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Items: 1 to 50 of 111

1.

Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection.

Martins Gomes SF, Westermann AJ, Sauerwein T, Hertlein T, Förstner KU, Ohlsen K, Metzger M, Shusta EV, Kim BJ, Appelt-Menzel A, Schubert-Unkmeir A.

Front Microbiol. 2019 May 29;10:1181. doi: 10.3389/fmicb.2019.01181. eCollection 2019.

PMID:
31191497
2.

Inactivation of farR Causes High Rhodomyrtone Resistance and Increased Pathogenicity in Staphylococcus aureus.

Nguyen MT, Saising J, Tribelli PM, Nega M, Diene SM, François P, Schrenzel J, Spröer C, Bunk B, Ebner P, Hertlein T, Kumari N, Härtner T, Wistuba D, Voravuthikunchai SP, Mäder U, Ohlsen K, Götz F.

Front Microbiol. 2019 May 28;10:1157. doi: 10.3389/fmicb.2019.01157. eCollection 2019.

PMID:
31191485
3.

Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus strains.

Hilgeroth A, Yasrebi K, Suzen S, Hertlein T, Ohlsen K, Lalk M.

Med Chem. 2019 Feb 8. doi: 10.2174/1573406415666190208170126. [Epub ahead of print]

PMID:
30747077
4.

Antistaphylococcal evaluation of indole-naphthalene hybrid analogs.

Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A.

Drug Des Devel Ther. 2019 Jan 10;13:275-283. doi: 10.2147/DDDT.S184965. eCollection 2019.

5.

Bringing together what belongs together: Optimizing murine infection models by using mouse-adapted Staphylococcus aureus strains.

Trübe P, Hertlein T, Mrochen DM, Schulz D, Jorde I, Krause B, Zeun J, Fischer S, Wolf SA, Walther B, Semmler T, Bröker BM, Ulrich RG, Ohlsen K, Holtfreter S.

Int J Med Microbiol. 2019 Jan;309(1):26-38. doi: 10.1016/j.ijmm.2018.10.007. Epub 2018 Oct 22.

6.

Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence.

Nagel A, Michalik S, Debarbouille M, Hertlein T, Gesell Salazar M, Rath H, Msadek T, Ohlsen K, van Dijl JM, Völker U, Mäder U.

MBio. 2018 Sep 18;9(5). pii: e01332-18. doi: 10.1128/mBio.01332-18.

7.

The serine/threonine kinase Stk and the phosphatase Stp regulate cell wall synthesis in Staphylococcus aureus.

Jarick M, Bertsche U, Stahl M, Schultz D, Methling K, Lalk M, Stigloher C, Steger M, Schlosser A, Ohlsen K.

Sci Rep. 2018 Sep 12;8(1):13693. doi: 10.1038/s41598-018-32109-7.

8.

Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound.

Bruchhagen C, Jarick M, Mewis C, Hertlein T, Niemann S, Ohlsen K, Peters G, Planz O, Ludwig S, Ehrhardt C.

Sci Rep. 2018 Jun 14;8(1):9114. doi: 10.1038/s41598-018-27445-7.

9.

Towards clinical application of non-invasive imaging to detect bacterial infections.

Ohlsen K, Hertlein T.

Virulence. 2018 Dec 31;9(1):943-945. doi: 10.1080/21505594.2018.1425072.

PMID:
29417876
10.

Novel Effective Small-Molecule Antibacterials against Enterococcus Strains.

Ashraf K, Yasrebi K, Hertlein T, Ohlsen K, Lalk M, Hilgeroth A.

Molecules. 2017 Dec 10;22(12). pii: E2193. doi: 10.3390/molecules22122193.

11.

Staphylococcal (phospho)lipases promote biofilm formation and host cell invasion.

Nguyen MT, Luqman A, Bitschar K, Hertlein T, Dick J, Ohlsen K, Bröker B, Schittek B, Götz F.

Int J Med Microbiol. 2018 Aug;308(6):653-663. doi: 10.1016/j.ijmm.2017.11.013. Epub 2017 Nov 29.

PMID:
29203111
12.

Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus.

Mielich-Süss B, Wagner RM, Mietrach N, Hertlein T, Marincola G, Ohlsen K, Geibel S, Lopez D.

PLoS Pathog. 2017 Nov 22;13(11):e1006728. doi: 10.1371/journal.ppat.1006728. eCollection 2017 Nov.

13.

A Novel Mechanism of Inactivating Antibacterial Nitro Compounds in the Human Pathogen Staphylococcus aureus by Overexpression of a NADH-Dependent Flavin Nitroreductase.

El-Hossary EM, Förstner KU, François P, Baud D, Streker K, Schrenzel J, Ohlsen K, Holzgrabe U.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01510-17. doi: 10.1128/AAC.01510-17. Print 2018 Feb.

14.

Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus.

García-Betancur JC, Goñi-Moreno A, Horger T, Schott M, Sharan M, Eikmeier J, Wohlmuth B, Zernecke A, Ohlsen K, Kuttler C, Lopez D.

Elife. 2017 Sep 12;6. pii: e28023. doi: 10.7554/eLife.28023.

15.

Competitive Fitness of Fluconazole-Resistant Clinical Candida albicans Strains.

Popp C, Hampe IAI, Hertlein T, Ohlsen K, Rogers PD, Morschhäuser J.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00584-17. doi: 10.1128/AAC.00584-17. Print 2017 Jul.

16.

The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans.

Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J.

Mol Microbiol. 2017 Jun;104(6):989-1007. doi: 10.1111/mmi.13674. Epub 2017 Apr 18.

17.

The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus.

Hardt P, Engels I, Rausch M, Gajdiss M, Ulm H, Sass P, Ohlsen K, Sahl HG, Bierbaum G, Schneider T, Grein F.

Int J Med Microbiol. 2017 Jan;307(1):1-10. doi: 10.1016/j.ijmm.2016.12.001. Epub 2016 Dec 12.

PMID:
27989665
18.

Antifungal potential of marine natural products.

El-Hossary EM, Cheng C, Hamed MM, El-Sayed Hamed AN, Ohlsen K, Hentschel U, Abdelmohsen UR.

Eur J Med Chem. 2017 Jan 27;126:631-651. doi: 10.1016/j.ejmech.2016.11.022. Epub 2016 Nov 14. Review.

PMID:
27936443
19.

Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes.

Blättner S, Das S, Paprotka K, Eilers U, Krischke M, Kretschmer D, Remmele CW, Dittrich M, Müller T, Schuelein-Voelk C, Hertlein T, Mueller MJ, Huettel B, Reinhardt R, Ohlsen K, Rudel T, Fraunholz MJ.

PLoS Pathog. 2016 Sep 15;12(9):e1005857. doi: 10.1371/journal.ppat.1005857. eCollection 2016 Sep.

20.

Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation.

Das S, Lindemann C, Young BC, Muller J, Österreich B, Ternette N, Winkler AC, Paprotka K, Reinhardt R, Förstner KU, Allen E, Flaxman A, Yamaguchi Y, Rollier CS, van Diemen P, Blättner S, Remmele CW, Selle M, Dittrich M, Müller T, Vogel J, Ohlsen K, Crook DW, Massey R, Wilson DJ, Rudel T, Wyllie DH, Fraunholz MJ.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3101-10. doi: 10.1073/pnas.1520255113. Epub 2016 May 16.

21.

Global antibody response to Staphylococcus aureus live-cell vaccination.

Selle M, Hertlein T, Oesterreich B, Klemm T, Kloppot P, Müller E, Ehricht R, Stentzel S, Bröker BM, Engelmann S, Ohlsen K.

Sci Rep. 2016 Apr 22;6:24754. doi: 10.1038/srep24754.

22.

Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase.

El-Sayed MT, Zoraghi R, Reiner N, Suzen S, Ohlsen K, Lalk M, Altanlar N, Hilgeroth A.

J Enzyme Inhib Med Chem. 2016 Dec;31(6):1666-71. doi: 10.3109/14756366.2015.1118685. Epub 2015 Dec 10.

PMID:
26653005
23.

Discovery of bisindolyl-substituted cycloalkane-anellated indoles as novel class of antibacterial agents against S. aureus and MRSA.

El-Sayed MT, Suzen S, Altanlar N, Ohlsen K, Hilgeroth A.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):218-21. doi: 10.1016/j.bmcl.2015.10.085. Epub 2015 Oct 29.

PMID:
26590101
24.

Surface functionalization allowing repetitive use of optical sensors for real-time detection of antibody-bacteria interaction.

Kutscher M, Rosenberger M, Schmauss B, Meinel L, Lorenz U, Ohlsen K, Hellmann R, Germershaus O.

J Biophotonics. 2016 Jul;9(7):730-7. doi: 10.1002/jbio.201500178. Epub 2015 Oct 21.

PMID:
26486822
25.

Correction: The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells.

Nguyen MT, Kraft B, Yu W, Demircioglu DD, Hertlein T, Burian M, Schmaler M, Boller K, Bekeredjian-Ding I, Ohlsen K, Schittek B, Götz F.

PLoS Pathog. 2015 Sep 25;11(9):e1005189. doi: 10.1371/journal.ppat.1005189. eCollection 2015 Sep. No abstract available.

26.

The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells.

Nguyen MT, Kraft B, Yu W, Demircioglu DD, Hertlein T, Burian M, Schmaler M, Boller K, Bekeredjian-Ding I, Ohlsen K, Schittek B, Götz F.

PLoS Pathog. 2015 Jun 17;11(6):e1004984. doi: 10.1371/journal.ppat.1004984. eCollection 2015 Jun. Erratum in: PLoS Pathog. 2015 Sep;11(9):e1005189. Demicrioglu, Dogan Doruk [corrected to Demircioglu, Dogan Doruk].

27.

Influence of salt type and ionic strength on self-assembly of dextran sulfate-ciprofloxacin nanoplexes.

Kutscher M, Cheow WS, Werner V, Lorenz U, Ohlsen K, Meinel L, Hadinoto K, Germershaus O.

Int J Pharm. 2015;486(1-2):21-9. doi: 10.1016/j.ijpharm.2015.03.022. Epub 2015 Mar 12.

PMID:
25772413
28.

Microarray-based identification of human antibodies against Staphylococcus aureus antigens.

Kloppot P, Selle M, Kohler C, Stentzel S, Fuchs S, Liebscher V, Müller E, Kale D, Ohlsen K, Bröker BM, Zipfel PF, Kahl BC, Ehricht R, Hecker M, Engelmann S.

Proteomics Clin Appl. 2015 Dec;9(11-12):1003-11. doi: 10.1002/prca.201400123. Epub 2015 Apr 1.

PMID:
25676254
29.

Modelling antibiotic and cytotoxic isoquinoline effects in Staphylococcus aureus, Staphylococcus epidermidis and mammalian cells.

Cecil A, Ohlsen K, Menzel T, François P, Schrenzel J, Fischer A, Dörries K, Selle M, Lalk M, Hantzschmann J, Dittrich M, Liang C, Bernhardt J, Ölschläger TA, Bringmann G, Bruhn H, Unger M, Ponte-Sucre A, Lehmann L, Dandekar T.

Int J Med Microbiol. 2015 Jan;305(1):96-109. doi: 10.1016/j.ijmm.2014.11.006. Epub 2014 Nov 27.

PMID:
25500547
30.

The effect of skin fatty acids on Staphylococcus aureus.

Neumann Y, Ohlsen K, Donat S, Engelmann S, Kusch H, Albrecht D, Cartron M, Hurd A, Foster SJ.

Arch Microbiol. 2015 Mar;197(2):245-67. doi: 10.1007/s00203-014-1048-1. Epub 2014 Oct 18.

31.

Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition.

Koch G, Yepes A, Förstner KU, Wermser C, Stengel ST, Modamio J, Ohlsen K, Foster KR, Lopez D.

Cell. 2014 Aug 28;158(5):1060-1071. doi: 10.1016/j.cell.2014.06.046.

32.

Characterization of the biological anti-staphylococcal functionality of hUK-66 IgG1, a humanized monoclonal antibody as substantial component for an immunotherapeutic approach.

Oesterreich B, Lorenz B, Schmitter T, Kontermann R, Zenn M, Zimmermann B, Haake M, Lorenz U, Ohlsen K.

Hum Vaccin Immunother. 2014;10(4):926-37. Epub 2014 Feb 4.

33.

The phosphoproteome and its physiological dynamics in Staphylococcus aureus.

Bäsell K, Otto A, Junker S, Zühlke D, Rappen GM, Schmidt S, Hentschker C, Macek B, Ohlsen K, Hecker M, Becher D.

Int J Med Microbiol. 2014 Mar;304(2):121-32. doi: 10.1016/j.ijmm.2013.11.020. Epub 2013 Dec 1.

PMID:
24457182
34.

Bioluminescence and 19F magnetic resonance imaging visualize the efficacy of lysostaphin alone and in combination with oxacillin against Staphylococcus aureus in murine thigh and catheter-associated infection models.

Hertlein T, Sturm V, Lorenz U, Sumathy K, Jakob P, Ohlsen K.

Antimicrob Agents Chemother. 2014;58(3):1630-8. doi: 10.1128/AAC.01422-13. Epub 2013 Dec 23.

35.

Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin α.

Grosz M, Kolter J, Paprotka K, Winkler AC, Schäfer D, Chatterjee SS, Geiger T, Wolz C, Ohlsen K, Otto M, Rudel T, Sinha B, Fraunholz M.

Cell Microbiol. 2014 Apr;16(4):451-65. doi: 10.1111/cmi.12233. Epub 2013 Nov 12.

36.

Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin.

van Oosten M, Schäfer T, Gazendam JA, Ohlsen K, Tsompanidou E, de Goffau MC, Harmsen HJ, Crane LM, Lim E, Francis KP, Cheung L, Olive M, Ntziachristos V, van Dijl JM, van Dam GM.

Nat Commun. 2013;4:2584. doi: 10.1038/ncomms3584.

PMID:
24129412
37.

The mevalonate auxotrophic mutant of Staphylococcus aureus can adapt to mevalonate depletion.

Yu W, Leibig M, Schäfer T, Bertram R, Ohlsen K, Götz F.

Antimicrob Agents Chemother. 2013 Nov;57(11):5710-3. doi: 10.1128/AAC.00726-13. Epub 2013 Aug 19.

38.

19F magnetic resonance imaging of perfluorocarbons for the evaluation of response to antibiotic therapy in a Staphylococcus aureus infection model.

Hertlein T, Sturm V, Jakob P, Ohlsen K.

PLoS One. 2013 May 28;8(5):e64440. doi: 10.1371/journal.pone.0064440. Print 2013.

39.

Roles of different peptide transporters in nutrient acquisition in Candida albicans.

Dunkel N, Hertlein T, Franz R, Reuß O, Sasse C, Schäfer T, Ohlsen K, Morschhäuser J.

Eukaryot Cell. 2013 Apr;12(4):520-8. doi: 10.1128/EC.00008-13. Epub 2013 Feb 2.

40.

Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus.

Feng J, Michalik S, Varming AN, Andersen JH, Albrecht D, Jelsbak L, Krieger S, Ohlsen K, Hecker M, Gerth U, Ingmer H, Frees D.

J Proteome Res. 2013 Feb 1;12(2):547-58. doi: 10.1021/pr300394r. Epub 2013 Jan 8.

PMID:
23253041
41.

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans.

Sasse C, Dunkel N, Schäfer T, Schneider S, Dierolf F, Ohlsen K, Morschhäuser J.

Mol Microbiol. 2012 Nov;86(3):539-56. doi: 10.1111/j.1365-2958.2012.08210.x. Epub 2012 Aug 28.

42.

RNase Y of Staphylococcus aureus and its role in the activation of virulence genes.

Marincola G, Schäfer T, Behler J, Bernhardt J, Ohlsen K, Goerke C, Wolz C.

Mol Microbiol. 2012 Sep;85(5):817-32. doi: 10.1111/j.1365-2958.2012.08144.x. Epub 2012 Jul 11.

43.

Structural analysis of Staphylococcus aureus serine/threonine kinase PknB.

Rakette S, Donat S, Ohlsen K, Stehle T.

PLoS One. 2012;7(6):e39136. doi: 10.1371/journal.pone.0039136. Epub 2012 Jun 11.

44.

Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis.

Donat S, Hasenberg M, Schäfer T, Ohlsen K, Gunzer M, Einsele H, Löffler J, Beilhack A, Krappmann S.

Virulence. 2012 Jan-Feb;3(1):51-61. doi: 10.4161/viru.3.1.18799. Epub 2012 Jan 1.

PMID:
22286700
45.

Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?

Tischer M, Pradel G, Ohlsen K, Holzgrabe U.

ChemMedChem. 2012 Jan 2;7(1):22-31. doi: 10.1002/cmdc.201100404. Epub 2011 Nov 24. Review.

PMID:
22113995
46.

The alternative sigma factor B modulates virulence gene expression in a murine Staphylococcus aureus infection model but does not influence kidney gene expression pattern of the host.

Depke M, Burian M, Schäfer T, Bröker BM, Ohlsen K, Völker U.

Int J Med Microbiol. 2012 Jan;302(1):33-9. doi: 10.1016/j.ijmm.2011.09.013. Epub 2011 Oct 22.

PMID:
22019488
47.

Integrin-mediated uptake of fibronectin-binding bacteria.

Hoffmann C, Ohlsen K, Hauck CR.

Eur J Cell Biol. 2011 Nov;90(11):891-6. doi: 10.1016/j.ejcb.2011.03.001. Epub 2011 May 10. Review.

PMID:
21561684
48.

The influence of SaeRS and σ(B) on the expression of superantigens in different Staphylococcus aureus isolates.

Kusch K, Hanke K, Holtfreter S, Schmudde M, Kohler C, Erck C, Wehland J, Hecker M, Ohlsen K, Bröker B, Engelmann S.

Int J Med Microbiol. 2011 Aug;301(6):488-99. doi: 10.1016/j.ijmm.2011.01.003. Epub 2011 Apr 6.

PMID:
21470910
49.

Visualization of abscess formation in a murine thigh infection model of Staphylococcus aureus by 19F-magnetic resonance imaging (MRI).

Hertlein T, Sturm V, Kircher S, Basse-Lüsebrink T, Haddad D, Ohlsen K, Jakob P.

PLoS One. 2011 Mar 24;6(3):e18246. doi: 10.1371/journal.pone.0018246.

50.

Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells.

Cecil A, Rikanović C, Ohlsen K, Liang C, Bernhardt J, Oelschlaeger TA, Gulder T, Bringmann G, Holzgrabe U, Unger M, Dandekar T.

Genome Biol. 2011;12(3):R24. doi: 10.1186/gb-2011-12-3-r24. Epub 2011 Mar 21.

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