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Intratumoral STING activations overcome negative impact of cisplatin on antitumor immunity by inflaming tumor microenvironment in squamous cell carcinoma.

Harabuchi S, Kosaka A, Yuki Y, Nagata M, Hayashi R, Kumai T, Ohara K, Nagato T, Oikawa K, Ohara M, Harabuchi Y, Ohkuri T, Kobayashi H.

Biochem Biophys Res Commun. 2019 Nov 23. pii: S0006-291X(19)32233-8. doi: 10.1016/j.bbrc.2019.11.107. [Epub ahead of print]


Crystal structure of the complex of the interaction domains of E. coli DnaB helicase and DnaC helicase loader: Structural basis implying a distortion-accumulation mechanism for the DnaB ring opening caused by DnaC binding.

Nagata K, Okada A, Ohtsuka J, Ohkuri T, Akama Y, Sakiyama Y, Miyazaki E, Horita S, Katayama T, Ueda T, Tanokura M.

J Biochem. 2019 Oct 30. pii: mvz087. doi: 10.1093/jb/mvz087. [Epub ahead of print]


A method to induce hen egg lysozyme-specific humoral immune tolerance in mice by pre-exposition with the protein's oligomers.

Ohkuri T, Yuge N, Sato K, Ueda T.

Biochem Biophys Rep. 2019 Aug 14;20:100679. doi: 10.1016/j.bbrep.2019.100679. eCollection 2019 Dec.


PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma.

Hirata-Nozaki Y, Ohkuri T, Ohara K, Kumai T, Nagata M, Harabuchi S, Kosaka A, Nagato T, Ishibashi K, Oikawa K, Aoki N, Ohara M, Harabuchi Y, Uno Y, Takei H, Celis E, Kobayashi H.

J Transl Med. 2019 Jun 20;17(1):207. doi: 10.1186/s12967-019-1957-5.


Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma.

Nagato T, Ueda S, Takahara M, Kishibe K, Komabayashi Y, Kumai T, Ohara K, Hirata-Nozaki Y, Harabuchi S, Hayashi R, Ohkuri T, Bernasconi M, Nadal D, Kobayashi H, Harabuchi Y.

Lab Invest. 2019 May;99(5):612-624. doi: 10.1038/s41374-018-0182-9. Epub 2019 Jan 21.


Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma.

Ohara K, Ohkuri T, Kumai T, Nagato T, Nozaki Y, Ishibashi K, Kosaka A, Nagata M, Harabuchi S, Ohara M, Oikawa K, Aoki N, Harabuchi Y, Celis E, Kobayashi H.

Oncoimmunology. 2018 Aug 1;7(9):e1466771. doi: 10.1080/2162402X.2018.1466771. eCollection 2018.


Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab.

Nakamura H, Oda-Ueda N, Ueda T, Ohkuri T.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):752-756. doi: 10.1016/j.bbrc.2018.06.071. Epub 2018 Jun 19.


A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab.

Nakamura H, Oda-Ueda N, Ueda T, Ohkuri T.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):7-11. doi: 10.1016/j.bbrc.2017.10.140. Epub 2017 Oct 31.


Effects of STING stimulation on macrophages: STING agonists polarize into "classically" or "alternatively" activated macrophages?

Ohkuri T, Kosaka A, Nagato T, Kobayashi H.

Hum Vaccin Immunother. 2018 Feb 1;14(2):285-287. doi: 10.1080/21645515.2017.1395995. Epub 2017 Dec 1.


Intratumoral injection of IFN-β induces chemokine production in melanoma and augments the therapeutic efficacy of anti-PD-L1 mAb.

Uehara J, Ohkuri T, Kosaka A, Ishibashi K, Hirata Y, Ohara K, Nagato T, Oikawa K, Aoki N, Harabuchi Y, Ishida-Yamamoto A, Kobayashi H.

Biochem Biophys Res Commun. 2017 Aug 19;490(2):521-527. doi: 10.1016/j.bbrc.2017.06.072. Epub 2017 Jun 15.


Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy.

Nagato T, Ohkuri T, Ohara K, Hirata Y, Kishibe K, Komabayashi Y, Ueda S, Takahara M, Kumai T, Ishibashi K, Kosaka A, Aoki N, Oikawa K, Uno Y, Akiyama N, Sado M, Takei H, Celis E, Harabuchi Y, Kobayashi H.

Cancer Immunol Immunother. 2017 Jul;66(7):877-890. doi: 10.1007/s00262-017-1987-x. Epub 2017 Mar 27.


Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site.

Ohkuri T, Kosaka A, Ishibashi K, Kumai T, Hirata Y, Ohara K, Nagato T, Oikawa K, Aoki N, Harabuchi Y, Celis E, Kobayashi H.

Cancer Immunol Immunother. 2017 Jun;66(6):705-716. doi: 10.1007/s00262-017-1975-1. Epub 2017 Feb 27.


Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy.

Ishibashi K, Kumai T, Ohkuri T, Kosaka A, Nagato T, Hirata Y, Ohara K, Oikawa K, Aoki N, Akiyama N, Sado M, Kitada M, Harabuchi Y, Celis E, Kobayashi H.

Oncoimmunology. 2016 Mar 30;5(6):e1169356. doi: 10.1080/2162402X.2016.1169356. eCollection 2016 Jun.


Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2.

Nakamura H, Ohkuri T, So T, Ueda T.

Biochim Biophys Acta. 2016 Oct;1860(10):2279-84. doi: 10.1016/j.bbagen.2016.04.014. Epub 2016 Apr 20.


Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.

Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H.

Sci Rep. 2015 Nov 5;5:16280. doi: 10.1038/srep16280.


Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas.

Ahn B, Kohanbash G, Ohkuri T, Kosaka A, Chen X, Ikeura M, Wang TC, Okada H.

Oncoimmunology. 2015 May 26;4(11):e1047581. eCollection 2015 Nov.


Protective role of STING against gliomagenesis: Rational use of STING agonist in anti-glioma immunotherapy.

Ohkuri T, Ghosh A, Kosaka A, Sarkar SN, Okada H.

Oncoimmunology. 2015 Jan 22;4(4):e999523. eCollection 2015 Apr.


c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma.

Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.

Oncoimmunology. 2015 Mar 6;4(2):e976077. eCollection 2015 Feb.


CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma.

Kumai T, Nagato T, Kobayashi H, Komabayashi Y, Ueda S, Kishibe K, Ohkuri T, Takahara M, Celis E, Harabuchi Y.

Cancer Immunol Immunother. 2015 Jun;64(6):697-705. doi: 10.1007/s00262-015-1675-7. Epub 2015 Mar 10.


Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma.

Johnson LA, Scholler J, Ohkuri T, Kosaka A, Patel PR, McGettigan SE, Nace AK, Dentchev T, Thekkat P, Loew A, Boesteanu AC, Cogdill AP, Chen T, Fraietta JA, Kloss CC, Posey AD Jr, Engels B, Singh R, Ezell T, Idamakanti N, Ramones MH, Li N, Zhou L, Plesa G, Seykora JT, Okada H, June CH, Brogdon JL, Maus MV.

Sci Transl Med. 2015 Feb 18;7(275):275ra22. doi: 10.1126/scitranslmed.aaa4963.


Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity.

Kosaka A, Ohkuri T, Ikeura M, Kohanbash G, Okada H.

Biochem Biophys Res Commun. 2015 Mar 13;458(3):549-554. doi: 10.1016/j.bbrc.2015.02.003. Epub 2015 Feb 10.


Role of the osmolyte taurine on the folding of a model protein, hen egg white lysozyme, under a crowding condition.

Abe Y, Ohkuri T, Yoshitomi S, Murakami S, Ueda T.

Amino Acids. 2015 May;47(5):909-15. doi: 10.1007/s00726-015-1918-0. Epub 2015 Jan 21.


Epithelium specific ETS transcription factor, ESE-3, of Protobothrops flavoviridis snake venom gland transactivates the promoters of venom phospholipase A2 isozyme genes.

Nakamura H, Murakami T, Hattori S, Sakaki Y, Ohkuri T, Chijiwa T, Ohno M, Oda-Ueda N.

Toxicon. 2014 Dec 15;92:133-9. doi: 10.1016/j.toxicon.2014.10.001. Epub 2014 Oct 22.


STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.

Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, Watkins SC, Sarkar SN, Okada H.

Cancer Immunol Res. 2014 Dec;2(12):1199-208. doi: 10.1158/2326-6066.CIR-14-0099. Epub 2014 Oct 9.


Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells.

Kosaka A, Ohkuri T, Okada H.

Cancer Immunol Immunother. 2014 Aug;63(8):847-57. doi: 10.1007/s00262-014-1561-8. Epub 2014 May 31.


Identification of novel helper epitope peptides of Survivin cancer-associated antigen applicable to developing helper/killer-hybrid epitope long peptide cancer vaccine.

Ohtake J, Ohkuri T, Togashi Y, Kitamura H, Okuno K, Nishimura T.

Immunol Lett. 2014 Sep;161(1):20-30. doi: 10.1016/j.imlet.2014.04.010. Epub 2014 Apr 30.


Identification of a meiosis-specific protein, MEIOB, as a novel cancer/testis antigen and its augmented expression in demethylated cancer cells.

Shiohama Y, Ohtake J, Ohkuri T, Noguchi D, Togashi Y, Kitamura H, Nishimura T.

Immunol Lett. 2014 Mar-Apr;158(1-2):175-82. doi: 10.1016/j.imlet.2014.01.004. Epub 2014 Jan 16.


Characterization of deamidation at Asn138 in L-chain of recombinant humanized Fab expressed from Pichia pastoris.

Ohkuri T, Murase E, Sun SL, Sugitani J, Ueda T.

J Biochem. 2013 Oct;154(4):333-40. doi: 10.1093/jb/mvt061. Epub 2013 Jul 12.


Domain separation and characterization of PriC, a replication restart primosome factor in Escherichia coli.

Aramaki T, Abe Y, Ohkuri T, Mishima T, Yamashita S, Katayama T, Ueda T.

Genes Cells. 2013 Sep;18(9):723-32. doi: 10.1111/gtc.12069. Epub 2013 Jul 2.


Angiotensin II modulates salty and sweet taste sensitivities.

Shigemura N, Iwata S, Yasumatsu K, Ohkuri T, Horio N, Sanematsu K, Yoshida R, Margolskee RF, Ninomiya Y.

J Neurosci. 2013 Apr 10;33(15):6267-77. doi: 10.1523/JNEUROSCI.5599-12.2013.


Mechanism for retardation of amyloid fibril formation by sugars in Vλ6 protein.

Abe M, Abe Y, Ohkuri T, Mishima T, Monji A, Kanba S, Ueda T.

Protein Sci. 2013 Apr;22(4):467-74. doi: 10.1002/pro.2228. Epub 2013 Feb 21.


Taste responses in mice lacking taste receptor subunit T1R1.

Kusuhara Y, Yoshida R, Ohkuri T, Yasumatsu K, Voigt A, Hübner S, Maeda K, Boehm U, Meyerhof W, Ninomiya Y.

J Physiol. 2013 Apr 1;591(7):1967-85. doi: 10.1113/jphysiol.2012.236604. Epub 2013 Jan 21.


Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts.

Ohno M, Ohkuri T, Kosaka A, Tanahashi K, June CH, Natsume A, Okada H.

J Immunother Cancer. 2013 Dec 16;1:21. doi: 10.1186/2051-1426-1-21. eCollection 2013.


Preparation and characterization of a monoclonal antibody against the refolded and functional extracellular domain of rat P2X4 receptor.

Igawa T, Higashi S, Abe Y, Ohkuri T, Tanaka H, Morimoto S, Yamashita T, Tsuda M, Inoue K, Ueda T.

J Biochem. 2013 Mar;153(3):275-82. doi: 10.1093/jb/mvs143. Epub 2012 Dec 7.


Defects in the peripheral taste structure and function in the MRL/lpr mouse model of autoimmune disease.

Kim A, Feng P, Ohkuri T, Sauers D, Cohn ZJ, Chai J, Nelson T, Bachmanov AA, Huang L, Wang H.

PLoS One. 2012;7(4):e35588. doi: 10.1371/journal.pone.0035588. Epub 2012 Apr 19.


Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice.

Ohkuri T, Horio N, Stratford JM, Finger TE, Ninomiya Y.

Chem Senses. 2012 Jul;37(6):523-32. doi: 10.1093/chemse/bjs004. Epub 2012 Feb 23.


First clinical trial of cancer vaccine therapy with artificially synthesized helper/ killer-hybrid epitope long peptide of MAGE-A4 cancer antigen.

Takahashi N, Ohkuri T, Homma S, Ohtake J, Wakita D, Togashi Y, Kitamura H, Todo S, Nishimura T.

Cancer Sci. 2012 Jan;103(1):150-3. doi: 10.1111/j.1349-7006.2011.02106.x.


Aggregates with lysozyme and ovalbumin show features of amyloid-like fibrils.

Sugimoto Y, Kamada Y, Tokunaga Y, Shinohara H, Matsumoto M, Kusakabe T, Ohkuri T, Ueda T.

Biochem Cell Biol. 2011 Dec;89(6):533-44. doi: 10.1139/o11-041. Epub 2011 Oct 17.


Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception.

Iguchi N, Ohkuri T, Slack JP, Zhong P, Huang L.

PLoS One. 2011;6(8):e23165. doi: 10.1371/journal.pone.0023165. Epub 2011 Aug 2.


Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen.

Noguchi D, Wakita D, Ohkuri T, Tajima M, Chamoto K, Kitamura H, Nishimura T.

Immunol Lett. 2011 May;136(2):146-55. doi: 10.1016/j.imlet.2011.01.004. Epub 2011 Jan 20.


Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L.

Tanaka S, Koizumi S, Masuko K, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Ohkuri T, Wakita D, Chamoto K, Kitamura H, Nishimura T.

Int Immunopharmacol. 2011 Feb;11(2):226-32. doi: 10.1016/j.intimp.2010.11.026. Epub 2010 Dec 7.


A protein's conformational stability is an immunologically dominant factor: evidence that free-energy barriers for protein unfolding limit the immunogenicity of foreign proteins.

Ohkuri T, Nagatomo S, Oda K, So T, Imoto T, Ueda T.

J Immunol. 2010 Oct 1;185(7):4199-205. doi: 10.4049/jimmunol.0902249. Epub 2010 Sep 3.


1α,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells.

Ikeda U, Wakita D, Ohkuri T, Chamoto K, Kitamura H, Iwakura Y, Nishimura T.

Immunol Lett. 2010 Nov 30;134(1):7-16. doi: 10.1016/j.imlet.2010.07.002. Epub 2010 Jul 23.


Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium.

Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha M, Ueda T, Hashioka S, Kanba S.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 1;34(7):1306-16. doi: 10.1016/j.pnpbp.2010.07.015. Epub 2010 Jul 21.


Taste preference for fatty acids is mediated by GPR40 and GPR120.

Cartoni C, Yasumatsu K, Ohkuri T, Shigemura N, Yoshida R, Godinot N, le Coutre J, Ninomiya Y, Damak S.

J Neurosci. 2010 Jun 23;30(25):8376-82. doi: 10.1523/JNEUROSCI.0496-10.2010.


A T(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma} production in order to induce airway hyperresponsiveness.

Ashino S, Wakita D, Shiohama Y, Iwakura Y, Chamoto K, Ohkuri T, Kitamura H, Nishimura T.

Int Immunol. 2010 Jun;22(6):503-13. doi: 10.1093/intimm/dxq034. Epub 2010 May 25.


Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis.

Wakita D, Sumida K, Iwakura Y, Nishikawa H, Ohkuri T, Chamoto K, Kitamura H, Nishimura T.

Eur J Immunol. 2010 Jul;40(7):1927-37. doi: 10.1002/eji.200940157.


Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL: its potentiation by combination with Th1 cell therapy.

Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.

Cancer Res. 2010 Apr 1;70(7):2697-706. doi: 10.1158/0008-5472.CAN-09-2982. Epub 2010 Mar 9.


3-Methylcholanthrene-induced transforming growth factor-beta-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy.

Chamoto K, Wakita D, Ohkuri T, Uchinami Y, Matsushima K, Kitamura H, Nishimura T.

Cancer Sci. 2010 Apr;101(4):855-61. doi: 10.1111/j.1349-7006.2009.01469.x. Epub 2009 Dec 11.


Endocannabinoids selectively enhance sweet taste.

Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):935-9. doi: 10.1073/pnas.0912048107. Epub 2009 Dec 22.

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