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Items: 1 to 50 of 115

1.

Enhancer function regulated by combinations of transcription factors and cofactors.

Nakagawa T, Yoneda M, Higashi M, Ohkuma Y, Ito T.

Genes Cells. 2018 Oct;23(10):808-821. doi: 10.1111/gtc.12634. Epub 2018 Aug 31. Review.

2.

Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.

Yamamoto S, Hagihara T, Horiuchi Y, Okui A, Wani S, Yoshida T, Inoue T, Tanaka A, Ito T, Hirose Y, Ohkuma Y.

Genes Cells. 2017 Mar;22(3):265-276. doi: 10.1111/gtc.12475. Epub 2017 Feb 2.

3.

High-Resolution Adaptive Optics Retinal Image Analysis at Early Stage Central Areolar Choroidal Dystrophy With PRPH2 Mutation.

Gocho K, Akeo K, Itoh N, Kameya S, Hayashi T, Katagiri S, Gekka T, Ohkuma Y, Tsuneoka H, Takahashi H.

Ophthalmic Surg Lasers Imaging Retina. 2016 Dec 1;47(12):1115-1126. doi: 10.3928/23258160-20161130-05.

PMID:
27977834
4.

Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution.

Miwa K, Kojima R, Obita T, Ohkuma Y, Tamura Y, Mizuguchi M.

J Mol Biol. 2016 Oct 23;428(21):4258-4266. doi: 10.1016/j.jmb.2016.09.008. Epub 2016 Sep 15.

PMID:
27639436
5.

Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation.

Wani S, Sugita A, Ohkuma Y, Hirose Y.

J Biochem. 2016 Aug;160(2):111-20. doi: 10.1093/jb/mvw018. Epub 2016 Feb 26.

PMID:
26920047
6.

A novel heterozygous splice site OPA1 mutation causes exon 10 skipping in Japanese patients with dominant optic atrophy.

Iida K, Ohkuma Y, Hayashi T, Katagiri S, Fujita T, Tsunoda K, Yamada H, Tsuneoka H.

Ophthalmic Genet. 2016 Sep;37(3):354-6. doi: 10.3109/13816810.2015.1066829. Epub 2016 Feb 8. No abstract available.

PMID:
26854526
7.

Trisection technique for the extraction of dislocated intraocular lenses through a small surgical incision.

Gekka T, Ogawa T, Ohkuma Y, Katagiri S, Shiba T, Tsuneoka H.

J Cataract Refract Surg. 2015 Oct;41(10):2040-2. doi: 10.1016/j.jcrs.2015.09.007.

PMID:
26703277
8.

Pedicle Internal Limiting Membrane Transposition Flap Technique for Refractory Macular Hole.

Gekka T, Watanabe A, Ohkuma Y, Arai K, Watanabe T, Tsuzuki A, Tsuneoka H.

Ophthalmic Surg Lasers Imaging Retina. 2015 Nov-Dec;46(10):1045-6. doi: 10.3928/23258160-20151027-10.

PMID:
26599248
9.

Mutation analysis of BEST1 in Japanese patients with Best's vitelliform macular dystrophy.

Katagiri S, Hayashi T, Ohkuma Y, Sekiryu T, Takeuchi T, Gekka T, Kondo M, Iwata T, Tsuneoka H.

Br J Ophthalmol. 2015 Nov;99(11):1577-82. doi: 10.1136/bjophthalmol-2015-306830. Epub 2015 Jul 22.

PMID:
26201355
10.

Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.

Fukasawa R, Iida S, Tsutsui T, Hirose Y, Ohkuma Y.

J Biochem. 2015 Nov;158(5):373-84. doi: 10.1093/jb/mvv055. Epub 2015 May 22.

PMID:
26002960
12.

PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.

Iida S, Chen W, Nakadai T, Ohkuma Y, Roeder RG.

Genes Dev. 2015 Feb 1;29(3):308-21. doi: 10.1101/gad.252809.114.

13.
14.

Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.

Tanaka A, Akimoto Y, Kobayashi S, Hisatake K, Hanaoka F, Ohkuma Y.

Genes Cells. 2015 Mar;20(3):203-16. doi: 10.1111/gtc.12212. Epub 2014 Dec 10.

15.

Human mediator MED17 subunit plays essential roles in gene regulation by associating with the transcription and DNA repair machineries.

Kikuchi Y, Umemura H, Nishitani S, Iida S, Fukasawa R, Hayashi H, Hirose Y, Tanaka A, Sugasawa K, Ohkuma Y.

Genes Cells. 2015 Mar;20(3):191-202. doi: 10.1111/gtc.12210. Epub 2014 Dec 7.

16.

Human mediator subunit MED15 promotes transcriptional activation.

Nakatsubo T, Nishitani S, Kikuchi Y, Iida S, Yamada K, Tanaka A, Ohkuma Y.

Drug Discov Ther. 2014 Oct;8(5):212-7.

17.

Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE.

Akimoto Y, Yamamoto S, Iida S, Hirose Y, Tanaka A, Hanaoka F, Ohkuma Y.

Genes Cells. 2014 Dec;19(12):879-90. doi: 10.1111/gtc.12187. Epub 2014 Oct 13.

18.

Retinal Ganglion Cell Loss in X-linked Adrenoleukodystrophy with an ABCD1 Mutation (Gly266Arg).

Ohkuma Y, Hayashi T, Yoshimine S, Tsuneoka H, Terao Y, Akiyama M, Ida H, Ohashi T, Okumura A, Ebihara N, Murakami A, Shimozawa N.

Neuroophthalmology. 2014 Oct 9;38(6):331-335. eCollection 2014.

19.

Fundus autofluorescence findings of acute posterior multifocal placoid pigment epitheliopathy with chronic thyroiditis and splenectomy.

Katagiri S, Ohkuma Y, Hayashi T, Gekka T, Tsuneoka H.

Clin Exp Optom. 2015 Mar;98(2):186-9. doi: 10.1111/cxo.12208. Epub 2014 Sep 3. No abstract available.

20.

Vertebrate Ssu72 regulates and coordinates 3'-end formation of RNAs transcribed by RNA polymerase II.

Wani S, Yuda M, Fujiwara Y, Yamamoto M, Harada F, Ohkuma Y, Hirose Y.

PLoS One. 2014 Aug 28;9(8):e106040. doi: 10.1371/journal.pone.0106040. eCollection 2014.

21.

Three-year visual outcome of photodynamic therapy plus intravitreal bevacizumab with or without subtenon triamcinolone acetonide injections for polypoidal choroidal vasculopathy.

Sakai T, Ohkuma Y, Kohno H, Hayashi T, Watanabe A, Tsuneoka H.

Br J Ophthalmol. 2014 Dec;98(12):1642-8. doi: 10.1136/bjophthalmol-2014-305189. Epub 2014 Jul 22.

PMID:
25053762
22.

Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module.

Kumafuji M, Umemura H, Furumoto T, Fukasawa R, Tanaka A, Ohkuma Y.

Genes Cells. 2014 Jul;19(7):582-93. doi: 10.1111/gtc.12155. Epub 2014 May 20.

23.

Retinal angiomatous proliferation associated with risk alleles of ARMS2/HTRA1 gene polymorphisms in Japanese patients.

Ohkuma Y, Hayashi T, Sakai T, Watanabe A, Yamada H, Akahori M, Itabashi T, Iwata T, Noda T, Tsuneoka H.

Clin Ophthalmol. 2014;8:143-8. doi: 10.2147/OPTH.S56483. Epub 2013 Dec 27.

24.

[Eight cases of calcific retropharyngeal tendinitis/retropharyngeal calcific tendinitis].

Ohtsuka Y, Chazono H, Suzuki H, Ohkuma Y, Sakurai T, Hanazawa T, Okamoto Y.

Nihon Jibiinkoka Gakkai Kaiho. 2013 Nov;116(11):1200-7. Japanese.

PMID:
24397117
25.

Efficacy of reduced-fluence photodynamic therapy for serous retinal pigment epithelial detachment with choroidal hyperpermeability.

Shibata A, Ohkuma Y, Hayashi T, Tsuneoka H.

Clin Ophthalmol. 2013;7:2123-6. doi: 10.2147/OPTH.S52475. Epub 2013 Oct 30.

26.

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

Tsutsui T, Fukasawa R, Shinmyouzu K, Nakagawa R, Tobe K, Tanaka A, Ohkuma Y.

J Biol Chem. 2013 Jul 19;288(29):20955-65. doi: 10.1074/jbc.M113.486746. Epub 2013 Jun 9.

27.

One-year results of reduced fluence photodynamic therapy for central serous chorioretinopathy: the outer nuclear layer thickness is associated with visual prognosis.

Ohkuma Y, Hayashi T, Sakai T, Watanabe A, Tsuneoka H.

Graefes Arch Clin Exp Ophthalmol. 2013 Aug;251(8):1909-17. doi: 10.1007/s00417-013-2289-4. Epub 2013 Mar 2.

PMID:
23456099
28.

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.

Fukasawa R, Tsutsui T, Hirose Y, Tanaka A, Ohkuma Y.

J Biochem. 2012 Sep;152(3):241-9. doi: 10.1093/jb/mvs065. Epub 2012 Jun 4.

PMID:
22668559
29.

Autosomal dominant occult macular dystrophy with an RP1L1 mutation (R45W).

Hayashi T, Gekka T, Kozaki K, Ohkuma Y, Tanaka I, Yamada H, Tsuneoka H.

Optom Vis Sci. 2012 May;89(5):684-91. doi: 10.1097/OPX.0b013e31824eea32.

PMID:
22504327
30.

Identification of target genes for the CDK subunits of the Mediator complex.

Tsutsui T, Fukasawa R, Tanaka A, Hirose Y, Ohkuma Y.

Genes Cells. 2011 Dec;16(12):1208-18. doi: 10.1111/j.1365-2443.2011.01565.x.

31.

The HIRA complex subunit Hip3 plays important roles in the silencing of meiosis-specific genes in Schizosaccharomyces pombe.

Mizuki F, Tanaka A, Hirose Y, Ohkuma Y.

PLoS One. 2011 Apr 29;6(4):e19442. doi: 10.1371/journal.pone.0019442.

32.

Double-sensor method for detection of oscillating electric field.

Ohkuma Y, Ikeyama T, Nogi Y.

Rev Sci Instrum. 2011 Apr;82(4):043501. doi: 10.1063/1.3571299.

PMID:
21529003
33.

[Re-treatment with epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI)for lung adenocarcinoma].

Miyamoto S, Ohkuma Y, Takagi Y, Shimokawa T, Hosomi Y, Iguchi M, Okamura T, Shibuya M.

Gan To Kagaku Ryoho. 2010 Oct;37(10):1907-11. Japanese.

PMID:
20948254
34.

[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].

Tsutsui T, Ohkuma Y.

Seikagaku. 2010 Mar;82(3):191-9. Review. Japanese. No abstract available.

PMID:
20408451
35.

[Preface: coordinated regulation of gene expression by "Nuclear Code"].

Ohkuma Y.

Seikagaku. 2010 Mar;82(3):177-9. Japanese. No abstract available.

PMID:
20408449
36.

[Catheter-assisted technique for endovascular treatment of a wide-neck aneurysm: a case report].

Haruma J, Ohkuma Y, Sasaki T, Tanabe T, Muraoka K, Terada K, Meguro T, Hirotsune N, Nishino S.

No Shinkei Geka. 2009 Nov;37(11):1095-8. Japanese.

PMID:
19938665
37.

Prolyl isomerase Pin1 shares functional similarity with phosphorylated CTD interacting factor PCIF1 in vertebrate cells.

Yunokuchi I, Fan H, Iwamoto Y, Araki C, Yuda M, Umemura H, Harada F, Ohkuma Y, Hirose Y.

Genes Cells. 2009 Sep;14(9):1105-18. doi: 10.1111/j.1365-2443.2009.01339.x. Epub 2009 Aug 13.

38.

Central forkhead domain of human TFIIE beta plays a primary role in binding double-stranded DNA at transcription initiation.

Tanaka A, Watanabe T, Iida Y, Hanaoka F, Ohkuma Y.

Genes Cells. 2009 Mar;14(3):395-405. doi: 10.1111/j.1365-2443.2008.01278.x. Epub 2009 Feb 4.

39.

Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation.

Tsutsui T, Umemura H, Tanaka A, Mizuki F, Hirose Y, Ohkuma Y.

Genes Cells. 2008 Aug;13(8):817-26. doi: 10.1111/j.1365-2443.2008.01208.x. Epub 2008 Jun 21.

40.

[Treatment of malignant pericardial effusion].

Hosomi Y, Ohkuma Y, Shibuya M.

Gan To Kagaku Ryoho. 2008 Jun;35(6):906-9. Japanese.

PMID:
18633218
41.

Silver-based compound metal island films for write-once optical data-storage media.

Baba K, Ohkuma Y, Yonezawa T, Miyagi M.

Appl Opt. 2001 Jun 1;40(16):2796-804.

PMID:
18357297
42.

Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH.

Okuda M, Tanaka A, Satoh M, Mizuta S, Takazawa M, Ohkuma Y, Nishimura Y.

EMBO J. 2008 Apr 9;27(7):1161-71. doi: 10.1038/emboj.2008.47. Epub 2008 Mar 20.

43.

Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II.

Hirose Y, Iwamoto Y, Sakuraba K, Yunokuchi I, Harada F, Ohkuma Y.

Biochem Biophys Res Commun. 2008 May 2;369(2):449-55. doi: 10.1016/j.bbrc.2008.02.042. Epub 2008 Feb 22.

PMID:
18294453
44.

Structural characterization of human general transcription factor TFIIF in solution.

Akashi S, Nagakura S, Yamamoto S, Okuda M, Ohkuma Y, Nishimura Y.

Protein Sci. 2008 Mar;17(3):389-400. doi: 10.1110/ps.073258108. Epub 2008 Jan 24.

45.
46.

A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.

Furumoto T, Tanaka A, Ito M, Malik S, Hirose Y, Hanaoka F, Ohkuma Y.

Genes Cells. 2007 Jan;12(1):119-32.

47.

Mitogenic activity of S100A9 (MRP-14).

Shibata F, Ito A, Ohkuma Y, Mitsui K.

Biol Pharm Bull. 2005 Dec;28(12):2312-4.

48.
49.

Studies of Schizosaccharomyces pombe TFIIE indicate conformational and functional changes in RNA polymerase II at transcription initiation.

Hayashi K, Watanabe T, Tanaka A, Furumoto T, Sato-Tsuchiya C, Kimura M, Yokoi M, Ishihama A, Hanaoka F, Ohkuma Y.

Genes Cells. 2005 Mar;10(3):207-24.

50.

Session 3 "Analyzer Workshop" evolution of therapeutic strategies in Parkinson's disease.

Yanagisawa N, Yamamoto M, Kikuchi S, Murata M, Ohkuma Y.

J Neurol. 2004 Oct;251 Suppl 7:vII24-30. No abstract available.

PMID:
15505751

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