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Items: 34


Environmental Exposures, the Epigenome, and African American Women's Health.

Ohm JE.

J Urban Health. 2019 Mar;96(Suppl 1):50-56. doi: 10.1007/s11524-018-00332-2. Review.


Establishing a role for environmental toxicant exposure induced epigenetic remodeling in malignant transformation.

Humphrey KM, Pandey S, Martin J, Hagoel T, Grand'Maison A, Ohm JE.

Semin Cancer Biol. 2019 Aug;57:86-94. doi: 10.1016/j.semcancer.2018.11.002. Epub 2018 Nov 16. Review.


MPP+ decreases store-operated calcium entry and TRPC1 expression in Mesenchymal Stem Cell derived dopaminergic neurons.

Sun Y, Selvaraj S, Pandey S, Humphrey KM, Foster JD, Wu M, Watt JA, Singh BB, Ohm JE.

Sci Rep. 2018 Aug 6;8(1):11715. doi: 10.1038/s41598-018-29528-x.


Effects of Maternal Vitamin D Supplementation on the Maternal and Infant Epigenome.

Anderson CM, Gillespie SL, Thiele DK, Ralph JL, Ohm JE.

Breastfeed Med. 2018 Jun;13(5):371-380. doi: 10.1089/bfm.2017.0231. Epub 2018 May 21.


Molecular Changes Associated With Tumor Initiation and Progression of Soft Tissue Sarcomas: Targeting the Genome and Epigenome.

Halcrow PW, Dancer M, Panteah M, Walden C, Ohm JE.

Prog Mol Biol Transl Sci. 2016;144:323-380. doi: 10.1016/bs.pmbts.2016.10.001. Epub 2016 Oct 26. Review.


The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells.

Raza S, Ohm JE, Dhasarathy A, Schommer J, Roche C, Hammer KD, Ghribi O.

Mol Cell Biochem. 2015 Dec;410(1-2):187-95. doi: 10.1007/s11010-015-2551-7. Epub 2015 Sep 8.


First trimester vitamin D status and placental epigenomics in preeclampsia among Northern Plains primiparas.

Anderson CM, Ralph JL, Johnson L, Scheett A, Wright ML, Taylor JY, Ohm JE, Uthus E.

Life Sci. 2015 May 15;129:10-5. doi: 10.1016/j.lfs.2014.07.012. Epub 2014 Jul 19.


DNA methylation as a biomarker for preeclampsia.

Anderson CM, Ralph JL, Wright ML, Linggi B, Ohm JE.

Biol Res Nurs. 2014 Oct;16(4):409-20. doi: 10.1177/1099800413508645. Epub 2013 Oct 28.


DNA methylation in complex disease: applications in nursing research, practice, and policy.

Wright ML, Ralph JL, Ohm JE, Anderson CM.

Nurs Outlook. 2013 Jul-Aug;61(4):235-241.e4. doi: 10.1016/j.outlook.2013.04.010.


Acetate reduces PGE2 release and modulates phospholipase and cyclooxygenase levels in neuroglia stimulated with lipopolysaccharide.

Soliman ML, Ohm JE, Rosenberger TA.

Lipids. 2013 Jul;48(7):651-62. doi: 10.1007/s11745-013-3799-x. Epub 2013 May 25.


The EPIIC hypothesis: intrapartum effects on the neonatal epigenome and consequent health outcomes.

Dahlen HG, Kennedy HP, Anderson CM, Bell AF, Clark A, Foureur M, Ohm JE, Shearman AM, Taylor JY, Wright ML, Downe S.

Med Hypotheses. 2013 May;80(5):656-62. doi: 10.1016/j.mehy.2013.01.017. Epub 2013 Feb 12.


Validation of DNA methylation patterns: potential biomarker for heritable risk of preeclampsia.

Wright ML, Anderson CM, Uthus EO, Ohm JE.

West J Nurs Res. 2012 Dec;34(8):1074-5. doi: 10.1177/0193945912453685. Epub 2012 Jul 19. No abstract available.


An integrative analysis of DNA methylation and RNA-Seq data for human heart, kidney and liver.

Xie L, Weichel B, Ohm JE, Zhang K.

BMC Syst Biol. 2011;5 Suppl 3:S4. doi: 10.1186/1752-0509-5-S3-S4. Epub 2011 Dec 23.


Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells.

Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, Schuebel KE, Cope L, Yen J, Mohammad HP, Cheng L, Baylin SB.

Cancer Res. 2010 Oct 1;70(19):7662-73. doi: 10.1158/0008-5472.CAN-10-1361. Epub 2010 Sep 14.


Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.

Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L.

Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.


Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.

Mohammad HP, Cai Y, McGarvey KM, Easwaran H, Van Neste L, Ohm JE, O'Hagan HM, Baylin SB.

Cancer Res. 2009 Aug 1;69(15):6322-30. doi: 10.1158/0008-5472.CAN-09-0065. Epub 2009 Jul 14.


PcG proteins, DNA methylation, and gene repression by chromatin looping.

Tiwari VK, McGarvey KM, Licchesi JD, Ohm JE, Herman JG, Schübeler D, Baylin SB.

PLoS Biol. 2008 Dec 2;6(12):2911-27. doi: 10.1371/journal.pbio.0060306.


Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.

Yi JM, Tsai HC, Glöckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB.

Cancer Res. 2008 Oct 1;68(19):8094-103. doi: 10.1158/0008-5472.CAN-07-6208.


Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells.

McGarvey KM, Van Neste L, Cope L, Ohm JE, Herman JG, Van Criekinge W, Schuebel KE, Baylin SB.

Cancer Res. 2008 Jul 15;68(14):5753-9. doi: 10.1158/0008-5472.CAN-08-0700.


A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations.

Tiwari VK, Cope L, McGarvey KM, Ohm JE, Baylin SB.

Genome Res. 2008 Jul;18(7):1171-9. doi: 10.1101/gr.073452.107. Epub 2008 May 23.


Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation?

Ohm JE, Baylin SB.

Cell Cycle. 2007 May 2;6(9):1040-3. Epub 2007 May 28. Review.


A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.

Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB.

Nat Genet. 2007 Feb;39(2):237-42. Epub 2007 Jan 9.


Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.

Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, Herman JG, Baylin SB.

PLoS Genet. 2006 Mar;2(3):e40. Epub 2006 Mar 31.


Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?

Baylin SB, Ohm JE.

Nat Rev Cancer. 2006 Feb;6(2):107-16. Review.


Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.

Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW.

Mol Cell Biol. 2005 Nov;25(21):9576-85.


Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.

Amann J, Kalyankrishna S, Massion PP, Ohm JE, Girard L, Shigematsu H, Peyton M, Juroske D, Huang Y, Stuart Salmon J, Kim YH, Pollack JR, Yanagisawa K, Gazdar A, Minna JD, Kurie JM, Carbone DP.

Cancer Res. 2005 Jan 1;65(1):226-35.


Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.

Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP.

J Immunol. 2005 Jan 1;174(1):215-22.


Combination therapy with conditionally replicating adenovirus and replication defective adenovirus.

Lee CT, Park KH, Yanagisawa K, Adachi Y, Ohm JE, Nadaf S, Dikov MM, Curiel DT, Carbone DP.

Cancer Res. 2004 Sep 15;64(18):6660-5.


VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.

Ohm JE, Gabrilovich DI, Sempowski GD, Kisseleva E, Parman KS, Nadaf S, Carbone DP.

Blood. 2003 Jun 15;101(12):4878-86. Epub 2003 Feb 13.


Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines.

Adachi Y, Lee CT, Coffee K, Yamagata N, Ohm JE, Park KH, Dikov MM, Nadaf SR, Arteaga CL, Carbone DP.

Gastroenterology. 2002 Oct;123(4):1191-204.


Immune dysfunction in cancer patients.

Ohm JE, Carbone DP.

Oncology (Williston Park). 2002 Jan;16(1 Suppl 1):11-8. Review.


VEGF as a mediator of tumor-associated immunodeficiency.

Ohm JE, Carbone DP.

Immunol Res. 2001;23(2-3):263-72. Review.


Effect of vascular endothelial growth factor and FLT3 ligand on dendritic cell generation in vivo.

Ohm JE, Shurin MR, Esche C, Lotze MT, Carbone DP, Gabrilovich DI.

J Immunol. 1999 Sep 15;163(6):3260-8.

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