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Items: 1 to 50 of 114

1.

Exploring disease-specific methylated CpGs in human male genital abnormalities by using MSD-AFLP.

Aiba T, Saito T, Hayashi A, Sato S, Yunokawa H, Fukami M, Hayashi Y, Mizuno K, Sato Y, Kojima Y, Ohsako S.

J Reprod Dev. 2019 Aug 29. doi: 10.1262/jrd.2019-069. [Epub ahead of print]

2.

Gene expression analysis of conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage.

Ueta M, Sotozono C, Nishigaki H, Ohsako S, Yokoi N, Mizushima K, Naito Y, Kinoshita S.

BMJ Open Ophthalmol. 2019 Jun 16;4(1):e000254. doi: 10.1136/bmjophth-2018-000254. eCollection 2019.

3.
4.

Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro.

Zong C, Hasegawa R, Urushitani M, Zhang L, Nagashima D, Sakurai T, Ichihara S, Ohsako S, Ichihara G.

Arch Toxicol. 2019 Jul;93(7):2007-2019. doi: 10.1007/s00204-019-02471-0. Epub 2019 May 9.

PMID:
31073625
5.

Distinctly regulated functions and mobilization of CD11c-positive cells elicited by TLR3- and IPS-1 signaling in the cornea.

Ueta M, Hamuro J, Ohsako S, Kinoshita S.

Immunol Lett. 2019 Feb;206:49-53. doi: 10.1016/j.imlet.2018.12.004. Epub 2018 Dec 17.

6.

Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells.

Yamane J, Aburatani S, Imanishi S, Akanuma H, Nagano R, Kato T, Sone H, Ohsako S, Fujibuchi W.

Nucleic Acids Res. 2019 Feb 20;47(3):1600. doi: 10.1093/nar/gky1285. No abstract available.

7.

Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique.

Aiba T, Saito T, Hayashi A, Sato S, Yunokawa H, Maruyama T, Fujibuchi W, Ohsako S.

Genes Environ. 2018 Jun 4;40:12. doi: 10.1186/s41021-018-0099-y. eCollection 2018.

8.

[Construction of a High-precision Chemical Prediction System Using Human ESCs].

Yamane J, Aburatani S, Imanishi S, Akanuma H, Nagano R, Kato T, Sone H, Ohsako S, Fujibuchi W.

Yakugaku Zasshi. 2018;138(6):815-822. doi: 10.1248/yakushi.17-00213-2. Review. Japanese.

9.

Isolation and characterisation of CD9-positive pituitary adult stem/progenitor cells in rats.

Horiguchi K, Fujiwara K, Yoshida S, Nakakura T, Arae K, Tsukada T, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y.

Sci Rep. 2018 Apr 3;8(1):5533. doi: 10.1038/s41598-018-23923-0.

10.

Detection of dioxin-induced demethylation of mouse Cyp1a1 gene promoter by a new labeling method for short DNA fragments possessing 5'-methylcytosine at the end.

Kurita H, Aiba T, Saito T, Ohsako S.

Genes Environ. 2018 Jan 10;40:1. doi: 10.1186/s41021-017-0089-5. eCollection 2018.

11.

Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter.

Ohsako S, Aiba T, Miyado M, Fukami M, Ogata T, Hayashi Y, Mizuno K, Kojima Y.

Arch Environ Contam Toxicol. 2018 Feb;74(2):240-247. doi: 10.1007/s00244-017-0466-x. Epub 2017 Oct 27.

12.

Methylated site display (MSD)-AFLP, a sensitive and affordable method for analysis of CpG methylation profiles.

Aiba T, Saito T, Hayashi A, Sato S, Yunokawa H, Maruyama T, Fujibuchi W, Kurita H, Tohyama C, Ohsako S.

BMC Mol Biol. 2017 Mar 9;18(1):7. doi: 10.1186/s12867-017-0083-2.

13.

Identification of THY1 as a novel thyrotrope marker and THY1 antibody-mediated thyrotrope isolation in the rat anterior pituitary gland.

Horiguchi K, Nakakura T, Yoshida S, Tsukada T, Kanno N, Hasegawa R, Takigami S, Ohsako S, Kato T, Kato Y.

Biochem Biophys Res Commun. 2016 Nov 11;480(2):273-279. doi: 10.1016/j.bbrc.2016.10.049. Epub 2016 Oct 17.

PMID:
27765629
14.

Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver.

Amenya HZ, Tohyama C, Ohsako S.

Sci Rep. 2016 Oct 7;6:34989. doi: 10.1038/srep34989.

15.

Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells.

Yamane J, Aburatani S, Imanishi S, Akanuma H, Nagano R, Kato T, Sone H, Ohsako S, Fujibuchi W.

Nucleic Acids Res. 2016 Jul 8;44(12):5515-28. doi: 10.1093/nar/gkw450. Epub 2016 May 20. Erratum in: Nucleic Acids Res. 2019 Feb 20;47(3):1600.

16.

CXCL10/CXCR3 signaling mediates inhibitory action by interferon-gamma on CRF-stimulated adrenocorticotropic hormone (ACTH) release.

Horiguchi K, Fujiwara K, Tsukada T, Yoshida S, Higuchi M, Tateno K, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y.

Cell Tissue Res. 2016 May;364(2):395-404. doi: 10.1007/s00441-015-2317-2. Epub 2015 Nov 14.

PMID:
26572542
17.

Expression of Slug in S100β-protein-positive cells of postnatal developing rat anterior pituitary gland.

Horiguchi K, Fujiwara K, Tsukada T, Yako H, Tateno K, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y.

Cell Tissue Res. 2016 Feb;363(2):513-24. doi: 10.1007/s00441-015-2256-y. Epub 2015 Aug 7.

PMID:
26246400
18.

Proton receptor GPR68 expression in dendritic-cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification.

Horiguchi K, Higuchi M, Yoshida S, Nakakura T, Tateno K, Hasegawa R, Takigami S, Ohsako S, Kato T, Kato Y.

Cell Tissue Res. 2014 Nov;358(2):515-25. doi: 10.1007/s00441-014-1958-x. Epub 2014 Aug 17.

PMID:
25129106
19.

A mouse strain less responsive to dioxin-induced prostaglandin E2 synthesis is resistant to the onset of neonatal hydronephrosis.

Aida-Yasuoka K, Yoshioka W, Kawaguchi T, Ohsako S, Tohyama C.

Toxicol Sci. 2014 Oct;141(2):465-74. doi: 10.1093/toxsci/kfu142. Epub 2014 Jul 11.

20.

Expression of chemokine CXCL10 in dendritic-cell-like S100β-positive cells in rat anterior pituitary gland.

Horiguchi K, Fujiwara K, Higuchi M, Yoshida S, Tsukada T, Ueharu H, Chen M, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y.

Cell Tissue Res. 2014 Sep;357(3):757-65. doi: 10.1007/s00441-014-1864-2. Epub 2014 Apr 27.

PMID:
24770897
21.
22.

Single administration of butylparaben induces spermatogenic cell apoptosis in prepubertal rats.

Alam MS, Ohsako S, Kanai Y, Kurohmaru M.

Acta Histochem. 2014 Apr;116(3):474-80. doi: 10.1016/j.acthis.2013.10.006. Epub 2013 Nov 13.

PMID:
24238989
23.

In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet.

Sugai E, Yoshioka W, Kakeyama M, Ohsako S, Tohyama C.

J Appl Toxicol. 2014 Mar;34(3):296-306. doi: 10.1002/jat.2881. Epub 2013 Jun 10.

PMID:
23749557
24.

Effect of low-dose thalidomide on dopaminergic neuronal differentiation of human neural progenitor cells: a combined study of metabolomics and morphological analysis.

Qin XY, Akanuma H, Wei F, Nagano R, Zeng Q, Imanishi S, Ohsako S, Yoshinaga J, Yonemoto J, Tanokura M, Sone H.

Neurotoxicology. 2012 Oct;33(5):1375-80. doi: 10.1016/j.neuro.2012.08.016. Epub 2012 Sep 7.

PMID:
22981892
25.

Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene.

Kurita H, Ohsako S, Hashimoto S, Yoshinaga J, Tohyama C.

J Nutr Biochem. 2013 Jan;24(1):256-66. doi: 10.1016/j.jnutbio.2012.05.013. Epub 2012 Aug 20.

PMID:
22917840
26.

Identification of Stage-Specific Gene Expression Signatures in Response to Retinoic Acid during the Neural Differentiation of Mouse Embryonic Stem Cells.

Akanuma H, Qin XY, Nagano R, Win-Shwe TT, Imanishi S, Zaha H, Yoshinaga J, Fukuda T, Ohsako S, Sone H.

Front Genet. 2012 Aug 7;3:141. doi: 10.3389/fgene.2012.00141. eCollection 2012.

27.

Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells.

He X, Imanishi S, Sone H, Nagano R, Qin XY, Yoshinaga J, Akanuma H, Yamane J, Fujibuchi W, Ohsako S.

Toxicol Lett. 2012 Jul 7;212(1):1-10. doi: 10.1016/j.toxlet.2012.04.011. Epub 2012 Apr 23.

PMID:
22555245
28.

Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.

Yoshioka W, Aida-Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, Uematsu S, Akira S, Tohyama C.

Toxicol Sci. 2012 Jun;127(2):547-54. doi: 10.1093/toxsci/kfs115. Epub 2012 Mar 19.

PMID:
22430074
29.

Multi-parametric profiling network based on gene expression and phenotype data: a novel approach to developmental neurotoxicity testing.

Nagano R, Akanuma H, Qin XY, Imanishi S, Toyoshiba H, Yoshinaga J, Ohsako S, Sone H.

Int J Mol Sci. 2012;13(1):187-207. doi: 10.3390/ijms13010187. Epub 2011 Dec 23.

30.

Intracapsular organization of ciliary zonules in monkey eyes.

Hiraoka M, Inoue K, Ohtaka-Maruyama C, Ohsako S, Kojima N, Senoo H, Takada M.

Anat Rec (Hoboken). 2010 Oct;293(10):1797-804. doi: 10.1002/ar.21220. Epub 2010 Jul 22.

31.

Di(n-butyl) phthalate induces vimentin filaments disruption in rat sertoli cells: a possible relation with spermatogenic cell apoptosis.

Alam MS, Ohsako S, Tay TW, Tsunekawa N, Kanai Y, Kurohmaru M.

Anat Histol Embryol. 2010 Jun;39(3):186-93. doi: 10.1111/j.1439-0264.2010.00993.x. Epub 2010 Mar 11.

PMID:
20331591
32.

Profiles of Chemical Effects on Cells (pCEC): a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals.

Sone H, Okura M, Zaha H, Fujibuchi W, Taniguchi T, Akanuma H, Nagano R, Ohsako S, Yonemoto J.

J Toxicol Sci. 2010 Feb;35(1):115-23.

33.

Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.

Ohsako S, Fukuzawa N, Ishimura R, Kawakami T, Wu Q, Nagano R, Zaha H, Sone H, Yonemoto J, Tohyama C.

Biol Reprod. 2010 Mar;82(3):636-43. doi: 10.1095/biolreprod.109.080812. Epub 2009 Dec 9.

PMID:
20007409
34.

Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate.

Alam MS, Ohsako S, Matsuwaki T, Zhu XB, Tsunekawa N, Kanai Y, Sone H, Tohyama C, Kurohmaru M.

Reproduction. 2010 Feb;139(2):427-37. doi: 10.1530/REP-09-0226. Epub 2009 Nov 10.

PMID:
19903717
35.

When does the sex ratio of offspring of the paternal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decrease: in the spermatozoa stage or at fertilization?

Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.

Reprod Toxicol. 2010 Jan;29(1):68-73. doi: 10.1016/j.reprotox.2009.09.009. Epub 2009 Oct 4.

PMID:
19808090
36.

Possible involvement of arylhydrocarbon receptor variants in TCDD-induced thymic atrophy and XRE-dependent transcriptional activity in Wistar Hannover GALAS rats.

Kawakami T, Ito T, Ohsako S, Shiizaki K, Murakami Y, Hirowatari K, Sato M, Tohyama C.

J Toxicol Sci. 2009 Apr;34(2):209-20.

37.

Dioxin-induced toxicity on vascular remodeling of the placenta.

Ishimura R, Kawakami T, Ohsako S, Tohyama C.

Biochem Pharmacol. 2009 Feb 15;77(4):660-9. doi: 10.1016/j.bcp.2008.10.030. Epub 2008 Nov 5. Review.

PMID:
19027717
38.

Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells.

Shiizaki K, Ohsako S, Kawanishi M, Yagi T.

Basic Clin Pharmacol Toxicol. 2008 Nov;103(5):468-75. doi: 10.1111/j.1742-7843.2008.00309.x. Epub 2008 Sep 12.

39.
40.

Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.

Sakata Y, Yoshioka W, Tohyama C, Ohsako S.

Biochem Biophys Res Commun. 2007 Apr 13;355(3):687-92. Epub 2007 Feb 9.

PMID:
17316563
41.

Relationship between catheter care and catheter-associated urinary tract infection at Japanese general hospitals: a prospective observational study.

Tsuchida T, Makimoto K, Ohsako S, Fujino M, Kaneda M, Miyazaki T, Fujiwara F, Sugimoto T.

Int J Nurs Stud. 2008 Mar;45(3):352-61. Epub 2006 Dec 14.

PMID:
17173921
42.

[Effect of environmental contaminants on DNA methyltransferase activity of mouse preimplantation embryos].

Wu Q, Zhou ZJ, Ohsako S.

Wei Sheng Yan Jiu. 2006 Jan;35(1):30-2. Chinese.

PMID:
16598927
43.

Suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.

Ishimura R, Kawakami T, Ohsako S, Nohara K, Tohyama C.

Toxicol Sci. 2006 May;91(1):265-74. Epub 2006 Feb 22.

PMID:
16495355
44.
45.

Comparison of study controls.

Ohsako S, Tohyama C.

Environ Health Perspect. 2005 Sep;113(9):A582; author reply A582-3. No abstract available.

46.

Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.

Shiizaki K, Ohsako S, Koyama T, Nagata R, Yonemoto J, Tohyama C.

Toxicol Lett. 2005 Dec 30;160(1):22-33. Epub 2005 Jul 28.

PMID:
16054781
48.

Comparative uterine gene expression analysis after dioxin and estradiol administration.

Watanabe H, Suzuki A, Goto M, Ohsako S, Tohyama C, Handa H, Iguchi T.

J Mol Endocrinol. 2004 Dec;33(3):763-71.

PMID:
15591033
49.

Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse.

Fukuzawa NH, Ohsako S, Wu Q, Sakaue M, Fujii-Kuriyama Y, Baba T, Tohyama C.

Mol Cell Endocrinol. 2004 Jun 30;221(1-2):87-96.

PMID:
15223135
50.

Fetal development of vomeronasal system in the goat.

Takigami S, Wakabayashi Y, Ohsako S, Ohkura S, Okamura H, Ikai A, Ichikawa M, Osada T.

Brain Res Dev Brain Res. 2004 Apr 19;149(2):113-20.

PMID:
15063091

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