promotes migration of adult neural stem/progenitor cells.

Hamanoue M, Morioka K, Ohsawa I, Ohsawa K, Kobayashi M, Tsuburaya K, Akasaka Y, Mikami T, Ogata T, Takamatsu K.

Sci Rep. 2016 Apr 12;6:24279. doi: 10.1038/srep24279.

13.

Nitrogen oxide cycle regulates nitric oxide levels and bacterial cell signaling.

Sasaki Y, Oguchi H, Kobayashi T, Kusama S, Sugiura R, Moriya K, Hirata T, Yukioka Y, Takaya N, Yajima S, Ito S, Okada K, Ohsawa K, Ikeda H, Takano H, Ueda K, Shoun H.

Sci Rep. 2016 Feb 25;6:22038. doi: 10.1038/srep22038.

14.

Helicobacter sp. MIT 01-6451 infection during fetal and neonatal life in laboratory mice.

Yamanaka H, Nakanishi T, Takagi T, Ohsawa M, Kubo N, Yamamoto N, Takemoto T, Ohsawa K.

Exp Anim. 2015;64(4):375-82. doi: 10.1538/expanim.15-0034. Epub 2015 Jul 2.

15.

Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights.

Hashizume M, Tan SL, Takano J, Ohsawa K, Hasada I, Hanasaki A, Ito I, Mihara M, Nishida K.

Int Rev Immunol. 2015 May;34(3):265-79. doi: 10.3109/08830185.2014.938325. Epub 2014 Aug 6. Review.

PMID:
25099958
16.

Identification and characterization of vancomycin-resistant Enterococcus species frequently isolated from laboratory mice.

Yamanaka H, Takagi T, Ohsawa M, Yamamoto N, Kubo N, Takemoto T, Sasano S, Masuyama R, Ohsawa K.

Exp Anim. 2014;63(3):297-304.

17.

Genome sequence of a pathogenic isolate of monkey B virus (species Macacine herpesvirus 1).

Ohsawa K, Black D, Ohsawa M, Eberle R.

Arch Virol. 2014 Oct;159(10):2819-21. doi: 10.1007/s00705-014-2130-3. Epub 2014 Jun 6.

18.

Lactobacillus helveticus-fermented milk improves learning and memory in mice.

Ohsawa K, Uchida N, Ohki K, Nakamura Y, Yokogoshi H.

Nutr Neurosci. 2015 Jul;18(5):232-40. doi: 10.1179/1476830514Y.0000000122. Epub 2014 Apr 3.

PMID:
24694020
19.

A single viral gene determines lethal cross-species neurovirulence of baboon herpesvirus HVP2.

Black D, Ohsawa K, Tyler S, Maxwell L, Eberle R.

Virology. 2014 Mar;452-453:86-94. doi: 10.1016/j.virol.2013.12.038. Epub 2014 Jan 29.

20.

Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant.

Iino D, Takakura Y, Fukano K, Sasaki Y, Hoshino T, Ohsawa K, Nakamura A, Yajima S.

J Struct Biol. 2013 Jul;183(1):76-85. doi: 10.1016/j.jsb.2013.05.023. Epub 2013 Jun 7.

PMID:
23747390
21.

Prevalence of an unidentified Helicobacter species in laboratory mice and its distribution in the hepatobiliary system and gastrointestinal tract.

Yamanaka H, Arita M, Oi R, Ohsawa M, Mizushima M, Takagi T, Kubo N, Yamamoto N, Takemoto T, Ohsawa K.

Exp Anim. 2013;62(2):109-16.

22.

A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate.

Ohsawa K, Yoshida M, Doi T.

J Org Chem. 2013 Apr 5;78(7):3438-44. doi: 10.1021/jo400056k. Epub 2013 Mar 21.

PMID:
23477294
23.

A reduction in age-enhanced gluconeogenesis extends lifespan.

Hachinohe M, Yamane M, Akazawa D, Ohsawa K, Ohno M, Terashita Y, Masumoto H.

PLoS One. 2013;8(1):e54011. doi: 10.1371/journal.pone.0054011. Epub 2013 Jan 14.

24.

Accumulating microglia phagocytose injured neurons in hippocampal slice cultures: involvement of p38 MAP kinase.

Katayama T, Kobayashi H, Okamura T, Yamasaki-Katayama Y, Kibayashi T, Kimura H, Ohsawa K, Kohsaka S, Minami M.

PLoS One. 2012;7(7):e40813. doi: 10.1371/journal.pone.0040813. Epub 2012 Jul 17.

25.
26.

Purinergic receptors in microglia: functional modal shifts of microglia mediated by P2 and P1 receptors.

Koizumi S, Ohsawa K, Inoue K, Kohsaka S.

Glia. 2013 Jan;61(1):47-54. doi: 10.1002/glia.22358. Epub 2012 Jun 1. Review.

PMID:
22674620
27.

Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats.

Sanagi T, Nakamura Y, Suzuki E, Uchino S, Aoki M, Warita H, Itoyama Y, Kohsaka S, Ohsawa K.

Glia. 2012 May;60(5):782-93. doi: 10.1002/glia.22308. Epub 2012 Feb 16.

PMID:
22344792
28.

Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration.

Ohsawa K, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.

J Neurochem. 2012 Apr;121(2):217-27. doi: 10.1111/j.1471-4159.2012.07693.x. Epub 2012 Mar 14.

29.

Correlation of dental health behavior with health awareness and subjective symptoms in a rural population in Japan.

Song W, Tamaki Y, Arakawa Y, Ogino D, Aoki K, Ohyama M, He D, Osawa T, Ohsawa K, Kadoma Y, Nomura Y, Arakawa H.

Asia Pac J Public Health. 2014 May;26(3):275-84. doi: 10.1177/1010539512436546. Epub 2012 Feb 13.

PMID:
22332177
30.

An active photoreceptor intermediate revealed by in situ photoirradiated solid-state NMR spectroscopy.

Tomonaga Y, Hidaka T, Kawamura I, Nishio T, Ohsawa K, Okitsu T, Wada A, Sudo Y, Kamo N, Ramamoorthy A, Naito A.

Biophys J. 2011 Nov 16;101(10):L50-2. doi: 10.1016/j.bpj.2011.10.022. Epub 2011 Nov 15.

31.

Dynamic motility of microglia: purinergic modulation of microglial movement in the normal and pathological brain.

Ohsawa K, Kohsaka S.

Glia. 2011 Dec;59(12):1793-9. doi: 10.1002/glia.21238. Epub 2011 Sep 7. Review.

PMID:
21901756
32.

Evaluation of promoters for gene expression in polyhydroxyalkanoate-producing Cupriavidus necator H16.

Fukui T, Ohsawa K, Mifune J, Orita I, Nakamura S.

Appl Microbiol Biotechnol. 2011 Mar;89(5):1527-36. doi: 10.1007/s00253-011-3100-2. Epub 2011 Jan 29.

PMID:
21279346
33.

Short communication: epidemiological evidence that simian T-lymphotropic virus type 1 in Macaca fuscata has an alternative transmission route to maternal infection.

Eguchi K, Ohsawa K, Fuse Kiyono M, Suzuki J, Kurokawa K, Yamamoto T.

AIDS Res Hum Retroviruses. 2011 Feb;27(2):113-4. doi: 10.1089/aid.2010.0082. Epub 2010 Sep 21.

PMID:
20854200
34.

Differential pressure measurement using a free-flying insect-like ornithopter with an MEMS sensor.

Takahashi H, Aoyama Y, Ohsawa K, Tanaka H, Iwase E, Matsumoto K, Shimoyama I.

Bioinspir Biomim. 2010 Sep;5(3):036005. doi: 10.1088/1748-3182/5/3/036005. Epub 2010 Aug 16.

PMID:
20710069
35.

Contact sex pheromone components of the seed beetle, Callosobruchus analis (F.).

Shimomura K, Akasaka K, Yajima A, Mimura T, Yajima S, Ohsawa K.

J Chem Ecol. 2010 Sep;36(9):955-65. doi: 10.1007/s10886-010-9841-z. Epub 2010 Aug 10.

PMID:
20697783
36.

Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis.

Sanagi T, Yuasa S, Nakamura Y, Suzuki E, Aoki M, Warita H, Itoyama Y, Uchino S, Kohsaka S, Ohsawa K.

J Neurosci Res. 2010 Sep;88(12):2736-46. doi: 10.1002/jnr.22424.

PMID:
20648658
37.

2,3-Dihydrohomofarnesal: female sex attractant pheromone component of Callosobruchus rhodesianus (Pic).

Shimomura K, Koshino H, Yajima A, Matsumoto N, Kagohara Y, Kamada K, Yajima S, Ohsawa K.

J Chem Ecol. 2010 Aug;36(8):824-33. doi: 10.1007/s10886-010-9824-0. Epub 2010 Jul 6.

PMID:
20607368
38.

Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding.

Takenoya M, Ohtaki A, Noguchi K, Endo K, Sasaki Y, Ohsawa K, Yajima S, Yohda M.

J Struct Biol. 2010 Jun;170(3):532-9. doi: 10.1016/j.jsb.2010.03.015. Epub 2010 Mar 29.

PMID:
20353826
39.

P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP.

Ohsawa K, Irino Y, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.

Glia. 2010 May;58(7):790-801. doi: 10.1002/glia.20963.

PMID:
20091784
40.

Serological evidence for hepatitis e virus infection in laboratory monkeys and pigs in animal facilities in Japan.

Yamamoto H, Li TC, Koshimoto C, Ito K, Kita M, Miyashita N, Arikawa J, Yagami K, Asano M, Tezuka H, Suzuki N, Kurosawa T, Shibahara T, Furuya M, Mohri S, Sato H, Ohsawa K, Ibuki K, Takeda N.

Exp Anim. 2008 Jul;57(4):367-76.

41.

Homofarnesals: female sex attractant pheromone components of the southern cowpea weevil, Callosobruchus chinensis.

Shimomura K, Nojima S, Yajima S, Ohsawa K.

J Chem Ecol. 2008 Apr;34(4):467-77. doi: 10.1007/s10886-008-9451-1. Epub 2008 Mar 20.

PMID:
18351422
42.

Producibility and digestibility of antihypertensive beta-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: analyses using an in vitro model of mammalian gastrointestinal digestion.

Ohsawa K, Satsu H, Ohki K, Enjoh M, Takano T, Shimizu M.

J Agric Food Chem. 2008 Feb 13;56(3):854-8. doi: 10.1021/jf072671n. Epub 2008 Jan 15.

PMID:
18193838
43.

Arginine-modified DNA aptamers that show enantioselective recognition of the dicarboxylic acid moiety of glutamic acid.

Ohsawa K, Kasamatsu T, Nagashima J, Hanawa K, Kuwahara M, Ozaki H, Sawai H.

Anal Sci. 2008 Jan;24(1):167-72.

44.

Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia.

Irino Y, Nakamura Y, Inoue K, Kohsaka S, Ohsawa K.

J Neurosci Res. 2008 May 15;86(7):1511-9. doi: 10.1002/jnr.21610.

PMID:
18183622
45.

Crystallization and preliminary crystallographic analysis of hygromycin B phosphotransferase from Escherichia coli.

Iino D, Takakura Y, Kuroiwa M, Kawakami R, Sasaki Y, Hoshino T, Ohsawa K, Nakamura A, Yajima S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):685-8. Epub 2007 Jul 21.

46.

Lymphocytic choriomeningitis infection undetected by dirty-bedding sentinel monitoring and revealed after embryo transfer of an inbred strain derived from wild mice.

Ike F, Bourgade F, Ohsawa K, Sato H, Morikawa S, Saijo M, Kurane I, Takimoto K, Yamada YK, Jaubert J, Berard M, Nakata H, Hiraiwa N, Mekada K, Takakura A, Itoh T, Obata Y, Yoshiki A, Montagutelli X.

Comp Med. 2007 Jun;57(3):272-81.

PMID:
17605342
47.

Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin.

Yajima S, Hara K, Iino D, Sasaki Y, Kuzuyama T, Ohsawa K, Seto H.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):466-70. Epub 2007 May 31.

48.

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.

Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, Joshi BV, Jacobson KA, Kohsaka S, Inoue K.

Nature. 2007 Apr 26;446(7139):1091-5. Epub 2007 Apr 4.

49.

Contact sex pheromone components of the cowpea weevil, Callosobruchus maculatus.

Nojima S, Shimomura K, Honda H, Yamamoto I, Ohsawa K.

J Chem Ecol. 2007 May;33(5):923-33. Epub 2007 Mar 30.

PMID:
17394050
50.

Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis.

Ohsawa K, Irino Y, Nakamura Y, Akazawa C, Inoue K, Kohsaka S.

Glia. 2007 Apr 15;55(6):604-16.

PMID:
17299767

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