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Items: 1 to 50 of 757

1.

Safety and efficacy of amnion-derived mesenchymal stem cells (AM01) in patients with steroid-refractory acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: a study protocol for a phase I/II Japanese trial.

Yamahara K, Hamada A, Soma T, Okamoto R, Okada M, Yoshihara S, Yoshihara K, Ikegame K, Tamaki H, Kaida K, Inoue T, Ohsugi Y, Nishikawa H, Hayashi H, Ito YM, Iijima H, Ohnishi S, Hashimoto D, Isoe T, Teshima T, Ogawa H, Sato N, Fujimori Y.

BMJ Open. 2019 Jul 9;9(7):e026403. doi: 10.1136/bmjopen-2018-026403.

2.

Clinical Impact of the Increase in Immunosuppressive Cell-Related Gene Expression in Urine Sediment during Intravesical Bacillus Calmette-Guérin.

Miyake M, Hori S, Ohnishi S, Owari T, Iida K, Ohnishi K, Morizawa Y, Gotoh D, Itami Y, Nakai Y, Inoue T, Anai S, Torimoto K, Aoki K, Fujii T, Tanaka N, Fujimoto K.

Diseases. 2019 Jun 18;7(2). pii: E44. doi: 10.3390/diseases7020044.

3.

Gastrointestinal: Endoscopic balloon dilations for an intestinal stricture in a patient with X-linked inhibitor of apoptosis deficiency.

Otagiri S, Sugiura R, Katsurada T, Yamanashi K, Nagashima K, Sugita J, Ohnishi S, Sakamoto N.

J Gastroenterol Hepatol. 2019 Jun 7. doi: 10.1111/jgh.14724. [Epub ahead of print] Review. No abstract available.

PMID:
31172569
4.

Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines.

Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H.

Neoplasia. 2019 Jun;21(6):545-556. doi: 10.1016/j.neo.2019.03.007. Epub 2019 Apr 28.

5.

BspR/BtrA, an Anti-σ Factor, Regulates the Ability of Bordetella bronchiseptica To Cause Cough in Rats.

Nakamura K, Shinoda N, Hiramatsu Y, Ohnishi S, Kamitani S, Ogura Y, Hayashi T, Horiguchi Y.

mSphere. 2019 Apr 24;4(2). pii: e00093-19. doi: 10.1128/mSphere.00093-19.

6.

Successful Prediction of Human Pharmacokinetics by Improving Calculation Processes of Physiologically Based Pharmacokinetic Approach.

Mayumi K, Ohnishi S, Hasegawa H.

J Pharm Sci. 2019 Aug;108(8):2718-2727. doi: 10.1016/j.xphs.2019.03.002. Epub 2019 Mar 12.

PMID:
30876861
7.

Mycoplasma genitalium Infection and Chronic Inflammation in Human Prostate Cancer: Detection Using Prostatectomy and Needle Biopsy Specimens.

Miyake M, Ohnishi K, Hori S, Nakano A, Nakano R, Yano H, Ohnishi S, Owari T, Morizawa Y, Itami Y, Nakai Y, Inoue T, Anai S, Torimoto K, Tanaka N, Fujii T, Furuya H, Rosser CJ, Fujimoto K.

Cells. 2019 Mar 2;8(3). pii: E212. doi: 10.3390/cells8030212.

8.

Unleashing floret fertility in wheat through the mutation of a homeobox gene.

Sakuma S, Golan G, Guo Z, Ogawa T, Tagiri A, Sugimoto K, Bernhardt N, Brassac J, Mascher M, Hensel G, Ohnishi S, Jinno H, Yamashita Y, Ayalon I, Peleg Z, Schnurbusch T, Komatsuda T.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5182-5187. doi: 10.1073/pnas.1815465116. Epub 2019 Feb 21.

9.

[Liver Fibrosis is Associated with Loss of Skeletal Muscle Mass in Community-Dwelling Older Adults with No History of Liver Diseases].

Ohnishi S, Miyai N, Utsumi M, Mure K, Takeshita T, Shiba M, Arita M.

Nihon Eiseigaku Zasshi. 2019;74(0). doi: 10.1265/jjh.18031. Japanese.

10.

Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist.

Watari R, Matsuda A, Ohnishi S, Hasegawa H.

Drug Metab Pharmacokinet. 2019 Apr;34(2):126-133. doi: 10.1016/j.dmpk.2018.12.002. Epub 2018 Dec 23.

PMID:
30770183
11.

Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats.

Ohara M, Ohnishi S, Hosono H, Yamamoto K, Yuyama K, Nakamura H, Fu Q, Maehara O, Suda G, Sakamoto N.

Stem Cells Int. 2018 Dec 24;2018:3212643. doi: 10.1155/2018/3212643. eCollection 2018.

12.

Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats.

Shimizu R, Horiguchi N, Yano K, Sakuramoto M, Kanegawa N, Shinohara S, Ohnishi S.

J Pharmacol Exp Ther. 2019 Apr;369(1):78-87. doi: 10.1124/jpet.118.252262. Epub 2019 Jan 23.

PMID:
30674560
13.

Outcomes of EUS-FNA in patients receiving antithrombotic therapy.

Polmanee P, Hara K, Mizuno N, Hijioka S, Kuwahara T, Okuno N, Iwaya H, Tajika M, Tanaka T, Ishihara M, Hirayama Y, Ohnishi S, Toriyama K, Bhanthomkomol P, Ito A, Kuraoka N, Matsumoto S, Niwa Y.

Endosc Int Open. 2019 Jan;7(1):E15-E25. doi: 10.1055/a-0735-9107. Epub 2019 Jan 3.

14.

Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation.

Mori Y, Kato S, Fujisawa Y, Ohnishi S, Hiraku Y, Kawanishi S, Murata M, Oikawa S.

Free Radic Res. 2019 Jan;53(1):115-123. doi: 10.1080/10715762.2018.1562179. Epub 2019 Jan 2.

PMID:
30572734
15.

Pooled extracellular receptor-ligand interaction screening using CRISPR activation.

Chong ZS, Ohnishi S, Yusa K, Wright GJ.

Genome Biol. 2018 Nov 26;19(1):205. doi: 10.1186/s13059-018-1581-3.

16.

Stent Recoil in Overlapping Stent 18 Years After Wiktor Stent Implantation.

Hashikata T, Matsushita M, Shindo A, Kakuda N, Tojo T, Ohnishi S, Yamasaki M.

Int Heart J. 2019 Jan 25;60(1):178-180. doi: 10.1536/ihj.18-261. Epub 2018 Nov 20.

17.

Dual benefit of supplementary oral 5-aminolevulinic acid to pelvic radiotherapy in a syngenic prostate cancer model.

Miyake M, Tanaka N, Hori S, Ohnishi S, Takahashi H, Fujii T, Owari T, Ohnishi K, Iida K, Morizawa Y, Gotoh D, Itami Y, Nakai Y, Inoue T, Anai S, Torimoto K, Aoki K, Fujimoto K.

Prostate. 2019 Mar;79(4):340-351. doi: 10.1002/pros.23740. Epub 2018 Nov 18.

PMID:
30450646
18.

Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells.

Fu Q, Ohnishi S, Sakamoto N.

Stem Cells Int. 2018 Oct 8;2018:4898152. doi: 10.1155/2018/4898152. eCollection 2018.

19.

Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects.

Ohnishi S, Fukumura K, Kubota R, Wajima T.

Xenobiotica. 2019 Sep;49(9):1044-1053. doi: 10.1080/00498254.2018.1536815. Epub 2019 Jan 4.

PMID:
30351180
20.

Five decades of research on mitochondrial NADH-quinone oxidoreductase (complex I).

Ohnishi T, Ohnishi ST, Salerno JC.

Biol Chem. 2018 Oct 25;399(11):1249-1264. doi: 10.1515/hsz-2018-0164. Review.

PMID:
30243012
21.

Recent development of balloon-occluded retrograde transvenous obliteration.

Kobayakawa M, Ohnishi S, Suzuki H.

J Gastroenterol Hepatol. 2019 Mar;34(3):495-500. doi: 10.1111/jgh.14463. Epub 2018 Sep 17. Review.

PMID:
30170340
22.

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine.

Akazawa T, Yoshida S, Ohnishi S, Kanazu T, Kawai M, Takahashi K.

Drug Metab Dispos. 2018 Nov;46(11):1497-1506. doi: 10.1124/dmd.118.083246. Epub 2018 Aug 22.

PMID:
30135242
23.

L-Carnitine Suppresses Loss of Skeletal Muscle Mass in Patients With Liver Cirrhosis.

Ohara M, Ogawa K, Suda G, Kimura M, Maehara O, Shimazaki T, Suzuki K, Nakamura A, Umemura M, Izumi T, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ohnishi S, Sakamoto N.

Hepatol Commun. 2018 Aug 6;2(8):906-918. doi: 10.1002/hep4.1207. eCollection 2018 Aug.

24.

Effects of human amnion-derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis.

Sugiura R, Ohnishi S, Ohara M, Ishikawa M, Miyamoto S, Onishi R, Yamamoto K, Kawakubo K, Kuwatani M, Sakamoto N.

Am J Transl Res. 2018 Jul 15;10(7):2102-2114. eCollection 2018.

25.

Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.

Ohara M, Ohnishi S, Hosono H, Yamamoto K, Fu Q, Maehara O, Suda G, Sakamoto N.

Front Pharmacol. 2018 Jul 13;9:709. doi: 10.3389/fphar.2018.00709. eCollection 2018.

26.

A novel growth function incorporating the effects of reproductive energy allocation.

Manabe A, Yamakawa T, Ohnishi S, Akamine T, Narimatsu Y, Tanaka H, Funamoto T, Ueda Y, Yamamoto T.

PLoS One. 2018 Jun 26;13(6):e0199346. doi: 10.1371/journal.pone.0199346. eCollection 2018.

27.

Evaluation of amnion-derived mesenchymal stem cells for treatment-resistant moderate Crohn's disease: study protocol for a phase I/II, dual-centre, open-label, uncontrolled, dose-response trial.

Otagiri S, Ohnishi S, Miura A, Hayashi H, Kumagai I, Ito YM, Katsurada T, Nakamura S, Okamoto R, Yamahara K, Cho KY, Isoe T, Sato N, Sakamoto N.

BMJ Open Gastroenterol. 2018 May 31;5(1):e000206. doi: 10.1136/bmjgast-2018-000206. eCollection 2018.

28.

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.

Nakahara K, Fuchino K, Komano K, Asada N, Tadano G, Hasegawa T, Yamamoto T, Sako Y, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI.

J Med Chem. 2018 Jul 12;61(13):5525-5546. doi: 10.1021/acs.jmedchem.8b00011. Epub 2018 Jun 14.

PMID:
29775538
29.

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain.

Fuchino K, Mitsuoka Y, Masui M, Kurose N, Yoshida S, Komano K, Yamamoto T, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Miyajima H, Hiroyama S, Koyabu K, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI.

J Med Chem. 2018 Jun 28;61(12):5122-5137. doi: 10.1021/acs.jmedchem.8b00002. Epub 2018 May 23.

PMID:
29733614
30.

Preventive effect of mesenchymal stem cell culture supernatant on luminal stricture after endoscopic submucosal dissection in the rectum of pigs.

Tsuda M, Ohnishi S, Mizushima T, Hosono H, Yamahara K, Ishikawa M, Abiko S, Katsurada T, Shimizu Y, Sakamoto N.

Endoscopy. 2018 Oct;50(10):1001-1016. doi: 10.1055/a-0584-7262. Epub 2018 Apr 24.

31.

Potential role of extracellular vesicle-mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy.

Ito T, Shiromizu T, Ohnishi S, Suzuki S, Mabe K, Hasegawa A, Ujiie H, Fujita Y, Sato Y, Terai S, Kato M, Asaka M, Tomonaga T, Shimizu H, Abe R.

J Allergy Clin Immunol. 2018 Aug;142(2):672-676.e12. doi: 10.1016/j.jaci.2018.02.046. Epub 2018 Apr 11. No abstract available.

PMID:
29653117
32.

Case of photosensitivity after the administration of olmesartan medoxomil.

Ozaki C, Ohnishi S, Yu A, Moriwaki S.

J Dermatol. 2018 Oct;45(10):e277-e278. doi: 10.1111/1346-8138.14310. Epub 2018 Mar 31. No abstract available.

PMID:
29603756
33.

Rapid detection of superficial head and neck squamous cell carcinoma by topically spraying fluorescent probe targeting dipeptidyl peptidase-IV.

Mizushima T, Ohnishi S, Shimizu Y, Hatanaka Y, Hatanaka KC, Kuriki Y, Kamiya M, Homma A, Yamamoto K, Ono S, Urano Y, Sakamoto N.

Head Neck. 2018 Jul;40(7):1466-1475. doi: 10.1002/hed.25126. Epub 2018 Mar 6.

PMID:
29509281
34.

Mechanism of oxidative DNA damage induced by metabolites of carcinogenic naphthalene.

Ohnishi S, Hiraku Y, Hasegawa K, Hirakawa K, Oikawa S, Murata M, Kawanishi S.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Mar;827:42-49. doi: 10.1016/j.mrgentox.2018.01.005. Epub 2018 Jan 16.

PMID:
29502736
35.

Yuzu (Citrus junos Tanaka) Peel Attenuates Dextran Sulfate Sodium-induced Murine Experimental Colitis.

Abe H, Ishioka M, Fujita Y, Umeno A, Yasunaga M, Sato A, Ohnishi S, Suzuki S, Ishida N, Shichiri M, Yoshida Y, Nakajima Y.

J Oleo Sci. 2018 Mar 1;67(3):335-344. doi: 10.5650/jos.ess17184. Epub 2018 Feb 19.

36.

Diagnostic accuracy of lip force and tongue strength for sarcopenic dysphagia in older inpatients: A cross-sectional observational study.

Sakai K, Nakayama E, Tohara H, Takahashi O, Ohnishi S, Tsuzuki H, Hayata M, Takehisa T, Takehisa Y, Ueda K.

Clin Nutr. 2019 Feb;38(1):303-309. doi: 10.1016/j.clnu.2018.01.016. Epub 2018 Feb 15.

PMID:
29398338
37.

Conditioned Medium Obtained from Amnion-Derived Mesenchymal Stem Cell Culture Prevents Activation of Keloid Fibroblasts.

Sato C, Yamamoto Y, Funayama E, Furukawa H, Oyama A, Murao N, Hosono H, Kawakubo K, Sakamoto N, Ohnishi S.

Plast Reconstr Surg. 2018 Feb;141(2):390-398. doi: 10.1097/PRS.0000000000004068.

PMID:
29369991
38.

Concomitant Regulation by a LacI-Type Transcriptional Repressor XylR on Genes Involved in Xylan and Xylose Metabolism and the Type III Secretion System in Rice Pathogen Xanthomonas oryzae pv. oryzae.

Ikawa Y, Ohnishi S, Shoji A, Furutani A, Tsuge S.

Mol Plant Microbe Interact. 2018 Jun;31(6):605-613. doi: 10.1094/MPMI-11-17-0277-R. Epub 2018 Apr 3.

PMID:
29360015
39.

Improved Human Pharmacokinetic Prediction of Hepatically Metabolized Drugs With Species-Specific Systemic Clearance.

Horiuchi K, Ohnishi S, Matsuzaki T, Funaki S, Watanabe A, Mizutare T, Matsumoto S, Nezasa KI, Hasegawa H.

J Pharm Sci. 2018 May;107(5):1443-1453. doi: 10.1016/j.xphs.2017.12.027. Epub 2018 Jan 10.

PMID:
29331382
40.

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal.

Tani H, Ohnishi S, Shitara H, Mito T, Yamaguchi M, Yonekawa H, Hashizume O, Ishikawa K, Nakada K, Hayashi JI.

Sci Rep. 2018 Jan 11;8(1):425. doi: 10.1038/s41598-017-18828-3.

41.

Slow-growing amelanotic malignant melanoma of the esophagus with long survival: a case report and review of the literature.

Hirayama Y, Masahiro T, Tanaka T, Ishihara M, Ohnishi S, Hara K, Mizuno N, Hijioka S, Okuno N, Abe T, Uemura N, Kawakami J, Kurahashi S, Shimizu Y, Yatabe Y, Niwa Y.

Endosc Int Open. 2017 Nov;5(11):E1076-E1080. doi: 10.1055/s-0043-117951. Epub 2017 Oct 27.

42.

Novel and Simple Ultrasonographic Methods for Estimating the Abdominal Visceral Fat Area.

Asano T, Kubota N, Koizumi N, Itani K, Mitake T, Yuhashi K, Liao H, Mitsuishi M, Takeishi S, Takahashi T, Ohnishi S, Sasaki S, Sakuma I, Kadowaki T.

Int J Endocrinol. 2017;2017:8796069. doi: 10.1155/2017/8796069. Epub 2017 Aug 22.

43.

Regulatory T Cells and Tumor-Associated Macrophages in the Tumor Microenvironment in Non-Muscle Invasive Bladder Cancer Treated with Intravesical Bacille Calmette-Guérin: A Long-Term Follow-Up Study of a Japanese Cohort.

Miyake M, Tatsumi Y, Gotoh D, Ohnishi S, Owari T, Iida K, Ohnishi K, Hori S, Morizawa Y, Itami Y, Nakai Y, Inoue T, Anai S, Torimoto K, Aoki K, Shimada K, Konishi N, Tanaka N, Fujimoto K.

Int J Mol Sci. 2017 Oct 19;18(10). pii: E2186. doi: 10.3390/ijms18102186.

44.

Indications for suboptimal low-dose direct oral anticoagulants for non-valvular atrial fibrillation patients.

Umei M, Kishi M, Sato T, Shindo A, Toyoda M, Yokoyama M, Matsushita M, Ohnishi S, Yamasaki M.

J Arrhythm. 2017 Oct;33(5):475-482. doi: 10.1016/j.joa.2017.05.008. Epub 2017 Jun 30.

45.

Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma.

Maehara O, Suda G, Natsuizaka M, Ohnishi S, Komatsu Y, Sato F, Nakai M, Sho T, Morikawa K, Ogawa K, Shimazaki T, Kimura M, Asano A, Fujimoto Y, Ohashi S, Kagawa S, Kinugasa H, Naganuma S, Whelan KA, Nakagawa H, Nakagawa K, Takeda H, Sakamoto N.

Carcinogenesis. 2017 Oct 26;38(11):1073-1083. doi: 10.1093/carcin/bgx095.

46.

Aortic fibromuscular dysplasia complicated by dissection: a case report and review of literature.

Tasaki T, Hatanaka K, Kirishima M, Ohnishi S, Goto Y, Kitazono I, Hiraki T, Yamada S, Higashi M, Tanimoto A.

Cardiovasc Pathol. 2017 Nov - Dec;31:41-46. doi: 10.1016/j.carpath.2017.07.007. Epub 2017 Aug 9. Review.

PMID:
28910688
47.

Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis.

Kawanishi S, Ohnishi S, Ma N, Hiraku Y, Murata M.

Int J Mol Sci. 2017 Aug 19;18(8). pii: E1808. doi: 10.3390/ijms18081808. Review.

48.

Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases.

Taniyama Y, Nakatani Y, Matsuoka T, Takahashi M, Shimizu K, Yamamoto S, Inoue Y, Ohnishi S, Kobayashi N, Nakano Y, Takami M, Arima S.

Ther Apher Dial. 2017 Jun;21(3):238-242. doi: 10.1111/1744-9987.12556.

PMID:
28661098
49.

Additive effect of rikkunshito, an herbal medicine, on chemotherapy-induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel: results of a randomized phase II study (JORTC KMP-02).

Ohnishi S, Watari H, Kanno M, Ohba Y, Takeuchi S, Miyaji T, Oyamada S, Nomura E, Kato H, Sugiyama T, Asaka M, Sakuragi N, Yamaguchi T, Uezono Y, Iwase S.

J Gynecol Oncol. 2017 Sep;28(5):e44. doi: 10.3802/jgo.2017.28.e44. Epub 2017 Mar 17.

50.

Mesenchymal stem cell therapy for acute and chronic pancreatitis.

Kawakubo K, Ohnishi S, Kuwatani M, Sakamoto N.

J Gastroenterol. 2018 Jan;53(1):1-5. doi: 10.1007/s00535-017-1363-9. Epub 2017 Jun 23. Review.

PMID:
28646417

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