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Items: 1 to 50 of 368

1.

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N.

Schizophr Bull. 2018 Oct 3. doi: 10.1093/schbul/sby140. [Epub ahead of print]

PMID:
30285260
2.

NgcESco Acts as a Lower-Affinity Binding Protein of an ABC Transporter for the Uptake of N,N'-Diacetylchitobiose in Streptomyces coelicolor A3(2).

Iinuma C, Saito A, Ohnuma T, Tenconi E, Rosu A, Colson S, Mizutani Y, Liu F, Świątek-Połatyńska M, van Wezel GP, Rigali S, Fujii T, Miyashita K.

Microbes Environ. 2018 Sep 29;33(3):272-281. doi: 10.1264/jsme2.ME17172. Epub 2018 Aug 7.

3.

Mode of action and specificity of a chitinase from unicellular microalgae, Euglena gracilis.

Feng Y, Kitaoku Y, Tanaka J, Taira T, Ohnuma T, Aachmann FL, Fukamizo T.

Plant Mol Biol. 2018 Aug;97(6):553-564. doi: 10.1007/s11103-018-0759-0. Epub 2018 Aug 6.

PMID:
30083952
4.

Structure and Enzymatic Properties of a Two-Domain Family GH19 Chitinase from Japanese Cedar ( Cryptomeria japonica) Pollen.

Takashima T, Numata T, Taira T, Fukamizo T, Ohnuma T.

J Agric Food Chem. 2018 Jun 6;66(22):5699-5706. doi: 10.1021/acs.jafc.8b01140. Epub 2018 May 23.

PMID:
29756783
5.

Unique GH18 chitinase from Euglena gracilis: full-length cDNA cloning and characterization of its catalytic domain.

Taira T, Gushiken C, Sugata K, Ohnuma T, Fukamizo T.

Biosci Biotechnol Biochem. 2018 Jul;82(7):1090-1100. doi: 10.1080/09168451.2018.1459463. Epub 2018 Apr 5.

PMID:
29621939
6.

Carbonyl Stress and Microinflammation-Related Molecules as Potential Biomarkers in Schizophrenia.

Ohnuma T, Nishimon S, Takeda M, Sannohe T, Katsuta N, Arai H.

Front Psychiatry. 2018 Mar 13;9:82. doi: 10.3389/fpsyt.2018.00082. eCollection 2018. Review.

7.

Predictors associated with unplanned hospital readmission of medical and surgical intensive care unit survivors within 30 days of discharge.

Ohnuma T, Shinjo D, Brookhart AM, Fushimi K.

J Intensive Care. 2018 Mar 1;6:14. doi: 10.1186/s40560-018-0284-x. eCollection 2018.

8.

NMR analysis of substrate binding to a two-domain chitinase: Comparison between soluble and insoluble chitins.

Takashima T, Ohnuma T, Fukamizo T.

Carbohydr Res. 2018 Mar 22;458-459:52-59. doi: 10.1016/j.carres.2018.02.004. Epub 2018 Feb 8.

PMID:
29459179
9.

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016).

Nishida O, Ogura H, Egi M, Fujishima S, Hayashi Y, Iba T, Imaizumi H, Inoue S, Kakihana Y, Kotani J, Kushimoto S, Masuda Y, Matsuda N, Matsushima A, Nakada TA, Nakagawa S, Nunomiya S, Sadahiro T, Shime N, Yatabe T, Hara Y, Hayashida K, Kondo Y, Sumi Y, Yasuda H, Aoyama K, Azuhata T, Doi K, Doi M, Fujimura N, Fuke R, Fukuda T, Goto K, Hasegawa R, Hashimoto S, Hatakeyama J, Hayakawa M, Hifumi T, Higashibeppu N, Hirai K, Hirose T, Ide K, Kaizuka Y, Kan'o T, Kawasaki T, Kuroda H, Matsuda A, Matsumoto S, Nagae M, Onodera M, Ohnuma T, Oshima K, Saito N, Sakamoto S, Sakuraya M, Sasano M, Sato N, Sawamura A, Shimizu K, Shirai K, Takei T, Takeuchi M, Takimoto K, Taniguchi T, Tatsumi H, Tsuruta R, Yama N, Yamakawa K, Yamashita C, Yamashita K, Yoshida T, Tanaka H, Oda S.

Acute Med Surg. 2018 Feb 5;5(1):3-89. doi: 10.1002/ams2.322. eCollection 2018 Jan.

10.

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016).

Nishida O, Ogura H, Egi M, Fujishima S, Hayashi Y, Iba T, Imaizumi H, Inoue S, Kakihana Y, Kotani J, Kushimoto S, Masuda Y, Matsuda N, Matsushima A, Nakada TA, Nakagawa S, Nunomiya S, Sadahiro T, Shime N, Yatabe T, Hara Y, Hayashida K, Kondo Y, Sumi Y, Yasuda H, Aoyama K, Azuhata T, Doi K, Doi M, Fujimura N, Fuke R, Fukuda T, Goto K, Hasegawa R, Hashimoto S, Hatakeyama J, Hayakawa M, Hifumi T, Higashibeppu N, Hirai K, Hirose T, Ide K, Kaizuka Y, Kan'o T, Kawasaki T, Kuroda H, Matsuda A, Matsumoto S, Nagae M, Onodera M, Ohnuma T, Oshima K, Saito N, Sakamoto S, Sakuraya M, Sasano M, Sato N, Sawamura A, Shimizu K, Shirai K, Takei T, Takeuchi M, Takimoto K, Taniguchi T, Tatsumi H, Tsuruta R, Yama N, Yamakawa K, Yamashita C, Yamashita K, Yoshida T, Tanaka H, Oda S.

J Intensive Care. 2018 Feb 2;6:7. doi: 10.1186/s40560-017-0270-8. eCollection 2018.

11.

A nationwide survey of intravenous antimicrobial use in intensive care units in Japan.

Ohnuma T, Hayashi Y, Yamashita K, Marquess J, Lefor AK, Sanui M; Japanese Survey of AntimiCRobial Use in ICU PatienTs (JSCRIPT) investigators.

Int J Antimicrob Agents. 2018 Apr;51(4):636-641. doi: 10.1016/j.ijantimicag.2018.01.022. Epub 2018 Feb 2.

PMID:
29408737
12.

Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells.

Ohnuma T, Sakamoto K, Shinoda A, Takagi C, Ohno S, Nishiyama T, Ogura K, Hiratsuka A.

Arch Biochem Biophys. 2017 Dec 1;635:66-73. doi: 10.1016/j.abb.2017.10.007. Epub 2017 Oct 16.

PMID:
29051069
13.

Physician attire in the intensive care unit in Japan influences visitors' perception of care.

Lefor AK, Ohnuma T, Nunomiya S, Yokota S, Makino J, Sanui M.

J Crit Care. 2018 Feb;43:288-293. doi: 10.1016/j.jcrc.2017.09.181. Epub 2017 Sep 28.

PMID:
28965038
14.

Crystal structure and thermodynamic dissection of chitin oligosaccharide binding to the LysM module of chitinase-A from Pteris ryukyuensis.

Ohnuma T, Taira T, Umemoto N, Kitaoku Y, Sørlie M, Numata T, Fukamizo T.

Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):736-741. doi: 10.1016/j.bbrc.2017.08.143. Epub 2017 Sep 1.

PMID:
28867184
15.

Cancer, Anorexia and Cachexia.

Ohnuma T, Adigun R.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2018 Mar 29.

16.

Medium-chain triglycerides given in the early stage of mild-to-moderate Alzheimer's disease enhance memory function.

Kimoto A, Ohnuma T, Toda A, Takebayashi Y, Higashiyama R, Tagata Y, Ito M, Ota T, Shibata N, Arai H.

Psychogeriatrics. 2017 Nov;17(6):520-521. doi: 10.1111/psyg.12257. Epub 2017 Apr 18. No abstract available.

PMID:
28417540
17.

Efficacy of polymyxin B-immobilized fiber hemoperfusion for patients with septic shock caused by Gram-negative bacillus infection.

Saito N, Sugiyama K, Ohnuma T, Kanemura T, Nasu M, Yoshidomi Y, Tsujimoto Y, Adachi H, Koami H, Tochiki A, Hori K, Wagatsuma Y, Matsumoto H.

PLoS One. 2017 Mar 30;12(3):e0173633. doi: 10.1371/journal.pone.0173633. eCollection 2017.

18.

High serum soluble tumor necrosis factor receptor 1 predicts poor treatment response in acute-stage schizophrenia.

Nishimon S, Ohnuma T, Takebayashi Y, Katsuta N, Takeda M, Nakamura T, Sannohe T, Higashiyama R, Kimoto A, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:145-154. doi: 10.1016/j.pnpbp.2017.03.006. Epub 2017 Mar 22.

PMID:
28341443
19.

Factors affecting prolonged length of stay in psychiatric patients in Japan: A retrospective observational study.

Shinjo D, Tachimori H, Sakurai K, Ohnuma T, Fujimori K, Fushimi K.

Psychiatry Clin Neurosci. 2017 Aug;71(8):542-553. doi: 10.1111/pcn.12521. Epub 2017 May 10.

20.

High doses of antipsychotic polypharmacy are related to an increase in serum levels of pentosidine in patients with schizophrenia.

Sannohe T, Ohnuma T, Takeuchi M, Tani E, Miki Y, Takeda M, Katsuta N, Takebayashi Y, Nakamura T, Nishimon S, Kimoto A, Higashiyama R, Shibata N, Gohda T, Suzuki Y, Yamagishi SI, Tomino Y, Arai H.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:42-48. doi: 10.1016/j.pnpbp.2017.02.019. Epub 2017 Mar 7.

PMID:
28282638
21.

Enzymatic properties of a GH19 chitinase isolated from rice lacking a major loop structure involved in chitin binding.

Tanaka J, Fukamizo T, Ohnuma T.

Glycobiology. 2017 May 1;27(5):477-485. doi: 10.1093/glycob/cwx016.

PMID:
28204489
22.

Observational Research Using Propensity Scores.

Raghunathan K, Layton JB, Ohnuma T, Shaw AD.

Adv Chronic Kidney Dis. 2016 Nov;23(6):367-372. doi: 10.1053/j.ackd.2016.11.010. Review.

PMID:
28115080
23.

Prediction Models and Their External Validation Studies for Mortality of Patients with Acute Kidney Injury: A Systematic Review.

Ohnuma T, Uchino S.

PLoS One. 2017 Jan 5;12(1):e0169341. doi: 10.1371/journal.pone.0169341. eCollection 2017. Review.

24.

NMR assignments and ligand-binding studies on a two-domain family GH19 chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen.

Takashima T, Ohnuma T, Fukamizo T.

Biomol NMR Assign. 2017 Apr;11(1):85-90. doi: 10.1007/s12104-016-9725-4. Epub 2016 Dec 28.

PMID:
28032262
25.

Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury: A multicenter randomized controlled trial.

Mitaka C, Ohnuma T, Murayama T, Kunimoto F, Nagashima M, Takei T, Iguchi N, Tomita M; JAPAN Investigators.

J Crit Care. 2017 Apr;38:253-258. doi: 10.1016/j.jcrc.2016.12.004. Epub 2016 Dec 11.

26.

Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers in Diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.

Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.

PLoS One. 2016 Dec 19;11(12):e0168816. doi: 10.1371/journal.pone.0168816. eCollection 2016.

27.

Case of metastatic uveal melanoma in which an antitumor effect appeared after ipilimumab discontinuation due to autoimmune hypophysitis.

Ohnuma T, Matsuzawa T, Kinoshita M, Sano S, Kawamura T, Shimada S, Inozume T.

J Dermatol. 2017 Nov;44(11):1325-1326. doi: 10.1111/1346-8138.13692. Epub 2016 Nov 18. No abstract available.

PMID:
27864834
28.

The chitin-binding domain of a GH-18 chitinase from Vibrio harveyi is crucial for chitin-chitinase interactions.

Suginta W, Sirimontree P, Sritho N, Ohnuma T, Fukamizo T.

Int J Biol Macromol. 2016 Dec;93(Pt A):1111-1117. doi: 10.1016/j.ijbiomac.2016.09.066. Epub 2016 Sep 22.

PMID:
27667544
29.

Chitin oligosaccharide binding to the lysin motif of a novel type of chitinase from the multicellular green alga, Volvox carteri.

Kitaoku Y, Fukamizo T, Numata T, Ohnuma T.

Plant Mol Biol. 2017 Jan;93(1-2):97-108. doi: 10.1007/s11103-016-0549-5. Epub 2016 Nov 2.

PMID:
27807643
30.

Estimated cognitive decline in patients with schizophrenia: A multicenter study.

Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, Hashimoto R; for COCORO.

Psychiatry Clin Neurosci. 2017 May;71(5):294-300. doi: 10.1111/pcn.12474. Epub 2016 Dec 15.

31.

Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study.

Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H.

Int J Geriatr Psychiatry. 2017 Dec;32(12):1241-1246. doi: 10.1002/gps.4600. Epub 2016 Oct 4.

PMID:
27699858
32.

Case of anal adenocarcinoma in situ with pagetoid spread but without macroscopic abnormality in anal mucosa.

Shimizu T, Inozume T, Takaki M, Ohnuma T, Sano S, Kawamura T, Shimada S.

J Dermatol. 2017 Sep;44(9):1076-1077. doi: 10.1111/1346-8138.13633. Epub 2016 Sep 26. No abstract available.

PMID:
27666572
33.

Hospital mortality of patients aged 80 and older after surgical repair for type A acute aortic dissection in Japan.

Ohnuma T, Shinjo D, Fushimi K.

Medicine (Baltimore). 2016 Aug;95(31):e4408. doi: 10.1097/MD.0000000000004408.

34.

Factors predicting successful discontinuation of continuous renal replacement therapy.

Katayama S, Uchino S, Uji M, Ohnuma T, Namba Y, Kawarazaki H, Toki N, Takeda K, Yasuda H, Izawa J, Tokuhira N, Nagata I; Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group.

Anaesth Intensive Care. 2016 Jul;44(4):453-7.

35.

Long-Term Survival in Patients With Acute Kidney Injury After Acute Type A Aortic Dissection Repair.

Sasabuchi Y, Kimura N, Shiotsuka J, Komuro T, Mouri H, Ohnuma T, Asaka K, Lefor AK, Yasunaga H, Yamaguchi A, Adachi H, Sanui M.

Ann Thorac Surg. 2016 Dec;102(6):2003-2009. doi: 10.1016/j.athoracsur.2016.05.006. Epub 2016 Jun 29.

PMID:
27372373
36.

Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.

Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.

Nat Commun. 2016 Apr 20;7:11466. doi: 10.1038/ncomms11466. No abstract available.

37.

Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population.

Suzuki A, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Takeshita Y, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H.

Dement Geriatr Cogn Dis Extra. 2016 Mar 16;6(1):90-7. doi: 10.1159/000444080. eCollection 2016 Jan-Apr.

38.

Mechanism of chitosan recognition by CBM32 carbohydrate-binding modules from a Paenibacillus sp. IK-5 chitosanase/glucanase.

Shinya S, Nishimura S, Kitaoku Y, Numata T, Kimoto H, Kusaoke H, Ohnuma T, Fukamizo T.

Biochem J. 2016 Apr 15;473(8):1085-95. doi: 10.1042/BCJ20160045. Epub 2016 Mar 2.

PMID:
26936968
39.

A glycosynthase derived from an inverting chitinase with an extended binding cleft.

Ohnuma T, Dozen S, Honda Y, Kitaoka M, Fukamizo T.

J Biochem. 2016 Aug;160(2):93-100. doi: 10.1093/jb/mvw014. Epub 2016 Feb 22.

PMID:
26908157
40.

Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia.

Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H.

Am J Med Genet B Neuropsychiatr Genet. 2016 Apr;171B(3):447-57. doi: 10.1002/ajmg.b.32426. Epub 2016 Feb 7.

PMID:
26852906
41.

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.

Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.

Nat Commun. 2016 Feb 3;7:10594. doi: 10.1038/ncomms10594. Erratum in: Nat Commun. 2016;7:11466.

42.

Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer's disease: a prospective, open-label pilot study.

Ohnuma T, Toda A, Kimoto A, Takebayashi Y, Higashiyama R, Tagata Y, Ito M, Ota T, Shibata N, Arai H.

Clin Interv Aging. 2016 Jan 8;11:29-36. doi: 10.2147/CIA.S95362. eCollection 2016.

43.

Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment.

Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.

PLoS One. 2016 Jan 7;11(1):e0146449. doi: 10.1371/journal.pone.0146449. eCollection 2016.

44.

Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract.

Ohnuma T, Anzai E, Suzuki Y, Shimoda M, Saito S, Nishiyama T, Ogura K, Hiratsuka A.

Arch Biochem Biophys. 2015 Nov 1;585:17-24. doi: 10.1016/j.abb.2015.09.007. Epub 2015 Sep 11.

PMID:
26365032
45.

External Validation for Acute Kidney Injury Severity Scores: A Multicenter Retrospective Study in 14 Japanese ICUs.

Ohnuma T, Uchino S, Toki N, Takeda K, Namba Y, Katayama S, Kawarazaki H, Yasuda H, Izawa J, Uji M, Tokuhira N, Nagata I; JSEPTIC (Japanese Society for Physicians and Trainees in Intensive Care) Clinical Trial Group.

Am J Nephrol. 2015;42(1):57-64.

PMID:
26337793
46.

Sepsis may not be a risk factor for mortality in patients with acute kidney injury treated with continuous renal replacement therapy.

Nagata I, Uchino S, Tokuhira N, Ohnuma T, Namba Y, Katayama S, Kawarazaki H, Toki N, Takeda K, Yasuda H, Izawa J, Uji M; JSEPTIC (Japanese Society for Physicians Trainees in Intensive Care) Clinical Trial Group.

J Crit Care. 2015 Oct;30(5):998-1002. doi: 10.1016/j.jcrc.2015.06.021. Epub 2015 Jun 26.

PMID:
26220246
47.

Modulation of the transglycosylation activity of plant family GH18 chitinase by removing or introducing a tryptophan side chain.

Umemoto N, Ohnuma T, Osawa T, Numata T, Fukamizo T.

FEBS Lett. 2015 Aug 19;589(18):2327-33. doi: 10.1016/j.febslet.2015.07.018. Epub 2015 Jul 26.

48.

Genetic or Psychogenic? A Case Study of "Folie à Quatre" Including Twins.

Ohnuma T, Arai H.

Case Rep Psychiatry. 2015;2015:983212. doi: 10.1155/2015/983212. Epub 2015 Jun 25.

49.

Associations of common copy number variants in glutathione S-transferase mu 1 and D-dopachrome tautomerase-like protein genes with risk of schizophrenia in a Japanese population.

Nakamura T, Ohnuma T, Hanzawa R, Takebayashi Y, Takeda M, Nishimon S, Sannohe T, Katsuta N, Higashiyama R, Shibata N, Arai H.

Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):630-6. doi: 10.1002/ajmg.b.32347. Epub 2015 Jul 14.

PMID:
26175060
50.

A class III chitinase without disulfide bonds from the fern, Pteris ryukyuensis: crystal structure and ligand-binding studies.

Kitaoku Y, Umemoto N, Ohnuma T, Numata T, Taira T, Sakuda S, Fukamizo T.

Planta. 2015 Oct;242(4):895-907. doi: 10.1007/s00425-015-2330-4. Epub 2015 May 22.

PMID:
25998529

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