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FTY720 Protects Against Ischemia-Reperfusion Injury by Preventing the Redistribution of Tight Junction Proteins and Decreases Inflammation in the Subacute Phase in an Experimental Stroke Model.

Wang Z, Higashikawa K, Yasui H, Kuge Y, Ohno Y, Kihara A, Midori YA, Houkin K, Kawabori M.

Transl Stroke Res. 2020 Feb 27. doi: 10.1007/s12975-020-00789-x. [Epub ahead of print]


Impact of the Fibrosis-4 Index on Risk Stratification of Cardiovascular Events and Mortality in Patients with Atrial Fibrillation: Findings from a Japanese Multicenter Registry.

Saito Y, Okumura Y, Nagashima K, Fukamachi D, Yokoyama K, Matsumoto N, Tachibana E, Kuronuma K, Oiwa K, Matsumoto M, Nishida T, Kojima T, Hanada S, Nomoto K, Sonoda K, Arima K, Takahashi F, Kotani T, Ohkubo K, Fukushima S, Itou S, Kondo K, Ando H, Ohno Y, Onikura M, Hirayama A.

J Clin Med. 2020 Feb 21;9(2). pii: E584. doi: 10.3390/jcm9020584.


"Screening for lung cancer: Does MRI have a role?' [European Journal of Radiology 86 (2017) 353-360].

Biederer J, Ohno Y, Hatabu H, Schiebler ML, van Beek EJR, Vogel-Claussen J, Kauczor HU.

Eur J Radiol. 2020 Feb 20;125:108896. doi: 10.1016/j.ejrad.2020.108896. [Epub ahead of print] No abstract available.


Fabrication of Carbon Nanotube Thin Films for Flexible Transistor Applications using a Cross-linked Amine Polymer.

Omachi H, Matsumoto K, Ueno K, Hirotani J, Ohno Y.

Chemistry. 2020 Feb 20. doi: 10.1002/chem.202000228. [Epub ahead of print]


Adjuvant chemotherapy improves overall survival in patients with localized upper tract urothelial carcinoma harboring pathologic vascular invasion: a propensity score-matched analysis of multi-institutional cohort.

Matsunaga T, Komura K, Hashimoto T, Muraoka R, Satake N, Tsutsumi T, Tsujino T, Yoshikawa Y, Takai T, Minami K, Taniguchi K, Tanaka T, Uehara H, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Ohno Y, Azuma H.

World J Urol. 2020 Feb 17. doi: 10.1007/s00345-020-03118-x. [Epub ahead of print]


Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω-O-acylceramide.

Yamamoto H, Hattori M, Chamulitrat W, Ohno Y, Kihara A.

Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2914-2922. doi: 10.1073/pnas.1917525117. Epub 2020 Jan 23.


[15. The Quality Management of the Radiation Therapy].

Ohno Y.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2020;76(1):93-103. doi: 10.6009/jjrt.2020_JSRT_76.1.93. Japanese. No abstract available.


Efficient Differentiation of Mouse Induced Pluripotent Stem Cells into Alveolar Epithelium Type II with a BRD4 Inhibitor.

Momozane T, Fukui E, Funaki S, Fujii M, Kinehara Y, Ito E, Miyagawa S, Ohno Y, Sawa Y, Okumura M, Shintani Y.

Stem Cells Int. 2019 Dec 27;2019:1271682. doi: 10.1155/2019/1271682. eCollection 2019.


Relationship between the Renal Function and Adverse Clinical Events in Patients with Atrial Fibrillation: A Japanese Multicenter Registry Substudy.

Yuzawa Y, Kuronuma K, Okumura Y, Yokoyama K, Matsumoto N, Tachibana E, Oiwa K, Matsumoto M, Kojima T, Haruta H, Nomoto K, Sonoda K, Arima K, Kogawa R, Takahashi F, Kotani T, Okubo K, Fukushima S, Itou S, Kondo K, Chiku M, Ohno Y, Onikura M, Hirayama A, On Behalf Of The Sakura Af Registry Investigators.

J Clin Med. 2020 Jan 8;9(1). pii: E167. doi: 10.3390/jcm9010167.


Hospital surgical volume and 3-year mortality in severe prognosis cancers: A population-based study using cancer registry data.

Taniyama Y, Tabuchi T, Ohno Y, Morishima T, Okawa S, Koyama S, Miyashiro I.

J Epidemiol. 2020 Jan 11. doi: 10.2188/jea.JE20190242. [Epub ahead of print]


Effect of high-dose strong statin for preventing periprocedural ischemic complications of carotid artery stenting.

Shinozaki N, Murakami T, Ohno Y, Nakano M, Fujii T, Nakazawa G, Yoshimachi F, Ikari Y.

Heart Vessels. 2020 Jan 10. doi: 10.1007/s00380-019-01552-5. [Epub ahead of print]


Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3.

Jojima K, Edagawa M, Sawai M, Ohno Y, Kihara A.

FASEB J. 2020 Feb;34(2):3318-3335. doi: 10.1096/fj.201902645R. Epub 2020 Jan 8.


Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis.

Nakamura A, Kohno A, Noguchi N, Kawa K, Ohno Y, Komatsu M, Yamanishi H.

PLoS One. 2020 Jan 7;15(1):e0227257. doi: 10.1371/journal.pone.0227257. eCollection 2020.


Rosiglitazone ameliorates senescence and promotes apoptosis in ovarian cancer induced by olaparib.

Wang Z, Gao J, Ohno Y, Liu H, Xu C.

Cancer Chemother Pharmacol. 2020 Feb;85(2):273-284. doi: 10.1007/s00280-019-04025-8. Epub 2020 Jan 6.


Incidence and In-Hospital Outcomes of Patients Presenting With Stent Thrombosis (from the Japanese Nationwide Percutaneous Coronary Intervention Registry).

Ohno Y, Yamaji K, Kohsaka S, Inohara T, Amano T, Ishii H, Kadota K, Nakamura M, Nakazawa G, Yoshimachi F, Ikari Y; J-PCI Registry Investigators.

Am J Cardiol. 2020 Mar 1;125(5):720-726. doi: 10.1016/j.amjcard.2019.12.005. Epub 2019 Dec 9.


Humanized Mice as an Effective Evaluation System for Peptide Vaccines and Immune Checkpoint Inhibitors.

Kametani Y, Ohno Y, Ohshima S, Tsuda B, Yasuda A, Seki T, Ito R, Tokuda Y.

Int J Mol Sci. 2019 Dec 16;20(24). pii: E6337. doi: 10.3390/ijms20246337. Review.


Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma.

Tsukahara T, Watanabe K, Murata K, Takahashi A, Mizushima E, Shibayama Y, Kameshima H, Hatae R, Ohno Y, Kawahara R, Murai A, Nakatsugawa M, Kubo T, Kanaseki T, Hirohashi Y, Terui T, Asanuma H, Hasegawa T, Sato N, Torigoe T.

Cancer Immunol Immunother. 2020 Feb;69(2):189-197. doi: 10.1007/s00262-019-02455-0. Epub 2019 Dec 18.


Roles of Two Major Alcohol Dehydrogenases, ADH1 (Class I) and ADH3 (Class III), in the Adaptive Enhancement of Alcohol Metabolism Induced by Chronic Alcohol Consumption in Mice.

Haseba T, Okuda T, Maruyama M, Akimoto T, Duester G, Ohno Y.

Alcohol Alcohol. 2020 Feb 7;55(1):11-19. doi: 10.1093/alcalc/agz091.


Hyperuricemia predicts the risk for developing hypertension independent of alcohol drinking status in men and women: the Saku study.

Tatsumi Y, Asayama K, Morimoto A, Satoh M, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T.

Hypertens Res. 2019 Nov 27. doi: 10.1038/s41440-019-0361-0. [Epub ahead of print]


Serial changes of L wave according to heart rates in a heart failure patient with persistent atrial fibrillation.

Morisawa D, Ohno Y, Ohta Y, Orihara Y, Masai K, Goda A, Asakura M, Ishihara M.

J Cardiol Cases. 2019 Sep 7;20(6):213-217. doi: 10.1016/j.jccase.2019.08.016. eCollection 2019 Dec.


Lymph Node Positivity in One-Step Nucleic Acid Amplification is a Prognostic Factor for Postoperative Cancer Recurrence in Patients with Stage II Colorectal Cancer: A Prospective, Multicenter Study.

Itabashi M, Yamamoto H, Tomita N, Inomata M, Murata K, Hayashi S, Miyake Y, Igarashi S, Kato T, Noura S, Furuhata T, Ozawa H, Takemasa I, Yasui M, Takeyama H, Okamura S, Ohno Y, Matsuura N.

Ann Surg Oncol. 2019 Nov 13. doi: 10.1245/s10434-019-07971-y. [Epub ahead of print]


Investigation of factors that cause insulin precipitation and/or amyloid formation in insulin formulations.

Ohno Y, Seki T, Kojima Y, Miki R, Egawa Y, Hosoya O, Kasono K, Seki T.

J Pharm Health Care Sci. 2019 Oct 30;5:22. doi: 10.1186/s40780-019-0151-5. eCollection 2019.


Prophylactic effect of rikkunshito, an herbal medicine, for chemotherapy-induced nausea in thoracic cancer patients receiving carboplatin-based chemotherapy.

Hirose C, Iihara H, Funaguchi N, Endo J, Ito F, Yanase K, Kaito D, Sasaki Y, Gomyo T, Sakai C, Ohno Y, Suzuki A.

Pharmazie. 2019 Oct 1;74(10):620-624. doi: 10.1691/ph.2019.9497.


The significance of micro-lymphatic invasion and pathological Gleason score in prostate cancer patients with pathologically organ-confined disease and negative surgical margins after robot-assisted radical prostatectomy.

Hashimoto T, Nakashima J, Inoue R, Komori O, Yamaguchi Y, Kashima T, Satake N, Nakagami Y, Namiki K, Nagao T, Ohno Y.

Int J Clin Oncol. 2020 Feb;25(2):377-383. doi: 10.1007/s10147-019-01561-4. Epub 2019 Oct 31.


Comparison of calcineurin inhibitors in combination with conventional methotrexate, reduced methotrexate, or mycophenolate mofetil for prophylaxis of graft-versus-host disease after umbilical cord blood transplantation.

Yoshida S, Ohno Y, Nagafuji K, Yoshimoto G, Sugio T, Kamimura T, Ohta T, Takase K, Henzan H, Muta T, Iwasaki H, Ogawa R, Eto T, Akashi K, Miyamoto T.

Ann Hematol. 2019 Nov;98(11):2579-2591. doi: 10.1007/s00277-019-03801-z. Epub 2019 Oct 18.


First isolation of voriconazole-resistant Candida albicans, C. tropicalis, and Aspergillus niger from the blowholes of bottlenose dolphins (Tursiops truncatus).

Ohno Y, Akune Y, Inoshima Y, Kano R.

J Vet Med Sci. 2019 Nov 29;81(11):1628-1631. doi: 10.1292/jvms.18-0749. Epub 2019 Oct 11.


Antipsychotic Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD): Management of Extrapyramidal Side Effects.

Ohno Y, Kunisawa N, Shimizu S.

Front Pharmacol. 2019 Sep 17;10:1045. doi: 10.3389/fphar.2019.01045. eCollection 2019. Review.


The Protective Effect of Brazilian Propolis against Glycation Stress in Mouse Skeletal Muscle.

Egawa T, Ohno Y, Yokoyama S, Yokokawa T, Tsuda S, Goto K, Hayashi T.

Foods. 2019 Sep 25;8(10). pii: E439. doi: 10.3390/foods8100439.


IL6 Modulates the Immune Status of the Tumor Microenvironment to Facilitate Metastatic Colonization of Colorectal Cancer Cells.

Toyoshima Y, Kitamura H, Xiang H, Ohno Y, Homma S, Kawamura H, Takahashi N, Kamiyama T, Tanino M, Taketomi A.

Cancer Immunol Res. 2019 Dec;7(12):1944-1957. doi: 10.1158/2326-6066.CIR-18-0766. Epub 2019 Sep 25.


Placental and breastmilk transfer of voriconazole to offspring from pregnant and lactating bottlenose dolphins (Tursiops truncatus).

Ohno Y, Kobayashi M, Akune Y, Inoshima Y.

Med Mycol. 2019 Aug 22. pii: myz086. doi: 10.1093/mmy/myz086. [Epub ahead of print]


Optimal dose of sunitinib for long-term treatment in Japanese patients with renal cell carcinoma.

Yamada Y, Ohno Y, Kato Y, Kobayashi R, Hayashi H, Miyahara S, Nakane K, Mizutani K, Yokoi S, Fujii H, Iihara H, Ishihara T, Deguchi T, Sugiyama T, Suzuki A.

Cancer Chemother Pharmacol. 2019 Nov;84(5):987-992. doi: 10.1007/s00280-019-03935-x. Epub 2019 Sep 3.


Evaluation of raw-data-based and calculated electron density for contrast media with a dual-energy CT technique.

Kawahara D, Ozawa S, Yokomachi K, Higaki T, Shiinoki T, Ohno Y, Murakami Y, Awai K, Nagata Y.

Rep Pract Oncol Radiother. 2019 Sep-Oct;24(5):499-506. doi: 10.1016/j.rpor.2019.07.013. Epub 2019 Aug 20.


Operando Analysis of Electron Devices Using Nanodiamond Thin Films Containing Nitrogen-Vacancy Centers.

Uchiyama H, Saijo S, Kishimoto S, Ishi-Hayase J, Ohno Y.

ACS Omega. 2019 Apr 24;4(4):7459-7466. doi: 10.1021/acsomega.9b00344. eCollection 2019 Apr 30.


Temozolomide has anti-tumor effects through the phosphorylation of cPLA2 on glioblastoma cells.

Tsuji S, Ohno Y, Nakamura S, Yamada T, Noda Y, Saio M, Iwama T, Shimazawa M, Hara H.

Brain Res. 2019 Nov 15;1723:146396. doi: 10.1016/j.brainres.2019.146396. Epub 2019 Aug 20.


Cell Adhesive Character of Phenylboronic Acid-Modified Insulin and Its Potential as Long-Acting Insulin.

Ohno Y, Kawakami M, Seki T, Miki R, Seki T, Egawa Y.

Pharmaceuticals (Basel). 2019 Aug 19;12(3). pii: E121. doi: 10.3390/ph12030121.


Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study.

Kanda J, Hayashi H, Ruggeri A, Kimura F, Volt F, Takahashi S, Labopin M, Kako S, Tozatto-Maio K, Yano S, Sanz G, Uchida N, Van Lint MT, Kato S, Mohty M, Forcade E, Kanamori H, Sierra J, Ohno Y, Saccardi R, Fukuda T, Ichinohe T, Takanashi M, Rocha V, Okamoto S, Nagler A, Atsuta Y, Gluckman E.

Leukemia. 2020 Jan;34(1):128-137. doi: 10.1038/s41375-019-0534-5. Epub 2019 Aug 14.


Fasting Blood Glucose Predicts Incidence of Hypertension Independent of HbA1c Levels and Insulin Resistance in Middle-Aged Japanese: The Saku Study.

Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T.

Am J Hypertens. 2019 Nov 15;32(12):1178-1185. doi: 10.1093/ajh/hpz123.


Adverse clinical events in Japanese atrial fibrillation patients with and without coronary artery disease-findings from the SAKURA AF Registry.

Fukamachi D, Okumura Y, Yokoyama K, Matsumoto N, Tachibana E, Kuronuma K, Oiwa K, Matsumoto M, Nishida T, Kojima T, Hanada S, Nomoto K, Sonoda K, Arima K, Kogawa R, Takahashi F, Kotani T, Ohkubo K, Fukushima S, Itou S, Kondo K, Chiku M, Ohno Y, Onikura M, Hirayama A; SAKURA AF Registry Investigators.

Curr Med Res Opin. 2019 Dec;35(12):2053-2062. doi: 10.1080/03007995.2019.1650014. Epub 2019 Sep 6.


Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity.

Ohta E, Itoh M, Ueda M, Hida Y, Wang MX, Hayakawa-Ogura M, Li S, Nishida E, Ohta K, Tana, Islam S, Nakagawa K, Sunayama T, Chen H, Hirata S, Endo M, Ohno Y, Nakagawa T.

PLoS One. 2019 Jul 22;14(7):e0219782. doi: 10.1371/journal.pone.0219782. eCollection 2019.


Dependence of enhancement factor on electrode size for field emission current from carbon nanotube on silicon wafer.

Funayama K, Tanaka H, Hirotani J, Shimaoka K, Ohno Y, Tadokoro Y.

Nanotechnology. 2019 Oct 18;30(42):425201. doi: 10.1088/1361-6528/ab33c8. Epub 2019 Jul 19.


Effects of pharmacokinetics-related genetic polymorphisms on the side effect profile of afatinib in patients with non-small cell lung cancer.

Hayashi H, Iihara H, Hirose C, Fukuda Y, Kitahora M, Kaito D, Yanase K, Endo J, Ohno Y, Suzuki A, Sugiyama T.

Lung Cancer. 2019 Aug;134:1-6. doi: 10.1016/j.lungcan.2019.05.013. Epub 2019 May 18.


Validation of Eurolung risk models in a Japanese population: a retrospective single-centre analysis of 612 cases.

Nagoya A, Kanzaki R, Kanou T, Ose N, Funaki S, Minami M, Shintani Y, Tsutsui A, Suga S, Tajima T, Ohno Y, Okumura M.

Interact Cardiovasc Thorac Surg. 2019 Nov 1;29(5):722-728. doi: 10.1093/icvts/ivz171.


Solitary Deaths in the Tokyo Metropolis and Labor Force Status: Characteristics of Unnatural Deaths at Home among Persons Living Alone.

Kanawaku Y, Ohno Y.

J Nippon Med Sch. 2020 Jan 10;86(6):360-363. doi: 10.1272/jnms.JNMS.2019_86-604. Epub 2019 Jul 15.


Clinical trial protocol of doublet therapy and olanzapine for carboplatin-induced nausea and vomiting in patients with thoracic cancer: a multicentre phase II trial.

Iihara H, Shimokawa M, Gomyo T, Fujita Y, Yoshida T, Funaguchi N, Minato K, Kaito D, Osawa T, Yamada M, Hirose C, Suzuki A, Ohno Y.

BMJ Open. 2019 Jul 4;9(7):e028056. doi: 10.1136/bmjopen-2018-028056.


The association between glycemic control and lung function impairment in individuals with diabetes: the Saku study.

Sonoda N, Morimoto A, Tatsumi Y, Asayama K, Ohkubo T, Izawa S, Ohno Y.

Diabetol Int. 2018 Nov 19;10(3):213-218. doi: 10.1007/s13340-018-0382-y. eCollection 2019 Jul.


Early Detection of Pancreatic Cancer in Patients With Chronic Liver Disease Under Hepatocellular Carcinoma Surveillance.

Kumagi T, Terao T, Yokota T, Azemoto N, Kuroda T, Imamura Y, Uesugi K, Kisaka Y, Tanaka Y, Shibata N, Koizumi M, Ohno Y, Yukimoto A, Tange K, Nishiyama M, Kanemitsu K, Miyake T, Miyata H, Ishii H, Hiasa Y; Ehime Pancreato-Cholangiology (EPOCH) Study Group.

Mayo Clin Proc. 2019 Oct;94(10):2004-2010. doi: 10.1016/j.mayocp.2018.12.034. Epub 2019 Jun 28.


University hospitals, general hospitals, private clinics: Place-based differences in patient characteristics and outcomes of AF-A SAKURA AF Registry Substudy.

Kogawa R, Okumura Y, Yokoyama K, Matsumoto N, Tachibana E, Kuronuma K, Oiwa K, Nishida T, Matsumoto M, Kojima T, Hanada S, Nomoto K, Sonoda K, Arima K, Takahashi F, Kotani T, Ohkubo K, Fukushima S, Itou S, Kondo K, Chiku M, Ohno Y, Onikura M, Hirayama A; SAKURA AF Registry Investigators.

J Cardiol. 2020 Jan;75(1):74-81. doi: 10.1016/j.jjcc.2019.04.015. Epub 2019 Jun 25.


Proposal of a Useful Surrogate Endpoint of the Overall Survival in Patients Undergoing Pulmonary Metastasectomy: The Time to Local Therapy Failure.

Kanzaki R, Kanou T, Ose N, Funaki S, Minami M, Tajima T, Fujii M, Ohno Y, Shintani Y.

World J Surg. 2019 Oct;43(10):2640-2646. doi: 10.1007/s00268-019-05071-2.


The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan.

Komura K, Hashimoto T, Tsujino T, Muraoka R, Tsutsumi T, Satake N, Matsunaga T, Yoshikawa Y, Takai T, Minami K, Taniguchi K, Uehara H, Tanaka T, Hirano H, Nomi H, Ibuki N, Takahara K, Inamoto T, Ohno Y, Azuma H.

Ann Surg Oncol. 2019 Sep;26(9):2994-3004. doi: 10.1245/s10434-019-07530-5. Epub 2019 Jun 25.


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